TheraRadar

Pharma Intelligence, Simplified

Landscape Oncology

Melanoma

1,078 clinical trials

500 active
/
1078 total (since 2015)
250
Phase 1 Active
590 total
303
Phase 2 Active
624 total
59
Phase 3 Active
99 total
6
Phase 4 Active
11 total

Top Sponsors (Industry)

Sorted by active Active Done Failed
Merck 7 10 2
Pfizer 7 2 9
Novartis 6 4 8
Regeneron 6 3 2
Iovance Biotherapeutics, Inc. 6 1 0
Bristol-Myers Squibb 5 15 5
Roche 4 14 2
Biocad 4 1 0
IDEAYA Biosciences 4 0 0
Immunocore Ltd 3 1 2
Innovent Biologics (Suzhou) Co. Ltd. 3 0 2
NGM Biopharmaceuticals, Inc 3 1 0
Replimune Inc. 3 0 0
Philogen S.p.A. 3 0 0
Binhui Biopharmaceutical Co., Ltd. 3 0 0
NCT02339571 ACTIVE NOT RECRUITING
A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma
National Cancer Institute (NCI) n=600
NCT06246149 RECRUITING
Adjuvant Tebentafusp in High Risk Ocular Melanoma
European Organisation for Research and Treatment of Cancer - EORTC n=290
NCT02506153 ACTIVE NOT RECRUITING
Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery
National Cancer Institute (NCI) n=1,301
NCT04657991 ACTIVE NOT RECRUITING
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma
Pfizer n=257
NCT06007690 RECRUITING
A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma
Aura Biosciences n=100
NCT06346067 ACTIVE NOT RECRUITING
A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)
Erasca, Inc. n=78
NCT07440290 NOT YET RECRUITING
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
Cancer Research UK n=30
NCT05549297 RECRUITING
Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
Immunocore Ltd n=540
NCT06112314 RECRUITING
IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
Immunocore Ltd n=680
NCT06743126 RECRUITING
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
Immatics US, Inc. n=360
NCT06246916 RECRUITING
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
Regeneron Pharmaceuticals n=560
NCT07015190 RECRUITING
Neoadjuvant Darovasertib in Primary Uveal Melanoma
IDEAYA Biosciences n=520
NCT02224781 ACTIVE NOT RECRUITING
Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma
National Cancer Institute (NCI) n=267
NCT06581406 RECRUITING
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
Replimune Inc. n=280
NCT05987332 ACTIVE NOT RECRUITING
IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma
IDEAYA Biosciences n=420
NCT06264180 RECRUITING
VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
Replimune Inc. n=400
NCT07221734 RECRUITING
Study to Compare Pharmacokinetics, Efficacy, Safety, and Immunogenicity of MB11 Versus EU-/US-Opdivo® in Subjects With Previously Untreated Advanced [Unresectable or Metastatic] Melanoma
mAbxience Research S.L. n=632
NCT06500455 RECRUITING
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
NRG Oncology n=269
NCT06054555 ACTIVE NOT RECRUITING
A Study to Evaluate ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Unresectable or Metastatic Melanoma
Amgen n=633
NCT07310758 RECRUITING
Contrast-enhanced Ultrasound for Sentinel Node Detection
The Netherlands Cancer Institute n=91
NCT05352672 ACTIVE NOT RECRUITING
Clinical Study of Fianlimab in Combination With Cemiplimab Versus Pembrolizumab in Adolescent and Adult Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma
Regeneron Pharmaceuticals n=1,546
NCT02821013 RECRUITING
Duration of Anti-PD-1 Therapy in Metastatic Melanoma
Canadian Cancer Trials Group n=614
NCT03567889 RECRUITING
Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients
Philogen S.p.A. n=186
NCT06794775 RECRUITING
SWE-NEO: Swedish NeoAdjuvant Trial Comparing Monotherapy to Combined Immunotherapy in Resectable Stage III Melanoma
Hildur Helgadottir n=128
NCT05522660 RECRUITING
Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer
ETOP IBCSG Partners Foundation n=180
NCT05770544 RECRUITING
DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.
Cancer Research UK n=30
NCT05768178 RECRUITING
DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.
Cancer Research UK n=30
NCT05770102 RECRUITING
DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
Cancer Research UK n=30
NCT07068074 NOT YET RECRUITING
A Randomized Phase III Study of Management of Treatment Naive Primary Melanoma in Elderly Patients
Eastern Cooperative Oncology Group n=428
NCT06697301 RECRUITING
Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.
Eikon Therapeutics n=740
NCT02362594 ACTIVE NOT RECRUITING
Study of Pembrolizumab (MK-3475) Versus Placebo After Complete Resection of High-Risk Stage III Melanoma (MK-3475-054/1325-MG/KEYNOTE-054)
Merck Sharp & Dohme LLC n=1,019
NCT04674683 ACTIVE NOT RECRUITING
Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma
HUYABIO International, LLC. n=450
NCT05933577 ACTIVE NOT RECRUITING
A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)
Merck Sharp & Dohme LLC n=1,089
NCT06624644 RECRUITING
A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma
Linnaeus Therapeutics, Inc. n=135
NCT03470922 ACTIVE NOT RECRUITING
A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma
Bristol-Myers Squibb n=714
NCT05155254 ACTIVE NOT RECRUITING
IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)
IO Biotech n=407
NCT04099251 ACTIVE NOT RECRUITING
Effectiveness Study of Nivolumab Compared to Placebo in Prevention of Recurrent Melanoma After Complete Resection of Stage IIB/C Melanoma
Bristol-Myers Squibb n=790
NCT05625399 ACTIVE NOT RECRUITING
A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma
Bristol-Myers Squibb n=579
NCT05868707 RECRUITING
OH2 Injection in Melanoma
Binhui Biopharmaceutical Co., Ltd. n=340
NCT05751928 ACTIVE NOT RECRUITING
A Study of Neoadjuvant Therapy With BCD-217 (Nurulimab + Prolgolimab) in Patients With Resectable Stage III Skin Melanoma
Biocad n=411
NCT05727904 RECRUITING
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
Iovance Biotherapeutics, Inc. n=670
NCT06640530 ACTIVE NOT RECRUITING
Clinical Study of the Efficacy and Safety of BCD-263 and Opdivo® as Monotherapy in Subjects With Advanced Melanoma of the Skin
Biocad n=392
NCT05078047 RECRUITING
Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3 Months in Patients in Response After 6 Months of Standard IO
UNICANCER n=646
NCT05502900 RECRUITING
Adjuvant Melatonin for Uveal Melanoma
Gustav Stalhammar n=100
NCT05608291 ACTIVE NOT RECRUITING
A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery
Regeneron Pharmaceuticals n=1,564
NCT05899465 RECRUITING
Perioperative Treatment With Tranexamic Acid in Melanoma
University of Aarhus n=1,204
NCT05732805 ACTIVE NOT RECRUITING
A Clinical Study of BCD-217 (Nurulimab + Prolgolimab) Followed by Anti-PD-1 Compared to Anti-PD-1 Monotherapy as First-Line Treatment in Subjects With Unresectable/Metastatic Melanoma
Biocad n=270
NCT05955924 RECRUITING
Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial
Women's College Hospital n=396
NCT03553836 ACTIVE NOT RECRUITING
Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)
Merck Sharp & Dohme LLC n=976
NCT06519266 RECRUITING
PHP in Combination With IPI1/NIVO3 Compared to IPI3/NIVO1 Only in Patients With Uveal Melanoma Liver Metastases
Vastra Gotaland Region n=40
NCT02938299 ACTIVE NOT RECRUITING
Neoadjuvant L19IL2/L19TNF- Pivotal Study
Philogen S.p.A. n=214
NCT06488482 NOT YET RECRUITING
Assessment of Short Immunotherapy After Radical Surgery of High-risk Malignant Melanoma
Uppsala University n=1,792
NCT06008106 RECRUITING
Comparing Tunlametinib Capsules and Combination Chemotherapy in Advanced NRAS-mutant Melanoma
Shanghai Kechow Pharma, Inc. n=165
NCT03755739 RECRUITING
Trans-Artery/Intra-Tumor Infusion of Checkpoint Inhibitors Plus Chemodrug for Immunotherapy of Advanced Solid Tumors
Second Affiliated Hospital of Guangzhou Medical University n=200
NCT04309409 ACTIVE NOT RECRUITING
Adjuvant Nivolumab Treatment in Stage II (IIA, IIB, IIC) High-risk Melanoma
University Hospital, Essen n=374
NCT06320353 ACTIVE NOT RECRUITING
Study сomparing the Efficacy and Safety of RPH-075 and Keytruda® in Patients With Unresectable or Metastatic Skin Melanoma
R-Pharm n=266
NCT04949113 ACTIVE NOT RECRUITING
Neoadjuvant Ipilimumab Plus Nivolumab Versus Standard Adjuvant Nivolumab in Macroscopic Stage III Melanoma
The Netherlands Cancer Institute n=423
NCT05270044 ACTIVE NOT RECRUITING
Adjuvant Encorafenib and Binimetinib in High-risk Stage II Melanoma With a BRAF Mutation.
Pierre Fabre Medicament n=815
NCT05789043 RECRUITING
Camrelizumab in Combination With Apatinib and Temozolomide as First-line Treatment in Advanced Acral Melanoma
Peking University Cancer Hospital & Institute n=140
NCT05907122 COMPLETED
A Study to Evaluate Similarity of ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Resected Melanoma
Amgen n=256
NCT06587451 TERMINATED
Integrated Pharmacokinetics (PK)/Efficacy, Safety, and Immunogenicity Study to Demonstrate Similarity of JPB898, a Proposed Biosimilar to Nivolumab, to Opdivo® in Combination With Yervoy®
Sandoz n=52
NCT03820986 COMPLETED
Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advance Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)
Merck Sharp & Dohme LLC n=674
NCT05002569 TERMINATED
A Study to Assess Adjuvant Immunotherapy With Nivolumab Plus Relatlimab Versus Nivolumab Alone After Complete Resection of Stage III-IV Melanoma
Bristol-Myers Squibb n=1,093
NCT04889118 COMPLETED
Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advanced Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)-China Extension Study
Merck Sharp & Dohme LLC n=131
NCT04157985 COMPLETED
Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors
Dan Zandberg n=161
NCT05665595 COMPLETED
A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010)
Merck Sharp & Dohme LLC n=1,594
NCT01861938 WITHDRAWN
Modified Melanoma Vaccine for High Risk or Low Residual Disease Patients
Hadassah Medical Organization
NCT02967692 TERMINATED
A Study of the Anti-PD1 Antibody PDR001, in Combination With Dabrafenib and Trametinib in Advanced Melanoma
Novartis Pharmaceuticals n=568
NCT04695977 TERMINATED
CMP-001 in Combination With Nivolumab Compared to Nivolumab Monotherapy in Subjects With Advanced Melanoma
Regeneron Pharmaceuticals n=20
NCT02752074 COMPLETED
A Phase 3 Study of Pembrolizumab + Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma (Keynote-252 / ECHO-301)
Incyte Corporation n=706
NCT02908672 COMPLETED
A Study of Atezolizumab Plus Cobimetinib and Vemurafenib Versus Placebo Plus Cobimetinib and Vemurafenib in Previously Untreated BRAFv600 Mutation-Positive Patients With Metastatic or Unresectable Locally Advanced Melanoma
Hoffmann-La Roche n=514
NCT04588246 TERMINATED
Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery
NRG Oncology n=19
NCT02166788 COMPLETED
Evaluation of Groin Lymphadenectomy Extent For Metastatic Melanoma
Melanoma and Skin Cancer Trials Limited n=634
NCT03551626 COMPLETED
Study of Dabrafenib+Trametinib in the Adjuvant Treatment of Stage III BRAF V600+ Melanoma After Complete Resection to Evaluate the Impact on Pyrexia Related Outcomes
Novartis Pharmaceuticals n=552
NCT02388906 COMPLETED
Efficacy Study of Nivolumab Compared to Ipilimumab in Prevention of Recurrence of Melanoma After Complete Resection of Stage IIIb/c or Stage IV Melanoma
Bristol-Myers Squibb n=906
NCT03635983 COMPLETED
A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma
Bristol-Myers Squibb n=783
NCT03172299 COMPLETED
Prevention of Neovascular Glaucoma by Intravitreal Injections of Anti-VEGF in Patients Treated with Proton Therapy for a Large Choroidal Melanoma
Centre Hospitalier Universitaire de Nice n=57
NCT04901988 TERMINATED
Circulating Tumour DNA guidEd Therapy for Stage IIB/C mElanoma After surgiCal resecTION
The Christie NHS Foundation Trust n=8
NCT05297565 COMPLETED
A Study to Compare Nivolumab Administered Subcutaneously vs Intravenous in Melanoma Participants Following Complete Resection
Bristol-Myers Squibb n=14
NCT02993315 COMPLETED
Melanoma Patients Immunized with Natural DenDritic Cells
Radboud University Medical Center n=148
NCT03430297 COMPLETED
A Randomized, Controlled, Multi-center, Phase III Clinical Study to Investigate Recombinant Humanized PD-1 Monoclonal Antibody Injection (JS001) Versus Dacarbazine as the 1st-line Therapy for Unresectable or Metastatic Melanoma
Shanghai Junshi Bioscience Co., Ltd. n=256
NCT03233828 TERMINATED
Pre-Treatment of Highly Suspicious Pigmented Skin Lesions With Interleukin-2
Carman Giacomantonio n=1
NCT02678572 COMPLETED
Percutaneous Hepatic Perfusion in Patients With Hepatic-dominant Ocular Melanoma
Delcath Systems Inc. n=102
NCT04410445 TERMINATED
Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrence
Nektar Therapeutics n=765
NCT04277663 TERMINATED
The Study of IBI310 in Combination With IBI308 Compared to High-Dose Interferon In Patients With Acral Melanoma That Has Been Removed by Surgery
Innovent Biologics (Suzhou) Co. Ltd. n=136
NCT03928275 WITHDRAWN
The Response to Intralesional IL-2 and/or BCG Treatment for Cutaneous Metastatic Melanoma
Carman Giacomantonio
NCT03294330 COMPLETED
SPY-X: A Study to Assess the Feasibility of Using SPY Alone for Sentinel Node Localization for Melanoma or Breast Cancer
Milton S. Hershey Medical Center n=35
NCT02997553 COMPLETED
Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery
Institut de Cancérologie de Lorraine n=744
NCT03445533 TERMINATED
A Study of Tilsotolimod in Combo With Ipilimumab vs Ipilimumab Alone in Subjects With Anti-PD-1 Refractory Melanoma
Idera Pharmaceuticals, Inc. n=481
NCT03273153 TERMINATED
A Study of Cobimetinib Plus Atezolizumab Versus Pembrolizumab in Participants With Previously Untreated Advanced BRAFv600 Wild-Type Melanoma
Hoffmann-La Roche n=446
NCT02714218 COMPLETED
A Study of Two Different Dose Combinations of Nivolumab in Combination With Ipilimumab in Subjects With Previously Untreated, Unresectable or Metastatic Melanoma
Bristol-Myers Squibb n=387
NCT02288897 TERMINATED
PV-10 vs Chemotherapy or Oncolytic Viral Therapy for Treatment of Locally Advanced Cutaneous Melanoma
Provectus Biopharmaceuticals, Inc. n=20
NCT03068455 COMPLETED
An Investigational Immuno-therapy Study of Nivolumab Combined With Ipilimumab Compared to Nivolumab by Itself After Complete Surgical Removal of Stage IIIb/c/d or Stage IV Melanoma
Bristol-Myers Squibb n=1,844
NCT03329846 COMPLETED
An Investigational Immuno-therapy Study of BMS-986205 Combined With Nivolumab, Compared to Nivolumab by Itself, in Patients With Advanced Melanoma
Bristol-Myers Squibb n=20
NCT02599402 COMPLETED
Nivolumab Combined With Ipilimumab Followed by Nivolumab Monotherapy as First-Line Treatment for Patients With Advanced Melanoma
Bristol-Myers Squibb n=533
NCT02905266 COMPLETED
A Safety and Efficacy Study of Multiple Administration Regimens for Nivolumab Plus Ipilimumab in Subjects With Melanoma
Bristol-Myers Squibb n=106
NCT02545075 COMPLETED
A Comparative Study in Chinese Subjects With Chemotherapy Naïve Stage IV Melanoma Receiving Ipilimumab (3 mg/kg) vs. Dacarbazine
Bristol-Myers Squibb n=182
NCT03131713 COMPLETED
Preoperative Acetaminophen and Carbohydrate Loading
Tufts Medical Center n=101
NCT02427893 WITHDRAWN
Trial of Vemurafenib and Cobimetinib in Patients With Advanced BRAFV600 Mutant Melanoma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins