296 active
/
495 total (since 2015)
87
Phase 1 Active
175 total
224
Phase 2 Active
351 total
33
Phase 3 Active
48 total
1
Phase 4 Active
2 total
Top Sponsors (Industry)
Sorted by active Active Done Failed
Regeneron 2 5 2
Merck 2 1 0
Alentis Therapeutics AG 2 0 0
Replimune Inc. 2 0 0
Ankyra Therapeutics, Inc 2 0 0
Incyte Corporation 1 3 1
AstraZeneca 1 1 0
PDS Biotechnology Corp. 1 1 0
Rakuten Medical, Inc. 1 0 1
Privo Technologies 1 1 0
Neonc Technologies, Inc. 1 0 0
Terremoto Biosciences Inc. 1 0 0
VSPharmTech Co.,Ltd. 1 0 0
ALX Oncology Inc. 1 0 0
Normunity AccelCo, Inc. 1 0 0
NCT05063552 ACTIVE NOT RECRUITING
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
National Cancer Institute (NCI) n=430
NCT03952585 ACTIVE NOT RECRUITING
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer
National Cancer Institute (NCI) n=384
NCT04444921 ACTIVE NOT RECRUITING
EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients
National Cancer Institute (NCI) n=205
NCT03233711 ACTIVE NOT RECRUITING
Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer
National Cancer Institute (NCI) n=344
NCT07061977 RECRUITING
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
National Cancer Institute (NCI) n=336
NCT06568172 RECRUITING
Testing the Addition of an Immunotherapy Drug, Cemiplimab (REGN2810), Plus Surgery to the Usual Surgery Alone for Treating Advanced Skin Cancer
National Cancer Institute (NCI) n=420
NCT06992427 RECRUITING
High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
Alliance for Clinical Trials in Oncology n=228
NCT07445048 NOT YET RECRUITING
Postoperative Radiotherapy Combined With Nimotuzumab Followed by Bemcentinib in High-Risk Patients With Head and Neck Squamous Cell Carcinoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University n=370
NCT02466971 ACTIVE NOT RECRUITING
Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers
National Cancer Institute (NCI) n=450
NCT05721755 RECRUITING
Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck
ECOG-ACRIN Cancer Research Group n=290
NCT06585410 RECRUITING
Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
Regeneron Pharmaceuticals n=369
NCT06589804 RECRUITING
Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
National Cancer Institute (NCI) n=158
NCT06563479 RECRUITING
A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer
Memorial Sloan Kettering Cancer Center n=291
NCT07371611 RECRUITING
Sintilimab Plus Chemotherapy as Neoadjuvant and Adjuvant Treatment for Locally Advanced Oral Squamous Cell Carcinoma
Qunxing Li,MD n=104
NCT04255849 ACTIVE NOT RECRUITING
Nine-valent HPV Vaccine to Prevent Persistent Oral HPV Infection in Men Living With HIV
Weill Medical College of Cornell University n=700
NCT04333537 RECRUITING
Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer
NRG Oncology n=686
NCT03801876 RECRUITING
Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer
NRG Oncology n=300
NCT07333274 RECRUITING
Compare Radiotherapy Plus Nimotuzumab Versus Radiotherapy Alone in Platinum-ineligible Patients With Locoregionally Advanced Head and Neck Squamous Cell Carcinoma
Shandong Cancer Hospital and Institute n=335
NCT06115499 ACTIVE NOT RECRUITING
The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer
Alliance for Clinical Trials in Oncology n=10
NCT07311057 ENROLLING BY INVITATION
Investigation of Effect of Formulated Methylene Blue on Treatment of Squamous Cell Carcinoma Skin Cancer in Inoperable Patients and Not Suitable for Radiotherapy
Daryoush Hamidi Alamdari, PhD n=20
NCT06790966 ACTIVE NOT RECRUITING
Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
PDS Biotechnology Corp. n=351
NCT07264075 NOT YET RECRUITING
Study Comparing Ivonescimab Alone or Ivonescimab in Combination With Ligufalimab Versus Pembrolizumab for the Treatment of SCCHN
Groupe Oncologie Radiotherapie Tete et Cou n=780
NCT05381597 RECRUITING
5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin Cancer
Boston University n=200
NCT05333523 RECRUITING
Personalized Elective Neck Irradiation Guided by Sentinel Lymph Node Biopsy in Larynx and Pharynx Cancer. The PRIMO Study.
Radboud University Medical Center n=242
NCT03969004 ACTIVE NOT RECRUITING
Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma
Regeneron Pharmaceuticals n=415
NCT05943795 ACTIVE NOT RECRUITING
A Clinical Study of SI-B001 Combined With Docetaxel in the Treatment of Non-small Cell Lung Adenocarcinoma and Lung Squamous Cell Carcinoma
Sichuan Baili Pharmaceutical Co., Ltd. n=589
NCT05893888 RECRUITING
Safety and Efficacy Study of PRV111 and PRV211 in Subjects With Oral Squamous Cell Carcinoma
Privo Technologies n=40
NCT02305654 RECRUITING
International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)
Institute of Cancer Research, United Kingdom n=200
NCT06030440 RECRUITING
De-Intensification of Postoperative Radiotherapy in Patients with Squamous Cell Carcinoma of the Head and Neck
University of Erlangen-Nürnberg Medical School n=508
NCT06692556 NOT YET RECRUITING
Study of a Strategy Integrating Adjuvant Radiation Therapy Versus Strategy Based on Monitoring in the Treatment of Carcinomas Spinocellular With High Risk of Recurrence
Centre Leon Berard n=266
NCT05798793 RECRUITING
Neoadjuvant Anti-PD-1 Immunotherapy With Chemotherapy in Resectable Locally Advanced Oral Squamous Cell Carcinoma
Hospital of Stomatology, Wuhan University n=309
NCT05125055 RECRUITING
Neoadjuvant Anti-PD-1 and TP Versus TPF on Pathological Response in OSCC
Shanghai Jiao Tong University School of Medicine n=80
NCT05050162 SUSPENDED
Comparing Cisplatin Every Three Weeks to Cisplatin Weekly When Combined With Radiation for Patients With Advanced Head and Neck Cancer
NRG Oncology n=1,714
NCT03258554 COMPLETED
Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin
National Cancer Institute (NCI) n=196
NCT04472429 COMPLETED
Carboplatin-paclitaxel With Retifanlimab or Placebo in Participants With Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (POD1UM-303/InterAACT 2).
Incyte Corporation n=308
NCT04458909 TERMINATED
Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer
National Cancer Institute (NCI) n=15
NCT06513884 WITHDRAWN
A Study of HB-202/HB-201 With Pembrolizumab in Patients With HPV16+ Recurrent/Metastatic Oropharyngeal Cancer
Hookipa Biotech GmbH
NCT03257267 COMPLETED
Study of Cemiplimab in Adults With Cervical Cancer
Regeneron Pharmaceuticals n=608
NCT03115476 TERMINATED
A Trial to Compare the Incidence of Squamous Cell Carcinoma (SCC) and Other Skin Neoplasia on Skin Areas Treated With Ingenol Disoxate Gel or Vehicle Gel for Actinic Keratosis on Face and Chest or Scalp
LEO Pharma n=563
NCT06781073 COMPLETED
Nimotuzumab in Combined With Chemotherapy for Treatment of IVB Stage,Rrecurrent or Persistent Cervical Carcinoma
Biotech Pharmaceutical Co., Ltd. n=118
NCT02923258 COMPLETED
Postoperative CCRT With Docetaxel vs Cisplatin in High Risk Oral Cavity Cancer
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University n=224
NCT02997553 COMPLETED
Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery
Institut de Cancérologie de Lorraine n=744
NCT03237325 COMPLETED
DOM-INNATE: Study of SGX942 for the Treatment of Oral Mucositis in Patients With Concomitant Chemoradiation Therapy for Head and Neck Cancer
Soligenix n=266
NCT04196075 COMPLETED
The Effect of Andrographis Paniculata (AP) on Palliative Management of Advanced Esophageal Cancer
Chinese University of Hong Kong n=30
NCT02236936 TERMINATED
Parenteral Nutrition for Patients Treated for Locally Advanced Inoperable Tumors of the Head and Neck
Arbeitsgemeinschaft medikamentoese Tumortherapie n=8
NCT04137627 COMPLETED
Melatonin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma
Indonesia University n=50
NCT02765919 COMPLETED
A Randomised Controlled Trial Between Two Different HDR Brachytherapy Schedule in Locally Advanced Carcinoma of Uterine Cervix
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh n=30
NCT03866382 RECRUITING
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
National Cancer Institute (NCI)
NCT04502407 ACTIVE NOT RECRUITING
Trial of De-Intensified Post-operative Chemoradiation Following Robotic Surgery for HPV-positive Oropharyngeal Cancer
Cedars-Sinai Medical Center
NCT04858334 RECRUITING
APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
National Cancer Institute (NCI)
NCT02834013 ACTIVE NOT RECRUITING
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors
National Cancer Institute (NCI)
NCT05108870 RECRUITING
TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers
University of Chicago
NCT05896839 RECRUITING
Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer
National Cancer Institute (NCI)
NCT04671667 RECRUITING
Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma
National Cancer Institute (NCI)
NCT05136196 RECRUITING
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
National Cancer Institute (NCI)
NCT07195734 RECRUITING
Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer
National Cancer Institute (NCI)
NCT06161532 RECRUITING
Sacituzumab Govitecan With or Without Atezolizumab Immunotherapy in Rare Genitourinary Tumors (SMART) Such as High Grade Neuroendocrine Carcinomas, Adenocarcinoma, and Squamous Cell Bladder/Urinary Tract Cancer, Renal Medullary Carcinoma and Penile C...
National Cancer Institute (NCI)
NCT02978625 ACTIVE NOT RECRUITING
Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers
National Cancer Institute (NCI)
NCT04929028 RECRUITING
Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer
National Cancer Institute (NCI)
NCT07042295 RECRUITING
Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System
National Cancer Institute (NCI)
NCT06747585 RECRUITING
A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors
Alentis Therapeutics AG
NCT04988074 RECRUITING
Trial of Cemiplimab, or Cemip-Chemo Followed by Biomarker-guided Treatment for Pts w/HPV H&N Ca
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT03493425 RECRUITING
Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery
ECOG-ACRIN Cancer Research Group
NCT02734537 RECRUITING
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
ECOG-ACRIN Cancer Research Group
NCT07281417 NOT YET RECRUITING
Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma
National Cancer Institute (NCI)
NCT04166318 ACTIVE NOT RECRUITING
Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study
ECOG-ACRIN Cancer Research Group
NCT06047379 RECRUITING
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Neonc Technologies, Inc.
NCT05681039 RECRUITING
Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).
M.D. Anderson Cancer Center
NCT07109726 RECRUITING
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
Terremoto Biosciences Inc.
NCT07435376 RECRUITING
Intra-lesional Tumor Boost for Bulky Cervical Cancer
Seoul National University Bundang Hospital
NCT07044635 RECRUITING
Shortened Course of Radiation Therapy After Trans-oral Robotic Surgery in Patients With HPV-Mediated Oropharyngeal Squamous Cell Carcinoma.
University of Utah
NCT05639972 RECRUITING
E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers
Christian Hinrichs
NCT05686226 RECRUITING
E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
Christian Hinrichs
NCT07209189 RECRUITING
Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT04349436 RECRUITING
Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies
Replimune Inc.
NCT04712851 RECRUITING
Pembrolizumab for the Treatment of Cervical Intraepithelial Neoplasia
Jonsson Comprehensive Cancer Center
NCT06959082 RECRUITING
Efficacy and Safety Evaluation of VS-101 in Combination With Chemoradiotherapy in Patients With Head and Neck Cancer
VSPharmTech Co.,Ltd.
NCT05888844 ACTIVE NOT RECRUITING
A Study to Evaluate INCB099280 in Participants With Advanced Cutaneous Squamous Cell Carcinoma
Incyte Corporation
NCT07428148 NOT YET RECRUITING
Lattice-Based Radiotherapy and Chemoimmunotherapy for Oropharyngeal Squamous Cell Carcinoma
NYU Langone Health
NCT05969860 RECRUITING
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Mayo Clinic
NCT06980038 RECRUITING
Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer
National Cancer Institute (NCI)
NCT07423078 NOT YET RECRUITING
Window of Opportunity in Preserving Laryngeal Function Trial
Matthew Spector
NCT07425054 NOT YET RECRUITING
HPV ctDNA Response-Adapted Chemoradiation +/- Retifanlimab Treatment in Advanced-Stage Anal Cancer
Jennifer Dorth
NCT07063212 RECRUITING
A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)
Memorial Sloan Kettering Cancer Center
NCT04675710 ACTIVE NOT RECRUITING
Pembrolizumab, Dabrafenib, and Trametinib Before Surgery for the Treatment of BRAF-Mutated Anaplastic Thyroid Cancer
M.D. Anderson Cancer Center
NCT04150900 ACTIVE NOT RECRUITING
1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck
University of Maryland, Baltimore
NCT07419464 NOT YET RECRUITING
5-Fluorouracil Response and Optimization STudy (The FROST Trial)
Washington University School of Medicine
NCT05268614 RECRUITING
Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma
University of Florida
NCT07418034 NOT YET RECRUITING
A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)
University of Maryland, Baltimore
NCT04171622 ACTIVE NOT RECRUITING
Lenvatinib and Pembrolizumab for the Treatment of Stage IVB Locally Advanced and Unresectable or Stage IVC Metastatic Anaplastic Thyroid Cancer
M.D. Anderson Cancer Center
NCT04030455 ACTIVE NOT RECRUITING
Cisplatin, Docetaxel, and Pembrolizumab in Treating Patients With Stage II-III Laryngeal Cancer
M.D. Anderson Cancer Center
NCT06041802 ACTIVE NOT RECRUITING
A Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) (Pembrolizumab Formulated With Berahyaluronidase Alfa (MK-5180)) in Japanese Participants With Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma (R/M cSCC) or Locally Advanced (LA) Unresectable cSCC (MK-3475A-E39)
Merck Sharp & Dohme LLC
NCT06995508 RECRUITING
Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO Trial
Roswell Park Cancer Institute
NCT06036836 ACTIVE NOT RECRUITING
Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)
Merck Sharp & Dohme LLC
NCT03085147 ACTIVE NOT RECRUITING
A Dye for the Detection of Cancer of the Tongue and Mouth
Memorial Sloan Kettering Cancer Center
NCT06636734 RECRUITING
Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial
Emory University
NCT04862650 ACTIVE NOT RECRUITING
Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
Marcelo Bonomi
NCT07062354 NOT YET RECRUITING
Combined Amivantamab, Carboplatin and Paclitaxel in Unresectable Locally Recurrent or Metastatic Head and Neck Cancer
SWOG Cancer Research Network
NCT07394244 NOT YET RECRUITING
Pucotenlimab Combined With Becotatug Vedotin in Advanced Cutaneous Squamous Cell Carcinoma
Fudan University
NCT07392580 NOT YET RECRUITING
Intralesional Chemotherapy (IC): Cisplatin + Epinephrine
University of Miami
NCT04852328 RECRUITING
Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma
Washington University School of Medicine
NCT07115043 RECRUITING
A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors
AstraZeneca
NCT05737199 ACTIVE NOT RECRUITING
Assessment of the Efficacy and Safety of Pembrolizumab for Ovarian Squamous Cell Carcinoma
Niigata University Medical & Dental Hospital
NCT03260023 ACTIVE NOT RECRUITING
Phase Ib/II of TG4001 and Avelumab in HPV16 Positive R/M Cancers
Transgene
NCT03944941 ACTIVE NOT RECRUITING
Avelumab With or Without Cetuximab in Treating Patients With Advanced Skin Squamous Cell Cancer
Alliance for Clinical Trials in Oncology
NCT05962242 RECRUITING
HPV DNA-Guided Radiotherapy De-intensification of Head and Neck Squamous Cell Carcinoma
University of Virginia
NCT07228442 NOT YET RECRUITING
L19IL2/L19TNF in Patients With Cutaneous Squamous Cell Carcinoma
Philogen S.p.A.
NCT06485778 RECRUITING
A Study of Radiation Therapy After Surgery in People With Oral Tongue Squamous Cell Carcinoma
Memorial Sloan Kettering Cancer Center
NCT06532279 RECRUITING
Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
NRG Oncology
NCT06319963 RECRUITING
A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer
Theravectys S.A.
NCT06949800 NOT YET RECRUITING
CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial
University of California, San Francisco
NCT05894083 RECRUITING
A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)
University of Michigan Rogel Cancer Center
NCT05070403 RECRUITING
Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma
H. Lee Moffitt Cancer Center and Research Institute
NCT07214987 NOT YET RECRUITING
PDT For Induction Therapy For Head And Neck Cancer
Massachusetts General Hospital
NCT02721732 ACTIVE NOT RECRUITING
Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic
M.D. Anderson Cancer Center
NCT06137274 ACTIVE NOT RECRUITING
Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC
H. Lee Moffitt Cancer Center and Research Institute
NCT04858269 RECRUITING
First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients
Wake Forest University Health Sciences
NCT07370337 RECRUITING
Induction Chemotherapy Combined With Tislelizumab for Locally Advanced Squamous Cell Carcinoma of the External Auditory Canal
Eye & ENT Hospital of Fudan University
NCT06764355 RECRUITING
Neoadjuvant Immunochemotherapy and Chemoradiotherapy Followed by Surgery for Advanced Esophageal Squamous Cell Carcinoma
National Taiwan University Hospital
NCT03323463 ACTIVE NOT RECRUITING
Major De-escalation to 30 Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma
Memorial Sloan Kettering Cancer Center
NCT07368985 NOT YET RECRUITING
Pembrolizumab and Lenvatinib in Patients With High Risk Locally Advanced Cervix Cancer
Prof. Dr. Remi A. Nout
NCT03386500 ACTIVE NOT RECRUITING
Safety Study of BMX-001 (Radio-protector) in Patients With Newly Diagnosed Anal Cancer
University of Nebraska
NCT06041503 RECRUITING
Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)
National Cancer Institute (NCI)
NCT03468218 ACTIVE NOT RECRUITING
Pembrolizumab & Cabozantinib in Patients With Head and Neck Squamous Cell Cancer
Emory University
NCT07346196 NOT YET RECRUITING
A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck
University of Chicago
NCT07346807 NOT YET RECRUITING
Lingual Nerve Disruption to Augment Neoadjuvant Chemoimmunotherapy in Locally Advanced Tongue Cancer
Shanghai Zhongshan Hospital
NCT05312710 ACTIVE NOT RECRUITING
Safety and Efficacy of APG-157 in Head and Neck Cancer
Aveta Biomics, Inc.
NCT07189871 RECRUITING
177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors
Radiopharm Theranostics, Ltd
NCT03410615 ACTIVE NOT RECRUITING
Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC
Canadian Cancer Trials Group
NCT07110038 RECRUITING
DEPECA-1 - A Phase II Study to Evaluate a First-line Systemic Therapy With Enfortumab Vedotin Plus Avelumab for Advanced and Metastatic Penile Carcinoma
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT04686682 RECRUITING
A First-in-Human, JAB-8263 in Adult Patients With Advanced Tumors
Jacobio Pharmaceuticals Co., Ltd.
NCT06831149 RECRUITING
Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction
Matthew Spector
NCT05714657 ACTIVE NOT RECRUITING
Shortened Course Adjuvant Radiotherapy Following TORS
Abramson Cancer Center at Penn Medicine
NCT07149207 NOT YET RECRUITING
Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors
Medical University of South Carolina
NCT03215719 RECRUITING
Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma
NYU Langone Health
NCT05858229 ACTIVE NOT RECRUITING
Neo-adjuvant Treatment for Squamous Cell Carcinoma Using Direct Tumor Injection With RP1.
Sherrif Ibrahim
NCT06567314 RECRUITING
Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma
M.D. Anderson Cancer Center
NCT06640283 RECRUITING
Dynamic ctDNA Assessment in Cervical and Anal Canal Tumors: Optimizing Follow-up and Clinical Outcomes
Instituto do Cancer do Estado de São Paulo
NCT07285044 RECRUITING
The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
Mayo Clinic
NCT07169734 RECRUITING
A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
Alentis Therapeutics AG
NCT06121505 RECRUITING
Phase II Trial: Low-Dose Radiation + SBRT + Sintilimab + Chemotherapy vs. Sintilimab + Chemotherapy in Locally Advanced or Metastatic Squamous Cell Lung Cancer
Sichuan University
NCT06288191 RECRUITING
Neoadjuvant Nivolumab and Relatlimab in Cutaneous Squamous Cell Carcinoma
Melanoma Institute Australia
NCT07280377 RECRUITING
A Study in Advanced or Metastatic Gastrointestinal Cancers Exploring Treatment Combinations With Pelareorep and Atezolizumab
Oncolytics Biotech
NCT06104618 RECRUITING
Enfortumab Vedotin for the Treatment of Patients With Metastatic or Unresectable Squamous Cell Carcinoma of the Penis
Mayo Clinic
NCT06353906 RECRUITING
Carboplatin/Paclitaxel + Pembrolizumab for Locoregionally Advanced Penile Cancer
The Netherlands Cancer Institute
NCT03370276 ACTIVE NOT RECRUITING
Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma
H. Lee Moffitt Cancer Center and Research Institute
NCT06448026 RECRUITING
Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity Squamous Cell Carcinoma (OCSCC).
M.D. Anderson Cancer Center
NCT03799445 ACTIVE NOT RECRUITING
Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma
M.D. Anderson Cancer Center
NCT05120271 ACTIVE NOT RECRUITING
BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors
Sotio Biotech Inc.
NCT07094685 RECRUITING
Ivonescimab Before Surgery for the Treatment of Resectable Stage II-IV Head and Neck Cancer
University of Michigan Rogel Cancer Center
NCT06364384 RECRUITING
Radical Concurrent Chemoradiotherapy With DDP/5-FU and PD-1 Antibody for Non-metastatic Rectal Squamous Cell Carcinoma
Sixth Affiliated Hospital, Sun Yat-sen University
NCT03449108 ACTIVE NOT RECRUITING
LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas
M.D. Anderson Cancer Center
NCT04315701 ACTIVE NOT RECRUITING
A PD-1 Checkpoint Inhibitor (Cemiplimab) for High-Risk Localized, Locally Recurrent, or Regionally Advanced Skin Cancer
University of Southern California
NCT07236190 NOT YET RECRUITING
Biomarker-based Trial of NPC-1 for Alzheimer's Pathology
Massachusetts General Hospital
NCT05027633 RECRUITING
Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Sinuses (I-NAPA)
M.D. Anderson Cancer Center
NCT04759911 ACTIVE NOT RECRUITING
Selpercatinib Before Surgery for the Treatment of RET-Altered Thyroid Cancer
M.D. Anderson Cancer Center
NCT06088381 RECRUITING
Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)
University of Maryland, Baltimore
NCT07223424 RECRUITING
Patient Preference for Subcutaneous vs. Intravenous Immune Therapy
Diwakar Davar
NCT05307939 RECRUITING
A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)
Memorial Sloan Kettering Cancer Center
NCT05541016 RECRUITING
De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA
Mayo Clinic
NCT05565417 ACTIVE NOT RECRUITING
Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas
Immunitas Therapeutics
NCT04580771 ACTIVE NOT RECRUITING
A Vaccine (PDS0101) and Chemoradiation for the Treatment of Stage IB3-IVA Cervical Cancer, the IMMUNOCERV Trial
M.D. Anderson Cancer Center
NCT04370587 RECRUITING
A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
ImmVira Pharma Co. Ltd
NCT05996523 ACTIVE NOT RECRUITING
Phase II Trial of Immunotherapeutic HPV Vaccine PRGN-2009 With Pembrolizumab Before Standard Treatment in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal Cancer
National Cancer Institute (NCI)
NCT07058805 NOT YET RECRUITING
Compartmentalized Postoperative Radiotherapy in Head and Neck Cancer
Olgun Elicin
NCT05582122 RECRUITING
SURVEILLE-HPV: Evaluation of HPV16 Circulating DNA as Biomarker to Detect the Recurrence, in Order to Improve Post Therapeutic Surveillance of HPV16-driven Oropharyngeal Cancers
UNICANCER
NCT07180576 NOT YET RECRUITING
The FORCE Trial Pilot: Fish Oil-enriched Nutrition for Radiotherapy in Cancer of the hEad and Neck
Anna Arthur, PhD
NCT07010692 RECRUITING
Treating Basal and Squamous Cell Carcinomas With Fractional Laser and Tirbanibulin Ointment
Bruce Robinson, MD
NCT05172258 ACTIVE NOT RECRUITING
Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck
National Cancer Institute (NCI)
NCT04369937 ACTIVE NOT RECRUITING
HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for "Intermediate Risk" HPV-16-associated Head and Neck Squamous Cell Carcinoma
Dan Zandberg
NCT03074513 ACTIVE NOT RECRUITING
Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors
M.D. Anderson Cancer Center
NCT07147426 NOT YET RECRUITING
Tislelizumab Combined With Chemotherapy for Different Cycles of Neoadjuvant Therapy for Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck (NeoTempo)
Tianjin Medical University Cancer Institute and Hospital
NCT07145931 NOT YET RECRUITING
Neoadjuvant Immunochemotherapy and Postoperative Adjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma Invading the Skull Base
Sun Yat-sen University
NCT07135804 NOT YET RECRUITING
Iparomlimab and Tuvonralimab Injection for Untreated Locally Advanced Nasopharyngeal Carcinoma
Second Affiliated Hospital of Nanchang University
NCT07137858 NOT YET RECRUITING
Adebrelimab Combined With Carboplatin and Albumin-bound Taxanol in the Treatment of Resectable Locally Advanced Oral Squamous Cell Carcinoma Cardiac, Randomized, Phase II Exploratory Study
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
NCT03621696 ACTIVE NOT RECRUITING
Surgery Followed by Risk-Directed Post-Operative Adjuvant Therapy for HPV-Related Oropharynx Squamous Cell Carcinoma: "The Minimalist Trial (MINT)"
Washington University School of Medicine
NCT06543576 RECRUITING
External Beam Radiation Therapy and Brachytherapy With Chemotherapy and Immunotherapy for the Treatment of Stage IVB Cervical Cancer
Jonsson Comprehensive Cancer Center
NCT07121595 RECRUITING
Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial
University of Michigan Rogel Cancer Center
NCT05574101 ACTIVE NOT RECRUITING
A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer
Memorial Sloan Kettering Cancer Center
NCT04430699 ACTIVE NOT RECRUITING
Cisplatin+Pembrolizumab+RT in Vulvar Cancer
Massachusetts General Hospital
NCT04900623 RECRUITING
Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study
Jonathan Schoenfeld, MD, MPH
NCT06627270 RECRUITING
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
Case Comprehensive Cancer Center
NCT04609280 ACTIVE NOT RECRUITING
Selective Avoidance of Nodal VolumEs at Minimal Risk (GCC 20110)
University of Maryland, Baltimore
NCT05756569 RECRUITING
Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology
Emory University
NCT07079410 NOT YET RECRUITING
Neoadjuvant and Adjuvant Sintilimab Plus Cetuximab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma
Shanghai Zhongshan Hospital
NCT05423197 NOT YET RECRUITING
89Zr-Panitumumab for Assessment of Suspected Metastatic Lesions on 18F-FDG-PET/CT in HNSCC
Stanford University
NCT06990737 RECRUITING
Phase 2 Pragmatic Trial of Sentinel Lymph Node Biopsy (SLNB) in Patients With Clinically Node-Negative (cN0), High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) of the Head and Neck
University of California, Davis
NCT06097468 RECRUITING
Nisin in Oral Cavity Squamous Cell Carcinoma (OCSCC)
University of California, San Francisco
NCT05286294 ACTIVE NOT RECRUITING
Microbiota Transplant to Cancer Patients Who Have Failed Immunotherapy Using Faeces From Clinical Responders
Oslo University Hospital
NCT07007364 RECRUITING
Neoadjuvant Low-Dose Radiotherapy Combined With Adebrelimab and Single-Agent Albumin-Bound Paclitaxel Chemotherapy for Early-Stage Oral Squamous Cell Carcinoma: A Prospective, Single-Arm Clinical Trial
Jun Jia
NCT05910827 RECRUITING
Study of an Anti-HER3 Antibody, HMBD-001, With Docetaxel +/- Cetuximab in Advanced Squamous Non-small Cell Lung Cancers, and HMBD-001 + Cetuximab in Advanced Squamous Cell Cancers
Hummingbird Bioscience
NCT04305795 ACTIVE NOT RECRUITING
An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors
Rakuten Medical, Inc.
NCT05419089 RECRUITING
The Sinai Robotic Surgery Trial in HPV-related Oropharyngeal Squamous Cell Carcinoma (SIRS 2.0 Trial)
Icahn School of Medicine at Mount Sinai
NCT03854032 ACTIVE NOT RECRUITING
Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck
Thomas Jefferson University
NCT06009861 ACTIVE NOT RECRUITING
Neoadjuvant Tislelizumab Plus Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer (NeoSPOT)
Peking University Hospital of Stomatology
NCT06418724 NOT YET RECRUITING
Neoadjuvant PD-1 Inhibitor and EGFR Inhibitor in Locally Advanced Cutaneous Squamous Cell Carcinoma
Melanoma and Skin Cancer Trials Limited
NCT06998342 NOT YET RECRUITING
MOHs Surgery and Short-Course Radiation Therapy With Structured Follow-Up for Head & Neck Squamous Cell Skin Cancer
University of Vermont Medical Center
NCT05387915 ACTIVE NOT RECRUITING
Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer
Emory University
NCT06277791 RECRUITING
The Combination of Adebrelimab and TP Regimen for Neoadjuvant Therapy in Patients With Stage IVB Oral Squamous Cell Carcinoma
Hospital of Stomatology, Wuhan University
NCT04808999 ACTIVE NOT RECRUITING
Neoadjuvant Study of PD-1 Inhibitor Pembrolizumab in PD-1 Naive Cutaneous Squamous Cell Carcinoma (cSCC)
Diwakar Davar
NCT06823479 RECRUITING
Towards Cure Via Only Ultra-short ICB in CSCC
The Netherlands Cancer Institute
NCT02314169 ACTIVE NOT RECRUITING
Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer
National Cancer Institute (NCI)
NCT03476330 ACTIVE NOT RECRUITING
Quercetin Chemoprevention for Squamous Cell Carcinoma in Patients With Fanconi Anemia
Children's Hospital Medical Center, Cincinnati
NCT06861712 NOT YET RECRUITING
Chemoimmunotherapy With or Without SBRT Before Surgery for Locally Advanced Oral and Oropharyngeal Cancer
Sun Yat-sen University
NCT06731933 RECRUITING
Impact of COL7A1 Gene Therapy on SCC Recurrence in RDEB Skin
Stanford University
NCT02437851 ACTIVE NOT RECRUITING
Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection
AIDS Malignancy Consortium
NCT05377905 RECRUITING
Microneedle Array Plus Doxorubicin in Cutaneous Squamous Cell Cancer (cSCC)
Falo, Louis, MD
NCT04802876 ACTIVE NOT RECRUITING
Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors
SOLTI Breast Cancer Research Group
NCT06876038 NOT YET RECRUITING
Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions
University of Massachusetts, Boston
NCT06876844 RECRUITING
Surufatinib Combined with Envolizumab As Second-line Treatment for Recurrent/Metastatic HNSCC
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
NCT04632433 ACTIVE NOT RECRUITING
Neoadjuvant Plus Adjuvant Treatment With Cemiplimab in Cutaneaous Squamous Cell Carcinoma
Fondazione Melanoma Onlus
NCT06223659 RECRUITING
EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers
Ohio State University Comprehensive Cancer Center
NCT04191460 RECRUITING
Fluorescence-guided Surgery Using cRGD-ZW800-1 in Oral Cancer
Erasmus Medical Center
NCT05752149 NOT YET RECRUITING
Fluorescence-guided Surgery in Laryngeal- and Hypopharyngeal Cancer: a Feasibility Trial
Erasmus Medical Center
NCT06323460 RECRUITING
Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer
Ohio State University Comprehensive Cancer Center
NCT04943445 ACTIVE NOT RECRUITING
Study of a Pembrolizumab-based Organ Preservation Strategy for Locally Advanced Larynx Cancers
Latin American Cooperative Oncology Group
NCT06797986 NOT YET RECRUITING
A Phase I/IIa Clinical Trial to Investigate BVAC-E6E7 in Subjects with HPV Positive HNSCC.
Cellid Co., Ltd.
NCT03708224 RECRUITING
Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck
Alain Algazi
NCT04050436 ACTIVE NOT RECRUITING
Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer
Replimune Inc.
NCT06489197 RECRUITING
AK112 Combined With Chemotherapy as the First-line Treatment in Advanced Esophageal Squamous Cell Carcinoma Patients
Tianjin Medical University Cancer Institute and Hospital
NCT05202860 ACTIVE NOT RECRUITING
Impact of Human Papillomavirus (HPV) Vaccination on Burden of Disease in Patients with Actinic Keratosis
Merete Haedersdal
NCT06759155 NOT YET RECRUITING
Phase II Clinical Trial of De-Intensified Therapy in Human Papilloma Virus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma
University of Vermont Medical Center
NCT06752798 RECRUITING
Bone Marrow Protective Effect of Trilaciclib in Postoperative CCRT for LA-HNSCC
Hunan Cancer Hospital
NCT04719988 ACTIVE NOT RECRUITING
Anti-PD-1 and mDCF Followed by Chemoradiotherapy in Patients With Stage III Squamous Cell Anal Carcinoma.
Centre Hospitalier Universitaire de Besancon
NCT06016920 RECRUITING
Safety and Efficacy of VB10.16 and Pembrolizumab in Patients with Head-Neck Squamous Cell Carcinoma
Nykode Therapeutics ASA
NCT06728618 NOT YET RECRUITING
Preoperative Tislelizumab -Cetuximab - Chemotherapy Followed by Salvage Surgery and Adjuvant Tislelizumab -Cetuximab for Resectable, Locally Recurrent Oral and Oropharyngeal Squamous Cell Carcinoma
Shanghai Zhongshan Hospital
NCT05878288 ACTIVE NOT RECRUITING
Deep sequencIng in Cutaneous Squamous CEll caRciNomas
Peter MacCallum Cancer Centre, Australia
NCT05620134 ACTIVE NOT RECRUITING
Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer
Salubris Biotherapeutics Inc
NCT06137378 RECRUITING
European Larynx Organ Preservation Study (ELOS) [MK-3475-C44]
University of Leipzig
NCT04718415 ACTIVE NOT RECRUITING
Neoadjuvant Sintilimab in Combination With Carboplatin and Nab-paclitaxel in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
NCT06578871 NOT YET RECRUITING
Surgery and Reducing Ionizing Radiation of the Unknown Primary
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
NCT06577311 RECRUITING
Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (SCCis)
The Center for Clinical and Cosmetic Research
NCT06531291 NOT YET RECRUITING
Surufatinib Combined With Serplulimab and Standard Chemotherapy as First-line Treatment in Advanced Solid Tumors With Neuroendocrine Differentiation
RenJi Hospital
NCT06505551 NOT YET RECRUITING
Phase 1/2 Study of Autologous SCG142 TCR T Cells in Patients With HPV16/52-positive Carcinoma
SCG Cell Therapy Pte. Ltd.
NCT03784066 ACTIVE NOT RECRUITING
Durvalumab With or Without Tremelimumab in Resectable Locally Advanced Squamous Cell Carcinoma of the Oral Cavity
Universitaire Ziekenhuizen KU Leuven
NCT03283605 ACTIVE NOT RECRUITING
Immunotherapy and SBRT for Metastatic Head and Neck Carcinomas
Centre hospitalier de l'Université de Montréal (CHUM)
NCT06050707 RECRUITING
MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach
University Health Network, Toronto
NCT05269381 RECRUITING
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors
Mayo Clinic
NCT04444869 RECRUITING
Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer
University of Missouri-Columbia
NCT03494322 ACTIVE NOT RECRUITING
EACH: Evaluating Avelumab in Combination With Cetuximab in Head and Neck Cancer
University College, London
NCT04204837 RECRUITING
Nivolumab for Treatment of Squamous Cell Carcinoma of the Skin
Salzburger Landeskliniken
NCT05905315 RECRUITING
Primary Chemoradiation VS. Neoadjuvant Chemotherapy Followed By Surgery As Treatment Strategy For LAVC
The Netherlands Cancer Institute
NCT05098119 RECRUITING
Neoadjuvant Sintilimab Combined With Reduction of Cycles of Chemotherapy in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma (OOC-002)
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
NCT04597476 RECRUITING
A Randomized, Double-blind Study to Evaluate the Clinical Effect and Safety of Fucoidan in Patients With Squamous Cell Carcinomas of the Head and Neck
Hi-Q Marine Biotech International, Ltd.
NCT04889742 NOT YET RECRUITING
Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
Charite University, Berlin, Germany
NCT04894370 RECRUITING
Combination of Spartalizumab, mDCF and Radiotherapy in Patients With Metastatic Squamous Cell Anal Carcinoma
Centre Hospitalier Universitaire de Besancon
NCT05069857 RECRUITING
Neoadjuvant Personalized Anti-PD-1 and Anti-VEGFR Therapy in OSCC Patients
Shanghai Jiao Tong University School of Medicine
NCT05661188 RECRUITING
Tiraglolumab Atezolizumab and Chemoradiotherapy in Localized Anal Carcinoma (TIRANUS)
Grupo Espanol Multidisciplinario del Cancer Digestivo
NCT05862168 RECRUITING
Neoadjuvant Treatment of Tislelizumab Combined Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma :A Single-arm, Prospective, Phase II Trial
Weijia Fang, MD
NCT05865132 RECRUITING
Palbociclib Combined With Afatinib for Advanced Squamous Carcinoma of Esophagus or Gastroesophageal Junction
AIPING ZHOU
NCT05803915 NOT YET RECRUITING
Neoadjuvant Toripalimab Plus Nimotuzumab in Oral Squamous Cell Carcinoma Prior to Radical Therapy
Peking Union Medical College Hospital
NCT04161664 RECRUITING
Treatment of Metastatic Vulvar Carcinoma With Carboplatin and Paclitaxel Chemotherapy
The Netherlands Cancer Institute
NCT04192253 RECRUITING
Treatment of Locally Advanced VULvar CArcinoma in a Neoadjuvant Setting With Carboplatin and Paclitaxel Chemotherapy (VULCANize)
The Netherlands Cancer Institute
NCT04018872 RECRUITING
Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer
Dallas VA Medical Center
NCT04220749 RECRUITING
Radiotherapy vs. Trans-Oral Surgery for HPV-Negative Oropharyngeal Squamous Cell Carcinoma
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
NCT05316688 TERMINATED
A Fluorescent Tumor Marking Agent, Tozuleristide, for Imaging Oral Cavity Squamous Cell Cancer and High-Grade Oral Cavity Dysplasia During Surgery
University of Washington
NCT05551117 TERMINATED
A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors
MacroGenics
NCT04913220 TERMINATED
A Study of SAR444245 Combined With Cemiplimab for the Treatment of Participants With Various Advanced Skin Cancers (Pegathor Skin 201)
Sanofi
NCT03082534 COMPLETED
Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma
University of California, San Diego
NCT03829722 COMPLETED
Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer
University of Michigan Rogel Cancer Center
NCT04799054 TERMINATED
A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors
Ascendis Pharma Oncology Division A/S
NCT02296684 COMPLETED
Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma
Washington University School of Medicine
NCT04260802 TERMINATED
A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers
Ocellaris Pharma, Inc.
NCT04031534 COMPLETED
Study of Hypoxia Measured in F-Miso PET/Scan and MRI in Patients With Squamous Cells Carcinoma
Centre Henri Becquerel
NCT04154943 COMPLETED
Study of Cemiplimab in Patients With Type of Skin Cancer Stage II to IV Cutaneous Squamous Cell Carcinoma
Regeneron Pharmaceuticals
NCT04445064 TERMINATED
Activity and Safety of Peptide-based Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck.
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
NCT04916002 TERMINATED
A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer
Regeneron Pharmaceuticals
NCT02369458 COMPLETED
Mitomycin C in Patients With Incurable p16 Positive Oropharyngeal and p16 Negative Head and Neck Squamous Cell Carcinoma (HNSCC) Resistant to Standard Therapies
Washington University School of Medicine
NCT05256381 TERMINATED
A Study of SOT101 in Combination With Pembrolizumab to Evaluate the Efficacy and Safety in Patients With Selected Advanced Solid Tumors
SOTIO Biotech AG
NCT03021993 COMPLETED
Trial of Nivolumab as a Novel Neoadjuvant Pre-Surgical Therapy for Locally Advanced Oral Cavity Cancer
Medical University of South Carolina
NCT04260126 COMPLETED
Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC
PDS Biotechnology Corp.
NCT04180215 COMPLETED
A Phase 1/2 Study in Patients With HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Other Cancers
Hookipa Biotech GmbH
NCT03597295 COMPLETED
A Study of INCMGA00012 in Squamous Carcinoma of the Anal Canal Following Platinum-Based Chemotherapy (POD1UM-202)
Incyte Corporation
NCT06762808 WITHDRAWN
Phase II Study of Atezolizumab and Tiragolumab With ctDNA for HPV-positive SCC
M.D. Anderson Cancer Center
NCT04620200 COMPLETED
Neo-adjuvant Nivolumab or Nivolumab With Ipilimumab in Advanced Cutaneous Squamous Cell Carcinoma Prior to Surgery
The Netherlands Cancer Institute
NCT03623646 COMPLETED
Cisplatin or ImmunoTHerapy in Association With Definitive Radiotherapy in HPV-related oropharyngEal Squamous Cell Carcinoma: a Randomized Phase II Trial.
Institut Claudius Regaud
NCT07038915 WITHDRAWN
STRIVE: A Single-arm Phase 2 Study on Treatment of Lung Squamous Cell Carcinoma by Tiragolumab Plus Ivonescimab for Patients Who Progressed on Platinum Doublets and Anti-PD-1/PD-L1
M.D. Anderson Cancer Center
NCT03795610 COMPLETED
IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma
Assuntina G. Sacco, MD
NCT05714553 TERMINATED
NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours
NuCana plc
NCT03737721 TERMINATED
The UNSCARRed Study: UNresctable Squamous Cell Carcinoma Treated With Avelumab and Radical Radiotherapy
AHS Cancer Control Alberta
NCT03357757 COMPLETED
Avelumab With Valproic Acid in Virus-associated Cancer
AHS Cancer Control Alberta
NCT07015489 COMPLETED
Concurrent Radiotherapy Following Induction Chemoimmunotherapy for Locally Advanced Esophageal Cancer
The First Affiliated Hospital with Nanjing Medical University
NCT04068896 COMPLETED
Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy
NGM Biopharmaceuticals, Inc
NCT03108131 COMPLETED
Cobimetinib and Atezolizumab in Treating Participants With Advanced or Refractory Rare Tumors
M.D. Anderson Cancer Center
NCT02760498 COMPLETED
Study of REGN2810 in Patients With Advanced Cutaneous Squamous Cell Carcinoma
Regeneron Pharmaceuticals
NCT04442126 TERMINATED
A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors
Numab Therapeutics AG
NCT03944915 COMPLETED
De-Escalation Therapy for Human Papillomavirus Negative Disease
University of Chicago
NCT04642287 WITHDRAWN
Immunotherapy After Transplantation for Skin Cancer Prevention in Organ Transplant Recipients
Massachusetts General Hospital
NCT04329221 WITHDRAWN
Immunotherapy Before Transplantation for Skin Cancer Prevention in Organ Transplant Recipients
Massachusetts General Hospital
NCT03107182 COMPLETED
Chemotherapy and Locoregional Therapy Trial (Surgery or Radiation) for Patients With Head and Neck Cancer
University of Chicago
NCT06644079 WITHDRAWN
Window of Opportunity Study of Topical Tranexamic Acid for Cutaneous Squamous Cell Carcinoma
University of Florida
NCT04595981 WITHDRAWN
Chemo-embolization for Head and Neck Cancer
University of Alabama at Birmingham
NCT03342911 COMPLETED
Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT03267680 TERMINATED
IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3
University of Southern California
NCT05608369 WITHDRAWN
Vorinostat in Combination With Chemoradiation in Locally Advanced HPV Negative HNSCC
Case Comprehensive Cancer Center
NCT03058289 COMPLETED
A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6
Intensity Therapeutics, Inc.
NCT03721757 COMPLETED
CA209-891: Neoadjuvant and Adjuvant Nivolumab as Immune Checkpoint Inhibition in Oral Cavity Cancer
The Clatterbridge Cancer Centre NHS Foundation Trust
NCT03190174 COMPLETED
Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers
Sarcoma Oncology Research Center, LLC
NCT06159842 COMPLETED
Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (isSCC)
The Center for Clinical and Cosmetic Research
NCT04812535 TERMINATED
Non-comparative Study of IFX-1 Alone or IFX-1+Pembrolizumab in Patients With Locally Advanced or Metastatic cSCC.
InflaRx GmbH
NCT04710498 COMPLETED
Neoadjuvant Atezolizumab in Surgically Resectable Advanced Cutaneous Squamous Cell Carcinoma
Stanford University
NCT03715946 COMPLETED
Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer
Robert L. Ferris, MD, PhD
NCT04649476 COMPLETED
Neoadjuvant PD-1 Blockade in Resectable Oral Squamous Cell Carcinoma
Hospital of Stomatology, Wuhan University
NCT03719924 COMPLETED
Nal-iri/lv5-fu Versus Paclitaxel as Second Line Therapy in Patients With Metastatic Oesophageal Squamous Cell Carcinoma
Federation Francophone de Cancerologie Digestive
NCT05007613 COMPLETED
Second-line Cabozantinib and Atezolizumab in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma
National Taiwan University Hospital
NCT04807777 TERMINATED
Study of Ruxolitinib in Solid Organ Transplant Recipients With Advanced Cutaneous Squamous Cell Carcinoma
Columbia University
NCT04939701 TERMINATED
Study of ASP0739 Alone and With Pembrolizumab in Advanced Solid Tumors With NY-ESO-1 Expression Participants
Astellas Pharma Global Development, Inc.
NCT05060471 COMPLETED
PD-1 Blockade Combined with Chemotherapy Followed by Concurrent Immunoradiotherapy for Locally Advanced SCCA Patients
Sun Yat-sen University
NCT02538510 COMPLETED
Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery
University of Washington
NCT03714828 COMPLETED
Study of TVEC in Patients With Cutaneous Squamous Cell Cancer
University of Arizona
NCT03422536 COMPLETED
Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma
University of Arizona
NCT03284424 COMPLETED
Study of Pembrolizumab (MK-3475) in Adults With Recurrent/Metastatic Cutaneous Squamous Cell Carcinoma (cSCC) or Locally Advanced Unresectable cSCC (MK-3475-629/KEYNOTE-629)
Merck Sharp & Dohme LLC
NCT03387111 TERMINATED
QUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Subjects With SCC Who Have Progressed
ImmunityBio, Inc.
NCT03423264 WITHDRAWN
PROGRESS Trial - Prophylactic Gabapentin for Relief of Symptoms and Improved Swallowing
University of Chicago
NCT06384820 WITHDRAWN
Study of Cemiplimab Alone or in Combination With Fianlimab and/or Other Experimental Agents in Adult Participants With Peri-operative Stage III/IV Cutaneous Squamous Cell Carcinoma (CSCC)
Regeneron Pharmaceuticals
NCT06084845 WITHDRAWN
Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer
ECOG-ACRIN Cancer Research Group
NCT02383927 COMPLETED
Phase II Study of Tipifarnib in Squamous Head and Neck Cancer With HRAS Mutations
Kura Oncology, Inc.
NCT04541355 COMPLETED
Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin
Hyunseok Kang, MD
NCT02964559 COMPLETED
Pembrolizumab in Patients With Locally Advanced or Metastatic Skin Cancer
Emory University
NCT04107103 COMPLETED
Nivolumab Plus Pemetrexed for Head and Neck Squamous Cell Carcinoma
AHS Cancer Control Alberta
NCT03847519 COMPLETED
Study of ADXS-503 With or Without Pembro in Subjects With Metastatic Non-Small Cell Lung Cancer
Advaxis, Inc.
NCT03601507 TERMINATED
Alpelisib in Treating Participants With Transorally Resectable HPV-Associated Stage I-IVA Oropharyngeal Cancer
University of Arizona
NCT04844983 COMPLETED
A Study to Evaluate Safety, Efficacy of Intralesional Injection of STP705 in Patients With isSCC
Sirnaomics
NCT05421013 COMPLETED
Study to Evaluate Safety, Efficacy of Intralesional Injection of STP705 in Adults With Facial isSCC
Sirnaomics
NCT03339843 COMPLETED
Multiorgan Metabolic Imaging Response Assessment of Abemaciclib
Jules Bordet Institute
NCT02830594 COMPLETED
Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer
City of Hope Medical Center
NCT02609386 COMPLETED
IRX-2 Regimen in Patients With Newly Diagnosed Stage II, III, or IVA Squamous Cell Carcinoma of the Oral Cavity
Brooklyn ImmunoTherapeutics, LLC
NCT03618134 TERMINATED
Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner
Jonsson Comprehensive Cancer Center
NCT02831933 TERMINATED
Trial of Radiation and Gene Therapy Before Nivolumab for Metastatic Non-Small Cell Lung Carcinoma and Uveal Melanoma
Eric Bernicker, MD
NCT05535023 WITHDRAWN
Phase 2 Study of Neoadjuvant SAR444245 Plus Cemiplimab in HPV Related Oropharynx Squamous Cell Carcinoma
M.D. Anderson Cancer Center
NCT03912818 TERMINATED
Durvalumab and Standard Chemotherapy Before Surgery in Treating Patients With Variant Histology Bladder Cancer
Stanford University
NCT03690921 COMPLETED
Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial
M.D. Anderson Cancer Center
NCT05582031 WITHDRAWN
Regorafenib With Tislelizumab in Patients With Selected Mismatch Repair-Proficient/Microsatellite Stable Cancers
Translational Research in Oncology
NCT03802058 TERMINATED
Concurrent Nab-P/Carboplatin and Thoracic Radiotherapy in Squamous Cell Lung Cancer
Wuhan University
NCT04611321 TERMINATED
Study of IBI318 in Patients With Advanced Cutaneous Squamous Cell Carcinoma
Innovent Biologics (Suzhou) Co. Ltd.
NCT02917629 TERMINATED
ACTOplus Met XR in Treating Patients With Stage I-IV Oral Cavity or Oropharynx Cancer Undergoing Definitive Treatment
National Cancer Institute (NCI)
NCT02921269 COMPLETED
Atezolizumab and Bevacizumab in Treating Patients With Recurrent, Persistent, or Metastatic Cervical Cancer
National Cancer Institute (NCI)
NCT03762564 COMPLETED
Study With Paclitaxel +/- Ramucirumab in Patients With Squamous-cell Carcinoma of the Esophagus After Prior Therapy
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
NCT04242173 TERMINATED
Cemiplimab-rwlc for Unresectable Locally Recurrent and/or Metastatic CSCC
H. Lee Moffitt Cancer Center and Research Institute
NCT03502148 COMPLETED
Safety and Efficacy Study of PRV111 in Subjects With Oral Squamous Cell Carcinoma
Privo Technologies
NCT04985825 WITHDRAWN
Imgatuzumab in Patients With Advanced Cutaneous Squamous Cell Carcinoma
Pega-One S.A.S.
NCT04831450 WITHDRAWN
Phase 2 Trial of Maintenance Cemiplimab for Head and Neck Squamous Cell Carcinoma (HNSCC)
University of Miami
NCT04001413 WITHDRAWN
Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT03834571 WITHDRAWN
Testing the Addition of Paclitaxel and Carboplatin Given After Standard Chemotherapy and Radiation for Cervical Cancer in HIV-positive Women
AIDS Malignancy Consortium
NCT02837042 TERMINATED
Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma
University of Alabama at Birmingham
NCT04293679 COMPLETED
Open Label, Dose Escalation Study for the Safety and Efficacy of STP705 in Adult Patients With isSCC
Sirnaomics
NCT03090412 TERMINATED
Photodynamic Therapy With HPPH Compared to Standard of Care Surgery in Treating Patients With Oral Cavity Cancer
Roswell Park Cancer Institute
NCT03684785 TERMINATED
Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors
Exicure, Inc.
NCT02417701 COMPLETED
Sapanisertib in Treating Patients With Stage IV or Recurrent Lung Cancer
National Cancer Institute (NCI)
NCT02873819 COMPLETED
Safety and Efficacy Study of GL-0817 (With Cyclophosphamide) for the Prevention of Recurrence of Squamous Cell Carcinoma of the Oral Cavity
Gliknik Inc.
NCT03430895 COMPLETED
Evaluating Immune Therapy, Durvalumab (MEDI4736) With Tremelimumab for Metastatic, Non-transitional Cell Carcinoma of the Urinary Tract
Memorial Sloan Kettering Cancer Center
NCT04499352 WITHDRAWN
A Study to Test BI 754091 Alone or in Combination With BI 836880 in People Who Have Advanced Anal Cancer
Boehringer Ingelheim
NCT03875859 TERMINATED
Topical Remetinostat Gel as Neoadjuvant Therapy in Patients With Squamous Cell Carcinoma (SCC)
Kavita Sarin
NCT02394652 COMPLETED
The Potential for Metformin to Improve Tumor Oxygenation in Locally Advanced Cervix Cancer: A Phase II Randomized Trial
University Health Network, Toronto
NCT04267913 WITHDRAWN
Testing of TAK228 (MLN0128, Sapanisertib) Plus Docetaxel to the Usual Standard of Care for Advanced Squamous Cell Lung Cancer (A Lung-MAP Treatment Trial)
SWOG Cancer Research Network
NCT02319044 COMPLETED
Phase II Study of MEDI4736, Tremelimumab, and MEDI4736 in Combination w/ Tremelimumab Squamous Cell Carcinoma of the Head and Neck
AstraZeneca
NCT02776137 COMPLETED
Postoperative Concurrent Chemoradiotherapy With Docetaxel for High-Risk Squamous Cell Carcinoma of Head and Neck
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
NCT02541903 TERMINATED
Trial Using Gilotrif for Advanced Penile Squamous Cell Carcinoma
University of Alabama at Birmingham
NCT02624999 WITHDRAWN
Study Comparing AlloVax™ to Chemotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head & Neck
Mirror Biologics, Inc.
NCT02713828 TERMINATED
Study of Glembatumumab Vedotin in gpNMB-Expressing, Advanced or Metastatic SCC of the Lung
PrECOG, LLC.
NCT02706691 TERMINATED
BGJ398 in Treating Patients With FGFR Positive Recurrent Head and Neck Cancer
University of Chicago
NCT02868892 TERMINATED
A Study of Pemetrexed in Recurrent Cervical Adenocarcinomas
Western Regional Medical Center
NCT03223662 TERMINATED
Metabolomic and BH3 Profiling of Esophageal Cancers: Identification of Novel Assessment Methods of Treatment Response for Precision Therapy
National Cancer Institute (NCI)
NCT02644122 TERMINATED
SF1126 in Recurrent or Progressive SCCHN and Mutations in PIK3CA Gene and/or PI-3 Kinase Pathway Genes
Ezra Cohen
NCT03307941 WITHDRAWN
Assessment of Metabolic & Path Response w/ RCT & ImT Before Surgery in Locally Advanced Esoph and Gastro-esoph Jction CA
Jules Bordet Institute
NCT02298595 WITHDRAWN
Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma
Julie E. Bauman, MD, MPH
NCT02279576 TERMINATED
Study With Pazopanib and Weekly Paclitaxel in Penile Carcinoma (PAZOPEN-SOGUG)
Spanish Oncology Genito-Urinary Group
NCT02562729 COMPLETED
Complete Nerve-Sparing Radical Hysterectomy for Cervical Cancer
Shanghai Gynecologic Oncology Group
NCT02014831 WITHDRAWN
Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma (PENILANE)
Centre Leon Berard
NCT04533750 ACTIVE NOT RECRUITING
Testing the Addition of M3814 (Peposertib) to Radiation Therapy for Patients With Advanced Head and Neck Cancer Who Cannot Take Cisplatin
National Cancer Institute (NCI)
NCT05172245 RECRUITING
Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer
National Cancer Institute (NCI)
NCT07156227 NOT YET RECRUITING
Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma
National Cancer Institute (NCI)
NCT06868433 RECRUITING
TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer
Emory University
NCT07217028 NOT YET RECRUITING
Study Evaluating [18F]NOTA-ABY030 for Safety and Tolerability of Indeterminate Primary and/or Metastatic Disease in Head and Neck Squamous Cell Carcinoma
Vanderbilt-Ingram Cancer Center
NCT07085091 RECRUITING
A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
ALX Oncology Inc.
NCT07182149 RECRUITING
A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors
Normunity AccelCo, Inc.
NCT06014086 ACTIVE NOT RECRUITING
Intratumoral PH-762 for Cutaneous Carcinoma
Phio Pharmaceuticals Inc.
NCT07390838 RECRUITING
A Study of SH009 Injection in Patients With Advanced Solid Tumors.
Nanjing Sanhome Pharmaceutical, Co., Ltd.
NCT04754321 RECRUITING
Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer
Ohio State University Comprehensive Cancer Center
NCT04391049 ACTIVE NOT RECRUITING
Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery
NRG Oncology
NCT07217171 RECRUITING
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas
EvolveImmune United, Inc
NCT07335380 NOT YET RECRUITING
Lattice-Based Radiotherapy and Chemo-Immunotherapy for Oral Cavity Squamous Cell Carcinoma
NYU Langone Health
NCT05085496 RECRUITING
Radiotherapy in Combination With Atezolizumab in Locally Advanced Borderline Resectable or Unresectable Cutaneous SCC
City of Hope Medical Center
NCT06997094 RECRUITING
Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer
Mayo Clinic
NCT05827614 ACTIVE NOT RECRUITING
Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications
Boundless Bio, Inc.
NCT06736379 RECRUITING
Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
VLP Therapeutics
NCT07284186 RECRUITING
First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors
Plexium, Inc.
NCT06236425 ACTIVE NOT RECRUITING
TBio-4101 and Pembro wi/ or w/o Chemo in Recurrent/Metastatic HNSCC
H. Lee Moffitt Cancer Center and Research Institute
NCT04616248 ACTIVE NOT RECRUITING
In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors
University of Southern California
NCT06999187 RECRUITING
A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas
Dren Bio
NCT07275073 RECRUITING
JMT106 Injection in the Treatment of Advanced Solid Tumors
Shanghai JMT-Bio Inc.
NCT04975152 ACTIVE NOT RECRUITING
Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell Carcinoma
H. Lee Moffitt Cancer Center and Research Institute
NCT02567422 ACTIVE NOT RECRUITING
Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer
National Cancer Institute (NCI)
NCT05859074 RECRUITING
A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer
Memorial Sloan Kettering Cancer Center
NCT06912087 RECRUITING
Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC
University of Chicago
NCT03983954 ACTIVE NOT RECRUITING
Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumor, Including a Cohort Expansion in Esophageal Cancer.
NeoTX Therapeutics Ltd.
NCT05973487 ACTIVE NOT RECRUITING
A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors
TScan Therapeutics, Inc.
NCT02595879 ACTIVE NOT RECRUITING
Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer
National Cancer Institute (NCI)
NCT03803774 ACTIVE NOT RECRUITING
Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma
National Cancer Institute (NCI)
NCT03114462 RECRUITING
Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal Cancer
M.D. Anderson Cancer Center
NCT03816332 ACTIVE NOT RECRUITING
Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers
National Cancer Institute (NCI)
NCT02496208 ACTIVE NOT RECRUITING
Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors
National Cancer Institute (NCI)
NCT05076760 RECRUITING
MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors
Memgen, Inc.
NCT04429542 RECRUITING
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
Bicara Therapeutics
NCT04428671 RECRUITING
Cemiplimab Before and After Surgery for the Treatment of High Risk Cutaneous Squamous Cell Cancer
Emory University
NCT07100925 NOT YET RECRUITING
A Study of Tolododekin Alfa (ANK-101) in Renal Allograft Recipients With High Risk Cutaneous Squamous Cell Carcinoma
Ankyra Therapeutics, Inc
NCT05540899 ACTIVE NOT RECRUITING
Testing the Safety of Giving a Standard Dose of Radiation Over a Shorter Period of Time for Patients Who Had Surgery for Intermediate-Risk Head and Neck Cancer
American College of Radiology
NCT06171750 RECRUITING
Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors
Ankyra Therapeutics, Inc
NCT06005324 RECRUITING
Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer
University of Chicago
NCT06747390 RECRUITING
Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery
Ryan Carey
NCT03212404 ACTIVE NOT RECRUITING
Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers
Checkpoint Therapeutics, Inc.
NCT04576091 ACTIVE NOT RECRUITING
Testing the Addition of an Anti-cancer Drug, BAY 1895344, With Radiation Therapy to the Usual Pembrolizumab Treatment for Recurrent Head and Neck Cancer
National Cancer Institute (NCI)
NCT06610071 NOT YET RECRUITING
NIFR Image-guided Surgery for Malignant Soft Tissue Tumor With Low-dose SWIG Technique
The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
NCT06589609 RECRUITING
Phase 1 Clinical Trial of FluBHPVE6E7 Immunotherapy for HPV16-Associated Oropharyngeal Cancer
BlueSky Immunotherapies GmbH
NCT05582590 NOT YET RECRUITING
Autologous T Cells Targeting HPV16 HPV18 & Survivin in Patients With R/R HPV-related Oropharyngeal Cancers
NexImmune Inc.
NCT06560645 TERMINATED
A Study of PRT7732, an Oral SMARCA2 Degrader, in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation
Prelude Therapeutics
NCT04163952 TERMINATED
Talimogene Laherparepvec and Panitumumab for the Treatment of Locally Advanced or Metastatic Squamous Cell Carcinoma of the Skin
Rutgers, The State University of New Jersey
NCT03978689 COMPLETED
A Phase 1 Study in Patients With HPV16+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma
Cue Biopharma
NCT03889912 COMPLETED
Intralesional Cemiplimab for Adult Patients With Cutaneous Squamous Cell Carcinoma or Basal Cell Carcinoma
Regeneron Pharmaceuticals
NCT02819752 TERMINATED
PEmbrolizumab Combined With Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck
Royal Marsden NHS Foundation Trust
NCT03381183 COMPLETED
IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma
H. Lee Moffitt Cancer Center and Research Institute
NCT03738228 COMPLETED
Atezolizumab Before and/or With Chemoradiotherapy in Immune System Activation in Patients With Node Positive Stage IB2, II, IIIB, or IVA Cervical Cancer
National Cancer Institute (NCI)
NCT04272034 TERMINATED
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors
Incyte Corporation
NCT04000529 TERMINATED
Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies
Novartis Pharmaceuticals
NCT03114319 TERMINATED
Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors
Novartis Pharmaceuticals
NCT04242199 COMPLETED
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors
Incyte Corporation
NCT04152018 TERMINATED
Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors.
Pfizer
NCT03524326 COMPLETED
Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma
Memorial Sloan Kettering Cancer Center
NCT04301011 TERMINATED
Study of TBio-6517 Given Alone or in Combination With Pembrolizumab in Solid Tumors
Turnstone Biologics, Corp.
NCT03894618 COMPLETED
SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas
Shattuck Labs, Inc.
NCT04502888 TERMINATED
Ph1 Study of SL-172154 Administered Intratumorally in Subjects With Squamous Cell Carcinoma of the Head and Neck or Skin
Shattuck Labs, Inc.
NCT04588038 TERMINATED
NT-I7 for the Treatment of Recurrent Squamous Cell Carcinoma of Head and Neck Undergoing Surgery
Hyunseok Kang, MD
NCT02381535 COMPLETED
Onalespib in Treating Patients With Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Radiation Therapy and Cisplatin
National Cancer Institute (NCI)
NCT04234113 TERMINATED
Study of Nanrilkefusp Alfa Alone and With Pembrolizumab in Adult Patients With Advanced/Metastatic Solid Tumors
SOTIO Biotech AG
NCT04870840 COMPLETED
Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer
M.D. Anderson Cancer Center
NCT04713891 COMPLETED
A Study of KF-0210 in Advanced Solid Tumors Patients
Keythera Pharmaceuticals (Australia) Pty Ltd
NCT04160065 COMPLETED
Immunotherapy With IFx-Hu2.0 Vaccine for Advanced Non-melanoma Skin Cancers
TuHURA Biosciences, Inc.
NCT03028766 COMPLETED
WEE1 Inhibitor with Cisplatin and Radiotherapy: a Trial in Head and Neck Cancer
University of Birmingham
NCT04925713 COMPLETED
IFx-Hu2.0 for the Treatment of Patients With Skin Cancer
TuHURA Biosciences, Inc.
NCT03641547 COMPLETED
M6620 Plus Standard Treatment in Oesophageal and Other Cancer
University of Oxford
NCT06357858 WITHDRAWN
ASTX727 and Nivolumab in Squamous Cell Carcinoma of the Head and Neck
Case Comprehensive Cancer Center
NCT03292822 COMPLETED
Effects of (Licochalcone A) and Paclitaxel on Human Oral Squamous Cell Carcinoma Cell Line
Cairo University
NCT03621982 TERMINATED
Study of ADCT-301 in Patients With Selected Advanced Solid Tumors
ADC Therapeutics S.A.
NCT02164461 COMPLETED
Axalimogene Filolisbac (ADXS11-001) High Dose in Women With Human Papillomavirus (HPV) + Cervical Cancer
Advaxis, Inc.
NCT05061537 TERMINATED
Study of PF-07263689 in Participants With Selected Advanced Solid Tumors
Pfizer
NCT04892875 WITHDRAWN
A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor / Adenosine 2b Receptor Inhibitor AB928 Therapies in Locally Advanced Head and Neck Cancers
Jennifer Choe
NCT03452332 COMPLETED
Stereotactic Body Radiation Therapy, Tremelimumab and Durvalumab in Treating Participants With Recurrent or Metastatic Cervical, Vaginal, or Vulvar Cancers
M.D. Anderson Cancer Center
NCT03215810 COMPLETED
Nivolumab and Tumor Infiltrating Lymphocytes (TIL) in Advanced Non-Small Cell Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute
NCT04572100 COMPLETED
Pilot Study of Chemotherapy for HPV-Associated Oropharyngeal Cancer
University of Chicago
NCT03841110 COMPLETED
FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors
Fate Therapeutics
NCT05220748 WITHDRAWN
RM-1995 Photoimmunotherapy, as Monotherapy or Combined With Pembrolizumab, in Patients With Advanced CuSCC and HNSCC
Rakuten Medical, Inc.
NCT03758781 COMPLETED
IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors
H. Lee Moffitt Cancer Center and Research Institute
NCT04413214 COMPLETED
Carrimycin in Patients With Locally Advanced, Recurrent, or Metastatic HNSCC (Non NPC): A Phase I Trial
Shanghai Jiao Tong University School of Medicine
NCT02890368 TERMINATED
Trial of Intratumoral Injections of TTI-621 in Subjects With Relapsed and Refractory Solid Tumors and Mycosis Fungoides
Pfizer
NCT05472220 WITHDRAWN
Alpelisib in Combination With Carboplatin in Patients With Solid Tumors and HPV-Positive Squamous Cell Carcinoma
Pamela Munster
NCT03517488 COMPLETED
A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors
Xencor, Inc.
NCT04596033 TERMINATED
TiTAN-1: Safety, Proliferation and Persistence of GEN-011 Autologous Cell Therapy
Genocea Biosciences, Inc.
NCT02775812 COMPLETED
Cisplatin, Intensity-Modulated Radiation Therapy, and Pembrolizumab in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma
National Cancer Institute (NCI)
NCT04611139 WITHDRAWN
Pilot Trial of SP-2577 Plus Pembrolizumab in Select Gynecologic Cancers
HonorHealth Research Institute
NCT02573259 COMPLETED
A Dose Escalation Study Of PF-06801591 In Melanoma, Head And Neck Cancer (SCCHN), Ovarian, Sarcoma, Non-Small Cell Lung Cancer, Urothelial Carcinoma or Other Solid Tumors
Pfizer
NCT03144778 COMPLETED
Durvalumab With or Without Tremelimumab in Treating Participants With Stage II-IVA Oropharyngeal Squamous Cell Cancer
M.D. Anderson Cancer Center
NCT03333694 TERMINATED
Safety, Tolerability, and Efficacy Study of CLL442 in Patients With Cutaneous Squamous Cell Carcinoma in Situ (SCCis)
Novartis Pharmaceuticals
NCT02464137 TERMINATED
HYpofractionateD RadioAblative (HYDRA) Treatment of Advanced Laryngeal Cancer
University of Texas Southwestern Medical Center
NCT03198130 COMPLETED
An Exploratory Tumor Biopsy-driven Study to Understand the Relationship Between Biomarkers and Clinical Response in Patients With Head and Neck Cancer Receiving REGN2810 (Anti-PD-1)
Regeneron Pharmaceuticals
NCT03575234 WITHDRAWN
Nivolumab & IRX-2 With Surgery for Resectable Stage III-IVA Oral Cavity Cancer or HPV-Positive Oropharyngeal Cancer
Emory University
NCT03652233 WITHDRAWN
Afatinib and Nivolumab as Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
Vanderbilt-Ingram Cancer Center
NCT02277197 COMPLETED
Ficlatuzumab and Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)
James J Lee
NCT02993991 WITHDRAWN
Pre-operative Mocetinostat (MGCD0103) and Durvalumab (MEDI4736) (PRIMED) for Squamous Cell Carcinoma of the Oral Cavity
University Health Network, Toronto
NCT07426484 NOT YET RECRUITING
Cosibelimab for CSCC in Patients With Kidney Transplant or Hematologic Malignancy
Dana-Farber Cancer Institute
NCT03388931 WITHDRAWN
Radiotherapy Dose Escalation in Locally Advanced Squamous Cell Carcinoma of the Larynx or Hypopharynx
University of Florida
Data: ClinicalTrials.gov