Landscape → Respiratory

COPD

536 clinical trials

132 active

536 total (since 2015)

Phase 1 Active

122 total

Phase 2 Active

178 total

Phase 3 Active

122 total

Phase 4 Active

143 total

Top Sponsors (Industry)

Sorted by active Active Done Failed

AstraZeneca 12 33 3

GSK 5 42 6

Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 5 4 2

Sanofi 4 7 0

Haisco Pharmaceutical Group Co., Ltd. 4 1 0

Roche 3 3 1

Joincare Pharmaceutical Group Industry Co., Ltd 3 1 0

Verona Pharma plc 2 12 0

Mabwell (Shanghai) Bioscience Co., Ltd. 2 2 0

CSPC ZhongQi Pharmaceutical Technology Co., Ltd. 2 0 0

Bambusa Therapeutics 2 0 0

Pulmair Medical, Inc. 2 0 0

Guangdong Hengrui Pharmaceutical Co., Ltd 1 1 0

Pfizer 1 0 1

Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. 1 1 0

NCT06883305 RECRUITING

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

AstraZeneca n=990

NCT06878261 RECRUITING

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

AstraZeneca n=990

NCT06283966 RECRUITING

A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

AstraZeneca n=5,000

NCT07190209 RECRUITING

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

Sanofi n=942

NCT05878769 RECRUITING

A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Hoffmann-La Roche n=2,000

NCT07190222 RECRUITING

Sanofi n=942

NCT05595642 RECRUITING

A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

Hoffmann-La Roche n=1,290

NCT07363694 NOT YET RECRUITING

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease

Pfizer n=1,156

NCT05166889 ACTIVE NOT RECRUITING

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

AstraZeneca n=1,132

NCT05158387 ACTIVE NOT RECRUITING

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.

AstraZeneca n=1,172

NCT05742802 ACTIVE NOT RECRUITING

Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).

AstraZeneca n=1,711

NCT07330310 NOT YET RECRUITING

A Phase 3 Trial of JKN2401 Injection in COPD

Joincare Pharmaceutical Group Industry Co., Ltd n=888

NCT05844462 RECRUITING

Tadalafil for Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease

Assistance Publique - Hôpitaux de Paris n=200

NCT06067828 ACTIVE NOT RECRUITING

A Study to Evaluate the Effect of Budesonide, Glycopyrronium, Formoterol Fumarate (BGF) Metered Dose Inhaler (MDI), Budesonide and Formoterol Fumarate (BFF) MDI and Placebo MDI on Exercise Parameters in Participants With Chronic Obstructive Pulmonary Disease (COPD).

AstraZeneca n=171

NCT06040086 ACTIVE NOT RECRUITING

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

AstraZeneca n=1,454

NCT04004117 RECRUITING

Effect of Sublingual Fentanyl on Breathlessness in COPD

McGill University Health Centre/Research Institute of the McGill University Health Centre n=40

NCT07177339 RECRUITING

eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation

GlaxoSmithKline n=1,196

NCT07039669 RECRUITING

Evaluation of 611 in Chinese Adults Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. n=594

NCT06376994 RECRUITING

Multi-Center Clean Air Randomized Controlled Trial in COPD

JHSPH Center for Clinical Trials n=770

NCT06959095 RECRUITING

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA -1)

GlaxoSmithKline n=981

NCT07147946 NOT YET RECRUITING

Evaluation of the Clinical Trial of Inhaled TQC3721 Suspension in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary Disease

Chia Tai Tianqing Pharmaceutical Group Co., Ltd. n=666

NCT06961214 RECRUITING

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

GlaxoSmithKline n=960

NCT07047092 NOT YET RECRUITING

Non-invasive Ventilation or CPAP in OSA-COPD Following Admission for an Acute Hypercapnic Respiratory Failure

Assistance Publique - Hôpitaux de Paris n=386

NCT06208306 ACTIVE NOT RECRUITING

A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD

Sanofi n=700

NCT06999343 NOT YET RECRUITING

Exploring the Anti-ageing Effects of Metformin in COPD

Fundación Instituto de Investigación Sanitaria de Navarra n=212

NCT06474039 RECRUITING

The Efficacy of Fluticasone Furoate/Vilanterol/Umeclidinium Compared With Vilanterol/Umeclidinium in Reducing Air Trapping and Airway and Blood Cytokine Levels in COPD

Mahidol University n=50

NCT05138250 ACTIVE NOT RECRUITING

A Pilot Study of the Use of 129Xe and 1H MRI to Measure the Modulation of Eosinophil-Related Inflammation by Mepolizumab In COPD

Sheffield Teaching Hospitals NHS Foundation Trust n=32

NCT06473701 RECRUITING

Reducing Breathlessness With Dronabinol in COPD Patients

Vejle Hospital n=30

NCT05265299 RECRUITING

Trial to Determine Effective Aspirin Dose in COPD

Johns Hopkins University n=48

NCT02984124 ACTIVE NOT RECRUITING

Communication During Hospitalization About Resuscitation Trial

University of Vermont n=182

NCT06234345 NOT YET RECRUITING

Study of Fluticasone/Formoterol/Glycopyrronium for the Treatment Chronic Obstructive Pulmonary Disease (TRIPLAR)

Eurofarma Laboratorios S.A. n=1,252

NCT06347536 RECRUITING

Supported Rescue Packs Post-discharge in Chronic Obstructive Pulmonary Disease

Guy's and St Thomas' NHS Foundation Trust n=1,400

NCT06785337 RECRUITING

"The Effect of Inhaled Nitroglycerin for COPD Patients

Beni-Suef University n=40

NCT06643078 RECRUITING

A Study to Evaluate the Safety and Efficacy of HL231 Solution for Inhalation in Patients with COPD

Haisco Pharmaceutical Group Co., Ltd. n=474

NCT06547333 NOT YET RECRUITING

A Study of CM310 in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease

CSPC ZhongQi Pharmaceutical Technology Co., Ltd. n=884

NCT06212765 NOT YET RECRUITING

Oral Citrulline Supplementation in COPD Patients With Malnutrition

University Hospital, Grenoble n=60

NCT04018729 RECRUITING

Cell Therapy Associated With Endobronchial Valve

Hospital de Clinicas de Porto Alegre n=34

NCT04636814 TERMINATED

A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR)

Chiesi Farmaceutici S.p.A. n=3,973

NCT04320342 COMPLETED

A Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination CHF 5993 With the Fixed Dose Dual Combination CHF 1535 in Subjects With COPD

Chiesi Farmaceutici S.p.A. n=3,433

NCT04636801 TERMINATED

A 52-week, Placebo-controlled Study to Evaluate the Efficacy and Safety of 2 Doses of CHF6001 DPI (Tanimilast), as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis (PILASTER)

Chiesi Farmaceutici S.p.A. n=4,710

NCT03794583 TERMINATED

Inhaled Treprostinil in Participants With Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (PH-COPD)

United Therapeutics n=41

NCT04751487 COMPLETED

Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)

Sanofi n=1,239

NCT04701983 COMPLETED

Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)

Sanofi n=1,127

NCT05573464 COMPLETED

A Study to Assess the Safety of Budesonide/Glycopyrronium/Formoterol Fumarate With a Next-Generation Propellant in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

AstraZeneca n=559

NCT02683668 COMPLETED

Airway Effects of Tiotropium in Patients With COPD

Imperial College London n=44

NCT06075095 COMPLETED

A Study to Investigate the Effect on Lung Function of an Approved COPD Treatment (BGF, With HFA Propellant) Compared to BGF Formulated With a Next-Generation Propellant in Participants 40 to 80 Years of Age With COPD

AstraZeneca n=297

NCT04053634 COMPLETED

Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations

AstraZeneca n=689

NCT04133909 COMPLETED

Mepolizumab as Add-on Treatment IN Participants With COPD Characterized by Frequent Exacerbations and Eosinophil Level

GlaxoSmithKline n=806

NCT05743075 COMPLETED

A Study to Evaluate the Efficacy and Safety of Ensifentrine for 24 Weeks in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Nuance Pharma (shanghai) Co., Ltd n=526

NCT04456673 COMPLETED

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

Sanofi n=935

NCT03917914 COMPLETED

Preventing Adverse Cardiac Events in COPD

The George Institute n=280

NCT06460493 COMPLETED

Effect of Ensifentrine Treatment on CAT Score

Verona Pharma plc n=20

NCT03022097 COMPLETED

Study to Assess Efficacy and Safety of Aclidinium Bromide and Aclidinium Bromide/Formoterol Fumarate in Stabile COPD Patients

AstraZeneca n=1,625

NCT03956888 COMPLETED

The Anti-oxidant Effects of N-Acetylcysteine in Chronic Obstructive Pulmonary Disease (COPD)

Siriraj Hospital n=35

NCT02887521 TERMINATED

Pulmonary Rehabilitation Before Lung Cancer Resection

Alliance for Clinical Trials in Oncology n=9

NCT03888131 COMPLETED

Foster® pMDI (CHF 1535) Versus Symbicort® Turbohaler in COPD Patient

Chiesi Farmaceutici S.p.A. n=750

NCT03984188 COMPLETED

Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPD

University of Miami n=100

NCT04517500 COMPLETED

A Home-based Module to Promote Mindful Breathing Awareness for COPD Patients

Mayo Clinic n=99

NCT05046795 COMPLETED

Revefenacin in Chinese Subjects With Moderate to Very Severe Chronic Obstructive Pulmonary Disease(COPD)

Mylan Pharma UK Ltd. n=258

NCT04075331 COMPLETED

Mepolizumab for COPD Hospital Eosinophilic Admissions Pragmatic Trial

University of Leicester n=238

NCT03930732 COMPLETED

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation

Sanofi n=939

NCT05986591 COMPLETED

Bioequivalence Study of Tiotropium 18 μg Inhalation Powder, Hard Capsule With Spiriva®Handihaler® 18 μg Inhalation Powder, Hard Capsule in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Xiromed LLC n=335

NCT03496623 TERMINATED

A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)

United Therapeutics n=188

NCT04535986 COMPLETED

A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD

Verona Pharma plc n=763

NCT04542057 COMPLETED

A Phase 3 Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD

Verona Pharma plc n=790

NCT05927155 COMPLETED

Effects of Acute Long-acting Bronchodilation on Oxygenation and Peripheral Ventilation in COPD

Erasme University Hospital n=30

NCT02867761 COMPLETED

RETHINC: REdefining THerapy In Early COPD for the Pulmonary Trials Cooperative

University of Michigan n=780

NCT05161156 COMPLETED

Bioequivalence Study of Tiotropium Bromide Inhalation Powder

Phargentis SA n=306

NCT04078126 COMPLETED

Study Comparing Dual Combination of Product (Budesonide and Formoterol) Given Via Two Different Inhalers. To See Which One Results in the Best Effect on Breathing.

AstraZeneca n=35

NCT02512510 COMPLETED

Efficacy Study of Nebulized TD-4208 for Chronic Obstructive Pulmonary Disease (COPD)

Mylan Inc. n=611

NCT03095456 COMPLETED

Revefenacin Peak Inspiratory Flow Rate (PIFR) Study in COPD

Mylan Inc. n=207

NCT02518139 COMPLETED

A 52-Week Parallel Group Safety Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)

Mylan Inc. n=1,060

NCT02459080 COMPLETED

Efficacy Study of Nebulized TD-4208 for Chronic Obstructive Pulmonary Disease (COPD)

Mylan Inc. n=619

NCT03573817 COMPLETED

A 42-day Parallel Group Safety Study of Revefenacin and Formoterol, Administered in Sequence and as a Combination, in Participants With COPD

Mylan Inc. n=122

NCT03674320 WITHDRAWN

Cycled Testosterone Administration During Pulmonary Rehabilitation in Early Stage COPD

The University of Texas Medical Branch, Galveston

NCT04876677 COMPLETED

Functional Respiratory Imaging Study

Chiesi Farmaceutici S.p.A. n=25

NCT03256695 COMPLETED

Evaluate the Relationship Between Use of Albuterol Multidose Dry Powder Inhaler With an eModule (eMDPI) and Exacerbations in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Teva Branded Pharmaceutical Products R&D, Inc. n=405

NCT02579850 COMPLETED

2-arm Parallel Group Study of Fixed Combination of CHF 5993 vs Ultibro® in COPD Patients

Chiesi Farmaceutici S.p.A. n=1,532

NCT02467452 COMPLETED

Non Inferiority of Fixed Combination of Beclomethasone Dipropionate (BDP) + Formoterol Fumarate (FF) + Glycopyrronium Bromide (GB) Versus Combination of Fluticasone Furoate (FlF)/Vilanterol (VI) + Tiotropium Bromide in Chronic Obstructive Pulmonary Disease (COPD)

Chiesi Farmaceutici S.p.A. n=1,479

NCT04446637 WITHDRAWN

Acute Bronchodilator Effects of Ipratropium/Levosalbutamol 20/50 mcg Fixed Dose Combination vs Salbutamol 100 mcg Inhaler Plus Ipratropium 20 mcg Inhalation Aerosol Free Combination in Patients With Stable COPD

Neutec Ar-Ge San ve Tic A.Ş

NCT02722304 TERMINATED

Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency

Baxalta now part of Shire n=7

NCT04879030 COMPLETED

Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD

Haiphong University of Medicine and Pharmacy n=170

NCT03137992 COMPLETED

Clinical Endpoint Bioequivalence Study of Test and Reference Inhalation Products in Patients With COPD With Device Robustness

Lupin, Inc. n=377

NCT03197818 COMPLETED

Active Controlled Trial of CHF5993 Pressurized Metered-dose Inhaler ( pMDI) vs Symbicort®Turbuhaler® in Patients With Chronic Obstructive Pulmonary Disease ( COPD)

Chiesi Farmaceutici S.p.A. n=990

NCT02536508 COMPLETED

Study to Assess the Safety and Tolerability of PT010, PT009 and PT003 in Subjects With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

Pearl Therapeutics, Inc. n=627

NCT03836677 COMPLETED

A Study to Evaluate the Effects of BGF and GFF on Specific Image Based Airway Volumes and Resistance in Subjects With Moderate to Severe COPD

AstraZeneca n=23

NCT02465567 COMPLETED

Study to Assess the Efficacy and Safety of PT010 Relative to PT003 and PT009 in Subjects With Moderate to Very Severe COPD (Ethos)

Pearl Therapeutics, Inc. n=8,588

NCT02587351 TERMINATED

Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

University of Minnesota n=532

NCT03324607 COMPLETED

Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI

Bastiaan Driehuys n=20

NCT03379233 TERMINATED

A Randomized Study to Evaluate the Effect of Reminder Notifications and Motivational/Adaptive Messaging on Treatment Adherence

Novartis Pharmaceuticals n=7

NCT02497001 COMPLETED

A Randomized, Double-Blind, Parallel-Group, 24-Week, Chronic-Dosing, Multi-Center Study to Assess the Efficacy and Safety of PT010, PT003, and PT009 Compared With Symbicort® Turbuhaler® (Kronos)

Pearl Therapeutics, Inc. n=1,902

NCT02067780 COMPLETED

Short Antibiotic Treatment Versus Duration Guided by Markers of Inflammation in the Treatment of AECOPD

University of Monastir n=310

NCT04479930 COMPLETED

Effects of an mHealth Web-Based Platform (HappyAir) on Adherence to a Maintenance Program After Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease

CEU San Pablo University n=44

NCT02184611 COMPLETED

A 24 Week Efficacy Study of Inhaled Umeclidinium (UMEC) in Patients of Chronic Obstructive Pulmonary Disease (COPD) Using a Novel Dry Powder Inhaler (NDPI)

GlaxoSmithKline n=308

NCT04361552 WITHDRAWN

Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)

Emory University

NCT03262012 COMPLETED

Study to Assess the Safety and Efficacy of PT010, PT003, and PT009 in Japanese Subjects With COPD Compared With Symbicort® Turbohaler®

Pearl Therapeutics, Inc. n=416

NCT03268226 COMPLETED

Functional Respiratory Imaging Study (FRI)

Chiesi Farmaceutici S.p.A. n=20

NCT02720822 COMPLETED

Breathlessness Exertion and Morphine Sulphate

Flinders University n=171

NCT04122547 COMPLETED

Efficacy of Roflumilast on Exacerbations in Patients With Non-cystic Fibrosis Bronchiectasis

Prince of Songkla University n=40

NCT02685293 TERMINATED

Study to Evaluate the Treatment Effect of PT003 on Cardiovascular Hemodynamics in Subjects With Moderate to Severe COPD

Pearl Therapeutics, Inc. n=4

NCT02937584 COMPLETED

A Study to Assess the Effects of PT001 and PT005 MDI on Specific Image Based Parameters in Subjects With Moderate to Severe COPD

Pearl Therapeutics, Inc. n=23

NCT02729051 COMPLETED

Comparative Study of Fluticasone Furoate(FF)/Umeclidinium Bromide (UMEC)/ Vilanterol (VI) Closed Therapy Versus FF/VI Plus UMEC Open Therapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline n=1,055

NCT02629965 COMPLETED

Comparing the Efficacy of Tiotropium + Olodaterol Fixed Dose Combination (FDC) Over Tiotropium in Improvement of Lung Hyperinflation, Exercise Capacity and Physical Activity in Japanese COPD Patients

Boehringer Ingelheim n=184

NCT03162055 COMPLETED

Efficacy and Safety of Glycopyrronium/Formoterol Fumarate Fixed-dose Combination Relative to Umeclidinium/Vilanterol Fixed-dose Combination Over 24 Weeks in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

AstraZeneca n=1,119

NCT02888444 TERMINATED

Smoking Relapse Prevention Among COPD Ex-smokers

University of Auckland, New Zealand n=8

NCT02643082 COMPLETED

A Study to Assess the Effects of PT003 and Placebo MDI on Specific Image Based Airway Volumes and Resistance in Subjects With Moderate to Severe COPD

Pearl Therapeutics, Inc. n=20

NCT02343458 COMPLETED

Study to Assess the Efficacy and Safety of PT003, PT005, and PT001 in Subjects With Moderate to Very Severe COPD

Pearl Therapeutics, Inc. n=1,756

NCT03008356 COMPLETED

L-carnitine for Fatigue in COPD

Mayo Clinic n=33

NCT02796677 COMPLETED

AMPLIFY - D6571C00001 Duaklir USA Phase III Study

AstraZeneca n=1,595

NCT03081247 WITHDRAWN

To Assess the Efficacy and Safety of PT010 Compared to PT009 in Subjects With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

Pearl Therapeutics, Inc.

NCT02347085 COMPLETED

24-hour Lung Function in Subjects With Moderate to Very Severe COPD After Treatment With PT003 and Placebo MDI

Pearl Therapeutics, Inc. n=43

NCT02345161 COMPLETED

A Comparison Study Between the Fixed Dose Triple Combination of Fluticasone Furoate/ Umeclidinium/ Vilanterol Trifenatate (FF/UMEC/VI) With Budesonide/Formoterol in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline n=1,811

NCT02296138 COMPLETED

Comparing the Efficacy of Tiotropium + Olodaterol (5/5 µg) Fixed Dose Combination (FDC) Over Tiotropium 5µg in Reducing Moderate to Severe Exacerbations in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease.

Boehringer Ingelheim n=7,903

NCT02487498 COMPLETED

Efficacy and Safety Study of Indacaterol Maleate/Glycopyrronium Bromide in Chronic Obstructive Pulmonary Disease (COPD) Patients.

Novartis Pharmaceuticals n=355

NCT02347761 COMPLETED

Efficacy and Safety Trial of 12 Weeks of Treatment With Nebulized SUN-101 in Patients With COPD

Sunovion Respiratory Development Inc. n=653

NCT02347774 COMPLETED

Efficacy and Safety Trial of 12 Weeks of Treatment With Nebulized SUN-101 in Patients With COPD (GOLDEN-4)

Sunovion Respiratory Development Inc. n=641

NCT02487446 COMPLETED

Efficacy and Safety Study of QVA149 in COPD Patients

Novartis Pharmaceuticals n=357

NCT02347072 COMPLETED

24-hour Lung Function in Subjects With Moderate to Very Severe COPD After Treatment With PT003, Open-Label Spiriva® Respimat® as an Active Control, and Placebo

Pearl Therapeutics, Inc. n=80

NCT02454959 COMPLETED

Crossover Study to Assess the Efficacy of PT003 With and Without a Valved Holding Chamber in Subjects With Moderate to Severe COPD

Pearl Therapeutics, Inc. n=80

NCT02594722 COMPLETED

Metabolism and Oxygen Consumption During Functional Electrical Stimulation Cycling in COPD

University Hospital, Rouen n=25

NCT02731846 WITHDRAWN

A Study Comparing the Closed Triple Therapy, Open Triple Therapy and a Dual Therapy for Effect on Lung Function in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT02455362 WITHDRAWN

Opioids for Refractory Breathlessness in Chronic Obstructive Pulmonary Disease

Flinders University

NCT05061368 RECRUITING

Oral Sildenafil for Exercise Capacity, Dyspnea and Cardiopulmonary Function in COPD

University of Alberta

NCT04231760 NOT YET RECRUITING

The Effect of Inhaled Nitric Oxide on Pulmonary Gas-exchange in COPD

University of Alberta

NCT06969573 RECRUITING

Inhaled Treprostinil for Dyspnea and Exercise Intolerance in Mild COPD

University of Alberta

NCT07440524 ACTIVE NOT RECRUITING

A Phase 2 Trial of JKN24011 in COPD

Joincare Pharmaceutical Group Industry Co., Ltd

NCT07441226 RECRUITING

Umbilical Cord Mesenchymal Stem Cells as Adjuvant Therapy in Group E COPD Patients

RSUP Persahabatan

NCT04778046 RECRUITING

Pulmonary Hypertension SOLAR

Bastiaan Driehuys

NCT06897748 ACTIVE NOT RECRUITING

A Study to Investigate Efficacy and Safety of Tozorakimab Injections Compared With Placebo in Adult Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations and Elevated Eosinophils

AstraZeneca

NCT07016412 RECRUITING

A Phase IIb Ensifentrine-glycopyrrolate Fixed-dose Combination Dose Ranging Study in Subjects With COPD

Verona Pharma plc

NCT07418736 RECRUITING

A Phase II Study of CM326 in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease

CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

NCT07059091 RECRUITING

Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD

Johns Hopkins University

NCT07082738 RECRUITING

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

AstraZeneca

NCT06940154 RECRUITING

Rademikibart Add-on Treatment of an Acute COPD Exacerbation (Seabreeze STAT COPD)

Connect Biopharm LLC

NCT05270525 RECRUITING

Effect of Ensifentrine on Sputum Markers of Inflammation in COPD

Verona Pharma plc

NCT06981078 RECRUITING

A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD

Upstream Bio Inc.

NCT05937854 RECRUITING

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

VA Office of Research and Development

NCT07402551 NOT YET RECRUITING

Phase II Study of RC1416 Injection in COPD

Nanjing RegeneCore Biotech Co., Ltd.

NCT07351734 RECRUITING

A Phase IIa, Randomized, Double-Blind, Placebo-Controlled Trial of JKN2403 in COPD

Joincare Pharmaceutical Group Industry Co., Ltd

NCT07349524 NOT YET RECRUITING

A Study to Evaluate the Efficacy and Safety of RSS0343 Tablets in Patients With Chronic Obstructive Pulmonary Disease

Reistone Biopharma Company Limited

NCT06496620 RECRUITING

A Study to Evaluate Solrikitug in Participants With COPD (ZION)

Uniquity One (UNI)

NCT03500731 RECRUITING

Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure

Paul Szabolcs

NCT05607719 RECRUITING

Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPD

University of Miami

NCT07331402 ACTIVE NOT RECRUITING

A Clinical Study Evaluating the Pharmacokinetics and Pharmacodynamics of HSK39004 Inhalation Suspension in COPD Patients

Haisco Pharmaceutical Group Co., Ltd.

NCT07252908 RECRUITING

A Phase II Clinical Trial on the Efficacy and Safety of TQC3721 Inhalation Powder

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

NCT07314242 NOT YET RECRUITING

A Study to Investigate the Biomarkers of Hemay005 in Adult Participants With Moderate to Severe COPD

Ganzhou Hemay Pharmaceutical Co., Ltd

NCT07292714 RECRUITING

A Study to Evaluate 9MW1911 in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Mabwell (Shanghai) Bioscience Co., Ltd.

NCT06110403 RECRUITING

Impact of Long-acting Bronchodilator- -Corticoid Inhaled Therapy on Ventilation, Lung Function and Breathlessness

University Hospital, Lille

NCT05237505 RECRUITING

The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

University of California, San Diego

NCT06707883 ACTIVE NOT RECRUITING

A Clinical Study of TQC2731 Injection in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.

NCT07037836 RECRUITING

Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia

Bastiaan Driehuys

NCT05612035 ACTIVE NOT RECRUITING

Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD

Merck Sharp & Dohme LLC

NCT07086339 NOT YET RECRUITING

A Trial of the Implantable Artificial Bronchus 50 Flex in Patients With Severe Emphysema

Pulmair Medical, Inc.

NCT07119229 NOT YET RECRUITING

A Multi Center Study Testing a New Implant for Adults With Severe Emphysema

Pulmair Medical, Inc.

NCT07125664 NOT YET RECRUITING

Intravenous Alpha-1 Antitrypsin for Hospitalized Patients With COPD Exacerbations (AECOPD Study)

Fondazione IRCCS Policlinico San Matteo di Pavia

NCT07108699 NOT YET RECRUITING

Evaluation of the Safety and Efficacy of HSK39004 Dry Powder Inhaler in Chinese Patients With Chronic Obstructive Pulmonary Disease (COPD)

Haisco Pharmaceutical Group Co., Ltd.

NCT06175351 ACTIVE NOT RECRUITING

Study to Evaluate the Pharmacokinetic Characteristics, Safety, Tolerability, and Preliminary Efficacy of 9MW1911 in Patients With Chronic Obstructive Pulmonary Disease (COPD).

Mabwell (Shanghai) Bioscience Co., Ltd.

NCT06980142 NOT YET RECRUITING

A Study of CM512 in Subjects With Moderate-to-Severe Chronic Obstructive Pulmonary Disease

Keymed Biosciences Co.Ltd

NCT06533553 ACTIVE NOT RECRUITING

A Study to Assess the Effects of Dexpramipexole in Participants With Eosinophilic COPD

Areteia Therapeutics

NCT06175065 ACTIVE NOT RECRUITING

Safety, PK and PD Relationships of RLS-0071 in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

ReAlta Life Sciences, Inc.

NCT06946953 NOT YET RECRUITING

Airway Basal Stem Cell Therapy in Chronic Obstructive Pulmonary Disease (COPD)

Ruijin Hospital

NCT05746039 RECRUITING

Feasibility of Semaglutide in Advanced Lung Disease

University of Pennsylvania

NCT06820749 ENROLLING BY INVITATION

A Study to Evaluate the Efficacy and Safety of HSK31858 Tablets in Patients with Airway Mucus Hypersecretion

Haisco Pharmaceutical Group Co., Ltd.

NCT06789289 NOT YET RECRUITING

A Clinical Study to Evaluate the Efficacy and Safety of TQC2938 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.

NCT06782724 NOT YET RECRUITING

Psilocybin Therapy for Psychological Distress in Palliative Patients

University Medical Center Groningen

NCT06731959 NOT YET RECRUITING

A Study to Investigate Using Inhaled Fexlamose to Treat Adult Participants Who Have Moderate to Severe COPD

Aer Therapeutics

NCT03002389 ACTIVE NOT RECRUITING

Hyperpolarized Xenon-129 MRI: a New Multi-dimensional Biomarker to Determine Pulmonary Physiologic Responses to COPD Therapeutics

University of Virginia

NCT05507242 RECRUITING

Effects of Blocking TSLP on Airway Inflammation and the Epithelial Immune-response to Exacerbation Triggers in Patients With COPD

Asger Sverrild

NCT06491043 RECRUITING

Treatment of Chronic Obstructive Pulmonary Disease by Infusion of Allogenic Mesenchymal Stem Cells

Meribank Biotech Co., Ltd.

NCT06434792 RECRUITING

Study to Evaluate Efficacy and Safety of Bronpass Tab. in Patients With Chronic Obstructive Pulmonary Disease

Hanlim Pharm. Co., Ltd.

NCT06003270 RECRUITING

Biological Effects of Quercetin in COPD Phase II

Temple University

NCT06324214 RECRUITING

Oral Supplementation During PR Participation in COPD

McGill University Health Centre/Research Institute of the McGill University Health Centre

NCT04427826 RECRUITING

Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa

University Hospital, Grenoble

NCT03331302 RECRUITING

Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

University of Virginia

NCT07450482 COMPLETED

Safety and Efficacy of JKN2304 Inhalation Solution in Patients With Moderate to Severe COPD

Joincare Pharmaceutical Group Industry Co., Ltd

NCT05037929 COMPLETED

A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

Genentech, Inc.

NCT04087590 TERMINATED

Impact of Inhaled PT003 on Complexity and Variability of Tidal Breathing and Oscillatory Mechanics in Stable COPD Patient

University Hospital, Lille

NCT06545500 COMPLETED

A Phase IIb Study of Glycopyrrolate Inhalation Solution Over 1 Week in Subjects With COPD

Verona Pharma plc

NCT07132983 COMPLETED

A Phase II Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Single Inhaled Doses of Ensifentrine-glycopyrrolate Fixed Dose Combination, Ensifentrine, and Glycopyrrolate in Subjects With Chronic Obstructive Pulmonary Disease

Verona Pharma plc

NCT06035393 TERMINATED

A Study to Assess the Efficacy and Safety of HRG2005 Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Jiangsu HengRui Medicine Co., Ltd.

NCT05660850 COMPLETED

A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamic Effects Of GDC-6599 In Patients With Chronic Cough

Genentech, Inc.

NCT05888597 COMPLETED

Efficacy of L-menthol on Breathlessness in Chronic Obstructive Pulmonary Disease

Region Skane

NCT06099652 COMPLETED

Evaluation of 611 in Chinese Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease

Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.

NCT05292950 TERMINATED

Study of ARO-MUC5AC in Healthy Subjects and Patients With Muco-Obstructive Lung Disease

Arrowhead Pharmaceuticals

NCT02978144 TERMINATED

Lung Imaging of Apoptosis in Chronic Obstructive Pulmonary Disease (COPD)

Columbia University

NCT06149494 COMPLETED

RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection

Altesa Biosciences, Inc.

NCT05492877 COMPLETED

An Efficacy and Safety Study of Mitiperstat (AZD4831) (MPO Inhibitor) vs Placebo in the Treatment of Moderate to Severe COPD.

AstraZeneca

NCT04306588 WITHDRAWN

Accessing Mobility Using Wearable Sensors

Baylor College of Medicine

NCT05326412 COMPLETED

Mechanistic Study of the Effect of Itepekimab on Airway Inflammation in Patients With COPD

Sanofi

NCT04315558 COMPLETED

Revefenacin in Acute Respiratory Insufficiency in COPD

University of California, Los Angeles

NCT06841640 COMPLETED

Phase 1/Phase 2a Study of AERO-007 Inhalation Solution, a Nebulized LABA/LAMA Combination for Maintenance Treatment of COPD

AeroRx Therapeutics Inc.

NCT05638776 COMPLETED

Treatment of Chronic Obstructive Pulmonary Disease (COPD) With Diffusion Capacity Defect by REGEND001 Cell Therapy

Regend Therapeutics

NCT05292196 TERMINATED

A Phase II Clinical Trial of TQC3721 Suspension for Inhalation

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

NCT05567562 COMPLETED

Anti-Platelets in Chronic Obstructive Pulmonary Disease

Brigham and Women's Hospital

NCT05987371 COMPLETED

A Clinical Trial of TQC3721 Suspension for Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease.

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

NCT06527144 COMPLETED

A Clinical Trial of TQC3721 Suspension for Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

NCT04631016 COMPLETED

A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis

AstraZeneca

NCT03651895 COMPLETED

Metformin to Reduce Airway Glucose in COPD Patients

Imperial College London

NCT04039113 COMPLETED

Tezepelumab COPD Exacerbation Study

AstraZeneca

NCT04858451 TERMINATED

COmmunity Patients at Risk of Viral Infections Including SARS-CoV-2

Thirty Respiratory Limited

NCT04353661 TERMINATED

A Study Of ¹²⁹XE MRI To Assess Disease Progression In Patients With COPD Treated With Or Without Azithromycin And Standard-of-Care Medications

Genentech, Inc.

NCT03085485 COMPLETED

The Topic Trial - Study to Determine the Safety and Efficacy of Ivacaftor

University of Alabama at Birmingham

NCT02662582 COMPLETED

A Study to Assess the Effect of CK-2127107 on Physical Function in Subjects With Chronic Obstructive Pulmonary Disease

Astellas Pharma Global Development, Inc.

NCT06619210 COMPLETED

A Trial to Evaluate the Safety and Efficacy of HL231 Solution for Inhalation in Patients with COPD

Haisco Pharmaceutical Group Co., Ltd.

NCT03679598 COMPLETED

Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency

University of Alabama at Birmingham

NCT06003049 COMPLETED

A Study to Evaluate Safety and Efficacy of BOTOX in Adults With Moderate COPD

RMW Testing

NCT04268823 TERMINATED

Clinical Study to Assess the Mode of Action of QBW251 in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Novartis Pharmaceuticals

NCT04433104 COMPLETED

Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Chronic Obstructive Pulmonary Disease

Vinmec Research Institute of Stem Cell and Gene Technology

NCT05411107 WITHDRAWN

Oral Iloprost for the Prevention of Lung Cancer In Former Smokers

National Cancer Institute (NCI)

NCT05262218 COMPLETED

Therapeutic Effect of PBF-680 in Patients With COPD

Palobiofarma SL

NCT05610514 COMPLETED

Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke Cigarettes

University of Vermont

NCT04795323 COMPLETED

Proof of Concept Study Assessing Technology-Assisted Respiratory Adherence Prototype Version 3 in Individuals With COPD

Boehringer Ingelheim

NCT05418777 TERMINATED

Treatment of Pneumocystis in COPD (the TOPIC Study)

Corewell Health East

NCT05572333 COMPLETED

Clinical Trial to Investigate the Safety and Tolerability of EP395 in Patients With COPD

EpiEndo Pharmaceuticals

NCT05643729 SUSPENDED

Zofin to Treat Chronic Obstructive Pulmonary Disease (COPD)

ZEO ScientifiX, Inc.

NCT05594303 COMPLETED

COPD Treatment by Transplantation of Autologous Bronchial Basal Cells

Guangzhou Institute of Respiratory Disease

NCT03244059 COMPLETED

Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies

University of Alabama at Birmingham

NCT02272634 COMPLETED

A Phase 2a Study to Assess Safety, Daily Symptoms, PK, and Biomarkers of YPL-001 in COPD Patients

Yungjin Pharm. Co., Ltd.

NCT05838703 WITHDRAWN

Tiotropium Handihaler vs. Tiotropium Respimat in COPD

Duke University

NCT04072887 COMPLETED

Dose-range Finding Efficacy and Safety Study for QBW251 in COPD Patients

Novartis Pharmaceuticals

NCT03188627 COMPLETED

Autologous Bronchial Basal Cell Transplantation for Treatment of COPD

Regend Therapeutics

NCT03570359 COMPLETED

A Study to Test a Potential New Treatment for COPD Patients Suffering From the Common Cold or Influenza

Synairgen Research Ltd.

NCT04441788 TERMINATED

A Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Participants With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis (CB)

Ionis Pharmaceuticals, Inc.

NCT04882124 COMPLETED

Study of Effect of CSJ117 on Symptoms, Pharmacodynamics and Safety in Patients With COPD

Novartis Pharmaceuticals

NCT03546907 COMPLETED

Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)

Sanofi

NCT04027439 COMPLETED

Study Evaluating 5 Doses of RPL554 and Placebo in COPD Patients Via a Dry Powder Inhaler

Verona Pharma plc

NCT04091360 COMPLETED

A Study of RPL554 Drug Administered by Metered Dose Inhaler to Treat Chronic Obstructive Pulmonary Disease

Verona Pharma plc

NCT03615040 COMPLETED

Anti-ST2 (MSTT1041A) in COPD (COPD-ST2OP)

University of Leicester

NCT05396131 COMPLETED

The Use of Aeriseal ® in the Management of Collateral Ventilation Positive COPD Patients Undergoing ELVR Utilizing Endobronchial Valves.

Macquarie University, Australia

NCT03636347 COMPLETED

A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.

Mereo BioPharma

NCT02178566 TERMINATED

Pulmonary Rehab in Chronic Obstructive Pulmonary Disease (COPD): Response to Tyvaso

Inova Health Care Services

NCT04540042 COMPLETED

Study to Assess the Safety and Efficacy of SelK2 on Airway Responses Following Allergen Challenge in Subjects With Asthma (Part 1) and in Subjects With Chronic Obstructive Pulmonary Disease (Part 2)

Tetherex Pharmaceuticals Corporation

NCT04066751 WITHDRAWN

The Multicenter Topic Trial

University of Alabama at Birmingham

NCT03810183 TERMINATED

A Proof-of-mechanism Study of Multiple, Oral Doses of Fevipiprant (QAW039) in COPD Patients With Eosinophilia

Novartis Pharmaceuticals

NCT02978885 TERMINATED

Imaging of Peri-operative (periOP) Lung Injury

Columbia University

NCT02522299 COMPLETED

A Study to Evaluate the Safety, Efficacy and Changes in Induced Sputum and Blood Biomarkers Following Daily Repeat Doses of Inhaled GSK2269557 in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Acute Exacerbation

GlaxoSmithKline

NCT03457103 COMPLETED

Capnometry-Assisted Breathing Training for COPD

NYU Langone Health

NCT02294734 COMPLETED

An Efficacy Study of GSK2269557 Added to Standard Care in Subjects With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease

GlaxoSmithKline

NCT03698682 COMPLETED

Short Compared With Standard Duration of Antibiotic Treatment for AECOPD

University of Monastir

NCT03345407 TERMINATED

Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03084796 COMPLETED

A 6-week Dose Ranging Study of CHF 5259 pMDI in Subjects With Chronic Obstructive Pulmonary Disease

Chiesi Farmaceutici S.p.A.

NCT03794557 COMPLETED

The Effect of Inhaled PUL-042 on Rhinovirus-induced Symptoms in Smokers With GOLD Stage 0 COPD

Pulmotect, Inc.

NCT04780984 COMPLETED

Tiotropium Bromide Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease

Nephron Pharmaceuticals Corporation

NCT03590379 COMPLETED

Efficacy of Fixed Combination of Beclomethasone Dipropionate (BDP) + Formoterol Fumarate (FF) + Glycopyrronium Bromide (GB) (CHF 5993)Administered Via Dry Powder Inhaler (DPI) in Chronic Obstructive Pulmonary Disease (COPD)

Chiesi Farmaceutici S.p.A.

NCT03250689 TERMINATED

Randomized Study Evaluating the Effect of Danirixin on Neutrophil Extracellular Traps (NETs) in Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03123692 COMPLETED

NBMI - Clinical Study on COPD

EmeraMed

NCT02774226 COMPLETED

Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary Disease

Augusta University

NCT03008915 COMPLETED

Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency

Columbia University

NCT02449018 COMPLETED

A Safety, Tolerability and Efficacy Study With QBW251 in COPD Patients With QBW251

Novartis Pharmaceuticals

NCT03645434 COMPLETED

A Single Inhalation Dose Study to Assess Efficacy, Pharmacokinetics (PK), Safety and Tolerability of AZD8871 in Patients With Long-term Lung Diseases.

AstraZeneca

NCT02700919 COMPLETED

Efficacy and Safety of BCT197 in Subjects With Acute Respiratory Exacerbations of Chronic Obstructive Pulmonary Disease

Mereo BioPharma

NCT03937479 COMPLETED

Study Investigating the Effect of 4 Doses of RPL554 Given in Addition to Tiotropium to Patients With COPD

Verona Pharma plc

NCT03034967 COMPLETED

Danirixin Dose Ranging Study in Participants With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03699904 TERMINATED

Epstein-Barr Virus Suppression in Chronic Obstructive Pulmonary Disease (EViSCO): a Phase 2 Randomised Control Trial

Belfast Health and Social Care Trust

NCT02680197 COMPLETED

Study to Evaluate Efficacy/Safety of 4 Doses of CHF5259 Via Dry Powder Inhaler (DPI) in Patients With COPD

Chiesi Farmaceutici S.p.A.

NCT03170232 TERMINATED

A Pilot Study of Danirixin for Disease Progression in Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03004417 COMPLETED

Pharmacodynamics, Pharmacokinetics and Safety of Two Doses of CHF6001 DPI in Subjects With Moderate, Severe COPD

Chiesi Farmaceutici S.p.A.

NCT02464059 COMPLETED

Cathelicidin and Vitamin D: Impact on Populations At-Risk and With COPD

University of North Carolina, Chapel Hill

NCT02573870 COMPLETED

Batefenterol/Fluticasone Furoate in Treatment of Chronic Obstructive Pulmonary Disease

GlaxoSmithKline

NCT03745196 TERMINATED

The Effect of PC945 on Aspergillus or Candida Lung Infections in Patients With Asthma or Chronic Respiratory Diseases

Pulmocide Ltd

NCT03378648 COMPLETED

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose in Healthy Volunteers, Repeat Doses in Asthmatic Patients and of Single Dose in COPD Patients of CHF6366

Chiesi Farmaceutici S.p.A.

NCT02815488 TERMINATED

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of CHF6297 in Healthy Subjects and Patients With COPD

Chiesi Farmaceutici S.p.A.

NCT03414541 COMPLETED

Safety And Efficacy Study Of Orally Administered DS102 In Patients With Chronic Obstructive Pulmonary Disease

Afimmune

NCT02674880 COMPLETED

Hyaluronic Acid in Acute Exacerbation of COPD - Duration Of Noninvasive Assistance

Campus Bio-Medico University

NCT02628769 TERMINATED

A Study to Evaluate the Anti-inflammatory Effects of Solithromycin in Chronic Obstructive Pulmonary Disease

Imperial College London

NCT02690038 COMPLETED

Ig PRx in AECOPD: Pilot Study

Ottawa Hospital Research Institute

NCT03018652 COMPLETED

Feasibility and Safety of Immunoglobulin (Ig) Treatment in COPD Outpatients With Frequent Exacerbations: Pilot Study 1

Ottawa Hospital Research Institute

NCT03673670 COMPLETED

Bronchodilator Effect of RPL554 Administered in Addition to Tiotropium/Olodaterol in Patients With COPD

Verona Pharma plc

NCT03196089 COMPLETED

Effect of Short-term Oxygen During CPET in COPD

University of Zurich

NCT03118765 COMPLETED

Pharmacodynamic and Pharmacokinetic Dose Ranging Study of Tiotropium Bromide Administered Via Inhalation Solution in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Glenmark Specialty S.A.

NCT03276078 COMPLETED

Pharmacokinetics, Safety and Tolerability of Twice-Daily Aclidinium Bromide/Formoterol Fumarate Fixed Dose Combination in Chinese Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

AstraZeneca

NCT02570165 COMPLETED

Dose-Finding Study of Batefenterol (GSK961081) Via Dry Powder Inhaler in Patients With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT02971293 COMPLETED

Efficacy, Pharmacokinetics (PK), Safety and Tolerability Study of Inhaled AZD8871

AstraZeneca

NCT03443414 COMPLETED

Dose Ranging Study of RPL554 in Chronic Obstructive Pulmonary Disease (COPD) Patients

Verona Pharma plc

NCT02671942 TERMINATED

A Multicenter Randomized Double-blind Clinical Study Evaluated the Safety, Pharmacokinetic and Pharmacodynamic Characteristics of Roflumilast in COPD Patients

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

NCT03028142 COMPLETED

The Effects of RPL554 in Addition to Tiotropium in COPD Patients

Verona Pharma plc

NCT02986321 COMPLETED

A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in Patients With COPD

Chiesi Farmaceutici S.p.A.

NCT02567708 COMPLETED

A Study to Investigate the Efficacy, Safety, and Tolerability of Repeat Doses of Inhaled GSK2269557 in Adults With Persistent, Uncontrolled Asthma

GlaxoSmithKline

NCT02519608 COMPLETED

ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts

University Hospital of Ferrara

NCT03487406 COMPLETED

Anti-platelet Therapy in the Prevention of Cardiovascular Disease in Patients With COPD (APPLE-COPD: ICON 2)

Newcastle-upon-Tyne Hospitals NHS Trust

NCT02451540 TERMINATED

Evaluation of the Effect of Roflumilast in Hyperinflated COPD Patients Using Functional Respiratory Imaging

FLUIDDA nv

NCT02796651 COMPLETED

Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb)

AstraZeneca

NCT03256552 COMPLETED

Study to Assess the Efficacy and Safety of Three Doses of PT001 in Japanese Subjects With Moderate to Severe COPD

Pearl Therapeutics, Inc.

NCT02302417 COMPLETED

Study Assessing Utility of a Clinical Questionnaire to Identify Subjects With Features of Both Asthma and Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT02546700 COMPLETED

A Study to Evaluate Safety and Efficacy of Lebrikizumab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Hoffmann-La Roche

NCT03012646 WITHDRAWN

Safety and Tolerability of Inhaled Treprostinil in Adult PH Due to COPD

United Therapeutics

NCT02542254 COMPLETED

The Effects of RPL554 on Top of Standard COPD Reliever Medications

Verona Pharma plc

NCT02444806 COMPLETED

PSG Versus Oxim-capnography to Setup Home NIV

Guy's and St Thomas' NHS Foundation Trust

NCT02366637 TERMINATED

An Evaluation Of PF-03715455 In Moderate To Severe Chronic Obstructive Pulmonary Disease

Pfizer

NCT07116915 RECRUITING

A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics for a Single Dose of HRS-9821 Powder for Inhalation and Inhalation Suspension Administered in Healthy Subjects and Multiple Doses in Patients With COPD.

Guangdong Hengrui Pharmaceutical Co., Ltd

NCT06603246 RECRUITING

A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease

Genentech, Inc.

NCT07076290 NOT YET RECRUITING

A Repeat Ascending Dosing Study of the Safety and Clinical Activity of R-3750 in Patients With Mild to Moderate COPD

Rise Therapeutics LLC

NCT07288554 RECRUITING

A Study of BBT002 in Healthy Volunteers (HVs) and in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Bambusa Therapeutics

NCT07275359 NOT YET RECRUITING

Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations

Duke University

NCT07267130 RECRUITING

A Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of TQC3302 Inhalation Spray in Healthy Adult Subjects

Chia Tai Tianqing Pharmaceutical (Guangzhou) Co., Ltd.

NCT07116889 ACTIVE NOT RECRUITING

A Study to Investigate GB-0895 in Adults With Mild to Moderate Asthma or COPD

Generate Biomedicines

NCT06154837 RECRUITING

A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease

GlaxoSmithKline

NCT07035652 NOT YET RECRUITING

The Phase Ib Clinical Trial of the XH-S004 Tablet in Patients With Chronic Obstructive Pulmonary Disease (COPD) to Evaluate Its Safety, Tolerability, Pharmacokinetic Characteristics and Pharmacodynamic Characteristics After Multiple Administrations

S-INFINITY Pharmaceuticals Co., Ltd

NCT06979518 NOT YET RECRUITING

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of GSK3862995B Administered as a Single Dose to Healthy Participants of Chinese, Japanese, and European Ancestry

GlaxoSmithKline

NCT06944925 RECRUITING

A Study of BBT002 in Healthy Volunteers (HVs) and in Adult Patients With Chronic Obstructive Pulmonary Disease (COPD)

Bambusa Therapeutics

NCT05147688 RECRUITING

Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Pulmonary Diseases

The Foundation for Orthopaedics and Regenerative Medicine

NCT04624490 RECRUITING

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Mario Castro, MD, MPH

NCT06748079 RECRUITING

A Clinical Study of TQC3721 Inhalation Powder in Patients With Chronic Obstructive Pulmonary Disease

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

NCT06487416 ACTIVE NOT RECRUITING

A Trial to Assess the Bioequivalence of Tiotropium Bromide Inhalation Powder in Healthy Adult Participants Under Fasting Conditions

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

NCT06326671 ACTIVE NOT RECRUITING

A Trial to Assess the Bioequivalence of Generic Tiotropium Bromide Inhalation Powder and Reference Product in Healthy Adult Participants Under Fasting Conditions (Pilot)

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

NCT03899298 NOT YET RECRUITING

Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions

R3 Stem Cell

NCT05803902 COMPLETED

An Evaluation of 9MW1911 Injection in Healthy Subjects

Mabwell (Shanghai) Bioscience Co., Ltd.

NCT06908642 COMPLETED

Evaluation the Safety of hemay005 Tablets

Anhui Hemay Pharmaceutical Co., Ltd

NCT04047810 COMPLETED

Mesenchymal Stem Cells in the Treatment of Subjects With Advance Chronic Obstructive Pulmonary Disease (COPD)

Mayo Clinic

NCT05433961 TERMINATED

Functional and Structural Assessment of Endobronchial Valve Recipients Using Dynamic Hyperpolarized Xenon-129 MRI

Xemed LLC

NCT06892756 COMPLETED

Effect of Cyclosporine Drug Interaction on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers. Drug-Drug Interaction 2 (DDI2) Study

Chiesi Farmaceutici S.p.A.

NCT05477108 COMPLETED

Study to Assess the Lung Exposure Bioequivalence of Budesonide, Glycopyrronium, and Formoterol Delivered by BGF MDI With Next-Generation Propellant Compared With BGF MDI With HFA Propellant

AstraZeneca

NCT05569421 COMPLETED

A Study to Assess the Total Systemic Exposure Bioequivalence of of Budesonide, Glycopyrronium, and Formoterol Delivered by BGF MDI With Next-Generation Propellant Compared With BGF MDI With HFA Propellant

AstraZeneca

NCT06711991 COMPLETED

A Clinical Trial of TQC3927 Powder for Inhalation in Chronic Obstructive Pulmonary Disease

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

NCT06297668 COMPLETED

A Study to Assess the Pharmacokinetics and Safety of Budesonide, Glycopyrronium, & Formoterol (BGF) Metered Dose Inhaler (MDI) With a Next-Generation Propellant (NGP) With a Spacer, BGF MDI Hydrofluoroalkane (HFA) With a Spacer, as Well as BGF MDI NGP Without a Spacer

AstraZeneca

NCT05622864 COMPLETED

Study on Single and Multiple Atomization Inhalation of HRS-9821 Suspension for Inhalation in Healthy Subjects and COPD Patients

Guangdong Hengrui Pharmaceutical Co., Ltd

NCT06597500 COMPLETED

A Study to Evaluate the Effect of Itraconazole on the Concentration of GSK3923868 in the Blood in Healthy Participants

GlaxoSmithKline

NCT04032535 COMPLETED

Investigate the Safety, Tolerability and Pharmacokinetics of CHF6523 in Healthy and in COPD Subjects

Chiesi Farmaceutici S.p.A.

NCT06408285 COMPLETED

A Study of TQC3927 Powder for Inhalation in Healthy Adult Subjects

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

NCT05677347 COMPLETED

Phase 1, Single and Repeat Dose Study to Assess Safety, Tolerability, and Pharmacokinetics (PK) of GSK3923868 in Participants With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03909750 SUSPENDED

Use of Autologous Stem/Stromal Cells In Chronic Lung Disorders: Obstructive (COPD) & Restrictive (RLD)

Healeon Medical Inc

NCT06114238 COMPLETED

Pharmacokinetic Study to Compare Itepekimab Exposure When Administered With an Autoinjector Versus Prefilled Syringe

Sanofi

NCT05830071 COMPLETED

A Thorough QT (TQT) Study of CHF5993 pMDI in Healthy Volunteers (HV)

Chiesi Farmaceutici S.p.A.

NCT05962645 COMPLETED

Phase 1 Study Into Pharmacokinetics and Food Effect of Vapendavir in Healthy Participants and Participants With COPD

Altesa Biosciences, Inc.

NCT06395610 COMPLETED

Effect of Erythromycin on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers

Chiesi Farmaceutici S.p.A.

NCT05398198 COMPLETED

Efficacy and Safety of GSK3923868 Inhalation Powder, During Experimental Human Rhinovirus Infection in Participants With Mild Asthma

GlaxoSmithKline

NCT05373953 COMPLETED

Clinical Study to Investigate the Pharmacokinetics, Safety and Tolerability Following Single Administration of CHF6001 in Subjects With Mild, Moderate and Severe Liver Impairment in Comparison With Matched Healthy Control Subjects

Chiesi Farmaceutici S.p.A.

NCT04756960 COMPLETED

Evaluation of the Absolute Bioavailability and Mass Balance of CHF6001 (Tanimilast) in Healthy Subjects

Chiesi Farmaceutici S.p.A.

NCT06118684 COMPLETED

Clinical Trial to Assess Effect of Verapamil on Systemic Exposure of EP395 and Effect of EP395 on Systemic Exposure of Midazolam and Digoxin

EpiEndo Pharmaceuticals

NCT04585009 COMPLETED

Safety, Tolerability and Pharmacokinetics of GSK3923868 Inhalation Powder in Healthy Participants and Stable Asthmatics

GlaxoSmithKline

NCT06254664 COMPLETED

Open Label Study to Assess the Effect of Patient Use and Robustness of Tiotropium 18ug Inhalation Powder, Hard Capsule,Zephir Inhaler Device

Xiromed LLC

NCT04014712 WITHDRAWN

O2 Transport and Utilization in Health and Lung Disease

University of Massachusetts, Amherst

NCT05170243 COMPLETED

A Clinical Study in Healthy Subjects to Evaluate 9MW1911 Injection

Mabwell (Shanghai) Bioscience Co., Ltd.

NCT04647383 COMPLETED

A Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Participants With Moderate to Severe Obstructive Sleep Apnea, and in Adult and Elderly Participants With Moderate to Severe Chronic Obstructive Pulmonary Disease

Eisai Inc.

NCT05516316 COMPLETED

Clinical Trial Comparing the Pharmacological Effects of EP395 With Placebo in Healthy Adults

EpiEndo Pharmaceuticals

NCT05758428 COMPLETED

A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Nebulized Ensifentrine in Healthy Chinese Subjects

Nuance Pharma (shanghai) Co., Ltd

NCT02267655 COMPLETED

3 Part Study to Assess Inhaled Nitric Oxide on Functional Pulmonary Imaging in Subj. Pulmonary Hypertension Associated w/ COPD and IPF

Bellerophon

NCT05718453 COMPLETED

Assessment of Trace Elements, Systemic Inflammation and Electrolytes

Egymedicalpedia

NCT05431426 COMPLETED

PK of CHF6001 in Subjects With Mild, Moderate and Severe Renal Impairment vs. Healthy Volunteers

Chiesi Farmaceutici S.p.A.

NCT04600505 COMPLETED

A Study to Assess Drug Absorption of Fixed Dose Combinations of Budesonide, Glycopyrronium, and Formoterol

AstraZeneca

NCT04759807 COMPLETED

A Phase 1b Study of PUR1800 in Patients With COPD

Pulmatrix Inc.

NCT03795350 TERMINATED

Lung Deposition of TRIMBOW® pMDI in Healthy Volunteers, Asthmatic and COPD Patients

Chiesi Farmaceutici S.p.A.

NCT05016687 COMPLETED

First-in-human Clinical Trial Evaluating CUR-N399 in Healthy Volunteers.

Curovir AB

NCT02474017 COMPLETED

An Open Study to Assess the Robustness of the CRC749 Inhaler

Mylan Pharma UK Ltd.

NCT02772159 COMPLETED

TD-4208 Absorption, Distribution, Metabolism and Excretion (ADME) Study in Healthy Male Subjects

Mylan Inc.

NCT02315144 TERMINATED

An Efficacy and Safety Profile of Inhaled TV48108 in Healthy Volunteers and COPD Patients

Teva Branded Pharmaceutical Products R&D, Inc.

NCT02315131 TERMINATED

Study in Healthy Volunteers and COPD Patients to Evaluate the Efficacy and Safety of Inhaled TV46017

Teva Branded Pharmaceutical Products R&D, Inc.

NCT03859414 COMPLETED

PK of BDP/FF/GB Single-inhaler Triple Therapy in Japanese vs. Caucasians

Chiesi Farmaceutici S.p.A.

NCT02663089 COMPLETED

A Phase 1 (Ph1), Single Dose (SD), GSK961081 Absorption, Distribution, Metabolism, and Excretion (ADME) Study in Healthy Subjects

Theravance Biopharma

NCT03494114 TERMINATED

Imaging Activated Macrophages in the Lungs

Vanderbilt University Medical Center

NCT02743013 COMPLETED

Clinical Pharmacology Study to Evaluate the Total Systemic Exposure and the Lung Availability of CHF 5993 in Healthy Volunteers

Chiesi Farmaceutici S.p.A.

NCT03457727 COMPLETED

GSK1325756 Relative Bioavailability Study in Healthy Elderly Subjects

GlaxoSmithKline

NCT04739774 COMPLETED

Investigation of the Effect of Inhibition of CYP3A4/5 by Itraconazole on the PK of CHF6001 (Tanimilast)

Chiesi Farmaceutici S.p.A.

NCT03906045 COMPLETED

A Scintigraphy Study of PT010 in COPD Patients

AstraZeneca

NCT03250182 COMPLETED

A Study to Assess the PK and Safety of PT010 in Subjects With COPD Following Single and Repeat Dose

Pearl Therapeutics, Inc.

NCT03075267 COMPLETED

Pharmacokinetics and Safety Study of PT010 and PT003 in Healthy Chinese Adult Subjects

Pearl Therapeutics, Inc.

NCT03096795 COMPLETED

Safety and Tolerability of MEDI3506 in Healthy Participants, in Participants With COPD and Healthy Japanese Participants

MedImmune LLC

NCT04494321 COMPLETED

A Bioequivalence Pivotal Study of SYN010 HFA Inhaler and Symbicort® 160/4.5 in Healthy Volunteers Without Charcoal Block

Intech Biopharm Ltd.

NCT03235726 COMPLETED

Study of Safety and Drug Levels of CCI15106 Inhalation Powder in Healthy Adults and Adults With Moderate Chronic Obstructive Pulmonary Disease. Study of CCI15106 Levels in People Standing Near the Person Inhaling the Drug

GlaxoSmithKline

NCT03243760 TERMINATED

Dose Escalating Study of CCI15106 Inhalation Capsules in Healthy Subjects and Moderate Chronic Obstructive Pulmonary Disease (COPD) Patients

GlaxoSmithKline

NCT03311373 COMPLETED

A Randomized, Open-label, Single-dose, Single-center, Crossover Study in Healthy Subjects to Assess the Relative Bioavailability of PT010

Pearl Therapeutics, Inc.

NCT03398421 COMPLETED

A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics (PK) of Nemiralisib

GlaxoSmithKline

NCT04199598 TERMINATED

Relative Bioavailability Study With Abediterol Administered Via Three Different Inhalation Devices in Healthy Volunteers.

AstraZeneca

NCT03315559 COMPLETED

Absorption & Elimination of Radiolabelled GSK2269557

GlaxoSmithKline

NCT03646864 COMPLETED

A Study to Evaluate the Effects of ACT-541468 on Respiration in Patients With Moderate Chronic Obstructive Pulmonary Disease

Idorsia Pharmaceuticals Ltd.

NCT03189589 COMPLETED

Safety, Tolerability and Pharmacokinetics (PK) Study of GSK2269557 in Healthy Subjects

GlaxoSmithKline

NCT02642614 COMPLETED

Safety, Tolerability and Pharmacokinetics and Effect on Inflammation of Oral BI 1026706 in Patients With COPD

Boehringer Ingelheim

NCT02968914 COMPLETED

Pharmacokinetic Comparability of Benralizumab Using Accessorized Pre-Filled Syringe or Autoinjector in Healthy Volunteers

AstraZeneca

NCT03136380 COMPLETED

Study of Danirixin in Japanese Healthy Elderly Male Subjects

GlaxoSmithKline

NCT02969317 COMPLETED

Bioavailability of Tiotropium + Olodaterol Fixed-dose Combination (5 μg/ 5 μg) in Chinese COPD Patients

Boehringer Ingelheim

NCT02814656 COMPLETED

Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Subjects

AstraZeneca

NCT03781895 COMPLETED

Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

NCT03740373 COMPLETED

A Study to Assess the Pulmonary Distribution of Budesonide, Glycopyrronium and Formoterol Fumarate

AstraZeneca

NCT02573155 COMPLETED

Two-part Safety, Tolerability, Pharmacodynamic and -Kinetic Study of Inhaled AZD8871 in Asthmatic and COPD Subjects

AstraZeneca

NCT02512302 COMPLETED

Study to Determine the Amount of Glycopyrrolate Absorbed in the Lungs After Taking the Medicine With a eFlow Nebulizer and Seebri® Breezhaler® With and Without Activated Charcoal in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD).

Sunovion Respiratory Development Inc.

NCT02453022 COMPLETED

A 5-Period, Single Dose, Phase 1 Study in Healthy Elderly Subjects to Assess Relative Bioavailability and Food Effect of Two Oral Formulations of GSK1325756 (Free Base vs HBr Salt) and Food Effect on the HBr Formulation When Given With Omeprazole

GlaxoSmithKline

NCT03480997 COMPLETED

Acute Bronchodilator Effect of Inhaled Albuterol Sulfate and Ipratropium Bromide in Patients With Stable COPD

Pneuma Respiratory, Inc

NCT02645253 COMPLETED

A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD7594 Inhaled Formulation in Healthy Japanese Men

AstraZeneca

NCT02967159 COMPLETED

A Study to Evaluate the Disposition of Drug in Body and Safety After Administration of Single Inhaled Doses of Drugs Abediterol and AZD7594 Administered Alone, in Fixed Dose Combination and in Free Combination Using the Dry Powder Inhaler in Healthy Male Participants

AstraZeneca

NCT02928354 COMPLETED

A Study to Assess the Effect of Particle Size of AZD7594 on Pharmacokinetics (PK) After a Single Inhaled Dose When Administered Using the Dry Powder Inhaler in Healthy Volunteers

AstraZeneca

NCT03159442 COMPLETED

Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Male Japanese Subjects

AstraZeneca

NCT02975843 COMPLETED

Lung Deposition of Beclometasone Dipropionate/Formoterol Fumarate/Glycopyrronium Bromide Administered Via pMDI in Healthy, Asthmatic and COPD Patients

Chiesi Farmaceutici S.p.A.

NCT02648438 COMPLETED

A Study to Assess the Bioavailability and to Compare the Pharmacokinetics of AZD7594 Inhaled Via Monodose Inhaler and Multiple-dose Dry Powder Inhalers (DPI) or Pressurized Metered-dose Inhaler (pMDI) in Healthy Male Subjects

AstraZeneca

NCT02551614 COMPLETED

Neutrophil Imaging in Healthy Subjects Following Lipopolysaccharide or Saline Challenge and in Subjects With Chronic Obstructive Pulmonary Disease

GlaxoSmithKline

NCT02666287 COMPLETED

GSK961081 Alone and With Fluticasone Furoate (FF), Phase 1 (Ph1), Single Dose Regimen (SD), Repeat Dose Regimen (RD), Pharmacokinetic (PK) Study in Healthy Volunteer (HV)

GlaxoSmithKline

NCT02619357 COMPLETED

Method Validation Study to Explore the Sensitivity of SenseWear Armband Gecko for Measuring Physical Activity in Subjects With Chronic Obstructive Pulmonary Disease (COPD) & Asthma

GlaxoSmithKline

NCT02262689 COMPLETED

To Evaluate Effects of GSK2256294 on Pulmonary Artery Pressure in Healthy Volunteers Under Normoxic and Hypoxic Conditions

GlaxoSmithKline

NCT02691325 COMPLETED

Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK2269557 Administered Via the ELLIPTA Dry Powder Inhaler to Healthy Subjects

GlaxoSmithKline

NCT02837380 COMPLETED

A Phase I Pharmacokinetic Study of Fluticasone Furoate /Umeclidinium Bromide/Vilanterol (100/62.5/25 Microgram [mcg]) After Single and Repeat Dose Administration From a Dry Powder Inhaler in Healthy Chinese Subjects

GlaxoSmithKline

NCT02972905 COMPLETED

Study to Evaluate Safety, Tolerability and Pharmacokinetics of GSK2269557 to Japanese Healthy Subjects

GlaxoSmithKline

NCT02441114 COMPLETED

Pharmacokinetics of Co-administration of Seretide 250 Diskus (HCP0910) and Spiriva Capsule for Inhalation (HGP1011)

Seoul National University Hospital

NCT03004495 COMPLETED

Pharmacokinetic Interaction and the Safety of Inhaled CHF5259 and CHF6001

Chiesi Farmaceutici S.p.A.

NCT02850484 COMPLETED

A Bioequivalence Pivotal Study of SYN010 HFA Inhaler and Symbicort® 160/4.5 in Healthy Volunteers With Charcoal Block

Intech Biopharm Ltd.

NCT07073950 RECRUITING

A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation

AstraZeneca

NCT07053423 RECRUITING

A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

Sanofi

NCT07362173 RECRUITING

Actualities in Procedural Sedation: Remimazolam

Iuliu Hatieganu University of Medicine and Pharmacy

NCT04069312 ACTIVE NOT RECRUITING

Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)

Johns Hopkins University

NCT07135427 RECRUITING

Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency

University of Alabama at Birmingham

NCT06531798 NOT YET RECRUITING

Post-marketing Phase 4 Safety & Tolerability Study of Breztri aerosphereTM in Indian Patients With Chronic Obstructive Pulmonary Disease

AstraZeneca

NCT07192016 NOT YET RECRUITING

129-Xe MRI Study of Single Triple Therapy Inhaler Effects in COPD Patients With Moderate-severe Dyspnea and/or Poor Health Status With High or Low Risk of Exacerbation

Western University, Canada

NCT07133880 RECRUITING

Compare the Effects of Nebulizer Versus Inhaler Based Therapy for COPD Using Long-acting Bronchodilators

University of Tennessee Graduate School of Medicine

NCT07114120 RECRUITING

Clinical Study on the Treatment of Stable Bronchiectasis With Bailing Capsules Combined With Guben Kechuan Granules

Second Affiliated Hospital, School of Medicine, Zhejiang University

NCT06152653 RECRUITING

The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)

University of California, San Francisco

NCT05703919 RECRUITING

Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease

Central Denmark Region

NCT07011225 ACTIVE NOT RECRUITING

Effects of Rehabilitation and Supplementation With Hydrolyzed Collagen vs. Whey Protein on the Cardiopulmonary, Renal, Muscular, and Immunohematological Response of COPD Patients

Federal University of São Paulo

NCT06991426 NOT YET RECRUITING

Effects of CreaSafe® on Kidney, Muscle, and Cardiopulmonary Function in Athletes and COPD Patients

Federal University of São Paulo

NCT04789057 RECRUITING

Atorvastatin Effect on Reduction of COPD Exacerbations

Medical University of Bialystok

NCT06929767 NOT YET RECRUITING

Do Blood Tests Help to Decide Which Patients With Flares of Chronic Obstructive Pulmonary Disease (COPD) Need Antibiotics and Steroids?

Ottawa Hospital Research Institute

NCT03566667 ACTIVE NOT RECRUITING

Beta-blockers to Patients With Chronic Obstructive Pulmonary Disease

Ole Frobert, MD, PhD

NCT06892210 NOT YET RECRUITING

Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

Copenhagen Respiratory Research

NCT06552364 NOT YET RECRUITING

Air Pollution and Inhaled Corticosteroids in COPD

University of British Columbia

NCT06334575 RECRUITING

Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels

Maria Joyera Rodríguez

NCT02989935 ACTIVE NOT RECRUITING

RELVAR Effects on Parasternal Muscle Activity, Diaphragm, and Ventilation in Severe COPD

University of Calgary

NCT06825013 RECRUITING

Bronchodilators and Lung Mechanics During Exercise in COPD

Dr. J. Alberto Neder

NCT06825728 NOT YET RECRUITING

Metoprolol in Patients With HFrEF and COPD

Xiangya Hospital of Central South University

NCT06571942 RECRUITING

Effect of the Inhaled Triple Therapies Over the Small Airway in Biomass Exposure

National Institute of Respiratory Diseases, Mexico

NCT04339270 RECRUITING

Chronic Airway Disease, Mucus Rheology and Exacerbations

University Hospital, Montpellier

NCT06257212 RECRUITING

Live Vaccines and Innate Immune Training in COPD.

Josefin Eklöf

NCT05772013 RECRUITING

Optimising Azithromycin Prevention Treatment in COPD to Reduce Exacerbations

Dr Ian B Wilkinson

NCT06905483 COMPLETED

Comparative Effects of Triple Inhaled Therapy With Budesonide/Glycopyrronium/Formoterol Versus Fluticasone Furoate/Umeclidinium/Vilanterol on Small Airway Disease in COPD Patients: A Randomized Crossover Study

Thammasat University

NCT04481555 COMPLETED

Eosinophil-guided Reduction of Inhaled Corticosteroids

Chronic Obstructive Pulmonary Disease Trial Network, Denmark

NCT03404180 COMPLETED

Peripheral Nerve Blocks for Above-the-knee Amputations

University of Florida

NCT05535972 COMPLETED

To Evaluate Real-World Effectiveness of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol (FF/UMEC/VI) in a Single Inhaler (Trelegy Ellipta) in Participants With Symptomatic COPD

GlaxoSmithKline

NCT05292053 COMPLETED

Outcomes of Once-Daily ICS/LABA/LAMA + PRN Respiratory Therapy Treatments in Hospitalized Patients With COPD Exacerbations

Baylor Research Institute

NCT03081156 COMPLETED

The Effect of BEVESPI AEROSPHERE ® Therapy on Exercise Tolerance in COPD

William Stringer, md

NCT06828120 COMPLETED

A Randomized, Safety and Efficacy Study of Taneasy 600mg Granules and Fluimucil 600mg Granules in COPD Subjects

Bun Yao Biotechnology Co., Ltd

NCT06282861 TERMINATED

ANTES B+ Clinical Trial

Fundacio Privada Mon Clinic Barcelona

NCT03851991 COMPLETED

The Efficacy and Safety of Arbidol in Reducing the Frequency of AECOPD.

Shengjing Hospital

NCT03834363 COMPLETED

Morphine or Fentanyl for Refractory Dyspnea in COPD

Huib A.M. Kerstjens

NCT04923347 COMPLETED

A Study to Evaluate the Safety and Efficacy of Fluticasone Furoate (FF)/Umeclidinium(UMEC)/Vilanterol (VI) in Participants With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT04538976 COMPLETED

Copd Exacerbation and Pulmonary Hypertension Trial

Chronic Obstructive Pulmonary Disease Trial Network, Denmark

NCT05052125 TERMINATED

Substudy of Protocol 2019-002498-80 - NCT04223050: Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation (O2flow-COPD)

Mikkel Brabrand

NCT05563675 COMPLETED

Once Daily Long-Acting Muscarinic Antagonists Administered in the Evening for Prevention of Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization or Death from Any Cause

Chronic Obstructive Pulmonary Disease Trial Network, Denmark

NCT06688292 COMPLETED

The Safety and Effectiveness of Taneasy and Actein in COPD Patients

Bun Yao Biotechnology Co., Ltd

NCT06346691 COMPLETED

Effects of Oral Doxofylline and Procaterol on Chronic Obstructive Pulmonary Disease

Thammasat University

NCT05400369 COMPLETED

A Study to Evaluate the Efficacy and Safety of Sitafloxacin in Adult Subjects With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Daiichi Sankyo

NCT05165485 COMPLETED

Phase 4 COPD and Suboptimal Inspiratory Flow Rate

Theravance Biopharma

NCT04061161 COMPLETED

Anti-inflammatory Effects of Tiotropium in Patients with Stable COPD

University Medical Center Groningen

NCT05059873 TERMINATED

Treatment Efficacy of Systemic Corticosteroids in AECOPD Patients With Higher Blood Eosinophil Levels

Capital Medical University

NCT05431218 COMPLETED

Association of Cathelicidin and Vitamin D Levels With the Category and Course of COPD

Karaganda Medical University

NCT03405090 COMPLETED

Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators

Dr. Denis O'Donnell

NCT04606901 COMPLETED

Comparison of Time to Extubation Using Sugammadex or Neostigmine

Temple University

NCT05970263 WITHDRAWN

IKANOS: Breztri Maintenance Versus Any Non-Triple Inhaled Therapy After Hospitalization for a COPD Exacerbation in the US

AstraZeneca

NCT03964207 COMPLETED

A Study on Whether Patients Prefer the Spiriva® Respimat® or the Spiriva® Handihaler® for Treating Their Chronic Obstructive Pulmonary Disease (COPD)

Boehringer Ingelheim

NCT03262142 TERMINATED

Targeted AntiBiotics for Chronic Pulmonary Diseases

Chronic Obstructive Pulmonary Disease Trial Network, Denmark

NCT04606394 COMPLETED

Peak Inspiratory Flow and Dry Powder Inhaler Performance in COPD

Pulmonary Research Institute of Southeast Michigan

NCT05466747 WITHDRAWN

A Study of RYMPHYSIA for Alpha1-Proteinase Inhibitor (A1PI) Therapy in Adults With A1PI Deficiency and Chronic Obstructive Pulmonary Disease (COPD)-Emphysema

Takeda

NCT04231214 COMPLETED

Effects of Spiolto® Respimat® (Tiotropium/Olodaterol) on Cardiac Function in Hyperinflated COPD Subjects

Fraunhofer-Institute of Toxicology and Experimental Medicine

NCT05097014 COMPLETED

CHF5993 and CHF1535 pMDI on Lung Hyperinflation and Exercise Endurance Time in Subjects With COPD

Chiesi Farmaceutici S.p.A.

NCT04088942 WITHDRAWN

TOBacco STOP in Chronic Obstructive Pulmonary Disease-Trial - Study Protocol

Pradeesh Sivapalan

NCT03662711 TERMINATED

Inhaled Long-acting Bronchodilators With or Without Inhaled Glucocorticosteroids for Preventing Hospitalizations and Death in Elderly Patients With Chronic Obstructive Pulmonary Disease

Università degli Studi di Ferrara

NCT02812862 WITHDRAWN

Cardiac Effects of Spiolto®/Respimat® in Patients With Congestive Heart Failure and COPD

RWTH Aachen University

NCT04042168 WITHDRAWN

Implications of Appropriate Use of Inhalers in Chronic Obstructive Pulmonary Disease (COPD)

University of Alabama at Birmingham

NCT03265145 COMPLETED

Assessment In a Real World Setting of the Effect of Inhaled Steroid-based Triple Therapy Versus the Combination of Tiotropium and Olodaterol on Reducing Chronic Obstructive Pulmonary Disease (COPD) Exacerbations [AIRWISE]

Boehringer Ingelheim

NCT03363503 TERMINATED

Salmeterol/Fluticasone 50/500 mcg Inhalation Powder Via Capsair vs Seretide Diskus 500 mcg Inhalation Powder in Patients With COPD

Neutec Ar-Ge San ve Tic A.Ş

NCT05342558 COMPLETED

Efficacy and Safety of ICS/LABA vs. LAMA/LABA in Patients With Different COPD Phenotypes.

National Institute of Respiratory Diseases, Mexico

NCT02813200 COMPLETED

Description of the Ability to Learn How to Handle Inhaler Devices in COPD

University Hospital, Bordeaux

NCT04671355 WITHDRAWN

TRIMBOW® and RELVAR® on Lung Stiffness Reduction Assessed Through Forced Oscillation Technique in Patients With COPD

Chiesi Farmaceutici S.p.A.

NCT04420455 TERMINATED

The Effects of Enoximone in Acute Exacerbation COPD

Rijnstate Hospital

NCT04223843 COMPLETED

A Study to Test the Combination of Tiotropium and Olodaterol Using the Respimat® Inhaler in People With Chronic Obstructive Pulmonary Disease (COPD) Who Have Different Abilities to Inhale

Boehringer Ingelheim

NCT03540901 COMPLETED

Effect of Acetazolamide on Lung Water Content by Ultrasound in Patients With Respiratory Disease at Altitude

University of Zurich

NCT03177811 COMPLETED

Effect of Acetazolamide on Postural Control in Patients With Respiratory Disease at Altitude

University of Zurich

NCT02872090 COMPLETED

Effects of Long Acting Bronchodilators on CARDiac Autonomic Control in Chronic Obstructive Pulmonary Disease (COPD)

Centre Hospitalier Universitaire de Besancon

NCT03474081 COMPLETED

A Comparative Study Between Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy Versus Tiotropium Monotherapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03219866 TERMINATED

Nebulizer Versus Dry Powdered Inhalers for Chronic Obstructive Pulmonary Disease (COPD)

Wake Forest University Health Sciences

NCT04414267 COMPLETED

Bacillus Calmette-guérin Vaccination to Prevent COVID-19

Hellenic Institute for the Study of Sepsis

NCT04155047 COMPLETED

A Clinical Study to Investigate if a Single Dose of an Approved Drug Product (Glycopyrrolate Inhalation Solution) Reduces Trapped Air in the Lungs of Participants With Chronic Obstructive Pulmonary Disease.

Sunovion Respiratory Development Inc.

NCT03466021 COMPLETED

Effects of Liraglutide in Chronic Obstructive Pulmonary Disease

Claus Bogh Juhl

NCT02634983 COMPLETED

QVA Mechanistic Efficacy Study (Receptor Effects, Etc)

Novartis Pharmaceuticals

NCT03159091 COMPLETED

Clinical Trial of Efficacy and Safety of Rengalin in the Treatment of Cough in Patients With Chronic Obstructive Pulmonary Disease

Materia Medica Holding

NCT03478683 COMPLETED

A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03478696 COMPLETED

A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC /VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT04440488 WITHDRAWN

ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study

Shire

NCT03467425 COMPLETED

INTREPID: Investigation of TRELEGY Effectiveness: Usual Practice Design

GlaxoSmithKline

NCT02416102 TERMINATED

Effect of Losartan on Airway Mucociliary Dysfunction in Patients With COPD and Chronic Bronchitis

University of Miami

NCT02845752 COMPLETED

The Effect of STIOLTO™ RESPIMAT® on Fatigue in Chronic Obstructive Pulmonary Disease

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

NCT04458636 COMPLETED

Stratified TreAtment to Reduce Risk in COPD

University of Oxford

NCT03152149 COMPLETED

INvestigating COPD Outcomes, Genomics and Neutrophilic Inflammation With Tiotropium and Olodaterol

University of Dundee

NCT02972476 COMPLETED

Microbiome Use to Stratify Use of Inhaled Corticosteroids: MUSIC Trial

University of Dundee

NCT03611699 COMPLETED

Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients

Gary L. Pierce

NCT03227445 COMPLETED

Comparative Study of ELLIPTA Dry Powder Inhaler (DPI) Versus DISKUS DPI Used With HandiHaler DPI in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03028701 COMPLETED

Assessment of Bronchodilator Efficacy of Formoterol/Budesonide 12/400 mcg Via Discair in COPD

Neutec Ar-Ge San ve Tic A.Ş

NCT02988869 COMPLETED

Tiotropium/Formoterol Via Discair® vs Tiotropium Monotherapy or Tiotropium + Formoterol Free Combination Treatment

Neutec Ar-Ge San ve Tic A.Ş

NCT03395002 COMPLETED

Tiotropium/Salmeterol/Fluticasone Fixed Dose Combination Tratment Via Discair vs Tiotropium Via Handihaler + Salmeterol/Fluticasone Via Diskus Free Combination Treatment

Neutec Ar-Ge San ve Tic A.Ş

NCT03388853 COMPLETED

Efficacy and Safety Study of Acetylcysteine/Doxofylline 1200/400 mg Effervescent Tablet in the Treatment of Moderate-Severe COPD.

Neutec Ar-Ge San ve Tic A.Ş

NCT03949842 WITHDRAWN

Legend: TRELEGY Real World Chronic Obstructive Pulmonary Disease (COPD) Effectiveness Study

GlaxoSmithKline

NCT02858180 COMPLETED

Hepatitis C Virus(HCV) Heart and Lung Study

Duke University

NCT03240575 COMPLETED

The ENERGITO® 2 Study Compares 2 Inhaled Medicines for Chronic Obstructive Pulmonary Disease (COPD). One Medicine is a Combination of Tiotropium and Olodaterol (Stiolto®) Taken Using the Respimat® Inhaler and the Other Medicine is a Combination of Fluticasone and Salmeterol Taken Using the Diskus

Boehringer Ingelheim

NCT03034915 COMPLETED

A 24-week Study to Compare Umeclidinium/Vilanterol (UMEC/VI), UMEC and Salmeterol in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03955770 COMPLETED

Effects of HFOT on Exercise Performance in Patients With COPD. A Randomized, Controlled Trial.

University of Zurich

NCT03842904 COMPLETED

A Study Comparing the Effects of Trimbow to Fostair in COPD

Medicines Evaluation Unit Ltd

NCT02982187 COMPLETED

A Clinical Study Assessing Critical Errors, Training/Teaching Time, and Preference Attributes of the ELLIPTA® Dry Powder Inhaler, in Comparison to Combinations of Dry Powder Inhalers Used to Provide Triple Therapy, in Patients With Chronic Obstructive Pulmonary Disease

GlaxoSmithKline

NCT02853123 COMPLETED

Effect of Tiotropium + Olodaterol on Breathlessness in COPD Patients

Boehringer Ingelheim

NCT02429050 COMPLETED

Morphine for Treatment of Dyspnea in Patients With COPD

Maastricht University Medical Center

NCT03461328 COMPLETED

Effect of Magnesium Sulphate Infusion on Lung Mechanics and Oxygenation in COPD Patients Undergoing Total Laryngeal

Cairo University

NCT03055988 COMPLETED

Cardiovascular Function in COPD Patients

Boehringer Ingelheim

NCT03177837 COMPLETED

Effect of Acetazolamide on Exercise Performance in Patients With Respiratory Disease at Altitude

University of Zurich

NCT03173508 COMPLETED

Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude

University of Zurich

NCT03167034 COMPLETED

Effect of Acetazolamide on Right Ventricular Function During Exercise in Patients With Respiratory Disease at Altitude

University of Zurich

NCT02371629 COMPLETED

A Study of the Efficacy and Safety of NVA237 in Patients With Moderate to Severe COPD

Novartis Pharmaceuticals

NCT02429765 COMPLETED

Effect of Aclidinium/Formoterol on Nighttime Lung Function and Morning Symptoms in Chronic Obstructive Pulmonary Disease

Queen's University

NCT02380053 COMPLETED

Chronic Beta-blockade and Cardiopulmonary Exercise in COPD

University of Dundee

NCT02567214 COMPLETED

Ultibro® Versus Spiriva® Alone to Reduce Exertional Dyspnea in Patients With Moderate to Severe COPD

Laval University

NCT03165890 COMPLETED

Effect of Acetazolamide on Cognition in Patients With Respiratory Disease at Altitude

University of Zurich

NCT02603393 COMPLETED

Evaluation of the Efficacy and Safety of QVA149 (110/50 μg o.d.) vs Tiotropium (18 µg o.d.) + Salmeterol/Fluticasone Propionate FDC (50/500 µg b.i.d.) in Patients With Moderate to Severe COPD

Novartis Pharmaceuticals

NCT02516592 COMPLETED

Assessment of Switching From Salmeterol/Fluticasone to Indacaterol/Glycopyrronium in a symtomaticCOPD Patient Cohort

Novartis Pharmaceuticals

NCT02857842 COMPLETED

Corticosteroid Reduction in COPD

Chronic Obstructive Pulmonary Disease Trial Network, Denmark

NCT03425617 COMPLETED

Effects of Dual Bronchodilator Treatment on Cardiopulmonary Interactions in COPD

Queen's University

NCT03177850 COMPLETED

Effect of Acetazolamide on Sleep Related Breathing Disturbances in Patients With Respiratory Disease at Altitude

University of Zurich

NCT03156231 COMPLETED

Effect Of Acetazolamide On Altitude Related Illness In Patients With Respiratory Disease

University of Zurich

NCT02442206 COMPLETED

Effect of QVA149 (Indacaterol Maleate/Glycopyrronium Bromide) on Cardiac Function in COPD Patients

Novartis Pharmaceuticals

NCT02864342 COMPLETED

Adherence Study in COPD Patients

AstraZeneca

NCT02786927 COMPLETED

Preference Attributes of ELLIPTA Dry Powder Inhaler (DPI) and HANDIHALER DPI in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT02424344 COMPLETED

Effect of Aclidinium/Formoterol on Lung Hyperinflation, Exercise Capacity and Physical Activity in Moderate to Severe COPD Patients

AstraZeneca

NCT02683109 COMPLETED

Fixed Dose Combination Versus Free Combination of Tiotropium and Olodaterol in COPD

Boehringer Ingelheim

NCT02275052 COMPLETED

A Study to Evaluate the Effect of the Combination of Umeclidinium (UMEC) and Vilanterol (VI) on Exercise Endurance Time (EET) in Participants With Chronic Obstructive Pulmonary Disease (COPD)

GlaxoSmithKline

NCT03623282 COMPLETED

Study Regarding the Clinical Efficacy of Synatura® in Patients With Chronic Bronchitis Type COPD

Ahn-Gook Pharmaceuticals Co.,Ltd

NCT02273830 COMPLETED

Benefits of Liquid Oxygen in COPD Patients Presenting Desaturation During Exercise.

Jtarrega

NCT02098369 COMPLETED

Comparative Effectiveness of a Peer-led O2 Infoline for Patients and Caregivers

University of Illinois at Chicago

NCT02773797 WITHDRAWN

Placebo Controlled Evaluation of Sedation and Physiological Response to Intranasal Dexmedetomidine in Severe COPD

Dayton VA Medical Center

NCT02533505 COMPLETED

Phase IV O2 Consumption Study in COPD Patients.

AstraZeneca

NCT02799784 COMPLETED

An Efficacy Study of Umeclidinium/Vilanterol With Tiotropium/Olodaterol in COPD Patients

GlaxoSmithKline

NCT02596009 COMPLETED

Inspiratory Flow Rates Achieved by the COPD Patients Through Breezhaler®, Ellipta® and Handihaler® Inhaler Devices

Novartis Pharmaceuticals

NCT02579772 COMPLETED

Effects of N-acetylcysteine on Cardiorespiratory Control in COPD Patients With Mild-to-moderate Airflow Obstruction

Queen's University

NCT02962999 COMPLETED

Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation

Cukurova University

NCT02498496 WITHDRAWN

Magnesium Sulfate to Prevent Hospitalisation of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Hôpital de Verdun

NCT02586493 COMPLETED

Ease of Use and Correct Use Study of Placebo ELLIPTA® Inhaler in COPD Subjects

GlaxoSmithKline

NCT02576626 COMPLETED

Single Dose Ultibro Breezhaler by Sd-DPI Versus Ipratropium/Salbutamol by Nebulizer in COPD

Wouter H. van Geffen

NCT02936817 COMPLETED

Study to Assess the Effect of the Aerobika Device in Addition to Standard of Care Treatment in Sputum Producing COPD Patients Using FRI

FLUIDDA nv

NCT02418468 COMPLETED

Effects of Indacaterol in Symptomatic COPD Patients With Low Risk of Exacerbations

Novartis Pharmaceuticals

NCT03181880 WITHDRAWN

To Evaluate Effectiveness of Aclidinium Bromide/Formoterol Fumarate Dihydrate in Chronic Obstructive Pulmonary Disease

AstraZeneca

NCT02450968 COMPLETED

Altitude Related Illness In Patients With Respiratory Disease

University of Zurich

NCT02375724 COMPLETED

BENEFITS OF ACLIDINIUM BROMIDE IN THE RELIEF OF COPD SYMPTOMS INCLUDING COUGH

AstraZeneca

NCT02363920 COMPLETED

Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics

IRCCS Azienda Ospedaliero-Universitaria di Bologna

NCT02366390 COMPLETED

Dialogue Aimed at Reducing Anxiety in Patients With Severe COPD

Nordsjaellands Hospital

NCT02450994 COMPLETED

Effect of Dexamethasone on Sleep Related Breathing Disturbances in Patients With COPD at Altitude

University of Zurich

Data: ClinicalTrials.gov