NCT03866382 RECRUITING Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
National Cancer Institute (NCI)
NCT02675829 ACTIVE NOT RECRUITING Trial of Ado-Trastuzumab Emtansine for Patients With HER2 Amplified or Mutant Cancers
Memorial Sloan Kettering Cancer Center
NCT04068194 ACTIVE NOT RECRUITING Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies
National Cancer Institute (NCI)
NCT05335941 ACTIVE NOT RECRUITING A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial Carcinoma
M.D. Anderson Cancer Center
NCT07061964 RECRUITING Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial
National Cancer Institute (NCI)
NCT03375307 RECRUITING Testing Olaparib in Patients With Advanced or Metastatic (Cancer That Has Spread) Bladder Cancer and Other Genitourinary Tumors With DNA-Repair Genetic Changes
National Cancer Institute (NCI)
NCT03609216 RECRUITING Gemcitabine and Cisplatin Without Cystectomy for Patients With Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations
Alliance for Clinical Trials in Oncology
NCT05564403 ACTIVE NOT RECRUITING Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)
National Cancer Institute (NCI)
NCT03237780 ACTIVE NOT RECRUITING Atezolizumab With or Without Eribulin Mesylate in Treating Patients With Recurrent Locally Advanced or Metastatic Urothelial Cancer
National Cancer Institute (NCI)
NCT06770582 RECRUITING Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial
National Cancer Institute (NCI)
NCT03854474 ACTIVE NOT RECRUITING Testing the Addition of Tazemetostat to the Immunotherapy Drug, Pembrolizumab (MK-3475), in Advanced Urothelial Carcinoma
National Cancer Institute (NCI)
NCT04164082 ACTIVE NOT RECRUITING Testing the Addition of an Anti-cancer Drug, Pembrolizumab, to the Usual Intravesical Chemotherapy Treatment (Gemcitabine) for the Treatment of BCG-Unresponsive Non-muscle Invasive Bladder Cancer
National Cancer Institute (NCI)
NCT03047213 ACTIVE NOT RECRUITING Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations
National Cancer Institute (NCI)
NCT06434350 RECRUITING Enfortumab Vedotin With Radiation for Locally Advanced Bladder Cancer (CONSOLIDATE)
M.D. Anderson Cancer Center
NCT06047379 RECRUITING Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Neonc Technologies, Inc.
NCT04138628 ACTIVE NOT RECRUITING Treatment Of Metastatic Bladder Cancer at the Time Of Biochemical reLApse Following Radical Cystectomy
Jørgen Bjerggaard Jensen
NCT07232602 RECRUITING KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04)
Merck Sharp & Dohme LLC
NCT05644041 RECRUITING Intravesical Gem/Doce in Patients With NMIBC
University of Arizona
NCT06668493 RECRUITING Low-grade UTUC Treated With Nadofaragene Firadenovec Administered to Renal Pelvis
Ferring Pharmaceuticals
NCT05581589 RECRUITING Sacituzumab Govitecan Before Radical Cystectomy for the Treatment of Non-Urothelial Muscle Invasive Bladder Cancer
University of Washington
NCT04895709 RECRUITING A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors
Bristol-Myers Squibb
NCT06695845 RECRUITING A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
Jazz Pharmaceuticals
NCT06630416 RECRUITING Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors
Northwestern University
NCT06809140 RECRUITING Enfortumab Vedotin Plus Pembrolizumab With Selective Bladder Sparing for Treatment of Muscle-invasive Bladder Cancer
Matthew Galsky
NCT07222488 RECRUITING A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)
Merck Sharp & Dohme LLC
NCT07193511 RECRUITING BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)
Avenzo Therapeutics, Inc.
NCT07420517 NOT YET RECRUITING Dutasteride in Patients With Low-grade Non-muscle Invasive Bladder Cancer
Paul Toren
NCT07221942 RECRUITING Pembrolizumab Maintenance After Enfortumab Vedotin (EV)/Pembro Induction in Front-Line Metastatic Urothelial Carcinoma
Fox Chase Cancer Center
NCT07421700 NOT YET RECRUITING A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
Pfizer
NCT06637423 RECRUITING A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)
Merck Sharp & Dohme LLC
NCT05710848 RECRUITING A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer
SURGE Therapeutics
NCT04644068 ACTIVE NOT RECRUITING Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
AstraZeneca
NCT05239624 RECRUITING Enfortumab Vedotin and Pembrolizumab in People With Bladder Cancer
Memorial Sloan Kettering Cancer Center
NCT07146646 RECRUITING Trifluridine/Tipiracil + Oxaliplatin in Participants With Advanced or Metastatic Biliary Tract Cancer
Case Comprehensive Cancer Center
NCT04848519 ACTIVE NOT RECRUITING Immune Checkpoint Inhibitors With or Without Propranolol Hydrochloride In Patients With Urothelial Carcinoma
Emory University
NCT06470282 RECRUITING Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy in Muscle Invasive Bladder Cancer
University of California, San Francisco
NCT07410676 RECRUITING EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors
Essen Biotech
NCT05137262 ACTIVE NOT RECRUITING A Phase II Multicenter Study of Chemotherapy Versus Chemotherapy Plus Durvalumab (MEDI 4736) in Patients With Lymph Node Positive Urothelial Carcinoma of the Bladder
M.D. Anderson Cancer Center
NCT05562830 ACTIVE NOT RECRUITING A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)
Merck Sharp & Dohme LLC
NCT07030257 RECRUITING Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
Tasca Therapeutics
NCT06483334 ACTIVE NOT RECRUITING A Study of Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04)
Merck Sharp & Dohme LLC
NCT07412171 NOT YET RECRUITING NECTAR Study: Neoadjuvant Toripalimab + 9MW2821 for Local UTUC
Peking University Third Hospital
NCT06972615 NOT YET RECRUITING Intravesical Chemotherapy in Combination With Systemic Pembrolizumab in NMIBC Unresponsive or Exposed to BCG Therapy
BLATAM
NCT06503614 RECRUITING A Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancer
John Sfakianos
NCT05868265 RECRUITING A Study of Enfortumab Vedotin in People With Urothelial Carcinoma of the Upper Urinary Tract
Memorial Sloan Kettering Cancer Center
NCT07414992 NOT YET RECRUITING A Study of Radiation Therapy and Cemiplimab With or Without Fianlimab In People With Bladder Cancer
Memorial Sloan Kettering Cancer Center
NCT03520491 ACTIVE NOT RECRUITING A Study to Test the Safety of Immunotherapy With Nivolumab Alone or With Ipilimumab Before Surgery for Bladder Cancer Patients Who Are Not Suitable for Chemotherapy
Memorial Sloan Kettering Cancer Center
NCT04585750 RECRUITING The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
PMV Pharmaceuticals, Inc
NCT06534983 RECRUITING A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-risk Muscle-invasive Urothelial Carcinoma (MIUC)
Hoffmann-La Roche
NCT05775471 RECRUITING Pembrolizumab and Enfortumab Vedotin With Pembrolizumab Prior to and After Radical Nephroureterectomy for High-Risk Upper Tract Urothelial Cancer
Jonsson Comprehensive Cancer Center
NCT06567743 RECRUITING Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC
CG Oncology, Inc.
NCT07183319 RECRUITING Circulating Tumor DNA Response In Urothelial Cancer
University of Oklahoma
NCT03768570 ACTIVE NOT RECRUITING Trimodality Therapy With/Out Durvalumab to Treat Patients With Muscle-Invasive Bladder Cancer
Canadian Cancer Trials Group
NCT02365597 ACTIVE NOT RECRUITING An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
Janssen Research & Development, LLC
NCT05645692 ACTIVE NOT RECRUITING A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer
Hoffmann-La Roche
NCT05796375 RECRUITING Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance
White River Junction Veterans Affairs Medical Center
NCT07374549 NOT YET RECRUITING SYS6002 vs PADCEV in Patients With Advanced Urothelial Carcinoma
CSPC Megalith Biopharmaceutical Co.,Ltd.
NCT02690558 ACTIVE NOT RECRUITING Phase 2 Study of Pembrolizumab in Combination With Gemcitabine and Cisplatin as Neoadjuvant Therapy
UNC Lineberger Comprehensive Cancer Center
NCT06172478 RECRUITING A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Daiichi Sankyo
NCT05951179 RECRUITING Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer
Protara Therapeutics
NCT06733363 RECRUITING A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer
Roswell Park Cancer Institute
NCT04752722 RECRUITING LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve
enGene, Inc.
NCT05327530 ACTIVE NOT RECRUITING A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)
EMD Serono Research & Development Institute, Inc.
NCT04630730 ACTIVE NOT RECRUITING Intravesical Recombinant BCG Followed by Perioperative Chemo-immunotherapy for Patients With MIBC
Swiss Cancer Institute
NCT07283835 RECRUITING Study of Cretostimogene Given in Patients With Non-Muscle Invasive Bladder Cancer ,Unresponsive to Bacillus-Calmette-Guerin
Lepu Biopharma Co., Ltd.
NCT07265947 RECRUITING Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma
Tyra Biosciences, Inc
NCT07341737 NOT YET RECRUITING SL-28 for Advanced Solid Tumours
Second Life Therapeutics
NCT03228667 ACTIVE NOT RECRUITING QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
ImmunityBio, Inc.
NCT06305767 ACTIVE NOT RECRUITING A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)
Merck Sharp & Dohme LLC
NCT05651022 ACTIVE NOT RECRUITING Study of DECOY20 With or Without Tislelizumab in Patients With Advanced Solid Tumors
Indaptus Therapeutics, Inc
NCT05544552 ACTIVE NOT RECRUITING Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations
Tyra Biosciences, Inc
NCT07332351 NOT YET RECRUITING Neoadjuvant Intravesical Nadofaragene Firadenovec With Gemcitabine, Cisplatin and Durvalumab for the Treatment of Muscle Invasive Bladder Cancer, TRIFECTA Trial
University of Washington
NCT03744793 ACTIVE NOT RECRUITING Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer
M.D. Anderson Cancer Center
NCT05656235 RECRUITING Renal Retention in High Grade Upper Tract Urothelial Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT07322263 NOT YET RECRUITING Intravesical GEM/DOCE for HR BCG-Unresponsive NMIBC
Michael A. O'Donnell
NCT04879329 RECRUITING A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
Seagen, a wholly owned subsidiary of Pfizer
NCT03171025 ACTIVE NOT RECRUITING Adjuvant Nivolumab Following Chemo-Radiation in Localized Muscle-Invasive Bladder Cancer
University of Utah
NCT02989584 ACTIVE NOT RECRUITING A Phase II Study of Atezolizumab in Combination With Cisplatin + Gemcitabine Before Surgery to Remove the Bladder Cancer
Memorial Sloan Kettering Cancer Center
NCT07314723 RECRUITING 9MW2821 Combined With Toripalimab in Perioperative Patients With Urothelial Cancer
Mabwell (Shanghai) Bioscience Co., Ltd.
NCT07310069 ENROLLING BY INVITATION Gemcitabine and Nab-Paclitaxel Combined With Iparomlimab and Tuvorilimab for Advanced Gallbladder Cancer
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
NCT07307456 RECRUITING Tremelimumab Combined With BCG Perfusion for the Treatment of HR-NMIBC After TURBT Surgery Exploration
Changhai Hospital
NCT03473743 ACTIVE NOT RECRUITING A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer
Janssen Research & Development, LLC
NCT07185945 NOT YET RECRUITING Zanzalintinib for Advanced Urothelial Carcinoma Progressing After Prior Therapy
Guru Sonpavde
NCT07285044 RECRUITING The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
Mayo Clinic
NCT04940299 ACTIVE NOT RECRUITING Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma
M.D. Anderson Cancer Center
NCT07296705 RECRUITING Neoadjuvant Zanidatamab + Tislelizumab + Chemotherapy for Selective Bladder Preservation in HER2-Positive MIBC
Fujian Medical University Union Hospital
NCT07279597 NOT YET RECRUITING A Phase II Study of Toripalimab Plus RC48-ADC With Radiotherapy for Bladder Preservation in HER2-Positive Muscle-Invasive Bladder Cancer
Tongji Hospital
NCT06511648 RECRUITING Erdafitinib Monotherapy or in Combination With Cetrelimab in Muscle-invasive Bladder Cancer Patients With Fibroblast Growth Factor Receptor (FGFR ) Gene Alterations
Spanish Oncology Genito-Urinary Group
NCT05327647 RECRUITING A Phase II Trial of Bicalutamide in Patients Receiving Intravesical BCG for Non-muscle Invasive Bladder Cancer
CHU de Quebec-Universite Laval
NCT04198766 ACTIVE NOT RECRUITING Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
Inhibrx Biosciences, Inc
NCT07241793 RECRUITING Phase II Study of Trastuzumab Rezetecan or in Combination With Adebrelimab in HER2-Expressing Locally Advanced or Metastatic Urothelial Carcinoma (la/mUC)
Sun Yat-sen University
NCT07169734 RECRUITING A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
Alentis Therapeutics AG
NCT04863885 ACTIVE NOT RECRUITING Combination of Ipi/Nivo Plus Sacituzumab Govitecan in Metastatic Cisplatin Ineligible Urothelial Carcinoma Patients
H. Lee Moffitt Cancer Center and Research Institute
NCT06263153 RECRUITING Futibatinib in Combination With Durvalumab Prior to Cystectomy for the Treatment of Muscle-Invasive Bladder Cancer Patients Who Are Ineligible for Cisplatin-based Therapy
Yuanquan Yang
NCT06210490 RECRUITING A Clinical Study of the Efficacy and Safety of Disitamab Vedotin in Combination With Radiotherapy for the Adjuvant Treatment of HER2 Overexpressing UTUC Patients With High Risk Factors for Recurrence After Radical Surgery
Peking University First Hospital
NCT06059547 ACTIVE NOT RECRUITING Neoadjuvant Immunotherapy Combined With the Anti-GDF-15 Antibody Visugromab to Treat Muscle Invasive Bladder Cancer
CatalYm GmbH
NCT06943521 RECRUITING A Study of MT-4561 in Patients With Various Advanced Solid Tumors
Tanabe Pharma America, Inc.
NCT05912816 RECRUITING Combination of DV and Tislelizumab for Renal Preservation in High-risk UTUC Patients
RenJi Hospital
NCT07087860 RECRUITING Therapeutic Plasma Exchange With Enfortumab Vedotin and Pembrolizumab for Treatment of Bladder Cancers
Mayo Clinic
NCT06091124 RECRUITING Neoadjuvant Adebrelimab Plus Etoposide and Cisplatin in Neuroendocrine Bladder Carcinoma
RenJi Hospital
NCT07048457 RECRUITING Consolidative Local Therapy (CLT) in Oligo-metastatic Urothelial Carcinoma
Yale University
NCT06265285 RECRUITING Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
Mayo Clinic
NCT07261592 NOT YET RECRUITING Entinostat & Chemotherapy for Locally Advanced or Metastatic Bladder Cancer
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
NCT07259226 RECRUITING Optimal Methods to Characterize ADC Resistance in Solid Tumors and Identify Clinically Useful Biomarkers
UNICANCER
NCT07257718 NOT YET RECRUITING The Combined Role of FAPI PET and Liquid Biopsy in the Staging and Clinical Management of Bladder Cancer - FUTURE Trial
Chiti Arturo
NCT03945162 RECRUITING Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Muscle Invasive Bladder Cancer ("NMIBC") Patients
Theralase® Technologies Inc.
NCT05661955 ACTIVE NOT RECRUITING A Study to Investigate the Antitumor Activity, Safety, Tolerability, and Pharmacokinetics of BGB-A445 in Combination With Tislelizumab in Participants With Select Advanced Solid Tumors.
BeiGene
NCT04428554 RECRUITING Consolidative Radiotherapy for Metastatic Urothelial Bladder Cancer Patients Without Progression and With no More Than Three Residual Metastatic Lesions Following First Line Systemic Therapy
Institut Claudius Regaud
NCT03697850 ACTIVE NOT RECRUITING Atezolizumab After Chemo-radiotherapy for MIBC Patients Not Eligible for Radical Cystectomy
UNICANCER
NCT04180371 ACTIVE NOT RECRUITING Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
BicycleTx Limited
NCT04386746 ACTIVE NOT RECRUITING Intravesical Gemcitabine and Docetaxel for BCG naïve Non-muscle Invasive Bladder Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT06822010 NOT YET RECRUITING SeqUential GeMcitabine and MITomycin Treatment for Favorable High-Risk Upper Urinary Tract Urothelial Carcinoma
Rutgers, The State University of New Jersey
NCT06503146 RECRUITING 18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection
National Cancer Institute (NCI)
NCT04216290 ACTIVE NOT RECRUITING A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, INSPIRE Trial
National Cancer Institute (NCI)
NCT03288545 ACTIVE NOT RECRUITING A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer
Astellas Pharma Global Development, Inc.
NCT02420847 ACTIVE NOT RECRUITING Ixazomib Citrate With Gemcitabine Hydrochloride and Doxorubicin Hydrochloride in Treating Patients With Urothelial Cancer That is Metastatic or Cannot Be Removed by Surgery
M.D. Anderson Cancer Center
NCT03504163 ACTIVE NOT RECRUITING Pembrolizumab (MK-3475) and Bacillus Calmette-Guérin (BCG) as First-Line Treatment for High-Risk T1 Non-Muscle-Invasive Bladder Cancer (NMIBC) and High-Grade Non-Muscle-Invasive Upper Tract Urothelial Carcinoma (NMI-UTUC)]
Memorial Sloan Kettering Cancer Center
NCT07225374 RECRUITING Cisplatin-Based Chemotherapy Followed by Maintenance Avelumab in UTUC
Samsung Medical Center
NCT04724018 RECRUITING Sacituzumab Govitecan Plus EV in Metastatic UC
Dana-Farber Cancer Institute
NCT05923190 RECRUITING Enfortumab Vedotin Schedule De-escalation in Metastatic Urothelial Carcinoma
Fox Chase Cancer Center
NCT05241340 ACTIVE NOT RECRUITING Neoadjuvant Sasanlimab With Radiation as an in Situ Vaccine for Cisplatin-ineligible Muscle Invasive Bladder Cancer
The Methodist Hospital Research Institute
NCT05706129 RECRUITING A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors
ITM Oncologics GmbH
NCT06829823 NOT YET RECRUITING Clinical Trial of Ablation Therapy in Participants With Intermediate-Risk Non-Muscle Invasive Papillary Bladder Cancer
ImmunityBio, Inc.
NCT03978624 ACTIVE NOT RECRUITING Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer
UNC Lineberger Comprehensive Cancer Center
NCT06814496 RECRUITING Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors
University of Arizona
NCT04953104 ACTIVE NOT RECRUITING ARID1A and/or KDM6A Mutation and CXCL13 Expression
M.D. Anderson Cancer Center
NCT02621151 ACTIVE NOT RECRUITING Pembrolizumab (MK3475), Gemcitabine, and Concurrent Hypofractionated Radiation Therapy for Muscle-Invasive Urothelial Cancer of the Bladder
NYU Langone Health
NCT03693014 ACTIVE NOT RECRUITING A Study of Several Radiation Doses for Patients With Progression on Immunotherapy/Checkpoint Inhibitors
Memorial Sloan Kettering Cancer Center
NCT03915678 RECRUITING Atezolizumab Combined With BDB001 AnD Immunogenic Radiotherapy in Patients With Advanced Solid Tumors
Institut Bergonié
NCT05296564 RECRUITING Anti-NY-ESO-1 TCR-Gene Engineered Lymphocytes Given by Infusion to Patients With NY-ESO-1 -Expressing Metastatic Cancers
Hadassah Medical Organization
NCT07201675 NOT YET RECRUITING Vedisertib (RC48/ADC) Combined With Toripalimab in Bladder-preserving Treatment
Qilu Hospital of Shandong University
NCT05965856 RECRUITING A Study of SI-B003 and BL-B01D1+SI-B003 in Patients With Locally Advanced or Metastatic Urothelial Carcinoma and Other Solid Tumors
Sichuan Baili Pharmaceutical Co., Ltd.
NCT07189793 NOT YET RECRUITING Toripalimab ± Sequential Intravesical Gemcitabine-Mitomycin C for BCG-Unresponsive/-Intolerant High-Risk NMIBC: Open-Label Randomized Phase 2 Study
First Affiliated Hospital of Wenzhou Medical University
NCT05219435 ACTIVE NOT RECRUITING Study of NIVOLUMAB/IPILIMUMAB Maintenance in Unresectable Locally Advanced or Metastatic Urothelial Cancer
Spanish Oncology Genito-Urinary Group
NCT04678362 RECRUITING TALazoparib and Avelumab as Maintenance Therapy in Platinum-Sensitive Metastatic or Locally Advanced URothelial Carcinoma
Centre Francois Baclesse
NCT06704191 RECRUITING In-home Intravesical Chemotherapy for the Treatment of Bladder Cancer, INVITE Trial
Mayo Clinic
NCT07184021 NOT YET RECRUITING Neoadjuvent Dose-dense Gemcitabine and Cisplatin In Muscle Invasive Bladder Cancer
Assiut University
NCT06184516 RECRUITING Assessment of Decision Tool to Select Women for Gynecologic Sparing Radical Cystectomy
University of Florida
NCT06394570 RECRUITING Enfortumab Vedotin and Stereotactic Radiation for Localized, Cisplatin Ineligible Muscle Invasive Bladder Cancer
University of Texas Southwestern Medical Center
NCT06388720 RECRUITING The Clinical Effectiveness and Safety of Intravesical Mitomycin-C and Gemcitabine Sequential Therapy
National Cancer Center, Korea
NCT05845814 ACTIVE NOT RECRUITING A Study of Efficacy and Safety of Pembrolizumab Plus Enfortumab Vedotin (EV) +/- Investigational Agents in First-Line Metastatic Urothelial Carcinoma (mUC) (MK-3475-04B/KEYMAKER-U04)
Merck Sharp & Dohme LLC
NCT04917809 ACTIVE NOT RECRUITING A Study of Oral Erdafitinib in People With Recurrent Non-Invasive Bladder Cancer
Memorial Sloan Kettering Cancer Center
NCT03185468 RECRUITING Intervention of Bladder Cancer by CAR-T
Shenzhen Geno-Immune Medical Institute
NCT04977453 RECRUITING GI-101 as a Single Agent or in Combination With Pembrolizumab, Lenvatinib or Local Radiotherapy in Advanced Solid Tumors
GI Innovation, Inc.
NCT05318573 ACTIVE NOT RECRUITING A Study to Evaluate Safety, Efficacy of FF-10832 in Combo With Pembrolizumab in Urothelial & Non-small Cell Lung Cancer
Fujifilm Pharmaceuticals U.S.A., Inc.
NCT06571708 RECRUITING Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT)
Columbia University
NCT05879653 RECRUITING Pembrolizumab and EV With Radiation Therapy for MIBC Patients (PEVRAD)
Kyoto University Hospital
NCT06683846 RECRUITING Ivonescimab in the Treatment of Multiple Advanced Tumors
Fudan University
NCT07126119 RECRUITING Neoadjuvant Tislelizumab in Combination With Nab-Paclitaxel for UTUC
Tianjin Medical University Second Hospital
NCT05864144 ACTIVE NOT RECRUITING A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors
Sensei Biotherapeutics, Inc.
NCT06983210 RECRUITING Clinical Trial of AM80 in Combination With Gemcitabine, Cisplatin, and Nivolumab in Patients With Urothelial Carcinoma
Nagoya University
NCT07122414 RECRUITING A Study of Intravesical FL115 Alone or in Combination With BCG in Non-Muscle Invasive Bladder Cancer
Suzhou Forlong Biotechnology Co., Ltd
NCT06632951 ACTIVE NOT RECRUITING Study to Evaluate Adverse Events and Change in Disease Activity When Intravenously (IV) Infused Livmoniplimab is Used in Combination With IV Infused Budigalimab in Adult Participants With Urothelial Carcinoma (UC)
AbbVie
NCT06364956 RECRUITING Clinical Trail of Neoadjuvant of Tislelizumab Combined With Palbociclib in Patients With Platinum-refractory Bladder Urothelial Carcinoma
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
NCT05057013 ACTIVE NOT RECRUITING A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
Cancer Research UK
NCT06356155 RECRUITING Study of Neoadjuvant Enfortumab Vedotin and Pembrolizumab in Cisplatin-eligible Upper Tract Urothelial Cancer
University of Michigan Rogel Cancer Center
NCT05756569 RECRUITING Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology
Emory University
NCT06971614 RECRUITING A Study of T3011 in Patients With BCG-Unresponsive NMIBC or BCG-Exposed, Chemotherapy-Unresponsive NMIBC
ImmVira Pharma Co. Ltd
NCT07043972 RECRUITING Gemcitabine and Carboplatin After Progression on Enfortumab Vedotin and Pembrolizumab in Advanced/Metastatic Urothelial Carcinoma
Fox Chase Cancer Center
NCT07064863 NOT YET RECRUITING A Tumor Immune Biomarker Guided Approach for Improving Response to BCG in Patients With High-risk NMIBC.
Queen's University
NCT02845323 ACTIVE NOT RECRUITING Neoadjuvant Nivolumab With and Without Urelumab in Cisplatin-Ineligible or Chemotherapy-refusing Patients With Muscle-Invasive Urothelial Carcinoma of the Bladder
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT05489211 RECRUITING Study of Dato-Dxd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
AstraZeneca
NCT07050771 NOT YET RECRUITING Comprehensive Multimodal Prehabilitation Alone or With Neoadjuvant Therapy Before Major Cancer Surgery
The Methodist Hospital Research Institute
NCT05086692 RECRUITING A Beta-only IL-2 ImmunoTherapY Study
Medicenna Therapeutics, Inc.
NCT05312671 RECRUITING Atezolizumab Plus Etoposide and Platinum in Small Cell Bladder Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT07034053 RECRUITING Clofarabine Therapy in Locally Advanced or Metastatic Urothelial Carcinoma
Ekaterina Laukhtina
NCT07025174 RECRUITING Sequential Anti-Angiogenic Therapy After Immunotherapy in Advanced Biliary Tract Cancer
First Affiliated Hospital of Zhejiang University
NCT04179162 ACTIVE NOT RECRUITING Bacillus Calmette-Guérin (BCG) and Gemcitabine in People With High-Grade Non-Muscle Invasive Bladder Cancer That Came Back After BCG Treatment
Memorial Sloan Kettering Cancer Center
NCT06663137 RECRUITING Open Label Study to Evaluate the Safety and Efficacy of NDV01 KIT in High Grade NMIBC
Relmada Therapeutics, Inc.
NCT05406713 ACTIVE NOT RECRUITING Pembrolizumab in Muscle-invasive Bladder Cancer
Matthew Galsky
NCT05712356 ACTIVE NOT RECRUITING A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors
Lisata Therapeutics, Inc.
NCT03682289 RECRUITING Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors
Rahul Aggarwal
NCT02717156 ACTIVE NOT RECRUITING Multicohort Phase II Trial of sEphB4-HSA+Pembrolizumab in Solid Tumors
University of Southern California
NCT05226117 RECRUITING Sacituzumab Govitecan, Preceding Radical Cystectomy, in Treating Patients With Muscle-invasive Bladder Cancer
IRCCS San Raffaele
NCT04140526 ACTIVE NOT RECRUITING Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
OncoC4, Inc.
NCT04941287 ACTIVE NOT RECRUITING Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Addition of a Third Anti-cancer Drug, Cobimetinib, for Advanced-Stage Biliary Tract Cancer
National Cancer Institute (NCI)
NCT04152499 ACTIVE NOT RECRUITING Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)
Klus Pharma Inc.
NCT04375813 RECRUITING Trial of Encapsulated Rapamycin (eRapa) for Bladder Cancer Prevention
Robert Svatek
NCT06963060 ENROLLING BY INVITATION Gem+Nab-P+LEN+TIS for Advanced Unresectable BTC (GALENT-BT)
Wei Gong
NCT06405425 RECRUITING A Study of BL-B01D1 + PD-1 in Patients With Locally Advanced or Metastatic Urothelial Carcinoma
Sichuan Baili Pharmaceutical Co., Ltd.
NCT06957561 NOT YET RECRUITING Disitamab Vedotin Combined With Ivonescimab in Cisplatin-Ineligible Muscle-Invasive Bladder Cancer
Sun Yat-sen University
NCT06948552 NOT YET RECRUITING Photodynamic Diagnosis of Upper Tract Urothelial Carcinoma Using Fluorescence Endoscopy and Oral 5-ALA
Henry Ford Health System
NCT03093922 ACTIVE NOT RECRUITING A Study of Two Dosing Schedules of Atezolizumab in Combination With Gemcitabine and Cisplatin as First-Line Treatment for Metastatic Bladder Cancer
Memorial Sloan Kettering Cancer Center
NCT03547973 RECRUITING Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread
Gilead Sciences
NCT03601455 ACTIVE NOT RECRUITING Radiation Therapy and Durvalumab With or Without Tremelimumab in Treating Participants With Unresectable, Locally Advanced, or Metastatic Bladder Cancer
Jonsson Comprehensive Cancer Center
NCT06257017 RECRUITING Surveillance of the Genetic Signature in Circulating Tumor DNA for Guiding Adjuvant Chemotherapy in Urothelial Carcinoma
Yung NA
NCT05535218 ACTIVE NOT RECRUITING Pembrolizumab-Sacituzumab Govitecan Combination to Treat High-risk, Localized Bladder Cancer
Claudia Guerrieri
NCT06904573 RECRUITING Probiotics in Advanced Urothelial Carcinoma
Sun Yat-sen University
NCT06682728 RECRUITING Adjuvant Sacituzumab Govitecan and Nivolumab in Muscle-Invasive Urothelial Carcinoma At High-Risk Recurrence
University of California, Irvine
NCT04046094 ACTIVE NOT RECRUITING Intravenous (IV) Vitamin C With Chemotherapy for Cisplatin Ineligible Bladder Cancer Patients
University of Kansas Medical Center
NCT05101096 ACTIVE NOT RECRUITING Study of Sacituzumab Govitecan (SG) in Japanese Participants With Advanced Solid Tumors
Gilead Sciences
NCT06823427 RECRUITING 9MW2821 + Toripalimab vs 9MW2821 for 1st Line Locally Advanced or Metastatic Urothelial Carcinoma
Mabwell (Shanghai) Bioscience Co., Ltd.
NCT04802876 ACTIVE NOT RECRUITING Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors
SOLTI Breast Cancer Research Group
NCT05024734 RECRUITING Guiding Instillation in Non Muscle-invasive Bladder Cancer Based on Drug Screens in Patient Derived Organoids
Roland Seiler-Blarer
NCT06488222 RECRUITING Intravesical Gemcitabine and Docetaxel for Low Grade Intermediate Risk Bladder Cancer
University of Florida
NCT06852287 RECRUITING Phase II Clinical Study of GemOX Hepatic Arterial Infusion Combined with Lenvatinib and Toripalimab for Advanced and Unresectable Intrahepatic Cholangiocarcinoma and Gallbladder Cancer
Tianjin Medical University Cancer Institute and Hospital
NCT06528990 RECRUITING Telehealth Intervention for Ostomy Self-Management
City of Hope Medical Center
NCT06493370 RECRUITING Intravenous Ascorbate Plus Gemcitabine/Carboplatin: A Novel and Cost-Effective Alternative With Evident Efficacy in Patients With Muscle Invasive Bladder Cancer
University of Kansas Medical Center
NCT04114136 RECRUITING Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies
Dan Zandberg
NCT06686381 NOT YET RECRUITING Tetra-modality Bladder Preservation Strategies in Muscle-invasive Bladder Cancer: TURBT+ Chemo/Immunotherapy+ Radiation Therapy+ Maintenance Immunotherapy vs. W&W
American University of Beirut Medical Center
NCT03317158 RECRUITING Modern Immunotherapy in BCG-Unresponsive, BCG-Relapsing and High Risk BCG-Naive Non-Muscle Invasive Urothelial Carcinoma of the Bladder
Noah Hahn, M.D.
NCT04308174 ACTIVE NOT RECRUITING Neoadjuvant Gemcitabine Plus Cisplatin With or Without Durvalumab in Resectable Biliary Tract Cancer
Asan Medical Center
NCT04902872 ACTIVE NOT RECRUITING Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors
Cybrexa Therapeutics
NCT05917158 RECRUITING A Study of RC48-ADC Combined with JS001 for Postoperative Adjuvant Treatment of Upper Tract Urothelial Carcinoma
Jinling Hospital, China
NCT06732531 RECRUITING Safety, Tolerability, and Preliminary Efficacy of BH011 in Subjects With Non-Muscle-Invasive Bladder Cancer
Zhuhai Beihai Biotech Co., Ltd
NCT02710734 ACTIVE NOT RECRUITING Risk Enabled Therapy After Initiating Neoadjuvant Chemotherapy for Bladder Cancer (RETAIN)
Fox Chase Cancer Center
NCT06717464 ACTIVE NOT RECRUITING Toripalimab Combined With Capecitabine as Postoperative Adjuvant Therapy for Patients With Resectable Advanced Extrahepatic Biliary Tract Cancer
Tianjin Medical University Cancer Institute and Hospital
NCT04289779 ACTIVE NOT RECRUITING Study of CAbozantinib in Combination with AtezolizumaB for Muscle-Invasive BladdEr Cancer
Deepak Kilari
NCT06341400 RECRUITING RC48 Combined with Toripalimab As Neoadjuvant Therapy for Cisplatin Ineligible MIBC Patients
Zhujiang Hospital
NCT04106115 RECRUITING DURvalumab in Combination With S-488210/S-488211 vAccine in Non-muscle Invasive Bladder CancEr
University College, London
NCT04562311 ACTIVE NOT RECRUITING Chidamide With Immunotherapy for Patients With Locally Advanced or Metastatic Urothelial Carcinoma
Sun Yat-sen University
NCT04861584 RECRUITING Neoadjuvant Toripalimab in Combination with Gemcitabine and Cisplatin Therapy in Local Advanced Bladder Cancer Subjects
Zhujiang Hospital
NCT06632262 RECRUITING A Phase 2 Clinical Study of ABSK061 and ABSK043
Abbisko Therapeutics Co, Ltd
NCT06639347 RECRUITING A Trial of SHR-A2102 With Antitumor Therapy in Advanced Urothelial Carcinoma
Shanghai Hengrui Pharmaceutical Co., Ltd.
NCT05620134 ACTIVE NOT RECRUITING Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer
Salubris Biotherapeutics Inc
NCT06623162 NOT YET RECRUITING Sasanlimab As Maintenance Treatment Based on Clinical Response to Neoadjuvant Treatment in Molecularly Categorized Muscle Invasive Bladder Cancer Patients
Fundación de investigación HM
NCT06591650 NOT YET RECRUITING Gemcitabine Hydrochloride, Cisplatin, Nab-Paclitaxel, and Durvalumab in Treating Patients with Locally Advanced or Metastatic Gallbladder Cancer
Fudan University
NCT06079112 RECRUITING 9MW2821 Combined With Toripalimab Injection in Subjects With Local Advanced or Metastatic Urothelial Cancer
Mabwell (Shanghai) Bioscience Co., Ltd.
NCT05229614 RECRUITING Immunotherapy and Carbon Ion Radiotherapy In Solid Cancers With Stable Disease
CNAO National Center of Oncological Hadrontherapy
NCT06551896 NOT YET RECRUITING Pemigatinib and Immune Checkpoint Inhibitor Treated FGFR1/2/3 Alteration Advanced Solid Tumor
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
NCT05232136 RECRUITING OH2 Oncolytic Viral Therapy in Non-Muscle-Invasive Bladder Cancer
Binhui Biopharmaceutical Co., Ltd.
NCT06528483 NOT YET RECRUITING Bladder Preservation With Sacituzumab Govitecan + Zimberelimab for Muscle-Invasive Bladder Cancer
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
NCT05077709 ACTIVE NOT RECRUITING IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBC
IO Biotech
NCT06310369 NOT YET RECRUITING Radiotherapy for BCG-unresponsive Non-muscle-invasive Carcinoma in Situ (CIS) Bladder Cancer
European Organisation for Research and Treatment of Cancer - EORTC
NCT05531123 RECRUITING Risk-stratification Based Bladder-sparing Modalities for Muscle-invasive Bladder Cancer
Fudan University
NCT06187506 RECRUITING Disitamab Vedotin Combined With BCG Therapy in HER2-expressing High-risk Non-muscle Invasive Bladder Cancer
Fudan University
NCT06378242 RECRUITING To Evaluate the Safety, Efficacy, and Pharmacokinetics of Intravesical Instiliations of Disitamab Vedotin in Patients With High-risk Non-muscular Invasive Bladder Cancer (NMIBC) That Express HER2
RemeGen Co., Ltd.
NCT05269381 RECRUITING Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors
Mayo Clinic
NCT06423170 RECRUITING A Single-arm Phase II Clinical Study of the Efficacy and Safety of Camrelizumab Combined With GEMOX for Unresectable GBCs
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
NCT04486781 RECRUITING A Study of Pembrolizumab+ sEphB4 in Metastatic Urothelial Carcinoma
Vasgene Therapeutics, Inc
NCT06354231 RECRUITING DV Combined With Toripalimab for Renal Preservation in Solitary Kidney or Renal Insufficiency or Bilateral Multiple UTUC
Fudan University
NCT05200988 ACTIVE NOT RECRUITING Checkpoint Inhibition and Chemoradiotherapy as Bladder Sparing Treatment in UC
The Netherlands Cancer Institute
NCT03549715 ACTIVE NOT RECRUITING NEoadjuvant Dose-dense MVAC In cOmbination With Durvalumab and Tremelimumab in Muscle-invasive Urothelial Carcinoma
Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie
NCT06022757 RECRUITING Study of XNW5004 Tablet in Combination With KEYTRUDA® (Pembrolizumab) in Subjects With Advanced Solid Tumors Who Failed Standard Treatments (KEYNOTE F19)
Evopoint Biosciences Inc.
NCT06255964 NOT YET RECRUITING A Study of IAP0971 in Combination With Bacillus Calmette Guerin in High Risk Non-muscular Invasive Bladder Cancer
SUNHO(China)BioPharmaceutical CO., Ltd.
NCT06227065 NOT YET RECRUITING Precise Neoadjuvant Chemoresection of Low Grade NMIBC
University of Bern
NCT06178601 RECRUITING A Study of RC48-ADC Combined With Cadonilimab(AK104)in the Treatment of HER2-expression Locally Advanced or Metastatic Urothelial Carcinoma
Shanxi Province Cancer Hospital
NCT03379909 RECRUITING Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT05600127 RECRUITING Chemotherapy and Sequential Immunotherapy for Locally Advanced Urothelial Cancer
Erasmus Medical Center
NCT05957757 RECRUITING RC48 Combined With Tislelizumab for Bladder Sparing Treatment in NMIBC With BCG Treatment Failure and HER2 Expression
RenJi Hospital
NCT05996952 NOT YET RECRUITING RC48-ADC in Adjuvant/Salvage Treatment of HER2 Positive Non-muscle-invasive Bladder Cancer
West China Hospital
NCT05919095 NOT YET RECRUITING A Clinical Study of a Preoperative Translational Therapy for Unresectable Gallbladder Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
NCT05912205 NOT YET RECRUITING Disitamab Vedotin Combined With Radiotherapy for Bladder Preservation
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT04617756 RECRUITING Safety & Efficacy of Durvalumab+Neoadjuvant Chemotherapy for High-risk Urothelial Carcinoma of the Upper Urinary Tract
Centre Hospitalier Universitaire de Nīmes
NCT05733000 RECRUITING CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors
Northwestern University
NCT05757336 RECRUITING Combination of Gemcitabine, Albumin-paclitaxel , Sintilimab and Bevacizumab in Unresectable Gallbladder Cancer
Lu Wang, MD, PhD
NCT04186013 ACTIVE NOT RECRUITING Efficacy of Atezolizumab Concurrent With Radiotherapy in Patients With Muscle-invasive Bladder cáncer
Spanish Oncology Genito-Urinary Group
NCT03844256 RECRUITING A Study of Mitomycin-c/ Capecitabine ChemoRadiotherapy Combined With Nivolumab Monotherapy or Ipilumimab and Nivolumab, as Bladder Sparing Curative Treatment for Muscle Invasive Bladder Cancer: the CRIMI Study
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT03836352 ACTIVE NOT RECRUITING Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors
ImmunoVaccine Technologies, Inc. (IMV Inc.)
NCT05072600 RECRUITING Pembrolizumab Monotherapy Following Tri-modality Treatment for Selected Patients With Muscle-invasive Bladder Cancer
Peking University First Hospital
NCT03179943 ACTIVE NOT RECRUITING Atezolizumab + Guadecitabine in Patients With Checkpoint Inhibitor Refractory or Resistant Urothelial Carcinoma
Fox Chase Cancer Center
NCT02447549 ACTIVE NOT RECRUITING Study of Tumour Focused Radiotherapy for Bladder Cancer
Institute of Cancer Research, United Kingdom
NCT06171789 TERMINATED PRO1107 in Patients With Advanced Solid Tumors
Genmab
NCT04426669 COMPLETED A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering
Intima Bioscience, Inc.
NCT05000294 SUSPENDED Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types
University of Florida
NCT04856189 TERMINATED Selinexor and Pembrolizumab for the Treatment of Cisplatin-Ineligible or Cisplatin-Refractory Locally Advanced or Metastatic Urothelial Carcinoma
Mamta Parikh
NCT03869190 COMPLETED Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)
Hoffmann-La Roche
NCT04701918 COMPLETED Cryoablation With Pembrolizumab Or Avelumab In Urothelial Carcinoma
Massachusetts General Hospital
NCT05512377 COMPLETED Brightline-2: A Study to Test Whether Brigimadlin (BI 907828) Helps People With Cancer in the Biliary Tract, Pancreas, Lung or Bladder
Boehringer Ingelheim
NCT04260802 TERMINATED A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers
Ocellaris Pharma, Inc.
NCT04553939 COMPLETED Neoadjuvant Toripalimab in Combination With Gemcitabine Therapy in Cisplatin Ineligible Local Advanved Bladder Cancer
Henan Cancer Hospital
NCT04601857 TERMINATED Futibatinib and Pembrolizumab Combination in the Treatment of Advanced or Metastatic Urothelial Carcinoma
Taiho Oncology, Inc.
NCT04779151 TERMINATED Basket Trial Exploring the Efficacy and Safety of the Combination of Niraparib and Dostarlimab
Gustave Roussy, Cancer Campus, Grand Paris
NCT02625961 COMPLETED Study of Pembrolizumab (MK-3475) and Pembrolizumab With Other Investigational Agents in Participants With High Risk Non-muscle Invasive Bladder Cancer (MK-3475-057/KEYNOTE-057)
Merck Sharp & Dohme LLC
NCT02316548 TERMINATED Surgery With or Without Postoperative Intensity Modulated Radiation Therapy in Treating Patients With Urothelial Bladder Cancer
NRG Oncology
NCT04003610 TERMINATED Pemigatinib + Pembrolizumab vs Pemigatinib Alone vs Standard of Care for Urothelial Carcinoma (FIGHT-205)
Incyte Corporation
NCT03747419 TERMINATED Avelumab and Radiation in Muscle-Invasive Bladder Cancer
Dana-Farber Cancer Institute
NCT04586244 TERMINATED An Umbrella Study to Determine the Safety and Efficacy of Various Monotherapy or Combination Therapies in Neoadjuvant Urothelial Carcinoma
Incyte Corporation
NCT05564416 WITHDRAWN Testing Anti-Cancer Drugs Erdafitinib With or Without Atezolizumab in Patients With Localized Bladder Cancer Not Able to Receive Cisplatin Chemotherapy, NERA Trial
National Cancer Institute (NCI)
NCT04995419 COMPLETED A Study to Evaluate Enfortumab Vedotin (ASG-22CE) in Chinese Participants With Locally Advanced or Metastatic Urothelial Cancer Who Previously Received Platinum-containing Chemotherapy and Programmed Cell Death Protein-1 ( PD 1) / (Programmed Death Ligand-1 (PD-L1) Inhibitor Therapy
Astellas Pharma China, Inc.
NCT03914794 COMPLETED A Study of Pemigatinib in Non-muscle Invasive Bladder Cancer Patients With Recurrent Low- or Intermediate-Risk Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT04985604 TERMINATED Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors
Day One Biopharmaceuticals, Inc.
NCT04383743 COMPLETED Pembrolizumab and Combination Chemotherapy Before Surgery for the Treatment of Muscle-Invasive Bladder Cancer
University of Washington
NCT04887831 TERMINATED Trilaciclib, a CDK 4/6 Inhibitor, in Patients With Advanced/Metastatic Bladder Cancer Receiving Chemotherapy Then Avelumab
G1 Therapeutics, Inc.
NCT05259696 COMPLETED Glycan Mediated Immune Regulation With a Bi-Sialidase Fusion Protein (GLIMMER-01)
Palleon Pharmaceuticals, Inc.
NCT04936230 TERMINATED Immunotherapy With or Without Radiation Therapy for Metastatic Urothelial Cancer
National Cancer Institute (NCI)
NCT02872714 COMPLETED A Study to Evaluate the Efficacy and Safety of Pemigatinib (INCB054828) in Subjects With Urothelial Carcinoma - (FIGHT-201)
Incyte Corporation
NCT04570410 COMPLETED Primary Excision Combined With Preoperative Neoadjuvant and Adjuvant Therapy for Oligometastasis of Urothelial Carcinoma
The First Affiliated Hospital with Nanjing Medical University
NCT02769962 COMPLETED Trial of EP0057, a Nanoparticle Camptothecin With Olaparib in People With Relapsed/Refractory Small Cell Lung Cancer
National Cancer Institute (NCI)
NCT02553642 COMPLETED Relationship Between Tumor Mutation Burden and Predicted Neo-antigen Burden in Patients With Advanced Melanoma or Bladder Cancer Treated With Nivolumab or Nivolumab Plus Ipilimumab (CA209-260)
Memorial Sloan Kettering Cancer Center
NCT05714553 TERMINATED NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours
NuCana plc
NCT03502785 COMPLETED INO-5401 + INO-9012 in Combination With Atezolizumab in Locally Advanced Unresectable or Metastatic/Recurrent Urothelial Carcinoma
Inovio Pharmaceuticals
NCT05563272 TERMINATED 89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors
Telix Pharmaceuticals (Innovations) Pty Ltd
NCT03081858 COMPLETED Proliposomal Intravesical Paclitaxel for Treatment of Low-Grade, Stage Ta, Non Muscle Invasive Bladder Cancer
Lipac Oncology LLC
NCT05687721 WITHDRAWN Copanlisib and Avelumab as a Maintenance Therapy for Advanced Bladder Cancer
VA Office of Research and Development
NCT05253053 COMPLETED To Evaluate Efficacy and Safety of TT-00420 (Tinengotinib) as Monotherapy and Combination Therapy in Patients With Advanced Solid Tumors
TransThera Sciences (Nanjing), Inc.
NCT04902040 TERMINATED Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies
M.D. Anderson Cancer Center
NCT04068896 COMPLETED Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy
NGM Biopharmaceuticals, Inc
NCT02844816 COMPLETED Atezolizumab in Treating Patients With Recurrent BCG-Unresponsive Non-muscle Invasive Bladder Cancer
National Cancer Institute (NCI)
NCT04383938 COMPLETED Phase 1/2 Study of APR-246 in Combination With Pembrolizumab in Subjects With Solid Tumor Malignancies
Aprea Therapeutics
NCT03406650 COMPLETED Neoadjuvant and Adjuvant Durvalumab in Combination With Neoadjuvant Chemotherapy in Patients With Operable Urothelial Cancer.
Swiss Cancer Institute
NCT02122172 TERMINATED Afatinib in Advanced Refractory Urothelial Cancer
University of Chicago
NCT04602078 COMPLETED Study of Atezolizumab Combined With Split-dose Gemcitabine Plus Cisplatin in Urothelial Carcinoma
Spanish Oncology Genito-Urinary Group
NCT04294277 TERMINATED Safety and Efficacy of Pemigatinib in Patients With High-risk Urothelial Cancer After Radical Surgery
European Association of Urology Research Foundation
NCT04383210 TERMINATED Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors
Elevation Oncology
NCT02365766 COMPLETED Neoadjuvant Pembrolizumab in Combination With Gemcitabine Therapy in Cis-eligible/Ineligible UC Subjects
Jason R. Brown
NCT04629339 TERMINATED Study of INCB086550 in Select Solid Tumors
Incyte Corporation
NCT02662309 COMPLETED Preoperative MPDL3280A in Transitional Cell Carcinoma of the Bladder
Queen Mary University of London
NCT03871036 COMPLETED Improve Checkpoint-blockade Response in Advanced Urothelial Cancer
The Netherlands Cancer Institute
NCT02567409 COMPLETED Cisplatin and Gemcitabine Hydrochloride With or Without Berzosertib in Treating Patients With Metastatic Urothelial Cancer
National Cancer Institute (NCI)
NCT05126433 TERMINATED Lurbinectedin Monotherapy in Participants With Advanced or Metastatic Solid Tumors
Jazz Pharmaceuticals
NCT03674424 COMPLETED Avelumab as Neoadjuvant Therapy in Subjects With Urothelial Muscle Invasive Bladder Cancers (AURA Trial)
Jules Bordet Institute
NCT04322643 TERMINATED Intermittent Checkpoint Inhibitor Therapy In Patients With Advanced Urothelial Carcinoma
Case Comprehensive Cancer Center
NCT03197571 WITHDRAWN QUILT-3.048: NANT Urothelial Cancer Vaccine: Combination Immunotherapy in Subjects With Urothelial Cancer Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy
ImmunityBio, Inc.
NCT03190174 COMPLETED Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers
Sarcoma Oncology Research Center, LLC
NCT04666688 COMPLETED LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors
PureTech
NCT01489813 COMPLETED Study of Genistein in Reducing Side Effects of Superficial Bladder Cancer Treatment
Emory University
NCT02662062 COMPLETED Pembrolizumab With Chemoradiotherapy as Treatment for Muscle Invasive Bladder Cancer
Australian and New Zealand Urogenital and Prostate Cancer Trials Group
NCT03240016 COMPLETED Abraxane With Anti-PD1/PDL1 in Patients With Advanced Urothelial Cancer
University of Michigan Rogel Cancer Center
NCT03272217 TERMINATED Atezolizumab With Bevacizumab in Previously Untreated Metastatic/Unresectable Urothelial Cancer
Arjun Balar, MD
NCT04228042 TERMINATED Infigratinib Before Surgery for the Treatment of Upper Tract Urothelial Cancer
M.D. Anderson Cancer Center
NCT03425201 COMPLETED Niraparib in Combination with Cabozantinib (XL184) in Patients with Advanced Urothelial Cancer (NICARAGUA)
Fundacion CRIS de Investigación para Vencer el Cáncer
NCT04871529 TERMINATED Testing the Addition of an Anti-Cancer Immunotherapy Drug, Avelumab, to Gemcitabine and Carboplatin Chemotherapy Prior to Surgery in Muscle Invasive Urinary Tract Cancer vs. Surgery Alone in Patients Who Are Not Able to Receive Cisplatin Therapy (SWOG GAP TRIAL)
SWOG Cancer Research Network
NCT04064190 WITHDRAWN Vactosertib with Durvalumab in Urothelial Carcinoma Failing Checkpoint Inhibition
MedPacto, Inc.
NCT03702179 COMPLETED Durvalumab Plus Tremelimumab With Concurrent Radiotherapy for Localized Muscle Invasive Bladder Cancer Treated With a Selective Bladder Preservation Approach
Spanish Oncology Genito-Urinary Group
NCT02891161 TERMINATED Durvalumab And Radiation Therapy Followed by Adjuvant Durvalumab in Patients With Urothelial Cancer (T2-4 N0-2 M0) of the Bladder
Monika Joshi, MD
NCT03534804 COMPLETED Cabozantinib Plus Pembrolizumab as First-Line Therapy for Cisplatin-Ineligible Advanced Urothelial Carcinoma
University of Utah
NCT03486197 TERMINATED Neutron Radiation Therapy and Pembrolizumab in Treating Participants With Advanced Urothelial Carcinoma
University of Washington
NCT03658304 COMPLETED Trial of Mitomycin C During Nephroureterectomy for Urothelial Carcinoma
University of Florida
NCT04004221 COMPLETED Study of Tislelizumab in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer
BeiGene
NCT04690699 TERMINATED LUMINOS-103: A Basket Trial of Safety & Efficacy of Lerapolturev With or Without Checkpoint Inhibitors
Istari Oncology, Inc.
NCT05012397 TERMINATED Milademetan in Advanced/Metastatic Solid Tumors
Rain Oncology Inc
NCT03207867 TERMINATED A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma
Novartis Pharmaceuticals
NCT06424717 WITHDRAWN Study of Avelumab and Tuvusertib in Participants With Advanced Urothelial Cancer That Has Progressed on Prior Anti-PD-(L)1 Therapy (JAVELIN DDRiver Bladder)
EMD Serono Research & Development Institute, Inc.
NCT05390645 WITHDRAWN A Study of MFA-370 in Patients with Metastatic Urothelial Cancer
Ectin Research AB
NCT04387461 COMPLETED Study of CG0070 Given in Combination With Pembrolizumab, in Non-Muscle Invasive Bladder Cancer, Unresponsive to Bacillus Calmette-Guerin
CG Oncology, Inc.
NCT04593862 COMPLETED Bladder Cancer and ExeRcise Training During IntraVesical ThErapy
University of Alberta
NCT03219333 COMPLETED A Study of Enfortumab Vedotin for Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer
Astellas Pharma Inc
NCT05574504 WITHDRAWN Phase II Trial of Lurbinectedin Combined With Avelumab as Switch Maintenance Firstline Therapy
AdventHealth
NCT03513952 COMPLETED Atezolizumab and CYT107 in Treating Participants With Locally Advanced, Inoperable, or Metastatic Urothelial Carcinoma
National Cancer Institute (NCI)
NCT03557918 COMPLETED Trial of Tremelimumab in Patients With Previously Treated Metastatic Urothelial Cancer
Matthew Galsky
NCT03558087 COMPLETED Gemcitabine, Cisplatin, Plus Nivolumab in Patients With Muscle-invasive Bladder Cancer With Selective Bladder Sparing
Matthew Galsky
NCT03319745 COMPLETED Pembrolizumab in Treating Patients With Bladder Cancer Undergoing Radical Cystectomy
M.D. Anderson Cancer Center
NCT04525131 COMPLETED Safety, Dose Tolerance, Pharmacokinetics, Pharmacodynamics of CPX-POM in Patients With Newly Diagnosed or Recurrent Bladder Tumors
CicloMed LLC
NCT03451331 COMPLETED Gemcitabine + Carboplatin + Nivolumab Versus Gemcitabine + Oxaliplatin + Nivolumab in Cisplatin-ineligible Patients With Metastatic Urothelial Cancer
Matthew Galsky
NCT04742959 COMPLETED Study of TT-00420 (Tinengotinib) Tablet as Monotherapy and Combination Therapy in Patients With Advanced Solid Tumors
TransThera Sciences (Nanjing), Inc.
NCT03311334 TERMINATED A Study of DSP-7888 Dosing Emulsion in Combination With Immune Checkpoint Inhibitors in Adult Patients With Advanced Solid Tumors
Sumitomo Pharma America, Inc.
NCT05338580 WITHDRAWN Clinical Trial of TJ271 Injection Combined With Pembrolizumab in the Treatment of Advanced Solid Tumors
TJ Biopharma Co., Ltd.
NCT03472560 TERMINATED A Study of Avelumab in Combination With Axitinib In Non-Small Cell Lung Cancer (NSCLC) or Urothelial Cancer (Javelin Medley VEGF)
Pfizer
NCT03339843 COMPLETED Multiorgan Metabolic Imaging Response Assessment of Abemaciclib
Jules Bordet Institute
NCT03665285 COMPLETED A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors
NextCure, Inc.
NCT06018116 WITHDRAWN A Canadian Trial of Bicalutamide in Patients Receiving Maintenance Avelumab for Metastatic Urothelial Cancer.
CHU de Quebec-Universite Laval
NCT03892642 COMPLETED Avelumab Plus Bacille Calmette-Guerin (BCG) in Patients With Non-muscle Invasive Bladder Cancer
University of Oklahoma
NCT03891238 COMPLETED Avelumab as Single Agent in Metastatic or Locally Advanced Urothelial Cancer in Patients Unfit for Cisplatin. The ARIES Study
Consorzio Oncotech
NCT03511391 COMPLETED CHEckpoint Inhibition in Combination With an Immunoboost of External Beam Radiotherapy in Solid Tumors
University Hospital, Ghent
NCT03992131 TERMINATED A Study to Evaluate Rucaparib in Combination With Other Anticancer Agents in Participants With a Solid Tumor (SEASTAR)
pharmaand GmbH
NCT04672330 COMPLETED Neoadjuvant PD-1 Monoclonal Antibody in Cisplatin-ineligible High Risk Upper Tract Urothelial Carcinoma
RenJi Hospital
NCT04496219 COMPLETED Acupuncture for the Treatment of Intravesical BCG-Related Adverse Events in High-Risk Non-muscle Invasive Bladder Cancer
Fred Hutchinson Cancer Center
NCT04073602 COMPLETED A Study of RC48-ADC in Subjects With HER2-negative Locally Advanced or Metastatic Urothelial Cancer
RemeGen Co., Ltd.
NCT02887248 TERMINATED Nab-paclitaxel Plus Gemcitabine as First-line Therapy for Cisplatin-ineligible or Cisplatin-incurable Advanced Urothelial Carcinoma
SCRI Development Innovations, LLC
NCT02795156 COMPLETED Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations
SCRI Development Innovations, LLC
NCT03809013 COMPLETED A Open-label, Single-arm, Multicenter, Phase II Study of RC48-ADC to Evaluate the Efficacy and Safety of Subjects With HER2 Overexpressing Locally Advanced or Metastatic Urothelial Cancer
RemeGen Co., Ltd.
NCT03448718 COMPLETED Trial of Olaparib in Patients With Metastatic Urothelial Cancer Harboring DNA Damage Response Gene Alterations
Matthew Galsky
NCT02599324 COMPLETED Study to Evaluate Ibrutinib Combination Therapy in Patients With Selected Gastrointestinal and Genitourinary Tumors
Pharmacyclics LLC.
NCT02527434 COMPLETED Study of Tremelimumab in Patients With Advanced Solid Tumors
AstraZeneca
NCT02232646 WITHDRAWN A Study of BBI503 in Adult Patients With Advanced Urologic Malignancies
Sumitomo Pharma America, Inc.
NCT06050954 WITHDRAWN A Pilot Study of Circulating Tumor DNA Adaptive Risk Maintenance Approach for Bladder Cancer (CARMA)
Fox Chase Cancer Center
NCT03260712 COMPLETED Pembrolizumab in Biliary Tract Cancer
European Organisation for Research and Treatment of Cancer - EORTC
NCT05120622 WITHDRAWN Trial of Local Cystoscopic Injection of Tremelimumab Plus Systemic Durvalumab for High Risk Non-Muscle Invasive Bladder Cancer
University of British Columbia
NCT03833661 COMPLETED M7824 Monotherapy in Locally Advanced or Metastatic Second Line (2L) Biliary Tract Cancer (Cholangiocarcinoma and Gallbladder Cancer)
EMD Serono Research & Development Institute, Inc.
NCT06090318 WITHDRAWN Milademetan in Combination With Atezolizumab in Patients With Advanced Solid Tumors With CDKN2A Loss
Rain Oncology Inc
NCT03390595 COMPLETED Avelumab Plus Carboplatin-gemcitabine in Urothelial Carcinoma
Associació per a la Recerca Oncologica, Spain
NCT04045613 COMPLETED Derazantinib and Atezolizumab in Patients With Urothelial Cancer
Basilea Pharmaceutica
NCT03639714 COMPLETED A Study of a Personalized Neoantigen Cancer Vaccine
Gritstone bio, Inc.
NCT03737123 TERMINATED Trial of Atezolizumab Plus Chemotherapy After Progression on PD-1 or PD-L1 in Cisplatin-ineligible Patients With Advanced Urothelial Carcinoma
Nabil Adra
NCT03912818 TERMINATED Durvalumab and Standard Chemotherapy Before Surgery in Treating Patients With Variant Histology Bladder Cancer
Stanford University
NCT03317496 TERMINATED Safety And Efficacy Study Of Avelumab Plus Chemotherapy With Or Without Other Anti-Cancer Immunotherapy Agents In Patients With Advanced Malignancies
Pfizer
NCT03606174 TERMINATED A Phase 2 Study of Sitravatinib in Combination With PD-(L)1 Checkpoint Inhibitor Regimens in Patients With Advanced or Metastatic Urothelial Carcinoma
Mirati Therapeutics Inc.
NCT03636256 COMPLETED Evaluation of NanoDoce® in Participants With Urothelial Carcinoma
NanOlogy, LLC
NCT04072445 COMPLETED Trifluridine/Tipiracil and Irinotecan for the Treatment of Advanced Refractory Biliary Tract Cancer
Mayo Clinic
NCT03421652 COMPLETED Nivolumab and RT in Treating Patients With Localized/Locally Advanced Urothelial Bladder Cancer Ineligible for Chemo
Barbara Ann Karmanos Cancer Institute
NCT04639245 TERMINATED Genetically Engineered Cells (MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells) and Atezolizumab for the Treatment of Metastatic Triple Negative Breast Cancer, Urothelial Cancer, or Non-small Cell Lung Cancer
Fred Hutchinson Cancer Center
NCT03602079 COMPLETED Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene
Klus Pharma Inc.
NCT03576131 TERMINATED GEN1029 (HexaBody®-DR5/DR5) Safety Trial in Patients With Malignant Solid Tumors
Genmab
NCT04424641 TERMINATED A Study on the Safety of GEN1044 (DuoBody®-CD3x5T4) in Patients With Malignant Solid Tumors
Genmab
NCT03679767 COMPLETED A Study of INCMGA00012 in Participants With Selected Solid Tumors (POD1UM-203)
Incyte Corporation
NCT02412670 COMPLETED Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer
ECOG-ACRIN Cancer Research Group
NCT03735680 COMPLETED A Study to Evaluate ONM-100, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer
OncoNano Medicine, Inc.
NCT03278106 COMPLETED TAS-102 in Treating Advanced Biliary Tract Cancers
Mayo Clinic
NCT02520141 COMPLETED Ramucirumab in Treating Patients With Advanced or Metastatic, Previously Treated Biliary Cancers That Cannot Be Removed by Surgery
M.D. Anderson Cancer Center
NCT03397394 TERMINATED Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma
pharmaand GmbH
NCT03637803 TERMINATED Live Biotherapeutic Product MRx0518 and Pembrolizumab Combination Study in Solid Tumors
4D pharma plc
NCT05107427 WITHDRAWN Study of MRx0518 and Avelumab in Patients With Urothelial Carcinoma
4D pharma plc
NCT05496192 WITHDRAWN A Study of Nivolumab Intravenous (IV) to Subcutaneous (SC) Switch in Adjuvant Melanoma and Bladder Cancer
Bristol-Myers Squibb
NCT03472274 COMPLETED Durvalumab (MEDI4736) and TREmelimumab in NEOadjuvant Bladder Cancer Patients (DUTRENEO)
Fundacion CRIS de Investigación para Vencer el Cáncer
NCT02371447 COMPLETED VPM1002BC in Recurrent Non-muscle Invasive Bladder Cancer
Swiss Cancer Institute
NCT04209192 COMPLETED Antimicrobial Prophylaxis in Patients Who Underwent a Transurethral Resection of Bladder (TURB)
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
NCT02983045 COMPLETED A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors
Nektar Therapeutics
NCT02335424 COMPLETED Study of Pembrolizumab (MK-3475) in Participants With Advanced Urothelial Cancer (MK-3475-052/KEYNOTE-052)
Merck Sharp & Dohme LLC
NCT03058757 COMPLETED The Effectiveness and Safety of Neoadjuvant Intravesical Mitomycin-C Instillation
National Cancer Center, Korea
NCT03212651 COMPLETED Study Evaluating Neoadjuvant Pembrolizumab Monotherapy in Patients With Muscle-Invasive Bladder Cancer to Explore in Vivo the Mechanisms of Action of Pembrolizumab
Gustave Roussy, Cancer Campus, Grand Paris
NCT02393248 TERMINATED Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101)
Incyte Corporation
NCT03617913 COMPLETED Avelumab in Combination With Fluorouracil and Mitomycin or Cisplatin and Radiation Therapy in Treating Participants With Muscle-Invasive Bladder Cancer
Mayo Clinic
NCT04851834 TERMINATED NTX-301 Monotherapy in Advanced Solid Tumours and in Combination With Platinum-based Chemotherapy in Advanced Ovarian & Bladder Cancer and in Combination With Temozolomide in High-grade Glioma
Xennials Therapeutics Australia Pty Ltd
NCT05219578 TERMINATED RTX-224 Monotherapy in Patients With Solid Tumors
Rubius Therapeutics
NCT02643303 COMPLETED A Study of Tremelimumab and IV Durvalumab Plus Poly-ICLC in Subjects With Biopsy-accessible Cancers
Ludwig Institute for Cancer Research
NCT03464734 COMPLETED Pembrolizumab and Nab Paclitaxel in Patients With Metastatic Urothelial Carcinoma
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
NCT03980041 COMPLETED Study to Evaluate the Efficacy/Safety of IPI-549 in Combination With Nivolumab in Patients With Advanced Urothelial Carcinoma (MARIO-275)
Infinity Pharmaceuticals, Inc.
NCT02500121 COMPLETED Testing the PD-1 Inhibitor Pembrolizumab as Maintenance Therapy After Initial Chemotherapy in Metastatic Bladder Cancer
Matthew Galsky
NCT03558503 COMPLETED A Phase 2b Study of UGN-102 for Low Grade Intermediate Risk Non-Muscle-Invasive Bladder Cancer
UroGen Pharma Ltd.
NCT02901548 TERMINATED Phase 2 Durvalumab (Medi4736) for Bacillus Calmette-Guérin (BCG) Refactory Urothelial Carcinoma in Situ of the Bladder
H. Lee Moffitt Cancer Center and Research Institute
NCT03945084 COMPLETED Maintenance With Niraparib In Patients With Advanced Urothelial Cancer After 1st-line Platinum-based Chemotherapy
University of Turin, Italy
NCT03628716 COMPLETED CV301 Combined With PD-1/L1 Blockade in Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer
Bavarian Nordic
NCT03633110 COMPLETED Safety, Tolerability, Immunogenicity, and Antitumor Activity of GEN-009 Adjuvanted Vaccine
Genocea Biosciences, Inc.
NCT05234606 WITHDRAWN A Safety and Preliminary Efficacy Study of SBT6290 Alone and in Combination With PD-(L)1 Inhibitors in Select Advanced Solid Tumors
Silverback Therapeutics
NCT04501094 TERMINATED A Phase II Study of Bintrafusp Alfa (M7824) in Checkpoint Inhibitor Naive and Refractory Subjects With Urothelial Carcinoma
National Cancer Institute (NCI)
NCT02392637 COMPLETED Gemcitabine Hydrochloride, Cisplatin, and Nab-Paclitaxel in Treating Patients With Advanced or Metastatic Biliary Cancers
M.D. Anderson Cancer Center
NCT02318277 COMPLETED A Study of Epacadostat (INCB024360) in Combination With Durvalumab (MEDI4736) in Subjects With Selected Advanced Solid Tumors (ECHO-203)
Incyte Corporation
NCT03294304 COMPLETED BLASST-1 (Bladder Cancer Signal Seeking Trial): Nivolumab, Gemcitabine, and Cisplatin in Treatment of Muscle Invasive Bladder Cancer (MIBC) Undergoing Cystectomy
Masonic Cancer Center, University of Minnesota
NCT03287050 TERMINATED Anti-PD(L)1 and SBRT in the Treatment of Advanced, Platinum-Refractory Urothelial Carcinoma
University of Michigan Rogel Cancer Center
NCT03111732 COMPLETED Pembrolizumab, a Monoclonal Antibody Against PD-1, in Combination With Capecitabine and Oxaliplatin (CAPOX) in People With Advanced Biliary Tract Carcinoma (BTC)
National Cancer Institute (NCI)
NCT03430895 COMPLETED Evaluating Immune Therapy, Durvalumab (MEDI4736) With Tremelimumab for Metastatic, Non-transitional Cell Carcinoma of the Urinary Tract
Memorial Sloan Kettering Cancer Center
NCT03520231 COMPLETED Study Comparing Denosumab With Standard Treatment in Urothelial Cancer Patients With Bone Metastases
University Health Network, Toronto
NCT04555343 COMPLETED Intravesical Antifibrinolytic for Patients With Hematuria and Clot Retention
Fraser Health
NCT03245736 COMPLETED Tisotumab Vedotin Continued Treatment in Patients With Solid Tumors.
Seagen Inc.
NCT02792192 TERMINATED Safety and Pharmacology Study of Atezolizumab Alone and in Combination With Bacille Calmette-Guérin (BCG) in High-Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) Participants
Hoffmann-La Roche
NCT03115801 TERMINATED A Phase II Randomized Trial of Immunotherapy Plus Radiotherapy in Metastatic Genitourinary Cancers
Weill Medical College of Cornell University
NCT04066595 TERMINATED Cabozantinib in Patients With Locally Advanced or Metastatic Urothelial Cell Carcinoma.
Johannes Gutenberg University Mainz
NCT04131634 TERMINATED Stereotactic Ablative Radiation for Oligo-Progression of Urothelial Cancer
University of Texas Southwestern Medical Center
NCT04579133 TERMINATED Neoadjuvant Durvalumab Alone Versus Durvalumab With Olaparib in Patients Ineligible for Cisplatin With Muscle-Invasive Urothelial Carcinoma of the Bladder Followed by Radical Cystectomy
Latin American Cooperative Oncology Group
NCT02693717 TERMINATED Pemetrexed Disodium in Treating Patients With Previously Treated Metastatic Urothelial Cancer
M.D. Anderson Cancer Center
NCT04464967 WITHDRAWN Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers
NKGen Biotech, Inc.
NCT02365818 COMPLETED Safety and Efficacy of CG0070 Oncolytic Virus Regimen for High Grade NMIBC After BCG Failure
CG Oncology, Inc.
NCT02552121 COMPLETED Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors
Seagen Inc.
NCT03832673 WITHDRAWN Pembrolizumab-Epacadostat Combination to Treat Muscle-invasive Bladder UrotheLIAl canceR: PECULIAR Study
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
NCT04184232 COMPLETED Treatment of Recurrent Bladder Cancer With Dendritic Cells
Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
NCT02197897 COMPLETED Evaluation the Treatment of Tamoxifen of Low/Intermediate Risk Bladder Tumors
Baylor College of Medicine
NCT02788201 COMPLETED Genomic Based Assignment of Therapy in Advanced Urothelial Carcinoma
National Cancer Institute (NCI)
NCT03498196 TERMINATED A Window of Opportunity Trial: Avelumab in Non-metastatic Muscle Invasive Bladder Cancer
Baylor College of Medicine
NCT03719300 TERMINATED Codex: Study of Inodiftagene Vixteplasmid (BC-819) in Unresponsive NMIBC
Anchiano Therapeutics Israel Ltd.
NCT02459119 COMPLETED Study of Regorafenib for Urothelial Cancer Following Chemotherapy (UAB 1477)
University of Alabama at Birmingham
NCT03167151 TERMINATED Pembrolizumab in Intermediate Risk Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)
University of Oxford
NCT03652298 TERMINATED Effects of a Neuroscience-based Technique on Cancer Patients Announced of a Palliative Disease Progression and Partners
Centre Oscar Lambret
NCT03672240 COMPLETED Study of APL-1202 in Non-Muscle Invasive Bladder Cancer Patients Who Are Resistant to One Induction Course of BCG Treatment
Asieris Pharmaceutical Technologies Co., Ltd.
NCT03234153 TERMINATED Neoadjuvant Immunotherapy With Durvalumab and Tremelimumab for Bladder Cancer Patients Ineligible for Cisplatin
Insel Gruppe AG, University Hospital Bern
NCT03517995 WITHDRAWN Randomized, Phase II Clinical Trial of Sulforaphane in Bladder Cancer Chemoprevention
H. Lee Moffitt Cancer Center and Research Institute
NCT03534492 COMPLETED Durvalumab Plus Olaparib Administered Prior to Surgery of Resectable Urothelial Bladder Cancer (NEODURVARIB)
Spanish Oncology Genito-Urinary Group
NCT03007719 TERMINATED Functional Imaging of T-Cell Activation With [18F]F-AraG in Urothelial Carcinoma Patients Receiving Neoadjuvant Therapy or Patients With Cancer Receiving Standard of Care Anti-PD-1/L1
Lawrence Fong
NCT03935347 WITHDRAWN Adoptive Cell Therapy With (LN-145) in Combination With Pembrolizumab in Treating Patients With Unresectable or Metastatic Transitional Cell Cancer Who Have Failed Cisplatin-Based Chemotherapy
Roswell Park Cancer Institute
NCT04040725 WITHDRAWN Rogaratinib for BCG Refractory High Risk Non-Muscle Invasive Bladder Cancer With FGFR1/2 Overexpression
Dana-Farber Cancer Institute
NCT02351739 COMPLETED Study of the Combination of ACP-196 and Pembrolizumab in Subjects With Platinum Resistant Urothelial Bladder Cancer
Acerta Pharma BV
NCT02999672 COMPLETED A Study to Determine Best Tumor Response With Trastuzumab Emtansine in Human Epidermal Growth Factor Receptor 2 (HER2) Overexpressing Solid Tumors
Hoffmann-La Roche
NCT03507166 COMPLETED A Phase II Study of RC48-ADC in Subjects With HER2 Positive Metastatic or Unresectable Urothelial Cancer
RemeGen Co., Ltd.
NCT03029832 TERMINATED A Study of MOXR0916 in Combination With Atezolizumab Versus Atezolizumab Alone in Participants With Untreated Locally Advanced or Metastatic Urothelial Carcinoma Who Are Ineligible for Cisplatin-Based Therapy
Genentech, Inc.
NCT03419130 WITHDRAWN Radiation Therapy and Pembrolizumab in Treating Patients With Localized Urothelial Bladder Cancer
University of California, San Francisco
NCT02334527 TERMINATED Phase II Trial of Palbociclib in Patients With Metastatic Urothelial Cancer After Failure of First-Line Chemotherapy
UNC Lineberger Comprehensive Cancer Center
NCT02605863 TERMINATED Enzalutamide for Bladder Cancer Chemoprevention
University of Rochester
NCT02845050 WITHDRAWN Phase Ib/II Study Assessing the Neo-adjuvant Combination Therapy of Vinflunine With Cisplatin Followed by Radical Cystectomy in Patients With Muscle-invasive Bladder Cancer (JaNEO)
Ligartis GmbH
NCT03150836 WITHDRAWN Radiation Therapy and Durvalumab, With or Without Tremelimumab, in Patients With Bladder Cancer
Terence Friedlander, MD
NCT02655081 COMPLETED Investigating the Use of a Preoperative High-Arginine Nutritional Supplement Prior to Radical Cystectomy
University of Pittsburgh
NCT02661100 WITHDRAWN A Trial of CDX-1401 in Combination With Poly-ICLC and Pembrolizumab, in Previously Treated Advanced Solid Tumor Patients
Case Comprehensive Cancer Center
NCT02718742 WITHDRAWN Paclitaxel Albumin-Stabilized Nanoparticle Formulation After Cisplatin-Based Chemotherapy and Surgery in Treating Patients With High-Risk Bladder Cancer
Mayo Clinic
NCT02479178 TERMINATED A Study of BIND-014 in Patients With Urothelial Carcinoma, Cholangiocarcinoma, Cervical Cancer and Squamous Cell Carcinoma of the Head and Neck
BIND Therapeutics