NCT06324357 RECRUITING Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Boehringer Ingelheim
NCT02465060 ACTIVE NOT RECRUITING Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
National Cancer Institute (NCI)
NCT07282912 RECRUITING Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels
Yale University
NCT07367516 RECRUITING Clinical Trial Evaluating TQB6411 Injection in Subjects With Esophageal Cancer
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
NCT07205731 RECRUITING Phase II Study Evaluating Safety and Efficacy of Tislelizumab for Elderly Patients Unfit for Chemotherapy, With Advanced Esophageal Squamous-cell Carcinoma
University Hospital, Clermont-Ferrand
NCT04939051 RECRUITING Obeticholic Acid for Prevention in Barrett's Esophagus
National Cancer Institute (NCI)
NCT06732388 NOT YET RECRUITING Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus
National Cancer Institute (NCI)
NCT06747585 RECRUITING A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors
Alentis Therapeutics AG
NCT06047379 RECRUITING Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Neonc Technologies, Inc.
NCT05319730 RECRUITING A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
Merck Sharp & Dohme LLC
NCT03403465 ACTIVE NOT RECRUITING Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
Duke University
NCT06469944 RECRUITING Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
Merck Sharp & Dohme LLC
NCT07109726 RECRUITING A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
Terremoto Biosciences Inc.
NCT07039162 RECRUITING Study of Tislelizumab Combined With Chemoradiotherapy and Surgery for Unresectable Esophageal Squamous Cell Carcinoma
Ming-Yu Lien
NCT06452602 RECRUITING Induction Immunochemotherapy Followed by Concurrent Chemoradiotherapy in Patients With ESCC.
Tianjin Medical University Cancer Institute and Hospital
NCT06078709 RECRUITING Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma
Mayo Clinic
NCT07435454 RECRUITING Exploratory Clinical Trial of Oral Paclitaxel Plus Radiotherapy in Patients With Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma
Jiangsu Cancer Institute & Hospital
NCT07437898 RECRUITING Neoadjuvant Adebrelimab Plus Chemotherapy for Esophageal Cancer: A Clinical Study
The Affiliated Hospital of Putian University
NCT07432295 RECRUITING Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)
I-Mab Biopharma US Limited
NCT06695845 RECRUITING A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
Jazz Pharmaceuticals
NCT05438420 ACTIVE NOT RECRUITING Oral Axl/Mer/CSF1R Selective Tyrosine Kinase Inhibitor Q702 in Combination With Pembrolizumab in Patients With Selected Advanced Solid Tumors
Qurient Co., Ltd.
NCT04430738 ACTIVE NOT RECRUITING Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers
Seagen, a wholly owned subsidiary of Pfizer
NCT04150640 RECRUITING Oxaliplatin and Liposomal Irinotecan (Plus Trastuzumab for HER2-positive Disease) in Advanced Esophageal and Gastric Adenocarcinoma
University of Wisconsin, Madison
NCT06005493 RECRUITING Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors
AstraZeneca
NCT03174275 ACTIVE NOT RECRUITING Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma
UNC Lineberger Comprehensive Cancer Center
NCT05969860 RECRUITING At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Mayo Clinic
NCT04868877 ACTIVE NOT RECRUITING Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
Merus B.V.
NCT07410676 RECRUITING EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors
Essen Biotech
NCT06780111 RECRUITING Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)
Merck Sharp & Dohme LLC
NCT06219941 RECRUITING AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
AstraZeneca
NCT07405151 NOT YET RECRUITING A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)
Merck Sharp & Dohme LLC
NCT06628310 RECRUITING A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma
AbbVie
NCT07403136 NOT YET RECRUITING Vebrekotuzumab ± Anti-PD-1 in Pretreated Advanced ESCC
Fudan University
NCT06921928 RECRUITING Study for AZD4360 in Participants With Advanced Solid Tumours
AstraZeneca
NCT07403435 NOT YET RECRUITING Short-course Radiotherapy Combined With Serplulimab and Chemotherapy as Neoadjuvant Treatment for Resectable ESCC
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NCT06109467 RECRUITING Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal Cancer
H. Lee Moffitt Cancer Center and Research Institute
NCT07115043 RECRUITING A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors
AstraZeneca
NCT04921904 ACTIVE NOT RECRUITING Abemaciclib Plus Ramucirumab for Esophageal/Gastroesophageal Junction Ca
Baylor Research Institute
NCT07385664 NOT YET RECRUITING Neoadjuvant Chemoimmunotherapy or Chemoradiotherapy in ESCC
Ji Yongling
NCT07162506 RECRUITING DCRT vs. Surgery in Resectable ESCC Patient Achiving cCR/PR After nCI
Tianjin Medical University Cancer Institute and Hospital
NCT07176312 RECRUITING Zanidatamab in Combination With Pembrolizumab and Chemotherapy in HER2 and PD-L1 Positive Metastatic Gastroesophageal Adenocarcinoma (GEA) Patients
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT03784326 ACTIVE NOT RECRUITING Phase I/II Study of Perioperative Chemotherapy Plus Immunotherapy Followed by Surgery in Localized Esophageal and Gastroesophageal Adenocarcinoma
M.D. Anderson Cancer Center
NCT07385001 RECRUITING A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC
Tang-Du Hospital
NCT05621707 ACTIVE NOT RECRUITING Chemoradiotherapy Following Immunotherapy Plus Chemotherapy for Locally-advanced Esophageal Squamous Cell Cancer (RICE)
Shanghai Chest Hospital
NCT06043427 RECRUITING Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma
Canadian Cancer Trials Group
NCT06123338 RECRUITING A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer
Memorial Sloan Kettering Cancer Center
NCT07376876 NOT YET RECRUITING Indocyanine Green-guided Omental Shield Anastomosis for Cervical Esophagogastric Anastomosis in Minimally Invasive McKeown Esophagectomy
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
NCT06172478 RECRUITING A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Daiichi Sankyo
NCT07266025 NOT YET RECRUITING Adebrelimab Combined With Induction Chemotherapy or SHR-8068 for Mismatch Repair-Deficient/Microsatellite Instability-High (dMMR/MSI-H) Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma:A Randomized, Non-comparative Phase 2 Study
Shanghai Zhongshan Hospital
NCT06921837 RECRUITING A First-in-Human Study Using BDC-4182 as a Single Agent in Advanced Gastric and Gastroesophageal Cancer
Bolt Biotherapeutics, Inc.
NCT07069712 RECRUITING A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma
AstraZeneca
NCT06445972 RECRUITING Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)
Merck Sharp & Dohme LLC
NCT05978193 RECRUITING Radiotherapy Combined With Immunochemotherapy in Metastatic Esophageal Squamous Cell Carcinoma
Shanghai Chest Hospital
NCT05705492 RECRUITING Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer
OHSU Knight Cancer Institute
NCT06468280 RECRUITING Synergistic Effects of PD-1 Antibody and Chemotherapy/Targeted Therapy Followed by Surgery-centric Local Treatment in Patients With Limited-metastatic Gastric Cancer
Shanghai Zhongshan Hospital
NCT03539822 RECRUITING Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal Malignancies
Anwaar Saeed
NCT07143604 RECRUITING A Study to Investigate the Effects of AZD0901 Monotherapy in Adult Participants With 2L+ Advanced or Metastatic Gastric or GEJ Adenocarcinoma Expressing CLDN18.2
AstraZeneca
NCT06710756 RECRUITING Lead-212 PSV359 Therapy for Patients With Solid Tumors
Perspective Therapeutics
NCT02584244 RECRUITING Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
Lumicell, Inc.
NCT07290985 NOT YET RECRUITING AACR Adaptive Biomarker-Driven Organ Preservation Trial in Gastroesophageal Adenocarcinomas
American Association for Cancer Research
NCT07189871 RECRUITING 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors
Radiopharm Theranostics, Ltd
NCT07341737 NOT YET RECRUITING SL-28 for Advanced Solid Tumours
Second Life Therapeutics
NCT07339488 ACTIVE NOT RECRUITING Intestinal Low-Dose Radiotherapy Plus Immunochemotherapy for Conversion of Borderline Resectable/Unresectable Esophageal Squamous Cell Carcinoma
Chuangzhen Chen
NCT04229459 ACTIVE NOT RECRUITING Trial of Nivolumab and Cetuximab After Chemoradiation in Esophageal Squamous Cell Carcinoma Patients.
Baruch Brenner
NCT06769113 RECRUITING A Phase II Clinical Study to Evaluate HLX43 in Patients With Recurrent/Metastatic ESCC Failed or Intolerance to Standard Therapy
Shanghai Henlius Biotech
NCT07059611 NOT YET RECRUITING Neoadjuvant Intra-tumoral RP2 and FLOT in Gastroesophageal Adenocarcinoma
Abramson Cancer Center at Penn Medicine
NCT07330583 NOT YET RECRUITING Stereotactic Body Radiation Therapy (SBRT) and Immunotherapy for Oligometastatic Esophageal Cancer
AHS Cancer Control Alberta
NCT06680622 ACTIVE NOT RECRUITING Bemarituzumab in FGFR2b+ Patients With Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction, Who Failed at Least One Prior Line of Palliative Chemotherapy
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT07038629 RECRUITING Chemoradiation Plus Iparomlimab Consolidation in Older With ESCC
Tianjin Medical University Cancer Institute and Hospital
NCT07315854 RECRUITING Iparomlimab and Tuvonralimab (QL1706) Combined With Chemotherapy for Previously Untreated Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer
Beijing Friendship Hospital
NCT04682158 RECRUITING Propranolol With Standard Chemoradiation for Esophageal Adenocarcinoma
Roswell Park Cancer Institute
NCT07263919 RECRUITING Perioperative Cadonilimab Combined With Neoadjuvant Chemotherapy in Resectable Esophageal Squamous Cell Carcinoma (ESCC)
Akeso
NCT07312578 ENROLLING BY INVITATION Nimotuzumab,Camrelizumab, and Neoadjuvant Chemotherapy(nCT) in the Treatment of Esophageal Squamous Cell Carcinoma
Peking University
NCT05480384 ACTIVE NOT RECRUITING Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction
Brown University
NCT05945823 ACTIVE NOT RECRUITING Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors
Taiho Oncology, Inc.
NCT06161818 RECRUITING Total Neoadjuvant Therapy for Lymph Node-positive Adenocarcinoma of the OESophagus and Oesophagogastric Junction
Erasmus Medical Center
NCT03610711 ACTIVE NOT RECRUITING REACTION (Radiation Enhanced Assessment of Combination Therapies in Immuno-ONcology) - Nivolumab or Nivolumab in Combination With Other Immuno-oncology (IO) Agents After Targeted Systemic Radiation in Patients With Advanced Esophagogastric Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT04140500 ACTIVE NOT RECRUITING Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors
Hoffmann-La Roche
NCT07213557 NOT YET RECRUITING Simvastatin Efficacy in ARID1A Mutated Advanced gastroESophageal Carcinoma Treated With Immunotherapy
National Cancer Institute, Naples
NCT07290010 RECRUITING The Efficacy and Safety of Iparomlimab and Tuvonralimab Injection Combined With Chemotherapy as the First-line Treatment for Esophageal Squamous Cell Carcinoma
Hebei Medical University Fourth Hospital
NCT07283991 NOT YET RECRUITING QL1706 Plus Chemotherapy for Borderline Resectable Esophageal Cancer
Ruijin Hospital
NCT02297217 RECRUITING Chemoradiotherapy for Advanced Esophageal Cancer
AHS Cancer Control Alberta
NCT05651594 RECRUITING Propranolol in Combination With Pembrolizumab and Standard Chemotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Adenocarcinoma
Roswell Park Cancer Institute
NCT03556228 RECRUITING VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
VM Oncology, LLC
NCT06943521 RECRUITING A Study of MT-4561 in Patients With Various Advanced Solid Tumors
Tanabe Pharma America, Inc.
NCT06245356 RECRUITING Safety of Trifluridine/Tipiracil in Patients With Dihydropyrimidine Dehydrogenase Deficiency Diagnosed With Metastatic Colorectal or Gastroesophageal Cancer
UNICANCER
NCT07272291 NOT YET RECRUITING A Phase II Study of Toripalimab Plus Chemotherapy and Low-Dose Radiotherapy for Neoadjuvant Therapy-Refractory Esophageal Squamous Cell Carcinoma
Tianjin Medical University Cancer Institute and Hospital
NCT07061704 RECRUITING Oncolytic Virus in Esophageal Squamous Cell Carcinoma
Sichuan University
NCT05322577 ACTIVE NOT RECRUITING A Study Evaluating Bemarituzumab in Combination With Other Anti-cancer Therapies in Subjects With Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer.
Amgen
NCT07266493 RECRUITING Efficacy and Safety of Neoadjuvant Envafolimab Combined With Albumin-bound Paclitaxel and Carboplatin for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma
Shanghai Zhongshan Hospital
NCT07266480 RECRUITING Clinical Study of Adbelimumab in the Adjuvant Treatment of Esophageal Squamous Cell Carcinoma.
Hebei Medical University Fourth Hospital
NCT06265285 RECRUITING Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
Mayo Clinic
NCT05659251 ACTIVE NOT RECRUITING Serplulimab Combined With Chemotherapy in Patients With Resectable Esophageal Squamous Cell Carcinoma
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT06576973 RECRUITING Adbelimumab Combined With Chemotherapy and Apatinib in Patients With Resectable Esophageal Squamous Cell Carcinoma
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT07244978 NOT YET RECRUITING Neoadjuvant Ivonescimab(AK112) Combined With Chemotherapy in Patients With Resectable Esophageal Squamous Cell Carcinoma
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT06251973 RECRUITING A Study of agenT-797 in Combination With Botensilimab, Balstilimab, Ramucirumab, and Paclitaxel for People With Esophageal, Gastric, or Gastro-esophageal Junction Cancer
Memorial Sloan Kettering Cancer Center
NCT06846346 RECRUITING Testing Ivonescimab in Combination With Chemotherapy in Advanced or Metastatic Gastric/Gastroesophageal Adenocarcinoma
UNICANCER
NCT07132918 RECRUITING HEARTS Trial for Thoracic Cancers
University of Wisconsin, Madison
NCT05189730 ACTIVE NOT RECRUITING Selected Chemotherapy Combined Immunotherapy Treated High Risk Patient After NCRT in Resected Locally Advanced ESCC
Sichuan Cancer Hospital and Research Institute
NCT07233850 NOT YET RECRUITING A Phase II Clinical Study Evaluating SSGJ-706 in Combination Therapy for Advanced Gastrointestinal Cancers
Shenyang Sunshine Pharmaceutical Co., LTD.
NCT06281886 ACTIVE NOT RECRUITING Induction Immuno-chemotherapy and Concurrent Chemoradiotherapy With or Without Apatinib in Unresectable, Locally Advanced Esophageal Squamous Cell Carcinoma
Sun Yat-sen University
NCT07086469 RECRUITING Surufatinib in Combination With Neoadjuvant Chemo-immunotherapy and Concurrent Chemoradiotherapy for Patients With Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma
Sun Yat-sen University
NCT06010303 ACTIVE NOT RECRUITING A Study to Evaluate LBL-007 in Combination With Tislelizumab Plus Chemotherapy in Participants With Unresectable Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma
BeiGene
NCT06912074 RECRUITING Hypofractionated vs. Conventional Chemoradiotherapy After Induction Chemo-immunotherapy for Unresectable Esophageal Squamous Cell Carcinoma
Sun Yat-sen University
NCT07223424 RECRUITING Patient Preference for Subcutaneous vs. Intravenous Immune Therapy
Diwakar Davar
NCT05563766 RECRUITING A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer
VA Office of Research and Development
NCT07222657 NOT YET RECRUITING Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma
Case Comprehensive Cancer Center
NCT02521285 ACTIVE NOT RECRUITING Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
National Cancer Institute (NCI)
NCT03161522 RECRUITING Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer
M.D. Anderson Cancer Center
NCT05565417 ACTIVE NOT RECRUITING Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas
Immunitas Therapeutics
NCT04931654 ACTIVE NOT RECRUITING A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer
AstraZeneca
NCT06869213 RECRUITING A Single-arm, Open, Single-center Exploratory Study of Adebrelimab (SHR-1316) in Combination With Chemotherapy for the Perioperative Treatment of Locally Advanced Resectable Esophageal Squamous Carcinoma
Peking University Cancer Hospital & Institute
NCT06869226 RECRUITING A Multicenter Phase II Clinical Study of Neoadjuvant Use of Camrelizumab in Combination With Chemotherapy for Organ Preservation in Esophageal Cancer
Peking University Cancer Hospital & Institute
NCT06008054 RECRUITING A Study of SI-B003, BL-B01D1+SI-B003 and BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Esophageal Cancer, Gastric Cancer, Colorectal Cancer and Other Gastrointestinal Tumors
Sichuan Baili Pharmaceutical Co., Ltd.
NCT05022654 ACTIVE NOT RECRUITING SI-B001 Combined With Irinotecan in the Treatment of Recurrent Metastatic Esophageal Squamous Cell Carcinoma.
Sichuan Baili Pharmaceutical Co., Ltd.
NCT07039526 RECRUITING Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detection of Malignant Tissue in Subjects Undergoing Surgical Resection for Cancer.
John Waters
NCT07188103 RECRUITING Ivonescimab Plus Short-Course Hypofractionated Radiotherapy as Second-Line Therapy for Esophageal Squamous Cell Carcinoma
Anhui Provincial Hospital
NCT06067438 RECRUITING Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer
OHSU Knight Cancer Institute
NCT06531434 RECRUITING Establishing Best Treatment Strategy for T4 Esophageal Cancer
National Cheng-Kung University Hospital
NCT06601309 RECRUITING Biomarker Based Neoadjuvant Strategies for Locally Advanced Resectable ESCC
Fujian Medical University Union Hospital
NCT03110926 ACTIVE NOT RECRUITING Induction Chemotherapy for Locally Advanced Esophageal Cancer
University of Rochester
NCT07164690 NOT YET RECRUITING Low-Dose Radiotherapy in Patients With Advanced Esophageal Squamous Cell Carcinoma Resistant to First-Line Chemotherapy Combined With Immunotherapy
Fudan University
NCT05632939 ACTIVE NOT RECRUITING ASKB589 in Combination With CAPOX and PD-1 Inhibitors in Patients With Advanced, and Unresectable G/GEJ Cancer.
AskGene Pharma, Inc.
NCT02962063 ACTIVE NOT RECRUITING Durvalumab, an Anti-PDLI Antibody, and Tremelimumab, an Anti-CTLA4 Antibody, and Chemoradiation Before Surgery for Esophageal Cancer
Memorial Sloan Kettering Cancer Center
NCT04929392 ACTIVE NOT RECRUITING Chemoradiation and Pembrolizumab Followed by Pembrolizumab and Lenvatinib Before Surgery for the Treatment of Non-metastatic Esophageal or Esophageal/Gastroesophageal Junction Cancer
City of Hope Medical Center
NCT04977453 RECRUITING GI-101 as a Single Agent or in Combination With Pembrolizumab, Lenvatinib or Local Radiotherapy in Advanced Solid Tumors
GI Innovation, Inc.
NCT07152678 RECRUITING Brachytherapy With Radiotherapy and Immunotherapy: Guided HDR Trial in Esophageal Squamous Cell Carcinoma
National Taiwan University Hospital
NCT06247956 ACTIVE NOT RECRUITING Study of SHR-8068 Combined With Adebrelimab and Platinum-containing Chemotherapy in the Treatment of Advanced Gastric and Esophageal Cancer
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
NCT06509568 RECRUITING Neoadjuvant ChemoRadiotherapy Followed by Immunotherapy and Surgery for Resectable Esophageal Squamous Cell Carcinoma(CRIS-2 Trial)
Zhejiang Cancer Hospital
NCT07142421 ACTIVE NOT RECRUITING A Study of Trifluridine/Tipiracil Combined With Anlotinib as Second-line Treatment for Recurrent and Metastatic Esophageal Squamous Cell Carcinoma
First Affiliated Hospital of Zhejiang University
NCT04111172 ACTIVE NOT RECRUITING A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma
Thomas Jefferson University
NCT07128693 NOT YET RECRUITING A Single-center, Multicohort, Phase II Clinical Study Evaluating the Combination Therapy of Sacituzumab Tirumotecan in Patients With Unresectable, Locally Advanced, Recurrent, or Metastatic Esophageal Squamous Cell Carcinoma
The First Affiliated Hospital of Zhengzhou University
NCT05864144 ACTIVE NOT RECRUITING A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors
Sensei Biotherapeutics, Inc.
NCT06298916 RECRUITING 64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer
Lantheus Medical Imaging
NCT04164979 ACTIVE NOT RECRUITING Ph II Study of Cabozantinib With Pembrolizumab in Metastatic Gastric and Gastroesophageal Adenocarcinoma
University of California, Irvine
NCT05057013 ACTIVE NOT RECRUITING A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
Cancer Research UK
NCT07112833 NOT YET RECRUITING A Phase II Clinical Study of Induction Adebrelimab Combined With Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma (ESCC)
Hebei Medical University Fourth Hospital
NCT06356688 RECRUITING A Clinical Study on the Efficacy and Safety of Paclitaxel Polymeric Micelles and Cisplatin Combined With Cadonilimab as a Neoadjuvant Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma
Sun Jing
NCT07108855 RECRUITING Detection of Upper Gastrointestinal Tumour Depth and Demarcation Using Systemic Administration of Indocyanine Green During Endoscopic Submucosal Dissection
University Medical Center Groningen
NCT04069273 RECRUITING Novel SEQUEnced Immunotherapy With Anti-angiogenesis and Chemotherapy in Advanced gastroesophageaL Adenocarcinoma
Harry H Yoon
NCT06767800 RECRUITING A Clinical Trial Evaluating TQB2102 for Injection in Combination With Behmosubaisumab/Payamprolizumab With or Without Chemotherapy in Unresectable Locally Advanced, Recurrent, or Metastatic Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastroesophageal Adenocarcinoma
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
NCT06290505 RECRUITING A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study
Australasian Gastro-Intestinal Trials Group
NCT05379972 ACTIVE NOT RECRUITING Study of SBRT/Olaparib Followed by Pembrolizumab/Olaparib in Gastric Cancers
University of Colorado, Denver
NCT06687876 RECRUITING Metformin as a Metabolic Intervention in Oesophageal Adenocarcinomas to Improve Response to Neoadjuvant Chemoradiotherapy
Amsterdam UMC, location VUmc
NCT05086692 RECRUITING A Beta-only IL-2 ImmunoTherapY Study
Medicenna Therapeutics, Inc.
NCT07049185 NOT YET RECRUITING QL1706 Plus Celecoxib in Advanced Esophageal Squamous Cell Carcinoma
Peking University Cancer Hospital & Institute
NCT03764553 ACTIVE NOT RECRUITING Liposomal iRInotecan, Carboplatin or oXaliplatin for Esophagogastric Cancer
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT06906887 RECRUITING PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer
Medical College of Wisconsin
NCT06165380 RECRUITING Cardenilimab Combined With Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma
Li Zhang
NCT04021108 ACTIVE NOT RECRUITING Phase II Study of Short Course FOLFOX Chemotherapy With Either Nivolumab or Nivolumab + Radiation in the First Line Treatment of Metastatic or Unresectable Gastroesophageal Cancers (BMS Protocol CA209-76L)
Weill Medical College of Cornell University
NCT05910827 RECRUITING Study of an Anti-HER3 Antibody, HMBD-001, With Docetaxel +/- Cetuximab in Advanced Squamous Non-small Cell Lung Cancers, and HMBD-001 + Cetuximab in Advanced Squamous Cell Cancers
Hummingbird Bioscience
NCT06239194 RECRUITING Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
ModeX Therapeutics, An OPKO Health Company
NCT07016724 RECRUITING Neoadjuvant Radiochemotherapy Combined With Cadonilizumab for Local Advanced Esophageal Squamous Cell Cancer
The First Affiliated Hospital of Zhengzhou University
NCT06446726 RECRUITING Low-dose Radiation Combined With Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma
Sichuan University
NCT06199895 RECRUITING Clinical Efficacy and Safety of Paclitaxel Polymeric Micelles for Injection in the Treatment of Patients With Taxans-resistant Pancreatic Adenocarcinoma, Cholangiocarcinoma, Lung Cancer, Gastric Cancer, Esophageal Carcinoma, or Breast Cancer
Liu Huang
NCT06421376 RECRUITING Induction Chemoimmunotherapy Combined With Chemoradiotherapy in Esophageal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06988956 RECRUITING Nimotuzumab Plus Definite Chemoradiotherapy(dCRT) in Elderly Patients With Esophageal Squamous Cell Carcinoma
The First Affiliated Hospital with Nanjing Medical University
NCT04140526 ACTIVE NOT RECRUITING Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
OncoC4, Inc.
NCT06985602 RECRUITING Adebrelimab With Chemoradiotherapy and Surgery for G/GEJ
Jiangsu Cancer Institute & Hospital
NCT06340711 RECRUITING Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma
Weill Medical College of Cornell University
NCT06861894 NOT YET RECRUITING Active Surveillance After Neoadjuvant Adebrelimab Combined With Chemoradiotherapy for Resectable ESCC
Zhigang Li
NCT04666090 ACTIVE NOT RECRUITING Carrelizumab, Chemotherapy and Apatinib in the Neoadjuvant Treatment of Resectable Esophageal Squamous Cell Carcinoma
Second Affiliated Hospital, School of Medicine, Zhejiang University
NCT05144698 RECRUITING RAPA-201 Therapy of Solid Tumors
Rapa Therapeutics LLC
NCT06965829 NOT YET RECRUITING The Effect of Neoadjuvant Chemoimmnotherapy Combined With Node Sparing Radiotherapy for cT3N+ EC
Shanghai Chest Hospital
NCT06422858 RECRUITING Sequential Tegafur-gimeracil-oteracil Potassium Capsule (s-1) and Serplulimab Following Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma
Zhejiang Cancer Hospital
NCT05964361 ACTIVE NOT RECRUITING First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer Patients
University Hospital, Antwerp
NCT03653052 ACTIVE NOT RECRUITING Do Changes in ctDNA Predict Response for Patients With Oesophageal Cancer Receiving Durvalumab
Simon C Pacey, MD
NCT04494009 ACTIVE NOT RECRUITING PD-1 Inhibitor INCMGA00012 as Consolidation Therapy After Definitive Concurrent Chemoradiotherapy
Asan Medical Center
NCT06908382 RECRUITING Neoadjuvant QL1706 Therapy for ESCC
Shandong Provincial Hospital
NCT06637163 RECRUITING Benmelstobart Combined With Radiochemotherapy as Neoadjuvant Treatment Iin ESCC
Shanghai Zhongshan Hospital
NCT06843889 RECRUITING A Phase II Study of Toripalimab Combined With Sequential Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squamous Cell Carcinoma
Nanfang Hospital, Southern Medical University
NCT04196465 ACTIVE NOT RECRUITING Phase II Study of Neoadjuvant Immune Checkpoint Inhibitor in Patients With Resectable Gastrointestinal Cancers
Asan Medical Center
NCT04166721 ACTIVE NOT RECRUITING WaKING: Wnt and checKpoint INhibition in Gastric Cancer
Royal Marsden NHS Foundation Trust
NCT06903871 NOT YET RECRUITING Toripalimab Adjuvant Therapy in Subjects With Resected Esophageal Squamous Cell Carcinoma Who Achieved Pathological Complete Response (pCR)
Hebei Medical University Fourth Hospital
NCT06690216 ENROLLING BY INVITATION Evaluation of [18F]AlF-NOTA-PCP2 PET/CT for PD-L1 Detection in Malignant Tumors
Man Hu
NCT05473156 RECRUITING A Study to Investigate the Safety, Pharmacokinetics, and Clinical Activity of AP203 in Patients with Locally Advanced or Metastatic Solid Tumors, and Expansion to Selected Malignancies
AP Biosciences Inc.
NCT04802876 ACTIVE NOT RECRUITING Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors
SOLTI Breast Cancer Research Group
NCT06885814 RECRUITING Efficacy and Safety of Adebrelimab Combined With Chemoradiotherapy in Patients With Unresectable Locally Advanced or Postoperative Recurrent Esophageal Squamous Cell Carcinoma
Nanfang Hospital, Southern Medical University
NCT02998268 ACTIVE NOT RECRUITING Study of Pembrolizumab in Locally Advanced Esophageal Adenocarcinoma
Weill Medical College of Cornell University
NCT06852456 NOT YET RECRUITING QL1706 in Combination With Neoadjuvant Chemotherapy Versus Neoadjuvant Chemotherapy for Locally Advanced, Resectable Esophageal Squamous Cell Carcinoma
Qilu Pharmaceutical Co., Ltd.
NCT05491616 ACTIVE NOT RECRUITING Nivolumab During Active Surveillance After Neoadjuvant Chemoradiation for Esophageal Cancer: SANO-3 Study
Erasmus Medical Center
NCT04114136 RECRUITING Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies
Dan Zandberg
NCT03526835 RECRUITING A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Merus B.V.
NCT05937438 RECRUITING Postoperative Radiotherapy Followed by Immunotherapy for Locally Advanced Esophageal Carcinoma
Anhui Provincial Hospital
NCT06489197 RECRUITING AK112 Combined With Chemotherapy as the First-line Treatment in Advanced Esophageal Squamous Cell Carcinoma Patients
Tianjin Medical University Cancer Institute and Hospital
NCT06422403 RECRUITING A Value-Driven Study on Reducing Immune Checkpoint Inhibitor Dosing Frequency in Advanced Cancers
National University Hospital, Singapore
NCT06474468 RECRUITING A Trial of SHR-A2102 With Adebrelimab With or Without Other Antitumor Therapy in Advanced or Metastatic Esophageal Cancer
Shanghai Hengrui Pharmaceutical Co., Ltd.
NCT05214222 RECRUITING Penpulimab Plus Chemotherapy With/Without Anlotinib for Patients With Advanced Esophageal Squamous Cell Carcinoma
Nanfang Hospital, Southern Medical University
NCT06746961 NOT YET RECRUITING Efficacy and Safety of QL1706 Plus Lenvatinib As 2nd Line Theapy in Patients with Metastatic Esophageal Carcinoma After Disease Progression on ICIs Therapy
The First Affiliated Hospital of Zhengzhou University
NCT06745193 NOT YET RECRUITING A Prospective, Randomized, Open, Phase II Clinical Study of Chidamide in Combination with Camrelizumab and Apatinib for Advanced Esophageal Cancer
Peking University
NCT03322267 ACTIVE NOT RECRUITING Adjuvant Pembrolizumab for Patients With Locally Advanced Esophageal Squamous Cell Carcinoma at High Risk of Recurrence
National Taiwan University Hospital
NCT05572684 ACTIVE NOT RECRUITING A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants with Advanced Unresectable or Metastatic Solid Tumors
NextCure, Inc.
NCT04278287 RECRUITING Chemoradiotherapy in Unresectable Esophageal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06718205 RECRUITING Nimotuzumab Combined With Sintilimab and Chemotherapy for Advanced Esophageal Squamous Cell Carcinoma
The First Affiliated Hospital of Zhengzhou University
NCT06603402 RECRUITING Low-Dose Involved-Field Radiotherapy Plus Immunochemotherapy for ESCC
Sichuan University
NCT06329869 RECRUITING Sacituzumab Govitecan for Advanced Esophageal Squamous Cell Carcinoma
National Taiwan University Hospital
NCT06709417 RECRUITING A Phase II Clinical Study of Sintilimab Combined with Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma (ESCC) (NICE-CS)
Shanghai Chest Hospital
NCT06703047 NOT YET RECRUITING Tislelizumab Combined with Chemotherapy and All Trans Retinoic Acid for Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma
Fudan University
NCT05738434 RECRUITING Camrelizumab in Combination With Apatinib Mesylate Plus Short-course Chemotherapy for Advanced ESCC
The First Affiliated Hospital of Zhengzhou University
NCT06632262 RECRUITING A Phase 2 Clinical Study of ABSK061 and ABSK043
Abbisko Therapeutics Co, Ltd
NCT05520619 ACTIVE NOT RECRUITING Combination of Tislelizumab and Chemoradiotherapy in Esophageal Cancer (EC-CRT-002)
Sun Yat-sen University
NCT05965479 RECRUITING Developing ctDNA Guided Adjuvant Therapy for Gastrooesophageal Cancer
University of Southampton
NCT06532799 RECRUITING TIL Therapy Combined With Pembrolizumab for Advanced or Metastatic Refractory Stomach and Esophageal Cancer
Essen Biotech
NCT06684600 RECRUITING Study of Dalpiciclib Isethionate Plus Pyrotinib Maleate in the Treatment of Advanced Esophageal Squamous Cell Carcinoma
Peking University
NCT06681285 NOT YET RECRUITING Cadonilimab Combined With Anlotinib Followed by Radiotherapy in Recurrent or Metastatic Esophageal Squamous Cell Carcinoma (CAR-RMEC)
Hebei Medical University Fourth Hospital
NCT06675201 RECRUITING Neoantigen Vaccines in Esophageal Squamous Cell Carcinoma
Sichuan University
NCT06663059 RECRUITING Adebrelimab Neoadjuvant Treatment for Resectable ESCC: 2 vs 4 Cycles Study
Tang-Du Hospital
NCT04492488 ACTIVE NOT RECRUITING A Study of MRG002 in Patients with HER2-Positive Advanced Solid Tumors and Locally Advanced or Metastatic Gastric/Gastroesophageal Junction (GEJ) Cancer
Shanghai Miracogen Inc.
NCT06650332 RECRUITING Cadonilimab Combination Regimen as First-line Treatment for HER2-expressing GC/GEJ Patients
Zhejiang Cancer Hospital
NCT05620134 ACTIVE NOT RECRUITING Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer
Salubris Biotherapeutics Inc
NCT04913337 ACTIVE NOT RECRUITING Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies
NGM Biopharmaceuticals, Inc
NCT06588335 NOT YET RECRUITING BTLA Inhibitor (JS004) Combined with Toripalimab and Chemotherapy in the Perioperative Treatment of Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
Henan Provincial People's Hospital
NCT03736863 RECRUITING A Phase II Exploratory Clinical Trial of Multiple Drug Combinations in the Treatment of Advanced Esophageal Squamous Cell Carcinoma
The First Affiliated Hospital of Zhengzhou University
NCT06598917 NOT YET RECRUITING Maintenance Chemotherapy With S-1, Locally Advanced Esophageal Cancer Receiving Definitive CCRT
China Medical University Hospital
NCT06510660 RECRUITING Adebrelimab ±Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Unresectable Locally Advanced ESCC
Fujian Medical University Union Hospital
NCT06599775 NOT YET RECRUITING Study of Adebrelimab With Chemotherapy, Endoscopy and Sequential Chemoradiotherapy In Inoperable Esophageal Cancer
Shanghai Zhongshan Hospital
NCT06586242 RECRUITING Efficacy and Safety of Penpulimab Combined With Anlotinib and Chemotherapy
Xijing Hospital
NCT06569459 RECRUITING Trilaciclib Combined With Concurrent Chemoradiotherapy and Immunotherapy in the Treatment of Esophageal Cancer
The First Affiliated Hospital with Nanjing Medical University
NCT05628610 NOT YET RECRUITING Tislelizumab Combined With Chemotherapy or Radiotherapy in the Treatment of Advanced or Recurrent Metastatic Elderly Esophageal Cancer
Fujian Cancer Hospital
NCT06006390 RECRUITING CEA Targeting Chimeric Antigen Receptor T Lymphocytes (CAR-T) in the Treatment of CEA Positive Advanced Solid Tumors
Chongqing Precision Biotech Co., Ltd
NCT06498752 RECRUITING MRD-Guided Consolidation Therapy Following Definitive Radiotherapy in Esophageal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT05177133 RECRUITING Anti-PD-1 and CapOx for the First-line Treatment of dMMR Esophagogastric Cancer (AuspiCiOus)
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT04554771 ACTIVE NOT RECRUITING Blood-borne Assessment of Stromal Activation in Esophageal Adenocarcinoma to Guide Tocilizumab Therapy
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT06512428 RECRUITING A Study of Simmitinib Plus Irinotecan in Advanced Esophageal Squamous Cell Carcinoma
Shanghai Runshi Pharmaceutical Technology Co., Ltd
NCT06508229 NOT YET RECRUITING Adebrelimab Combined With Albumin Paclitaxel and Nedaplatin as Neoadjuvant Therapy for Locally Advanced Resectable ESCC
Harbin Medical University
NCT06354140 RECRUITING PPIO-008 Tislelizumab Combined With S-1 in Patients With ypT+N0 ESCC After Radical Resection With Neoadjuvant STUDY
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
NCT06413342 RECRUITING Sintilimab After Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma
Zhejiang Cancer Hospital
NCT05394740 ACTIVE NOT RECRUITING Clinical Study of Regorafenib and Nivolumab Plus Chemotherapy
National Cancer Center Hospital East
NCT06487702 NOT YET RECRUITING A Phase lb/lI Clinical Study in Advanced or Metastatic Esophageal Squamous Cell Carcinoma
Rui-hua Xu, MD, PhD
NCT06385730 RECRUITING Neoadjuvant PD-1 Blockade for Elderly Esophageal Squamous Cell Carcinoma (BLESS)
Shanghai Chest Hospital
NCT06469060 NOT YET RECRUITING Neoadjuvant Immunochemotherapy for Adenocarcinoma of the Esophagogastric Junction
Shanghai Chest Hospital
NCT05187338 RECRUITING Triplex Checkpoint Inhibitors Therapy for Advanced Solid Tumors
Second Affiliated Hospital of Guangzhou Medical University
NCT06468670 NOT YET RECRUITING Short-course Radiotherapy Combined With Sintilimab for Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma
Fujian Cancer Hospital
NCT06468644 NOT YET RECRUITING Phase II Study of Different Doses of Radiotherapy Combined With Sintilimab in the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma
Fujian Cancer Hospital
NCT06463834 RECRUITING A Study of Sintilimab Combined With Chemotherapy for Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma
Fujian Cancer Hospital
NCT06464614 NOT YET RECRUITING Adebrelimab in Combination With Apatinib and Chemotherapy/Chemoradiotherapy in Immuno-experienced Second-line ESCC.
The First Affiliated Hospital of Henan University of Science and Technology
NCT06084897 RECRUITING Radiotherapy in Patients With Metastatic Esophageal Cancer Responding to PD-1 Inhibitor Plus Chemotherapy
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06342167 ACTIVE NOT RECRUITING Efficacy and Safety of Concurrent PD-1 Inhibitor and Radiotherapy With Immunonutrition for Esophageal Squamous Cell Carcinoma
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06429839 RECRUITING Nimotuzumab Concurrent With Chemoradiotherapy for Esophageal Cancer Patients
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06426797 NOT YET RECRUITING Neoadjuvant Cadonilimab Combined With Anlotinib in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma
Peking University People's Hospital
NCT05490719 RECRUITING A Phase II Study of CRT Combined With QL1706 in ESCC Patients
Tianjin Medical University Cancer Institute and Hospital
NCT06410651 RECRUITING Nimotuzumab Concurrent With Chemoradiotherapy for Patients With Unresectable Esophageal Squamous Cell Carcinoma
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT06403878 RECRUITING Safety and Efficacy of Neoadjuvant Immunochemotherapy in Elderly Patients With Resectable Esophageal Cancer
Sichuan University
NCT06398405 RECRUITING A Phase II Clinical Study of Epigallocatechin-3-gallate in Patients With Esophageal Squamous Cancer
Shandong Cancer Hospital and Institute
NCT06392971 RECRUITING Deep-sea Fish Oil for Prevention of Acute Radiation-induced Esophagitis
First Affiliated Hospital of Chengdu Medical College
NCT06354218 RECRUITING Serplulimab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old Age
The First Affiliated Hospital with Nanjing Medical University
NCT06339619 RECRUITING Combination Immunotherapy of Adebrelimab With Apatinib and Tegafur for Immune Rechallenge Therapy in Esophageal Squamous Cell Carcinoma
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
NCT06304350 RECRUITING Pembrolizumab Combined With Preoperative Chemotherapy (Albumin Paclitaxel+Carboplatin) Neoadjuvant Therapy for Resectable Locally Advanced (Stage II/III) Esophageal Squamous Cell Carcinoma
Tongji University
NCT06187597 RECRUITING Consolidation of Toripalimab After Chemoradiotherapy in Elderly Esophageal Cancer (EC-CRT-007)
Sun Yat-sen University
NCT06303583 ENROLLING BY INVITATION Neoadjuvant Chemoradiotherapy Followed by Sequential Immunotherapy for Thoracic Esophageal Squamous Cell Carcinoma
Qiu Guoqin
NCT06241469 NOT YET RECRUITING Efficacy and Safety of Sintilimab Combined With Nab-paclitaxel and Tegio (aTS) as First-line Treatment of Unresectable Locally Advanced, Recurrent or Metastatic Adenocarcinoma of Gastric and Gastroesophageal Junction,a Phase II Clinical Study
Wu Jun
NCT05403242 RECRUITING RC48-ADC Combined With S-1 for First-line Treatment of Advanced Gastroesophageal Adenocarcinoma With Moderate Expression of HER2
Chinese PLA General Hospital
NCT06190639 RECRUITING A Clinical Study of Sintilimab as Adjuvant Therapy in Node-positive ESCC
Zhejiang Cancer Hospital
NCT06186609 RECRUITING PD-1 Inhibitor Combined With Radiotherapy for Elderly ESCC
Affiliated Hospital of Nantong University
NCT06061146 RECRUITING Tislelizumab Plus Concurrent Chemoradiation in Older With ESCC
Tianjin Medical University Cancer Institute and Hospital
NCT04889742 NOT YET RECRUITING Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
Charite University, Berlin, Germany
NCT06178211 NOT YET RECRUITING Neoadjuvant Adebrelimab Plus Chemotherapy for Resectable ESCC: a Single Arm, Prospective Phase 2 Clinical Trial
Shanghai Chest Hospital
NCT06173986 RECRUITING Immunotherapy in Combination With Chemoradiotherapy in Unresectable Locally Advanced Esophageal Cancer
Shanghai Chest Hospital
NCT06152978 NOT YET RECRUITING A Perioperative Sintilimab and Chemotherapy in Esophageal Squamous Cell Carcinoma
Fudan University
NCT06122493 RECRUITING Optimization of Treatment Strategy for Unresectable cN3 Esophageal Squamous Cell Carcinoma
Ruijin Hospital
NCT03964753 RECRUITING Neoadjuvant Therapy With Nab-paclitaxel and Cisplatin for Locally Advanced Esophageal Squamous Cell Carcinoma
Hebei Medical University Fourth Hospital
NCT06056336 RECRUITING Perioperative Tislelizumab Plus Chemotherapy for Resectable Thoracic Oesophageal Squamous Cell Carcinoma
Guo Xufeng
NCT06055166 NOT YET RECRUITING A Clinical Study of Chemoradiotherapy Sequential Fluzoparib in Pan-solid Tumors
Chongqing University Cancer Hospital
NCT06010212 NOT YET RECRUITING Fruquintinib as First Line Treatment in Patients With Recurrent Esophageal Squamous Cell Carcinoma
The First Affiliated Hospital with Nanjing Medical University
NCT06006650 RECRUITING Neoadjuvant Therapy for Stage II-IVA Resectable Esophageal Squamous Cell
Tang-Du Hospital
NCT05996484 NOT YET RECRUITING Neoadjuvant Therapy of Anlotinib Combined With Toripalimab and Chemotherapy for Resectable Esophageal Carcinoma
Nanfang Hospital, Southern Medical University
NCT05986227 NOT YET RECRUITING The Sequential Combination of FOLFOX and Toripalimab for Perioperative Immuno-Oncology Therapy of HER2-negative Adenocarcinoma of the Esophagogastric Junction (Siewert I/II):
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT04764227 ACTIVE NOT RECRUITING Phase II Study of Postoperative Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma (ESO- Shanghai 17)
Fudan University
NCT05281003 RECRUITING Pembrolizumab Plus Chemo in Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma (Eastern Cooperative Thoracic Oncology Projects 2004, ECTOP-2004)
Fudan University
NCT05896787 NOT YET RECRUITING Candonilimab (AK104) Plus Preoperative Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma (ESCC)
The First Affiliated Hospital of Zhengzhou University
NCT05833971 NOT YET RECRUITING Cadonilimab in Combination With Chemotherapy for Locally Advaced Esophageal Squamous Cell Carcinoma
Guangzhou Institute of Respiratory Disease
NCT05791136 NOT YET RECRUITING Immunotherapy After Radiotherapy in Elderly ESCC
The Central Hospital of Lishui City
NCT03544736 ACTIVE NOT RECRUITING Safety and Feasibility of Irradiation and Nivolumab in Esophageal Cancer (INEC)
Oslo University Hospital
NCT05732662 NOT YET RECRUITING SBRT Combined With AK104 to Treatment Relapsed or Metastatic ESCC
The First People's Hospital of Changzhou
NCT05252078 RECRUITING Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients
Jiangxi Provincial Cancer Hospital
NCT05507411 RECRUITING Watch and Wait for NeoAdjuvant Concurrent Radiochemotherapy Combined With Camrelizumab in Patients With Resectable ESCC
Zhejiang Cancer Hospital
NCT05182944 RECRUITING A Study of Perioperative Camrelizumab Combined With Chemotherapy in Patients With Resectable ESCC
The First Affiliated Hospital of Zhengzhou University
NCT02490735 NOT YET RECRUITING CIK in Treating Patients With Esophageal Cancer
The First People's Hospital of Changzhou
NCT06171789 TERMINATED PRO1107 in Patients With Advanced Solid Tumors
Genmab
NCT04426669 COMPLETED A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering
Intima Bioscience, Inc.
NCT05312372 WITHDRAWN S095033 in Combination With Paclitaxel as 2nd- or 3rd-line Treatment in Participants With Advanced or Metastatic ESCC
Institut de Recherches Internationales Servier
NCT03008278 COMPLETED Olaparib and Ramucirumab in Treating Patients With Metastatic or Locally Recurrent Gastric or Gastroesophageal Junction Cancer That Cannot Be Removed by Surgery
National Cancer Institute (NCI)
NCT06682806 TERMINATED A Study of PRT3789 in Combination With Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation
Prelude Therapeutics
NCT05070247 TERMINATED A Study of TAK-500 With or Without Pembrolizumab in Adults With Select Locally Advanced or Metastatic Solid Tumors
Takeda
NCT04505553 COMPLETED Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer
University of Washington
NCT05342636 COMPLETED A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A)
Merck Sharp & Dohme LLC
NCT04974047 COMPLETED Study of Tislelizumab in Participants With Resectable Esophageal Squamous Cell Carcinoma
BeiGene
NCT04779151 TERMINATED Basket Trial Exploring the Efficacy and Safety of the Combination of Niraparib and Dostarlimab
Gustave Roussy, Cancer Campus, Grand Paris
NCT05795595 COMPLETED A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors
CRISPR Therapeutics AG
NCT05383482 COMPLETED Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1
Laekna Limited
NCT05169437 TERMINATED Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors
Tempus AI
NCT04363801 TERMINATED A Study of DKN-01 in Combination With Tislelizumab ± Chemotherapy in Patients With Gastric or Gastroesophageal Cancer
Leap Therapeutics, Inc.
NCT04189445 TERMINATED Futibatinib in Patients With Specific FGFR Aberrations
Taiho Oncology, Inc.
NCT05104567 COMPLETED A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)
Sanofi
NCT04278144 TERMINATED A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors
Bolt Biotherapeutics, Inc.
NCT03929666 COMPLETED A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer
Jazz Pharmaceuticals
NCT06410534 WITHDRAWN A Phase II Study Evaluating an Organ Preservation Strategy Using Immune Checkpoint Blockade for Participants With Primary Colorectal or Gastroesophageal Cancer
National Cancer Institute (NCI)
NCT05880082 COMPLETED PPIO-004 Clinical Application of Efficacy Prediction Model Based on Epigenomics Sequencing Technology in Neoadjuvant Immunotherapy for Esophageal Cancer
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
NCT05071053 TERMINATED Tusamitamab Ravtansine (SAR408701) in Combination With Ramucirumab in Pretreated Participants With Gastric Cancer
Sanofi
NCT03314935 COMPLETED A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors
Incyte Corporation
NCT03320629 TERMINATED A Study of Apatinib Plus Radiotherapy and S-1 for Treatment of Refractory or Metastatic Esophageal Squamous Cell Carcinoma
Hebei Medical University Fourth Hospital
NCT03797625 COMPLETED Endostar Combined With IP Second-line Treatment of Advanced Esophageal Squamous Cell Carcinomas
Fudan University
NCT05714553 TERMINATED NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours
NuCana plc
NCT05834543 TERMINATED Clinical Trial to Evaluate the Safety and Effectiveness of TQB2618 Injection Combined Therapy in Patients With Advanced Esophageal Squamous Cell Carcinoma
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
NCT05563272 TERMINATED 89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors
Telix Pharmaceuticals (Innovations) Pty Ltd
NCT06048913 COMPLETED Nimotuzumab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old Age
The First Affiliated Hospital with Nanjing Medical University
NCT06812403 COMPLETED Combination COMBO Endoscopy Oropharyngeal Airway With High-Flow Nasal Cannula Oxygenation in Sedated Gastrointestinal Endoscopy for Obese Patients
Zhejiang University
NCT04908111 SUSPENDED A Trial of ChAdOx1 and MVA Vaccines Against MAGE-A3 and NY-ESO-1
Cancer Research UK
NCT05461794 TERMINATED Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell Carcinoma
BeiGene
NCT04548440 COMPLETED Efficacy and Safety of Preoperative Sintilimab Plus Nab-paclitaxel and Cisplatin in BR-ESCC Patients
Sun Yat-sen University
NCT04727151 TERMINATED TAC T-cells for the Treatment of HER2-positive Solid Tumors
Triumvira Immunologics, Inc.
NCT04068896 COMPLETED Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy
NGM Biopharmaceuticals, Inc
NCT06804876 COMPLETED COMBO Endoscopy Oropharyngeal Airway in Sedated Gastrointestinal Endoscopy for Obese Patients
Zhejiang University
NCT03212469 COMPLETED A Trial of Durvalumab and Tremelimumab in Combination With SBRT in Patients With Metastatic Cancer
Gustave Roussy, Cancer Campus, Grand Paris
NCT04467515 TERMINATED A Study to Evaluate Safety, Tolerability, Dosimetry, and Preliminary Efficacy of the HER2 Directed Radioligand CAM-H2 in Patients With Advanced/Metastatic HER2-Positive Breast, Gastric, and Gastro-Esophageal Junction (GEJ) Cancer
Precirix
NCT04097028 COMPLETED Use of Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy for the Treatment of Resectable Esophageal or Gastroesophageal Junction (GEJ) Adenocarcinoma
Roswell Park Cancer Institute
NCT04383210 TERMINATED Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors
Elevation Oncology
NCT03829501 TERMINATED A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of Alomfilimab (KY1044) as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advanced Malignancies
Kymab Limited
NCT05299476 COMPLETED CAPOX + Bevacizumab + Tislelizumab Treating PD-L1 CPS < 5 Locally Advanced or Metastatic GEA
Chinese PLA General Hospital
NCT02689284 COMPLETED Combination Margetuximab and Pembrolizumab for Advanced, Metastatic HER2(+) Gastric or Gastroesophageal Junction Cancer
MacroGenics
NCT04032704 TERMINATED A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors
Seagen Inc.
NCT04785820 COMPLETED A Study of Lomvastomig (RO7121661) and Tobemstomig (RO7247669) Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus
Hoffmann-La Roche
NCT06840561 COMPLETED Local Triamcinolone Injection Combined With Fibrin Glue Spray in Preventing Esophageal Stricture After Big-range Endoscopic Submucosal Dissection for Esophageal Early Cancer
Sun Yat-sen University
NCT04732494 COMPLETED Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Combined With or Without Anti-TIGIT Monoclonal Antibody Ociperlimab (BGB-A1217) in Participants With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma
BeiGene
NCT05944809 COMPLETED The Effect of Prophylactic TPO Combined with BMS-IMRT to Esophageal Cancer Patients
JIANYANG WANG
NCT05007613 COMPLETED Second-line Cabozantinib and Atezolizumab in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma
National Taiwan University Hospital
NCT05500508 TERMINATED Oral AMXT 1501 Dicaprate in Combination With IV DFMO
Aminex Therapeutics, Inc.
NCT05207722 TERMINATED CYNK-101 in Combination with Trastuzumab and Pembrolizumab in Patients with Locally Advanced Unresectable or Metastatic HER2-Positive Gastric or Gastroesophageal Junction (G/GEJ) Adenocarcinoma
Celularity Incorporated
NCT04212598 COMPLETED The Value of Sintilimab Consolidation Therapy After Definitive Concurrent Chemoradiotherapy for Locally Advanced Thoracic Esophageal Cancer
Wuhan University
NCT04276493 COMPLETED Anti-HER2 Bispecific Antibody Zanidatamab (ZW25) Activity in Combination With Chemotherapy With/Without Tislelizumab
BeiGene
NCT04508140 TERMINATED Study of BO-112 With Pembrolizumab for Colorectal or Gastric/GEJ Cancer With Liver Metastasis
Highlight Therapeutics
NCT02647125 COMPLETED A Study of Comparing Huachansu Plus Thoracic RT Versus RT Alone For ESCC
Fudan University
NCT02844075 COMPLETED Preoperative Chemoradiotherapy and MK-3475 for Esophageal Squamous Cell Carcinoma (ACTS-29)
Yonsei University
NCT06691503 COMPLETED A Clinical Trial of Esophagectomy for Esophageal Carcinoma
Sun Yat-sen University
NCT03985046 COMPLETED Sintilimab Plus Chemotherapy Followed by dCRT in Locally Advanced ESCC
Fudan University
NCT04294784 TERMINATED Nab-paclitaxel Plus PD-1 Inhibitor Versus Nab-paclitaxel As Second-line Treatment in Advanced Gastric Cancer
Huazhong University of Science and Technology
NCT04871204 COMPLETED Octreotide Treatment to Improve Nutritional Recovery After Surgery for Patients with Esophageal or Gastric Cancer
Fredrik Klevebro
NCT03941873 COMPLETED A Study to Investigate Sitravatinib as Monotherapy and in Combination With Tislelizumab in Participants With Unresectable Locally Advanced or Metastatic Hepatocellular Carcinoma or Gastric/Gastroesophageal Junction Cancer
BeiGene
NCT03486730 COMPLETED BT1718 in Patients with Advanced Solid Tumours.
Cancer Research UK
NCT03469557 COMPLETED BGB A317 in Combination With Chemotherapy as First-Line Treatment in Adults With Inoperable, Locally Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Carcinoma
BeiGene
NCT03904927 COMPLETED Local Therapy for Oligorecurrent and Oligometastatic Esophageal Squamous Cell Carcinoma
Fudan University
NCT04683939 TERMINATED Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT141 in Patients With Unresectable or Metastatic CLDN18.2-positive Gastric, Pancreatic, Ovarian and Biliary Tract Tumors
BioNTech SE
NCT03565003 COMPLETED A First-in-Human Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors in China
Jacobio Pharmaceuticals Co., Ltd.
NCT04721223 COMPLETED JAB-3068 Activity in Adult Patients With Advanced Solid Tumors
Jacobio Pharmaceuticals Co., Ltd.
NCT04752358 TERMINATED ADP-A2M4CD8 in HLA-A2+ Subjects With MAGE-A4 Positive Esophageal or Esophagogastric Junction Cancers (SURPASS-2)
Adaptimmune
NCT03647969 COMPLETED Modified FOLFOX Plus/Minus Nivolumab and Ipilimumab vs. FLOT Plus Nivolumab in Patients With Previously Untreated Advanced or Metastatic Gastric Cancer
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT05898828 WITHDRAWN Phase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG With Entinostat and Nivolumab as Adjuvant Therapy Following Chemoradiation Therapy With or Without Surgery for Locally Advanced Esophageal Cancer
National Cancer Institute (NCI)
NCT03490292 COMPLETED Avelumab With Chemoradiation for Stage II/III Resectable Esophageal and Gastroesophageal Cancer
University of Wisconsin, Madison
NCT04839471 COMPLETED BI-754091 and Afatinib for Refractory Esophageal Squamous Cell Carcinoma (BEAR Study)
National Health Research Institutes, Taiwan
NCT04435197 COMPLETED Pre-Operative Pembrolizumab + Chemoradiation in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma
Ruijin Hospital
NCT03840967 TERMINATED A Study Evaluating Safety and Efficacy of Niraparib in Patients With Previously Treated Metastatic Esophageal/Gastroesophageal Junction/Proximal Gastric Adenocarcinoma
Shadia Jalal, MD
NCT04089904 TERMINATED Phase II Trial of Neoadjuvant Pembrolizumab for Patients With Early Stage Gastroesophageal Adenocarcinoma
University of Chicago
NCT04207918 COMPLETED A Phase II Study of Chemoradiotherapy With Nimotuzumab in Unresectable Esophageal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
NCT03165994 COMPLETED APX005M With Concurrent Chemoradiation for Resectable Esophageal and Gastroesophageal Junction Cancers
Apexigen America, Inc.
NCT03321630 COMPLETED A Phase II a Study of Lenvatinib, a Multi-targeted Tyrosine Kinase Inhibitor, Combined With Pembrolizumab (PD-1 Inhibitor) for the Treatment of Metastatic Gastroesophageal Cancer Patients Who Have Progressed on First or Subsequent Line Therapies
NYU Langone Health
NCT02735239 COMPLETED Study of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Oesophageal Cancer
Ludwig Institute for Cancer Research
NCT03339843 COMPLETED Multiorgan Metabolic Imaging Response Assessment of Abemaciclib
Jules Bordet Institute
NCT03925974 COMPLETED KN026 in Patients With HER2 Expressing Gastric/Gastroesophageal Junction Cancer
Jiangsu Alphamab Biopharmaceuticals Co., Ltd
NCT03997448 TERMINATED Abemaciclib and Pembrolizumab in Locally Advanced Unresectable or Metastatic Gastroesophageal Adenocarcinoma: Big Ten Cancer Research Consortium BTCRC-GI18-149
Nataliya Uboha
NCT02830594 COMPLETED Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer
City of Hope Medical Center
NCT03543813 COMPLETED PROCLAIM-CX-2029: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2029 for Patients With Solid Tumors or DLBCL
CytomX Therapeutics
NCT03196232 COMPLETED Epacadostat and Pembrolizumab in Treating Patients With Metastatic or Unresectable Gastroesophageal Junction or Gastric Cancer
George Albert Fisher
NCT04568200 COMPLETED Study of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Resectable Esophageal Squamous Cell Carcinoma
Peking Union Medical College Hospital
NCT03472365 COMPLETED A Study of SHR-1210 in Combination With Capecitabine + Oxaliplatin or Apatinib in Treatment of Advanced Gastric Cancer
Jiangsu HengRui Medicine Co., Ltd.
NCT02916511 COMPLETED Study of Extensive Clinical Target Volumes in Postoperative Radiotherapy Concurrent With Chemotherapy for Esophageal Squamous Cell Carcinoma
Fudan University
NCT03783936 COMPLETED Trial of mFOLFOX6 + Trastuzumab + Avelumab in Gastric and Esophageal Adenocarcinomas
Ashwin Somasundaram
NCT05302011 COMPLETED Neoadjuvant Pembrolizumab Plus Chemotherapy for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma
Peking Union Medical College Hospital
NCT02639065 COMPLETED A Study of Durvalumab (MEDI4736) in Esophageal Cancer
Shadia Jalal, MD
NCT02716688 WITHDRAWN S-1 and Radiotherapy for Elderly Esophageal Cancer Patients
Zhejiang Provincial People's Hospital
NCT02971956 COMPLETED Pembrolizumab in Refractory Advanced Esophageal Cancer
Dana-Farber Cancer Institute
NCT03991104 WITHDRAWN SOX-based CRT for Esophageal Cancer.
Zhejiang Provincial People's Hospital
NCT03639714 COMPLETED A Study of a Personalized Neoantigen Cancer Vaccine
Gritstone bio, Inc.
NCT04424641 TERMINATED A Study on the Safety of GEN1044 (DuoBody®-CD3x5T4) in Patients With Malignant Solid Tumors
Genmab
NCT02530437 TERMINATED Taladegib, Paclitaxel, Carboplatin, and Radiation Therapy in Treating Patients With Localized Esophageal or Gastroesophageal Junction Cancer
M.D. Anderson Cancer Center
NCT02489201 TERMINATED A Study of Donafenib Monotherapy in Advanced Oesophageal Cancer
Suzhou Zelgen Biopharmaceuticals Co.,Ltd
NCT02344810 WITHDRAWN C-Met Inhibitor AMG 337, Oxaliplatin, Leucovorin Calcium, and Fluorouracil in Treating Patients With Advanced Stomach or Esophageal Cancer
Eastern Cooperative Oncology Group
NCT03888092 COMPLETED Z650 in Advanced Esophageal Squamous Cell Carcinoma With EGFR Over Expression or Gene Amplification
Sunshine Lake Pharma Co., Ltd.
NCT02954536 COMPLETED Phase II Trial of Pembrolizumab With Trastuzumab and Chemotherapy in Advanced HER2 Positive Esophagogastric (EG) Cancer
Memorial Sloan Kettering Cancer Center
NCT02976909 COMPLETED Efficacy and Safety of TPF Induction Chemotherapy for Borderline-resectable Esophageal Squamous Cell Carcinoma
Yuhong Li
NCT02976896 COMPLETED Apatinib for Esophageal Squamous Cell Cancer After the Failure of Standard Treatment
Yuhong Li
NCT02350517 COMPLETED Endostar Combined With Paclitaxel and Nedaplatin in Treating Patients With Recurrent or Metastatic Esophageal Cancer
Yuhong Li
NCT02965976 COMPLETED Botulinum Toxin Type A in Preventing Complications After Surgery in Patients With Esophageal Cancer
Roswell Park Cancer Institute
NCT04099641 COMPLETED An Open Label Study of Bavituximab and Pembrolizumab in Advanced Gastric and GEJ Cancer Patients
OncXerna Theraputics, Inc.
NCT05135845 SUSPENDED Combination of Capmatinib + Spartalizumab in Advanced Oesogastric Adenocarcinoma
Assistance Publique - Hôpitaux de Paris
NCT04510285 TERMINATED A Single-Arm Pilot Study of Adjuvant Pembrolizumab Plus Trastuzumab in HER2+ Esophagogastric Tumors With Persistent Circulating Tumor DNA Following Curative Resection
Memorial Sloan Kettering Cancer Center
NCT03251417 TERMINATED Apatinib and Irinotecan Combination Treatment in Unresectable or Metastatic Esophageal Squamous Cell Carcinoma
Peking University
NCT02501603 COMPLETED Afatinib, Paclitaxel, 2nd Line, Advanced Gastric Cancer
Yonsei University
NCT03982173 WITHDRAWN Basket Trial for Combination Therapy With Durvalumab (Anti-PDL1) (MEDI4736) and Tremelimumab (Anti-CTLA4) in Patients With Metastatic Solid Tumors
Gustave Roussy, Cancer Campus, Grand Paris
NCT04380480 COMPLETED Percutaneous Endoscopic Gastrostomy Before Definitive Concurrent Chemoradiation Therapy for Esophageal Squamous Cell Carcinoma
Sun Yat-sen University
NCT05245760 WITHDRAWN ChemoRadiation And Tislelizumab for Esophageal/EGJ Cancer
Zhonglin Hao
NCT03660449 COMPLETED Moderately Hypofractionated Conformal Radiation Combined With S-1 for Esophageal Squamous Cell Carcinoma
Sun Yat-sen University
NCT03416244 COMPLETED A Multicenter Open-label Phase II Trial to Evaluate Nivolumab and Ipilimumab for 2nd Line Therapy in Elderly Patients With Advanced Esophageal Squamous Cell Cancer
AIO-Studien-gGmbH
NCT02559687 COMPLETED Study of Pembrolizumab (MK-3475) in Previously-Treated Participants With Advanced Carcinoma of the Esophagus or Esophagogastric Junction (MK-3475-180/KEYNOTE-180)
Merck Sharp & Dohme LLC
NCT04005170 COMPLETED Combination of Toripalimab and Chemoradiotherapy in Esophageal Cancer
Mian XI
NCT03925870 COMPLETED KN046 in Subjects With Late Stage Esophageal Squamous Cell Carcinoma
Jiangsu Alphamab Biopharmaceuticals Co., Ltd
NCT02317991 COMPLETED Study of Nab-Paclitaxel and Ramucirumab as Second-line Treatment for Patients With Metastatic Gastroesophageal Cancer
SCRI Development Innovations, LLC
NCT03365791 COMPLETED PDR001 Plus LAG525 for Patients With Advanced Solid and Hematologic Malignancies
Novartis Pharmaceuticals
NCT03409848 COMPLETED Ipilimumab or FOLFOX in Combination With Nivolumab and Trastuzumab in HER2 Positive EsophagoGastric Adenocarcinoma
AIO-Studien-gGmbH
NCT03278626 TERMINATED Immune Checkpoint Therapy With Nivolumab Esophageal Squamous Cell Carcinoma
NYU Langone Health
NCT03592407 WITHDRAWN Epacadostat and Pembrolizumab Before Surgery in Treating Participants With Stage II-III Esophageal or Gastroesophageal Cancer
City of Hope Medical Center
NCT02999893 TERMINATED A Study of APR-246 in Oesophageal Cancer
Peter MacCallum Cancer Centre, Australia
NCT03529266 COMPLETED Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage for Esophageal or Junctional Carcinoma.
Sun Yat-sen University
NCT04464967 WITHDRAWN Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers
NKGen Biotech, Inc.
NCT04084158 SUSPENDED A Study of Toripalimab Combined With Concurrent Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Zhejiang Cancer Hospital
NCT03116152 COMPLETED Study of IBI308 With Advanced/Metastatic Esophageal Squamous Cell Carcinoma After Failure of First-line Treatment
Innovent Biologics (Suzhou) Co. Ltd.
NCT04225364 COMPLETED Efficacy of Neoadjuvant PD-1 Blockade Plus Chemotherapy for Esophageal Squamous Cell Carcinoma
Guangzhou Institute of Respiratory Disease
NCT03528876 TERMINATED FOLFIRI Alternate With FOLFOX in Untreated Metastatic Gastric and Esophageal Adenocarcinoma
University of Saskatchewan
NCT02606916 COMPLETED Radiotherapy Combined With S-1/DDP for Elderly Esophageal Squamous Cell Cancer.
Sun Yat-sen University
NCT03187314 COMPLETED Combination of Radiation Therapy and Anti-PD-1 Antibody SHR-1210 in Treating Patients With Esophageal Cancer
Hangzhou Cancer Hospital
NCT03087864 COMPLETED PDL-1 Targeting in Resectable Oesophageal Cancer
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT03818997 WITHDRAWN Combination of Targeted and Immunotherapy for Advanced Biliary Tract and Esophagogastric Gastric Cancer
European Organisation for Research and Treatment of Cancer - EORTC
NCT02726399 TERMINATED Phase II Study of Ramucirumab With Chemotherapy in Patients With Metastatic Gastroesophageal Junction and Gastric Cancer
Memorial Sloan Kettering Cancer Center
NCT02843581 COMPLETED Combination of Cryosurgery and NK Immunotherapy for Advanced Esophageal Cancer
Fuda Cancer Hospital, Guangzhou
NCT02649361 COMPLETED Study of Anlotinib in Patients With Esophageal Squamous Cell Carcinoma (ALTER1102)
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
NCT03122548 TERMINATED Safety and Efficacy of CRS-207 With Pembrolizumab in Gastric, Gastroesophageal Junction or Esophageal Cancers
Aduro Biotech, Inc.
NCT03234842 WITHDRAWN Dose Escalated Proton Beam Therapy or Photon Therapy for Esophageal Cancer
University of Florida
NCT03292757 COMPLETED FLOTOR Pilot Study
Oxford University Hospitals NHS Trust
NCT02669914 TERMINATED MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors
Washington University School of Medicine
NCT03223662 TERMINATED Metabolomic and BH3 Profiling of Esophageal Cancers: Identification of Novel Assessment Methods of Treatment Response for Precision Therapy
National Cancer Institute (NCI)
NCT03220009 WITHDRAWN Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in Treating Patients With High Risk Localized, Locoregionally Advanced, or Recurrent Mucosal Melanoma
National Cancer Institute (NCI)
NCT02638909 TERMINATED Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal Malignancies
Criterium, Inc.
NCT02392377 TERMINATED Molecular Phenotyping in Predicting Response in Patients With Stage IB-III Esophageal Cancer Receiving Combination Chemotherapy
Case Comprehensive Cancer Center