Landscape → Gastrointestinal

GERD

67 clinical trials

17 active

67 total (since 2015)

Phase 1 Active

27 total

Phase 2 Active

11 total

Phase 3 Active

14 total

Phase 4 Active

18 total

Top Sponsors (Industry)

Sorted by active Active Done Failed

Cinclus Pharma Holding AB 2 2 0

Takeda 1 3 1

Addpharma Inc. 1 3 0

Onconic Therapeutics Inc. 1 1 0

Daewoong Pharmaceutical Co. LTD. 1 1 0

Valenta Pharm JSC 1 0 0

Carnot Laboratories 1 0 0

Phathom Pharmaceuticals, Inc. 0 4 0

Chong Kun Dang Pharmaceutical 0 4 0

Neutec Ar-Ge San ve Tic A.Ş 0 2 1

Ironwood Pharmaceuticals, Inc. 0 2 1

NCT07310927 RECRUITING

Alginate vs Sucralfate for GERD Symptomatic Relief

CMH Lahore Medical College and Institute of Dentistry n=140

NCT07313774 NOT YET RECRUITING

A Study Comparing the Effect and Safety of Linaprazan Glurate to Lansoprazole in Maintenance of Healing in Participants With Healed Erosive Esophagitis (EE) Due to Gastroesophageal Reflux Disease (GERD)

Cinclus Pharma Holding AB n=1,050

NCT07037875 NOT YET RECRUITING

A Study Comparing the Effect and Safety of Linaprazan Glurate to Lansoprazole in Participants With Erosive Esophagitis (EE) Due to Gastroesophageal Reflux Disease (GERD)

Cinclus Pharma Holding AB n=500

NCT07160790 NOT YET RECRUITING

Phase 3 Study of JP-1366: Efficacy and Safety of JP-1366 in Patients With Non-erosive Gastroesophageal Reflux Disease

Onconic Therapeutics Inc. n=321

NCT07063576 RECRUITING

Effect of Baclofen in Management of Patients With Gastroesophageal Reflux Disease Symptoms

Adnan Imtiaj Rahul n=60

NCT07049315 NOT YET RECRUITING

Mandibular Advancement Devices for Reflux in Obstructive Sleep Apnea

Tuiuti University of Paraná n=40

NCT05195528 COMPLETED

A Study to Evaluate the Efficacy and Safety of Vonoprazan Compared to Placebo for Relief of Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease (NERD)

Phathom Pharmaceuticals, Inc. n=776

NCT03561090 TERMINATED

A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)

Ironwood Pharmaceuticals, Inc. n=495

NCT03561883 COMPLETED

Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)

Ironwood Pharmaceuticals, Inc. n=609

NCT03367195 TERMINATED

Efficacy and Safety of DLBS2411 in the Management of GERD

Dexa Medica Group n=32

NCT04080726 COMPLETED

Efficacy and Safety of HIP1601 Capsule

Hanmi Pharmaceutical Company Limited n=213

NCT02954848 COMPLETED

Phase 3 Study of TAK-438 10 mg in the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD)

Takeda n=484

NCT02873689 COMPLETED

Efficacy and Safety of Dexlansoprazole on Heartburn Relief in Chinese Patients

Takeda n=217

NCT03516188 COMPLETED

Efficacy of Gaviscon-Advance® in Suppressing Post-supper Acid-pocket and Night-time Acid-reflux in Obese Participants

Universiti Sains Malaysia n=24

NCT07421011 RECRUITING

Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers.

Valenta Pharm JSC

NCT05107219 ACTIVE NOT RECRUITING

GCC Agonist Signal in the Small Intestine

University of Wisconsin, Madison

NCT06916130 NOT YET RECRUITING

A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-120 and AD-120A

Addpharma Inc.

NCT06437951 NOT YET RECRUITING

to Evaluate the Safety/Tolerability and Pharmacokinetics, and Pharmacodynamics of DWP14012 Injection

Daewoong Pharmaceutical Co. LTD.

NCT07308041 COMPLETED

A Study to Investigate the Effect of Linaprazan Glurate on the Pharmacokinetics of Amoxicillin

Cinclus Pharma Holding AB

NCT07364838 COMPLETED

Study to Evaluate the Effect of Food on the Pharmacokinetics and Pharmacodynamics Characteristics in Healthy Adult Volunteers

Daewon Pharmaceutical Co., Ltd.

NCT07107672 COMPLETED

Mass Balance Study of [14C]X842 in Healthy Adult Male Subjects

Jiangsu Sinorda Biomedicine Co., Ltd

NCT05742984 COMPLETED

Investigate Linaprazan Glurate/Linaprazan in Healthy Subjects

Cinclus Pharma Holding AB

NCT06391177 COMPLETED

A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily

Phathom Pharmaceuticals, Inc.

NCT06106022 COMPLETED

A Study to Evaluate Vonoprazan in Children Who Have Symptomatic Gastroesophageal Reflux Disease

Phathom Pharmaceuticals, Inc.

NCT05282914 COMPLETED

A Study to Compare PK, PD and Safety of UI058 and UIC202004 in Healthy Subjects

Korea United Pharm. Inc.

NCT06293326 COMPLETED

A First-in-Human Study to Learn How Well a Bi-Layer Calcium Carbonate Antacid Tablet Works Compared to a Standard, Non-Layered Calcium Carbonate Tablet in Healthy Male Participants

Bayer

NCT04703868 COMPLETED

A Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of YPI 011 to Rabeprazole in Healthy Adult Subjects

Yungjin Pharm. Co., Ltd.

NCT06141577 COMPLETED

A Study to Compare Pharmacokinetics, Pharmacodynamics and Safety of UI059 and UIC202201 in Healthy Subjects

Korea United Pharm. Inc.

NCT05062876 COMPLETED

A Study to Compare PK, PD and Safety of the AD-214 and AD-2141

Addpharma Inc.

NCT03069963 COMPLETED

PH Metry Study to Compare the Antacid Activity of Z0063 Versus Gaviscon Double Action Tablets, in Healthy Adult Subjects

Sanofi

NCT03065816 COMPLETED

Scintigraphy Study to Compare the Antireflux Activity of the Z0063 Versus Gaviscon Double Action Tablets, in Healthy Adult Subjects

Sanofi

NCT04568772 COMPLETED

Study to Evaluate the Influence of Tegoprazan on the Pharmacokinetics of Proguanil in Healthy Volunteers

Seoul National University Hospital

NCT04830930 COMPLETED

A Study to Investigate the Effect of Food on the PK, PD of CKD-381 in Healthy Volunteers

Chong Kun Dang Pharmaceutical

NCT04494243 COMPLETED

A Study to Compare PK, PD and Safety of the AD-214 10/600mg and Rabeprazole

Addpharma Inc.

NCT04622358 COMPLETED

A Study to Compare PK, PD and Safety of the AD-214-02 and Rabeprazole

Addpharma Inc.

NCT03985319 COMPLETED

Clinical Trial to Assess the PK/PD of YYD601 20mg After Oral Administration if Healthy Adult Subjects (Phase1)

Yooyoung Pharmaceutical Co., Ltd.

NCT02442752 WITHDRAWN

Phase 1 Dexlansoprazole Delayed-Release Capsules for Acid-Related Disorders in Infants Aged 1 to 11 Months

Takeda

NCT03558425 COMPLETED

A Study to Compare PK, PD and Safety of CKD-381 and D026 in Healthy Subjects

Chong Kun Dang Pharmaceutical

NCT03558477 COMPLETED

PK/PD Clinical Trial of YYD601 in Healthy Adult Male

Yooyoung Pharmaceutical Co., Ltd.

NCT03444402 COMPLETED

A Study to Compare PK and Safety of CKD-381 and D026 in Healthy Male Subjects

Chong Kun Dang Pharmaceutical

NCT03211143 COMPLETED

A Study to Compare PK, PD and Safety of CKD-381 in Healthy Subjects

Chong Kun Dang Pharmaceutical

NCT07268820 RECRUITING

Heartburn, Gastroesophageal Reflux Disease

Incheon St.Mary's Hospital

NCT06991348 RECRUITING

Clinical Trial for the Comparative Evaluation of Acid Suppression and Symptom Management of Gastroesophageal Reflux Disease With the Administration of Tegoprazan or Pantoprazole

Carnot Laboratories

NCT06241183 RECRUITING

Famotidine and Antacids for Treatment of Dyspepsia

Stony Brook University

NCT05629143 ACTIVE NOT RECRUITING

Primary carE PPi dEprescRibing Trial

Universitaire Ziekenhuizen KU Leuven

NCT06564246 RECRUITING

Clinical Study Evaluating The Role of Vonoprazan Versus Pantoprazole in Patients With Gastroesophageal Reflux Disease

Tanta University

NCT06778395 COMPLETED

Therapeutic Effect of Vonoprazan Versus Dexlansoprazole in Treatment of Gastroesophageal Reflux Disease

Ayman Magd Eldin Mohammad Sadek

NCT04248335 COMPLETED

Effect of Obesity on Proton Pump Inhibitors

Children's Mercy Hospital Kansas City

NCT02401035 TERMINATED

PREA, PK And Safety PASS Study Of IV Pantoprazole In Pediatric Subjects

Pfizer

NCT04028466 TERMINATED

Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features

St. Luke's Medical Center, Philippines

NCT03355170 WITHDRAWN

Cardiac Safety of Lansoprazole and Domperidon Combination

Neutec Ar-Ge San ve Tic A.Ş

NCT03238534 COMPLETED

Efficacy and Safety Evaluation of Neobianacid® in GERD and EPS

Aboca Spa Societa' Agricola

NCT02505945 COMPLETED

The CALIBER Study Randomized Controlled Trial of LINX Versus Double-Dose Proton Pump Inhibitor Therapy for Reflux Disease

Torax Medical Incorporated

NCT03037606 COMPLETED

Comparison of the Effect of Rabeprazole 50 mg DDR Capsules and 20 mg Enteric-coated Tablets

Neutec Ar-Ge San ve Tic A.Ş

NCT02351960 COMPLETED

Dexlansoprazole in Asian Participants With Gastroesophageal Reflux Disease

Takeda

NCT03079050 COMPLETED

An Open-Label Trial of Dexlansoprazole 60mg for the Relief of Heartburn During the Fasting Month of Ramadan

American University of Beirut Medical Center

NCT02689999 COMPLETED

The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity

Neutec Ar-Ge San ve Tic A.Ş

NCT02708355 COMPLETED

Pilot Study To Investigate The Association Between Acid Control And Heartburn Symptoms After Proton Pump Inhibitor Treatment

Pfizer

NCT02470117 COMPLETED

Alginate-based Reflux Suppressant and Magnesium-aluminium Antacid Gel for Treatment of Heartburn in Pregnancy

Chulalongkorn University

Data: ClinicalTrials.gov