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Epilepsy

294 clinical trials

95 active
/
294 total (since 2015)
24
Phase 1 Active
62 total
36
Phase 2 Active
119 total
34
Phase 3 Active
88 total
14
Phase 4 Active
56 total

Top Sponsors (Industry)

Sorted by active Active Done Failed
UCB Biopharma SRL 5 5 6
Xenon Pharmaceuticals Inc. 5 0 2
SK Life Science, Inc. 4 3 0
Biohaven Therapeutics Ltd. 4 0 0
Praxis Precision Medicines 4 0 0
Supernus Pharmaceuticals, Inc. 3 1 0
NeuroPro Therapeutics, Inc. 2 2 0
Neurona Therapeutics 2 0 0
NeuroPace 2 0 0
Shanghai Zhimeng Biopharma, Inc. 2 0 0
Jazz Pharmaceuticals 1 13 2
Eisai Inc. 1 3 3
Rapport Therapeutics Inc. 1 1 0
Epiminder America, Inc. 1 0 0
Zogenix, Inc. 1 0 0
NCT04666610 RECRUITING
A Study to Evaluate the Efficacy, Safety, and Tolerability of Brivaracetam as Monotherapy in Patients 2 to 25 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy
UCB Biopharma SRL n=160
NCT06309966 RECRUITING
Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Biohaven Therapeutics Ltd. n=390
NCT05135091 RECRUITING
Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))
Neurona Therapeutics n=88
NCT05077904 RECRUITING
A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures
UCB Biopharma SRL n=350
NCT06442748 RECRUITING
Short Versus Long-term Levetiracetam in Brain Tumors
Tata Memorial Centre n=604
NCT05716100 RECRUITING
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
Xenon Pharmaceuticals Inc. n=360
NCT05718817 ENROLLING BY INVITATION
An Open-label Study of XEN1101 in Epilepsy
Xenon Pharmaceuticals Inc. n=880
NCT05667142 RECRUITING
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
Xenon Pharmaceuticals Inc. n=160
NCT06132893 RECRUITING
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Biohaven Therapeutics Ltd. n=390
NCT05076617 ENROLLING BY INVITATION
A Study to Test the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures
UCB Biopharma SRL n=300
NCT07377032 RECRUITING
TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders
Meyer Children's Hospital IRCCS n=40
NCT06425159 ACTIVE NOT RECRUITING
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Idiopathic Generalized Epilepsy With Generalized Tonic-clonic Seizures
Biohaven Therapeutics Ltd. n=242
NCT06315322 RECRUITING
A Study to Test the Long-term Safety and Tolerability of Brivaracetam in Study Participants With Childhood Absence Epilepsy or Juvenile Absence Epilepsy
UCB Biopharma SRL n=120
NCT07234695 RECRUITING
LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau n=120
NCT03961568 ENROLLING BY INVITATION
Cenobamate Open-Label Extension Study for YKP3089C025
SK Life Science, Inc. n=145
NCT05064878 ACTIVE NOT RECRUITING
A Study to Investigate the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder
Zogenix, Inc. n=87
NCT05614063 ACTIVE NOT RECRUITING
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures
Xenon Pharmaceuticals Inc. n=360
NCT07287163 ENROLLING BY INVITATION
Clinical Trial of Vormatrigine in Adult Patients With Epilepsy
Praxis Precision Medicines n=700
NCT07281027 NOT YET RECRUITING
COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"
Yale University n=438
NCT05121324 RECRUITING
Pediatric Dose Optimization for Seizures in Emergency Medical Services
Stanford University n=6,700
NCT05067634 RECRUITING
Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures
SK Life Science, Inc. n=140
NCT07165262 ACTIVE NOT RECRUITING
Effect of Different Anesthetic Drugs on Electrocorticography (ECOG).
Children's Cancer Hospital Egypt 57357 n=88
NCT04274179 RECRUITING
Ketogenic Diet for New-Onset Absence Epilepsy
Johns Hopkins University n=40
NCT05219617 RECRUITING
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
SK Life Science, Inc. n=252
NCT05147571 ACTIVE NOT RECRUITING
RNS System NAUTILUS Study
NeuroPace n=100
NCT04715646 RECRUITING
A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures
UCB Biopharma SRL n=70
NCT06579573 RECRUITING
ONO-2017 Study Japanese Patients With Primary Generalized Tonic Clonic Seizures.
Ono Pharmaceutical Co. Ltd n=15
NCT06999902 RECRUITING
Double-blind, Randomized Trial of PRAX-628 in Adults With Focal Seizures to Evaluate Efficacy and Safety (POWER1)
Praxis Precision Medicines n=230
NCT06262594 RECRUITING
Lemborexant Treatment of Insomnia Linked to Epilepsy
University of Manitoba n=26
NCT05670847 RECRUITING
Exogenous Ketone Esters for Drug Resistant Epilepsy
Sohag University n=60
NCT05897658 NOT YET RECRUITING
Levetiracetam Prophylaxis in Brain Tumor Resection Pilot
Hamilton Health Sciences Corporation n=70
NCT06622564 NOT YET RECRUITING
Decreasing Postoperative Blood Loss and Seizures by Timing of Intravenous Tranexamic Acid 2 Pilot Trial
Hamilton Health Sciences Corporation n=40
NCT04945213 RECRUITING
Biperiden Trial for Epilepsy Prevention
Hospital Sirio-Libanes n=312
NCT04573803 NOT YET RECRUITING
Pharmacological Management of Seizures Post Traumatic Brain Injury
Cambridge University Hospitals NHS Foundation Trust n=1,649
NCT04485104 TERMINATED
Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled Seizures
Jazz Pharmaceuticals n=3
NCT05109234 COMPLETED
A Study to Test the Long-term Safety, Tolerability and Efficacy of Brivaracetam in Study Participants 2 to 26 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy
UCB Biopharma SRL n=84
NCT03083665 COMPLETED
A Study to Evaluate the Efficacy and Safety of Brivaracetam in Study Participants (>=16 to 80 Years of Age) With Epilepsy
UCB Biopharma SRL n=449
NCT02332447 COMPLETED
Efficacy of Naloxone in Reducing Postictal Central Respiratory Dysfunction in Patients With Epilepsy
Hospices Civils de Lyon n=485
NCT05439876 COMPLETED
Getting SMART for Pediatric Epilepsy
National Taiwan University Hospital n=147
NCT04627285 COMPLETED
A Study to Test the Long-term Use of Oral Lacosamide in Pediatric Study Participants Who Completed NCT01964560 (EP0034) or NCT00938912 (SP848) and Received Lacosamide Treatment
UCB Biopharma SRL n=48
NCT02348073 COMPLETED
Efficacy of Phosphatidylserine Enriched With n-3 PUFA Supplementation on ADHD in Children With Epilepsy
Hospices Civils de Lyon n=77
NCT03250377 COMPLETED
A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization
UCB Biopharma SRL n=207
NCT03678753 COMPLETED
Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in PGTC Seizures
SK Life Science, Inc. n=169
NCT04912856 TERMINATED
An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE
Xenon Pharmaceuticals Inc. n=8
NCT05288283 TERMINATED
Efficacy and Safety of GWP42003-P Oral Solution in Children With Epilepsy With Myoclonic-atonic Seizures
Jazz Pharmaceuticals n=3
NCT05722951 COMPLETED
Metformin Efficacy and Safety in Epileptic Patients
Tanta University n=60
NCT03790137 COMPLETED
Treatment of Sunflower Syndrome With ZX008 (Fenfluramine Hydrochloride) in Children and Young Adults (Ages 4-25).
Elizabeth Anne Thiele n=20
NCT04378075 TERMINATED
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy
PTC Therapeutics n=68
NCT04639310 TERMINATED
XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy
Xenon Pharmaceuticals Inc. n=8
NCT03340064 COMPLETED
A Study of Levetiracetam as Monotherapy or Adjunctive Treatment of Partial Seizures in Pediatric Epileptic Subjects Ranging From 1 Month to Less Than 4 Years of Age
UCB Japan Co. Ltd. n=38
NCT03475225 COMPLETED
Vitamine D in Drug Resistant Epilepsy
Centre Hospitalier St Anne n=88
NCT02535091 COMPLETED
Safety and Pharmacokinetic Study of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures
SK Life Science, Inc. n=1,345
NCT03325439 TERMINATED
A Study to Test the Pharmacokinetics, Efficacy, and Safety of Brivaracetam in Newborns With Repeated Electroencephalographic Seizures
UCB Biopharma SRL n=9
NCT05297695 COMPLETED
Helicobacter Pylori Eradication Therapy for Epileptic Children
Sohag University n=126
NCT02408549 COMPLETED
Safety and Efficacy of Lacosamide as Additional Therapy in Patients Suffering From Epileptic Tonic-Clonic Seizures
UCB BIOSCIENCES, Inc. n=239
NCT03954314 TERMINATED
DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
Population Health Research Institute n=3,242
NCT04320940 TERMINATED
Efficacy and Safety of Intravenous Phenobarbital in Neonatal Seizures
NEMA Research, Inc. n=4
NCT02682927 COMPLETED
A Trial of Two Fixed Doses of ZX008 (Fenfluramine HCl) in Children and Young Adults With Dravet Syndrome
Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc. n=262
NCT02519439 TERMINATED
A Two-year Open-label Extension Study of Ganaxolone in Patients With Drug-resistant Partial-onset Seizures
Marinus Pharmaceuticals n=26
NCT02582866 COMPLETED
A Clinical Study to Investigate the Long-term Use of Lacosamide as Monotherapy in Subjects Who Completed Study SP0994
UCB Biopharma S.P.R.L. n=106
NCT02710890 COMPLETED
Study to Investigate Safety and Tolerability of Intravenous Lacosamide in Children.
UCB BIOSCIENCES, Inc. n=103
NCT03739840 TERMINATED
A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy
UCB Biopharma SRL n=232
NCT02849626 COMPLETED
Perampanel as Adjunctive Therapy in Pediatrics With Partial Onset Seizures or Primary Generalized Tonic Clonic Seizures
Eisai Inc. n=180
NCT02544763 COMPLETED
A Randomized Controlled Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6)
Jazz Pharmaceuticals n=224
NCT02224690 COMPLETED
A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults
Jazz Pharmaceuticals n=171
NCT02224560 COMPLETED
Efficacy and Safety of GWP42003-P for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults
Jazz Pharmaceuticals n=225
NCT02224703 COMPLETED
GWPCARE2 A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P) in Children and Young Adults With Dravet Syndrome
Jazz Pharmaceuticals n=199
NCT02091375 COMPLETED
Antiepileptic Efficacy Study of GWP42003-P in Children and Young Adults With Dravet Syndrome (GWPCARE1)
Jazz Pharmaceuticals n=120
NCT02544750 COMPLETED
An Open-label Extension Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6)
Jazz Pharmaceuticals n=199
NCT02881957 COMPLETED
Hypovitaminosis D in Neurocritical Patients
University of Utah n=274
NCT02224573 COMPLETED
An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Adults With Dravet or Lennox-Gastaut Syndromes
GW Research Ltd n=681
NCT02721069 COMPLETED
Repeat Dose Safety Study of NRL-1 in Epilepsy Subjects
Neurelis, Inc. n=175
NCT03536845 COMPLETED
Vitamin D Supplementation to Prevent Vitamin D Deficiency for Children With Epilepsy
King Saud University n=116
NCT03201900 COMPLETED
Study for Verification of Efficacy and Safety for Perampanel Monotherapy in Untreated Participants With Partial Onset Seizures (Including Secondarily Generalized Seizures (FREEDOM Study)
Eisai Co., Ltd. n=91
NCT03428360 COMPLETED
Safety and Tolerability Study of Diazepam Buccal Film (DBF) in Subjects With Epilepsy
Aquestive Therapeutics n=149
NCT02477839 COMPLETED
Efficacy and Safety of Lacosamide as Adjunctive Therapy in Subjects ≥1 Month to <4 Years With Partial-onset Seizures
UCB BIOSCIENCES, Inc. n=255
NCT03115489 WITHDRAWN
Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus
University of Alabama at Birmingham
NCT03685630 COMPLETED
A Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam (BRV) as Replacement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization
UCB Biopharma S.P.R.L. n=10
NCT02408523 COMPLETED
A Study to Assess the Safety and Efficacy of Lacosamide Versus Placebo (a Pill Without Active Medication) in Patients With Idiopathic Generalised Epilepsy Who Are Already Taking Anti-epileptic Medications
UCB BIOSCIENCES, Inc. n=242
NCT03808935 TERMINATED
Cannabis Extract in Refractory Epilepsy Study
The Epilepsy Research Program of the Ontario Brain Institute n=17
NCT02697292 TERMINATED
IVIG in Patients With VGKC Ab Associated Autoimmune Epilepsy
Mayo Clinic n=17
NCT03602118 WITHDRAWN
Study to Evaluate Phenobarbital Sodium Injection for the Treatment of Neonatal Seizures
PharPoint Research, Inc.
NCT03580707 COMPLETED
Does BRV Have Faster Onset Time & Greater Effect Than LEV in Epilepsy Pts Using PPR Pharmacodynamic Efficacy Endpoint
Rosenfeld, William E., M.D. n=16
NCT02484001 COMPLETED
Eslicarbazepine Acetate (BIA 2-093) as Monotherapy in Patients With Newly Diagnosed Partial-onset Seizures
Bial - Portela C S.A. n=206
NCT02318602 COMPLETED
Cannabidiol Oral Solution as an Adjunctive Treatment for Treatment-resistant Seizure Disorder
INSYS Therapeutics Inc n=52
NCT02427607 COMPLETED
An Open-label Extension Study to Evaluate the Safety and Tolerability of Perampanel (E2007) Administered as an Adjunctive Therapy in Epilepsy Subjects
Eisai Co., Ltd. n=7
NCT03108729 WITHDRAWN
A Pediatric Drug Study to Determine the Long-term Safety and Tolerability in Children and Adolescents (4-17 Years in Age) Taking the Drug
Sumitomo Pharma America, Inc.
NCT03014752 COMPLETED
Comparison of the Effectiveness of the Outpatient Classical Ketogenic Diet and Modified Atkins Diet on Seizures Frequency, Nutritional Status and Some Biochemical Factors in Children and Adolescents With Intractable Epilepsy
Tehran University of Medical Sciences n=50

Data: ClinicalTrials.gov