Landscape → Metabolic

Type 1 Diabetes

463 clinical trials

124 active

463 total (since 2015)

Phase 1 Active

159 total

Phase 2 Active

203 total

Phase 3 Active

95 total

Phase 4 Active

64 total

Top Sponsors (Industry)

Sorted by active Active Done Failed

Eli Lilly 6 24 2

Sanofi 5 11 2

Novo Nordisk 4 27 0

Vertex Pharmaceuticals Incorporated 3 0 0

Diamyd Medical AB 2 1 0

Mannkind Corporation 1 7 0

Gan and Lee Pharmaceuticals, USA 1 4 1

Tolerion, Inc. 1 0 2

vTv Therapeutics 1 1 0

Zucara Therapeutics Inc. 1 0 1

CRISPR Therapeutics AG 1 1 0

Otsuka Pharmaceutical Factory, Inc. 1 0 0

Sernova Biotherapeutics Inc. 1 0 0

Creative Medical Technology Holdings Inc 1 0 0

SAb Biotherapeutics, Inc. 1 0 0

NCT05819138 RECRUITING

Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes

University of Colorado, Denver n=60

NCT07222137 RECRUITING

A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults

Eli Lilly and Company n=150

NCT05018585 ACTIVE NOT RECRUITING

A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes

Diamyd Medical AB n=330

NCT06962280 ACTIVE NOT RECRUITING

A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight

Eli Lilly and Company n=465

NCT07222332 NOT YET RECRUITING

A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)

Eli Lilly and Company n=300

NCT06914895 ACTIVE NOT RECRUITING

A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight

Eli Lilly and Company n=905

NCT07088068 RECRUITING

A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes

Sanofi n=723

NCT06334133 RECRUITING

Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes

vTv Therapeutics n=150

NCT06630585 RECRUITING

GIP/GLP-1RA as Adjunctive to Automated Insulin Delivery in Adults With Type 1 Diabetes

University of Bern n=42

NCT01320345 ACTIVE NOT RECRUITING

The Fenofibrate And Microvascular Events in Type 1 Diabetes Eye.

University of Sydney n=412

NCT07076199 RECRUITING

A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes

Novo Nordisk A/S n=877

NCT07284511 NOT YET RECRUITING

A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar

Melissa-Rosina Pasqua n=105

NCT07258394 NOT YET RECRUITING

Clinical Study for Dimethyl Fumarate in Preserving Islet β-Cell Function in Type 1 Diabetes Mellitus

Nanjing Medical University n=90

NCT04583462 ACTIVE NOT RECRUITING

Impact of Metformin on Peripheral Arterial Calcification in Type 1 Diabetes

Assistance Publique - Hôpitaux de Paris n=230

NCT07211802 NOT YET RECRUITING

CKM For Safe Use of SGLT2i in Type 1 Diabetes

University of California, San Diego n=52

NCT06832410 RECRUITING

An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant

Vertex Pharmaceuticals Incorporated n=10

NCT06909006 NOT YET RECRUITING

Semaglutide Treatment in Type 1 Diabetes

Nordsjaellands Hospital n=122

NCT04786262 RECRUITING

A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes

Vertex Pharmaceuticals Incorporated n=52

NCT06951074 RECRUITING

Insulin Producing Stem Cell Transplantation Clinical Trial in Type 1 Diabetes

Ain Shams University n=20

NCT03899402 ACTIVE NOT RECRUITING

Triple Therapy in T1DM

State University of New York at Buffalo n=78

NCT03941132 ACTIVE NOT RECRUITING

Clinical Phase II/III Trial of Ustekinumab to Treat Type 1 Diabetes (UST1D2)

University of British Columbia n=66

NCT06082063 RECRUITING

Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes

Steno Diabetes Center Copenhagen n=2,000

NCT06387199 RECRUITING

Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide

McGill University Health Centre/Research Institute of the McGill University Health Centre n=26

NCT04011020 RECRUITING

Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes

Throne Biotechnologies Inc. n=50

NCT06046417 RECRUITING

A Fully Automated Lyumjev and Pramlintide Delivery System for Adults With Type 1 Diabetes

McGill University Health Centre/Research Institute of the McGill University Health Centre n=30

NCT05219409 NOT YET RECRUITING

Effects of Sitagliptin in Relatives of T1D Patients

University of Milan n=70

NCT07282054 COMPLETED

Efficacy and Safety of THDB0206 Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes

Tonghua Dongbao Pharmaceutical Co.,Ltd n=550

NCT04588259 COMPLETED

Research Study to Compare a New Medicine "Fast-acting Insulin Aspart" to Another Medicine "Insulin Aspart" in Chinese People With Diabetes

Novo Nordisk A/S n=331

NCT04848480 COMPLETED

A Research Study to Compare a New Weekly Insulin, Insulin Icodec, and an Available Daily Insulin, Insulin Degludec, Both in Combination With Mealtime Insulin in People With Type 1 Diabetes (ONWARDS 6)

Novo Nordisk A/S n=582

NCT06418880 COMPLETED

Automated Insulin Delivery for Inpatients With Dysglycemia

Emory University n=130

NCT05901831 COMPLETED

A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 Diabetes

Bayer n=241

NCT04429503 COMPLETED

Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease

Regeneron Pharmaceuticals n=660

NCT07070752 COMPLETED

Evaluation of Insulin Glulisine (GP40321) Compared to Insulin Glulisine (Apidra® SoloStar®) in Type 1 Diabetes Mellitus Patients

Geropharm n=224

NCT05378672 COMPLETED

A Study to Inv. Safety, Efficacy & PD of Dasiglucagon as Hypoglycemia Rescue Therapy in Children <6 Years With T1D

Zealand Pharma n=8

NCT05463744 COMPLETED

A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy

Eli Lilly and Company n=692

NCT02936843 COMPLETED

Targeting Inflammation With Salsalate in Type 1 Diabetes Neuropathy

University of Michigan n=61

NCT04974528 COMPLETED

Afrezza® INHALE-1 Study in Pediatrics

Mannkind Corporation n=319

NCT04409795 COMPLETED

Oral Hypoglycemic Therapy for Monogenic Variant Carriers of the Joslin Medalist Study

Joslin Diabetes Center n=3

NCT05205928 COMPLETED

Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care

McGill University Health Centre/Research Institute of the McGill University Health Centre n=28

NCT02897219 COMPLETED

A Study of ASP1941 in Combination With Insulin in Patients With Type 1 Diabetes Mellitus

Astellas Pharma Inc n=175

NCT03046927 COMPLETED

Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes

Benjamin U. Nwosu, MD n=48

NCT03371082 COMPLETED

Gan & Lee Insulin Glargine Target Type (1) Evaluating Research

Gan and Lee Pharmaceuticals, USA n=576

NCT03875729 COMPLETED

Recent-Onset Type 1 Diabetes Trial Evaluating Efficacy and Safety of Teplizumab

Provention Bio, Inc. n=328

NCT03874715 COMPLETED

Comparison of SAR341402 to NovoLog in Adult Patients With Type 1 Diabetes Mellitus Also Using Insulin Glargine

Sanofi n=210

NCT06348706 COMPLETED

Effect of Dipeptidyl Peptidase- 4 Inhibitors on Non-Alcoholic Steatohepatitis and Type 1 Diabetes

Ain Shams University n=60

NCT02518945 COMPLETED

Dapagliflozin As Additional Treatment To Liraglutide And Insulin In Patients With Type 1 Diabetes

University at Buffalo n=26

NCT04049110 COMPLETED

Dapagliflozin in Physical Exercise in Type 1 Diabetes

Insel Gruppe AG, University Hospital Bern n=39

NCT03174522 TERMINATED

The Efficacy and Safety of REX-001 to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM

Ixaka Ltd n=49

NCT04035031 COMPLETED

Effects of Dapagliflozin on Hormonal Glucose Homeostasis in Type 1 Diabetes

Insel Gruppe AG, University Hospital Bern n=13

NCT05467514 COMPLETED

Effect of Liraglutide on Subclinical Atherosclerosis in Patients With Type 1 Diabetes Mellitus

David Sanchez Garcia n=35

NCT03895697 COMPLETED

A Trial to Compare the Efficacy and Safety of 2 Different Batches of Subcutaneous Dasiglucagon in Patients With T1DM

Zealand Pharma n=92

NCT03952130 COMPLETED

A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 1 Diabetes

Eli Lilly and Company n=354

NCT03377699 COMPLETED

Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes

Novo Nordisk A/S n=225

NCT03262116 TERMINATED

Individualizing Automated Closed Loop Glucose Control Through Pharmacokinetic Profiling in an Insulin-Only Bionic Pancreas

Massachusetts General Hospital n=20

NCT02735044 COMPLETED

Comparison of the Safety and Efficacy of HOE901-U300 With Lantus in Children and Adolescents With Type 1 Diabetes Mellitus

Sanofi n=463

NCT02666430 COMPLETED

Extension Study to Assess Safety and Efficacy of Mylan's Insulin Glargine and Lantus® in Type 1 Diabetes Mellitus (T1DM) Patients

Mylan Inc. n=127

NCT03376789 COMPLETED

Mylan Insulin Glargine Study

Mylan Inc. n=219

NCT03760068 COMPLETED

Mylan Insulin Aspart Study

Mylan Inc. n=478

NCT03740919 COMPLETED

A Study Comparing LY900014 to Insulin Lispro (Humalog) in Children and Adolescents With Type 1 Diabetes

Eli Lilly and Company n=751

NCT04932213 COMPLETED

Effect of Tropicamide 0.5% vs Tropicamide 1% on Intraocular Pressure of Diabetic Patients

Semnan University of Medical Sciences n=98

NCT03378635 COMPLETED

A Trial to Confirm the Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in Type 1 Diabetes Subjects

Zealand Pharma n=170

NCT03688711 COMPLETED

Trial to Confirm the Clinical Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in Subjects With T1DM

Zealand Pharma n=45

NCT04879511 COMPLETED

Effect of Metformin in Children With Type 1 Diabetes

Ain Shams University n=80

NCT03111238 TERMINATED

The Efficacy and Safety of REX-001 to Treat Ischemic Rest Pain in Subjects With CLI Rutherford Category 4 and DM

Ixaka Ltd n=3

NCT03216226 COMPLETED

A Trial to Evaluate the Immunogenicity of Dasiglucagon and GlucaGen in Patients With Type 1 Diabetes Mellitus

Zealand Pharma n=112

NCT03911843 COMPLETED

Omega-3 and Vitamin D Supplements in Childhood T1D

Azienda Ospedaliero Universitaria Maggiore della Carita n=64

NCT03338023 COMPLETED

A Study of LY2963016 Compared to Lantus® in Adult Chinese Participants With Type 1 Diabetes Mellitus

Eli Lilly and Company n=272

NCT03830281 COMPLETED

A Study Comparing LY900014 to Insulin Lispro (Humalog) in Adults With Type 1 Diabetes Using Insulin Pump Therapy

Eli Lilly and Company n=471

NCT03977727 COMPLETED

FIasp® vs. Novolog® in Type 1 Diabetics Using 670G Medtronic Pump

Texas Diabetes & Endocrinology, P.A. n=40

NCT04079413 COMPLETED

Efficacy and Safety of GP40071 Compared to NovoRapid® Penfill® in Type 1 Diabetes Mellitus Patients

Geropharm n=264

NCT03738865 COMPLETED

G-Pen Compared to Glucagen Hypokit for Severe Hypoglycemia Rescue in Adults With Type 1 Diabetes

Xeris Pharmaceuticals n=132

NCT03214367 COMPLETED

A Study of LY900014 in Participants With Type 1 Diabetes

Eli Lilly and Company n=1,392

NCT03263494 COMPLETED

CGM Intervention in Teens and Young Adults With Type 1 Diabetes (T1D)

Jaeb Center for Health Research n=153

NCT03439072 COMPLETED

G-Pen™ Compared to Lilly Glucagon for Hypoglycemia Rescue in Adults With Type 1 Diabetes

Xeris Pharmaceuticals n=81

NCT02531035 COMPLETED

A Phase 3 Study to Evaluate the Safety of Sotagliflozin in Patients With Type 1 Diabetes Who Have Inadequate Glycemic Control With Insulin Therapy Alone

Lexicon Pharmaceuticals n=1,405

NCT02384941 COMPLETED

Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy

Lexicon Pharmaceuticals n=793

NCT02351232 COMPLETED

The Lira Pump Trial

Hvidovre University Hospital n=44

NCT02421510 COMPLETED

Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy

Lexicon Pharmaceuticals n=782

NCT04254380 WITHDRAWN

Gan & Lee Evaluation of New Biosimilar for Type 1 Lispro

Gan and Lee Pharmaceuticals, USA

NCT03840278 COMPLETED

The Bihormonal iLet Bionic Pancreas Feasibility Study

Massachusetts General Hospital n=12

NCT02825251 COMPLETED

Efficacy and Safety of Continuous Subcutaneous Insulin Infusion of Faster-acting Insulin Aspart Compared to NovoRapid® in Adults With Type 1 Diabetes

Novo Nordisk A/S n=472

NCT04022993 COMPLETED

Efficacy and Safety of Insulin RinGlar® Compared to Lantus® SoloStar® in Type 1 Diabetes Mellitus Patients

Geropharm n=180

NCT02500706 COMPLETED

Efficacy and Safety of Faster-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec in Adults With Type 1 Diabetes

Novo Nordisk A/S n=1,108

NCT02670915 COMPLETED

Efficacy and Safety of Faster-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec in Children and Adolescents With Type 1 Diabetes

Novo Nordisk A/S n=834

NCT02582814 COMPLETED

The Safety and Efficacy of Dapagliflozin Therapy in Combination With Insulin in Japanese Subjects With T1DM

AstraZeneca n=151

NCT02460978 COMPLETED

Dapagliflozin Evaluation in Patients With Inadequately Controlled Type 1 Diabetes

AstraZeneca n=815

NCT02414958 COMPLETED

Empagliflozin as Adjunctive to InSulin thErapy Over 52 Weeks in Patients With Type 1 Diabetes Mellitus (EASE-2)

Boehringer Ingelheim n=730

NCT03091673 COMPLETED

Glucose Response of G-Pen (Glucagon Injection) in Pediatric T1D Patients

Xeris Pharmaceuticals n=31

NCT02580591 COMPLETED

Empagliflozin as Adjunctive to Insulin Therapy Over 26 Weeks in Patients With T1DM (EASE-3)

Boehringer Ingelheim n=977

NCT02656069 COMPLETED

Safety and Efficacy of G-Pen Compared to Lilly Glucagon for Hypoglycemia Rescue in Adult Type 1 Diabetics

Xeris Pharmaceuticals n=80

NCT03504046 COMPLETED

Safety and Feasibility Evaluation of the APS APP

Sansum Diabetes Research Institute n=6

NCT02735031 COMPLETED

Exenatide and Impaired Hypoglycaemic Awareness in Type 1 Diabetes

Radboud University Medical Center n=10

NCT02568501 COMPLETED

Behavioral Economic Incentives to Improve Glycemic Control Among Adolescents and Young Adults

University of Pennsylvania n=90

NCT02705053 COMPLETED

At Home Study of a Zone-Model Predictive Control (MPC) Controller and a Health Monitoring System (HMS) With the Diabetes Assistant (DiAs) System and Run-to-Run Adaptation

Sansum Diabetes Research Institute n=32

NCT01762644 WITHDRAWN

The Insulin Independence Trial (IIT) Evaluating the Safety and Efficacy of Oral Cyclosporine and Oral Omeprazole for Insulin Independence Among Recent Onset Type 1 Diabetes Patients

Perle Bioscience, Inc.

NCT06575426 RECRUITING

A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

Otsuka Pharmaceutical Factory, Inc.

NCT07061574 NOT YET RECRUITING

A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes

City of Hope Medical Center

NCT07186660 RECRUITING

Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes

University of Virginia

NCT03513939 ACTIVE NOT RECRUITING

A Safety, Tolerability and Efficacy Study of Sernova's Cell Pouch™ for Clinical Islet Transplantation

Sernova Biotherapeutics Inc.

NCT07430332 NOT YET RECRUITING

GLP-1 RA for Stage 1 Type 1 Diabetes

Children's Hospital Medical Center, Cincinnati

NCT03746769 RECRUITING

Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes

City of Hope Medical Center

NCT07216391 NOT YET RECRUITING

Platform Trial to Delay Stage 3 Diabetes: Comparing Teplizumab With ATG

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05626712 RECRUITING

Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes

Creative Medical Technology Holdings Inc

NCT03929601 ACTIVE NOT RECRUITING

Rituximab-pvvr and Abatacept vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT07421518 NOT YET RECRUITING

Ketone Monitoring Approaches for Diabetic Ketoacidosis Risk Mitigation in People With T1D on Adjunctive SGLT-2 Inhibitors

AdventHealth Translational Research Institute

NCT06111586 RECRUITING

FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)

Sanofi

NCT07187531 RECRUITING

SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

SAb Biotherapeutics, Inc.

NCT06227221 NOT YET RECRUITING

Efficacy and Safety of Sorafenib in New-Onset Type 1 Diabetes Mellitus

Second Xiangya Hospital of Central South University

NCT06812988 ACTIVE NOT RECRUITING

Treatment of Type 1 Diabetes With Anti-OX40L Bispecific With Anti-TNF Activity In a Single Nanobody® Molecule

Sanofi

NCT07224321 RECRUITING

INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes

Mannkind Corporation

NCT06783309 RECRUITING

CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)

COUR Pharmaceutical Development Company, Inc.

NCT07325201 NOT YET RECRUITING

Reducing Risk of Diabetic Ketoacidosis in Type 1 Diabetes and Kidney Disease Using Continuous Ketone Monitoring

HealthPartners Institute

NCT05683990 RECRUITING

Study to Evaluate the Safety and Feasibility of Diamyd® in Individuals at Risk for Type 1 Diabetes

Diamyd Medical AB

NCT05949281 ACTIVE NOT RECRUITING

Repurposing Colchicine for Reduction of Residual Inflammatory Risk in Type 1 Diabetes

Asger Lund, MD

NCT06688331 RECRUITING

Treatment of Presymptomatic (Stage 1) Type 1 Diabetes Pediatric Patients With Treg Cell Preparations and Anti-CD20 Antibody

PolTREG S.A.

NCT06791291 RECRUITING

Efficacy and Safety of Teplizumab in Japanese Participants With Stage 2 Type 1 Diabetes

Sanofi

NCT07247734 RECRUITING

The Effect of Colchicine, on Insulin Sensitivity in Individuals With Type 1 Diabetes and Systemic Low-grade Inflammation

Asger Lund, MD

NCT05180591 RECRUITING

Repeat BCG Vaccinations For The Treatment Of Pediatric Type 1 Diabetes

Massachusetts General Hospital

NCT05866536 RECRUITING

Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years

Massachusetts General Hospital

NCT05762107 RECRUITING

A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes

Zucara Therapeutics Inc.

NCT06455319 RECRUITING

Precision Administration of Anti-thymocyte Globulin With or Without Verapamil

University of Florida

NCT07225465 NOT YET RECRUITING

Evaluating Safe Ketone Thresholds To Minimise Ketosis in People With Type 1 Diabetes Using Dapagliflozin

St Vincent's Hospital Melbourne

NCT04141761 ACTIVE NOT RECRUITING

Probiotics in Newly Diagnosed T1D

Medical College of Wisconsin

NCT06976619 RECRUITING

The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes

Mayo Clinic

NCT06820281 NOT YET RECRUITING

Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes

Garvan Institute of Medical Research

NCT06072326 NOT YET RECRUITING

dApagliflozin SC0062 and Prevention of Renal Injury; a Randomized Evaluation

University Medical Center Groningen

NCT05743244 ACTIVE NOT RECRUITING

Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT07199946 RECRUITING

A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil

Johnny Ludvigsson

NCT07142252 NOT YET RECRUITING

Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05594563 RECRUITING

TArgeting Type 1 Diabetes Using POLyamines (TADPOL)

Emily K. Sims

NCT05822609 RECRUITING

Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes

University of Washington

NCT07126873 RECRUITING

A Safety, Tolerability, and Efficacy Study of E-islet 01 in Participants With Type 1 Diabetes

EndoCell Therapeutics, Inc.

NCT06435156 RECRUITING

Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes

University of Dundee

NCT06238778 ACTIVE NOT RECRUITING

Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec

Diasome Pharmaceuticlas, Inc.

NCT05791201 ACTIVE NOT RECRUITING

A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes

Vertex Pharmaceuticals Incorporated

NCT06180616 NOT YET RECRUITING

Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity

Royal North Shore Hospital

NCT06524960 RECRUITING

Denosumab for Type 1 Diabetes

City of Hope Medical Center

NCT05414409 RECRUITING

The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action

Heba M. Ismail

NCT07083882 RECRUITING

Faecal Autologous Capsule Transplantation for Type 1 Diabetes Mellitus

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

NCT07041268 RECRUITING

Immunotherapy of the Recent-onset Type 1 Diabetes in Adolescents With Repeated Courses of Rituximab

Pirogov Russian National Research Medical University

NCT04933851 RECRUITING

ACT1VATE: Addressing Emotional Distress to Improve Outcomes Among Diverse Adults With Type 1 Diabetes

Scripps Whittier Diabetes Institute

NCT05153070 RECRUITING

Ciclosporin Followed by Low-dose IL-2 in Patients With Recently Diagnosed Type 1 Diabetes

Assistance Publique - Hôpitaux de Paris

NCT06981234 RECRUITING

Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial

University of California, San Diego

NCT06810726 RECRUITING

Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.

Estar Medical dba Medical Technologies, LTD

NCT04779645 ACTIVE NOT RECRUITING

Effects of GRA in Patients With Type 1

University of California, San Diego

NCT04335656 ACTIVE NOT RECRUITING

Reducing Innate Inflammation in New Onset Type 1 Diabetes

Medical College of Wisconsin

NCT03961854 ACTIVE NOT RECRUITING

Lactobacillus Johnsonii in Children and Adolescents With T1D

University of Florida

NCT03961347 ACTIVE NOT RECRUITING

Lactobacillus Johnsonii Supplementation in Adults With T1D

University of Florida

NCT03977662 ACTIVE NOT RECRUITING

Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes

Peter Stock

NCT06147232 NOT YET RECRUITING

Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia

Steno Diabetes Center Copenhagen

NCT06474598 RECRUITING

An Adaptive Design Study of MTX228

University of Alberta

NCT05957055 RECRUITING

Lisdexamphetamine Vs Methylphenidate for Pediatric Patients with ADHD and Type 1 Diabetes

Medical University of Lodz

NCT05696366 RECRUITING

Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes

University of California, San Diego

NCT04545151 ACTIVE NOT RECRUITING

Verapamil SR in Adults With Type 1 Diabetes

Medical University of Graz

NCT05565248 RECRUITING

An Open-Label, FIH Study Evaluating the Safety, Tolerability, and Efficacy of VCTX211 Combination Product in Subjects With T1D

CRISPR Therapeutics AG

NCT06021158 RECRUITING

A Trial to Compare Automated Lyumjev Delivery With Carbohydrate Counting, Qualitative Meal-size Estimation, and Meal Detection in Type 1 Diabetes

McGill University Health Centre/Research Institute of the McGill University Health Centre

NCT03895437 ACTIVE NOT RECRUITING

Diabetes Autoimmunity Withdrawn In New Onset and In Established Patients

Tolerion, Inc.

NCT05574335 TERMINATED

Siplizumab in T1DM

National Institute of Allergy and Infectious Diseases (NIAID)

NCT02586831 WITHDRAWN

Diabetes Islet Preservation Immune Treatment

Camillo Ricordi and Jay Skyler

NCT05742243 COMPLETED

Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes

Melbourne Health

NCT04247620 COMPLETED

DiaBetter Together for Young Adults With Type 1 Diabetes

Baylor College of Medicine

NCT05478707 SUSPENDED

Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

University of Virginia

NCT04291703 TERMINATED

STOP-T1D Low-Dose (ATG)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT03406897 COMPLETED

Pilot Study of OMEGA-3 and Vitamin D in High-Dose in Type I Diabetic Patients

Rodolfo Alejandro

NCT06152042 TERMINATED

Phase 2 Trial of BMF-219 in Participants With Type 1 Diabetes Mellitus

Biomea Fusion Inc.

NCT05537233 COMPLETED

ADJUnct Semaglutide Treatment in Type 1 Diabetes

Viral N. Shah

NCT06025110 TERMINATED

A Study of TCD601 (Siplizumab) in New Onset Type 1 Diabetes Patients

ITB-Med LLC

NCT06062069 COMPLETED

A Study of CT-868 in Type 1 Diabetes Mellitus

Carmot Therapeutics, Inc.

NCT05018416 COMPLETED

Study of Renal Autologous Cell Therapy (REACT) in Subjects With Type 1 or 2 Diabetes and Chronic Kidney Disease (REGEN-007)

Prokidney

NCT05960565 TERMINATED

Glucagon Enhanced Insulin Absorption in Diabetes Mellitus Type 1

St. Olavs Hospital

NCT06854861 SUSPENDED

Premixed Glucagon/Insulin Solution for Faster Insulin Absorption in Type 1 Diabetes

St. Olavs Hospital

NCT02218619 COMPLETED

Tauroursodeoxycholic Acid (TUDCA) in New-Onset Type 1 Diabetes

Robin Goland, MD

NCT03366337 COMPLETED

A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney Diseases - PHOENIX

Biogen

NCT05473364 COMPLETED

Acetazolamide in Persons With Type 1 Diabetes - Dose Finding

University of California, San Diego

NCT04899271 TERMINATED

A Study to Assess Efficacy/Safety of Ladarixin in Type 1 Diabetes Patients With Preserved ß-cell Function at Baseline.

Dompé Farmaceutici S.p.A

NCT04129528 COMPLETED

Study of Safety and Efficacy of CFZ533 in Type 1 Diabetes Pediatric and Young Adult Subjects

Novartis Pharmaceuticals

NCT03895996 COMPLETED

Safety, Tolerability and Potential Efficacy of AVT001 in Patients With Type 1 Diabetes

Avotres Inc.

NCT04270942 COMPLETED

At-Risk for Type 1 Diabetes Extension Study (TN-10 Extension)

Provention Bio, a Sanofi Company

NCT02846545 COMPLETED

A Study of SIMPONI® to Arrest Beta-cell Loss in Type 1 Diabetes

Janssen Research & Development, LLC

NCT05368402 TERMINATED

Clinical Trial on Ladarixin Adjunctive Therapy to Improve Glycemic Control in Type 1 Diabetes.

Dompé Farmaceutici S.p.A

NCT04509791 COMPLETED

MELD-ATG: Phase II, Dose Ranging, Efficacy Study of Anti-thymocyte Globulin (ATG) Within 6 Weeks of Diagnosis of Type 1 Diabetes (T1D)

Universitaire Ziekenhuizen KU Leuven

NCT04774224 COMPLETED

Baricitinib in New-onset Type 1 Diabetes

St Vincent's Institute of Medical Research

NCT03163511 COMPLETED

A Safety, Tolerability, and Efficacy Study of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus and Hypoglycemia Unawareness

ViaCyte

NCT02529449 COMPLETED

Pharmacodynamics, Pharmacokinetics, and Safety of ASP1941 in Patients With Type 1 Diabetes Mellitus

Astellas Pharma Inc

NCT04432090 COMPLETED

GPR119 Agonist for Hypoglycemia in Type 1 Diabetes

AdventHealth Translational Research Institute

NCT03364868 COMPLETED

GPPAD-POInT (Global Platform of Autoimmune Diabetes - Primary Oral Insulin Trial)

Technical University of Munich

NCT02620072 COMPLETED

Fr1da Insulin Intervention

Technical University of Munich

NCT03182426 COMPLETED

Stem Cell Mobilization (Plerixafor) and Immunologic Reset in Type 1 Diabetes (T1DM)

University of Alberta

NCT04524949 TERMINATED

IMCY-0098 Proof of ACtion in Type 1 Diabetes (IMPACT Study)

Imcyse SA

NCT03243058 WITHDRAWN

Low-dose IL-2 in Established T1D - The "PROREG" Study

Jay S. Skyler

NCT03867851 TERMINATED

Study to Evaluate Safety and Efficacy of IBsolvMIR in Islet Transplantation

TikoMed AB

NCT03149770 COMPLETED

Naloxone, Hypoglycemia and Exercise

University of Minnesota

NCT04074317 COMPLETED

Phase 2, Randomized, Open-Label, Crossover, PD/PK Study of a Novel Pram-Insulin Co-Formulation in Adults With T1D

Xeris Pharmaceuticals

NCT02505893 COMPLETED

Minimal Islet Transplant at Diabetes Onset

Ospedale San Raffaele

NCT02354911 WITHDRAWN

Autologous Immunoregulatory Dendritic Cells for Type 1 Diabetes Therapy

DiaVacs, Inc.

NCT05454709 WITHDRAWN

A Stable Glucagon Analog Administered by a Bihormonal Closed Loop System

Inreda Diabetic B.V.

NCT02464878 COMPLETED

Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant

Massachusetts General Hospital

NCT05351879 COMPLETED

Evaluation of a Booster Administration of GAD-alum (Diamyd®) in Individuals With Type 1 Diabetes

Linkoeping University

NCT04678557 TERMINATED

A Study to Evaluate Safety, Engraftment, and Efficacy of VC-01 in Subjects With T1 Diabetes Mellitus

ViaCyte

NCT02411253 COMPLETED

Low-dose rhIL-2 in Patients With Recently-diagnosed Type 1 Diabetes

Assistance Publique - Hôpitaux de Paris

NCT03335371 COMPLETED

Evaluation of TTP399 in Patients With Type 1 Diabetes

vTv Therapeutics

NCT02700048 TERMINATED

Intra-nasal Naloxone for Treatment of Impaired Awareness of Hypoglycemia

University of Minnesota

NCT04545411 COMPLETED

Combination GRA and SGLT-2i Treatment in Type 1 Diabetes

University of California, San Diego

NCT05480657 WITHDRAWN

Safety, Tolerability, and Efficacy of Immunomodulation With AT-1501 in Combination With Transplanted Islet Cells in Adults With Brittle T1D

Eledon Pharmaceuticals

NCT03345004 COMPLETED

Diamyd Administered Into Lymph Nodes in Combination With Vitamin D in Type 1 Diabetes

Diamyd Medical AB

NCT03635437 COMPLETED

Evaluation of Safety and Diabetes Status Upon Oral Treatment With GABA in Patients With Longstanding Type-1 Diabetes

Per-Ola Carlsson

NCT04450407 COMPLETED

A Study of LY3209590 in Participants With Type 1 Diabetes

Eli Lilly and Company

NCT04079881 TERMINATED

Glucagon Response to Prandial Insulin Administration in Persons With Type 1 Diabetes

Washington University School of Medicine

NCT04764968 COMPLETED

Pen-Administered Low-Dose Dasiglucagon for Prevention and Treatment of Hypoglycemia in People With Type 1 Diabetes

Steno Diabetes Center Copenhagen

NCT04711226 WITHDRAWN

Safety, Tolerability and Efficacy of Immunomodulation With AT-1501 in Islet Cell Transplantation

Anelixis Therapeutics, LLC

NCT04956263 COMPLETED

A Comparison of Postprandial Glucose After a MMTT, and the Metabolic Effects of Insulin Withdrawal in a Crossover Study in Subjects With Type 1 Diabetes

Youngene Therapeutics Inc., Ltd.

NCT03919617 COMPLETED

Metabolic Pathways of GRA in Patients With Type 1 Diabetes

University of California, San Diego

NCT04816890 COMPLETED

A Trial to Assess the Efficacy and Safety of M1 Pram P037 Prandial Insulin in Subjects With Type 1 Diabetes (T1DM)

Adocia

NCT04585776 COMPLETED

A Study of LY900014 and Insulin Degludec in Participants With Type 1 Diabetes

Eli Lilly and Company

NCT04150107 COMPLETED

A Study to Compare ORMD-0801 Once Daily to ORMD-0801 Three Times Daily in Subjects With Type 1 Diabetes

Oramed, Ltd.

NCT02520076 COMPLETED

Aralast NP in Islet Transplant

University of Alberta

NCT03537131 TERMINATED

Dapagliflozin During Exercise for the PrevenTion of Hypoglycaemia

University of Oxford

NCT02821026 COMPLETED

Omental Islet Transplant

University of Alberta

NCT03618420 COMPLETED

Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function

University of Colorado, Denver

NCT02898506 COMPLETED

Incretin-based Therapy in Late Preclinical Type 1 Diabetes

University of Oulu

NCT02908087 COMPLETED

Incretin-based Therapy in Early Diagnosed Type 1 Diabetes

University of Oulu

NCT04729296 WITHDRAWN

Anti-TNFα to Delay or Prevent Progression to Stage 3 T1D

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02544321 COMPLETED

Bromocriptine Quick Release (BCQR) as Adjunct Therapy in Type 1 Diabetes

University of Colorado, Denver

NCT02293837 COMPLETED

Tocilizumab (TCZ) in New-onset Type 1 Diabetes

National Institute of Allergy and Infectious Diseases (NIAID)

NCT03182322 COMPLETED

PINIT Study: Primary Intranasal Insulin Trial

Technical University of Munich

NCT03800875 COMPLETED

Insulin-plus-pramlintide Closed-loop Strategy to Regulate Glucose Levels Without Carbohydrate Counting

McGill University

NCT02443155 COMPLETED

A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function

Novo Nordisk A/S

NCT02527265 COMPLETED

Afrezza Safety and Pharmacokinetics Study in Pediatric Patients

Mannkind Corporation

NCT02464033 COMPLETED

EDCR Study - Etanercept Diamyd Combination Regimen -Open Trial to Evaluate Safety in Children With Type 1 Diabetes

Johnny Ludvigsson

NCT02971228 COMPLETED

Feasibility Trial Testing the Bionic Pancreas With ZP4207

Zealand Pharma

NCT03490942 TERMINATED

Glucagon Infusion in T1D Patients With Recurrent Severe Hypoglycemia: Effects on Counter-Regulatory Responses

Xeris Pharmaceuticals

NCT04449692 COMPLETED

Low-dose Dasiglucagon for Prevention of Insulin-Induced Hypoglycemia in People With Type 1 Diabetes

Steno Diabetes Center Copenhagen

NCT03325114 TERMINATED

Safety and Efficacy of Chlorthalidone in Type 1 Diabetes

University of Rochester

NCT03794960 WITHDRAWN

Diabetes AutoimmunitY Withdrawn in Established Patients (DAY)

Tolerion, Inc.

NCT03794973 WITHDRAWN

Diabetes Autoimmunity Withdrawn in New Onset Patients (DAWN)

Tolerion, Inc.

NCT03981627 COMPLETED

A Trial to Assess Safety and Efficacy of ADO09 Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus

Adocia

NCT02387164 TERMINATED

Prevention Trial: Immune-tolerance With Alum-GAD (Diamyd) and Vitamin D3 to Children With Multiple Islet Autoantibodies

Lund University

NCT02617654 COMPLETED

Liraglutide Effect on Beta-cell Function in C-peptide Positive Type 1 Diabetes

Per-Ola Carlsson

NCT02803892 COMPLETED

Monotherapy With Rapamycin in Long-standing Type 1 Diabetes

Piemonti Lorenzo

NCT03161964 TERMINATED

Propranolol in Treating Hypoglycemia Unawareness

Anu Sharma

NCT02580877 COMPLETED

Immune Effects of Oral Insulin in Relatives at Risk for Type 1 Diabetes Mellitus (TN20)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02632747 COMPLETED

Empagliflozin and ACEi- Effects on Hyperfiltration: BETWEEN Study

Boehringer Ingelheim

NCT03816761 COMPLETED

Research Study to Look at Fast-acting Insulin Aspart With the Insulin Pump System 'iLet™' in Adults With Type 1 Diabetes

Novo Nordisk A/S

NCT02846831 COMPLETED

Closed-loop Control of Glucose Levels (Artificial Pancreas) for 12 Days in Adults With Type 1 Diabetes

Institut de Recherches Cliniques de Montreal

NCT03938740 COMPLETED

Comparison of Different Insulin Dosing Algorithms Using Hepatic Directed Vesicle-Insulin Lispro and Insulin Degludec

Diasome Pharmaceuticals

NCT03556033 COMPLETED

Effect of Dapagliflozin on IAH in T1DM

Radboud University Medical Center

NCT02660242 COMPLETED

The Use of Mini-dose Glucagon to Prevent Exercise-induced Hypoglycemia in Type 1 Diabetes

Jaeb Center for Health Research

NCT02411578 COMPLETED

Mini-Dose Glucagon to Treat Non-Severe Hypoglycemia

Jaeb Center for Health Research

NCT02814123 COMPLETED

Effect of Basal-Bolus Closed-Loop Co-Administration of Insulin and Pramlintide on Improving the Glycemic Control in Type 1 Diabetes

McGill University

NCT02383940 COMPLETED

Efficacy and Safety of Sotagliflozin in Young Adult Patients With Type 1 Diabetes Mellitus and Elevated Hemoglobin A1C

Lexicon Pharmaceuticals

NCT02459899 COMPLETED

Dose-ranging Study in Patients With Type 1 Diabetes Mellitus

Lexicon Pharmaceuticals

NCT02372253 COMPLETED

Verapamil for Beta Cell Survival Therapy in Type 1 Diabetes

University of Alabama at Birmingham

NCT02206152 COMPLETED

A Randomized Double Blinded Study to Examine the Use of N-acetyl Cysteine for the Prevention and Treatment of HAAF in Patients With Type 1 Diabetes

University of Minnesota

NCT03017352 COMPLETED

Meal-time Administration of Exenatide for Glycaemic Control in Type 1 Diabetic Cases

Filip Krag Knop

NCT02535715 COMPLETED

A Euglycemic Insulin Clamp Study in Type 1 Diabetic Patients With Oral Insulin (ORAMED)

The University of Texas Health Science Center at San Antonio

NCT02855307 COMPLETED

Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes

Institut de Recherches Cliniques de Montreal

NCT02794155 COMPLETED

Study of HDV Insulin Versus Insulin in Type 1 Diabetes Subjects (ISLE-1)

Diasome Pharmaceuticals

NCT03096392 COMPLETED

Comparison of Hepatic Directed Vesicle (HDV)-Insulin Lispro Versus Insulin Lispro to Further Improve Glycemic Control

Diasome Pharmaceuticals

NCT02509429 COMPLETED

Comparison of an Artificial Pancreas Versus Threshold Low Glucose Suspend in Type 1 Diabetic Children

University Hospital, Montpellier

NCT03335501 WITHDRAWN

Comparison of the Efficacy of Rapid-acting Aspart and Faster Acting Aspart Within the Context of Single-hormone Closed-loop Strategy at Regulating Postprandial Glucose Levels

Institut de Recherches Cliniques de Montreal

NCT03111433 COMPLETED

Efficacy of Coenzyme q10 in Pediatrics With Type 1 Diabetes Mellitus

Ain Shams University

NCT02702011 COMPLETED

Empa Add on to Insulin in Japanese Patient With Type 1 Diabetes Mellitus

Boehringer Ingelheim

NCT02547519 COMPLETED

Pre-POINT-Early Study

Technical University of Munich

NCT02488616 WITHDRAWN

Closed-loop Control of Glucose Levels (Artificial Pancreas) for 5 Days in Adults With Type 1 Diabetes

Institut de Recherches Cliniques de Montreal

NCT02769884 COMPLETED

MMPPC Outpatient Clinical Protocol 2016

Rensselaer Polytechnic Institute

NCT02774876 COMPLETED

Closed-loop Control of Postprandial Glucose Levels After Meals With Different Macronutrients Content in Adults With Type 1 Diabetes

Institut de Recherches Cliniques de Montreal

NCT02490098 WITHDRAWN

Closed-loop Control of Postprandial Glucose Levels in Children and Adults With Type 1 Diabetes

Institut de Recherches Cliniques de Montreal

NCT02204397 COMPLETED

Study of Tolerability and Safety of Adding Ustekinumab to INGAP Peptide for 12 Weeks in Adult Patients With TD1 Melitis

Jewish General Hospital

NCT02714972 COMPLETED

Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms, Pump Suspension, and Insulin Dosing in Children and Young Adolescents

Jaeb Center for Health Research

NCT02798250 COMPLETED

Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation - Part 2

Institut de Recherches Cliniques de Montreal

NCT02861157 COMPLETED

Mobile Technology & Online Tools to Track Adherence in Chronic Illness Patients

3-C Institute for Social Development

NCT02627911 COMPLETED

Diabeloop WP6.2 : Crossover Evaluation of Glycemic Control

Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète

NCT02408705 COMPLETED

Investigating the Effect of Liraglutide on the Endogenous Glucose Production During in Tye 1 Diabetes Subjects

Medical University of Graz

NCT02438189 COMPLETED

Reduction of Nocturnal Hypoglycemia and Hyperglycemia in the Home Using Predictive Algorithms

Jaeb Center for Health Research

NCT02739906 COMPLETED

A Trial to Investigate Post Prandial Blood Glucose Control With Fast-acting Human Insulin HinsBet® Compared to Insulin Lispro (Humalog®) and Regular Human Insulin (Huminsulin® Normal) After Ingestion of a Standardized Meal in Subjects With T1DM

Adocia

NCT02626936 COMPLETED

Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation

Institut de Recherches Cliniques de Montreal

NCT02416765 COMPLETED

Closed-loop Control of Postprandial Glucose Levels in Adults With Type 1 Diabetes

Institut de Recherches Cliniques de Montreal

NCT02256293 WITHDRAWN

Acceptability and Feasibility of an ACT-Based Group to Improve Diabetes Self-Management

Duke University

NCT06919354 RECRUITING

A Study of GNTI-122 in Adults Recently Diagnosed With T1D

GentiBio, Inc

NCT04590872 ACTIVE NOT RECRUITING

An Immunotherapy Vaccine (PIpepTolDC) for the Treatment of Patients With Type 1 Diabetes

City of Hope Medical Center

NCT06280703 RECRUITING

A Study of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus (T1DM)

Eli Lilly and Company

NCT07341373 RECRUITING

A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500

Portal Diabetes, Inc.

NCT06945406 RECRUITING

A Study of LY4057996 in Healthy Participants and Participants With Type 1 and Type 2 Diabetes

Eli Lilly and Company

NCT07305805 RECRUITING

A Research Study of a New Medicine NNC0363-1063 in Participants With Type 1 Diabetes

Novo Nordisk A/S

NCT07090824 RECRUITING

Subcutaneous Pharmacokinetic Evaluation of Monomeric Insulin and Lyumjev in Adults With Type 1 Diabetes

Stanford University

NCT07242664 RECRUITING

Clamp Study to Estimate the Relative Potency of GZR33 Versus Insulin Degludec at Steady State

Gan and Lee Pharmaceuticals, USA

NCT06685185 RECRUITING

A Research Study of a New Medicine NNC0363-1063 in Healthy Participants and Participants With Type 1 Diabetes

Novo Nordisk A/S

NCT06731218 RECRUITING

Phase I Clinical Study to Evaluate the Safety and Efficacy of RGB-5088 in Patients With Type 1 Diabetes Mellitus

Hangzhou Reprogenix Bioscience, Inc

NCT07087795 RECRUITING

A Study to See the Effect of NNC0194-0499 Alone or in Combination With Semaglutide on Blood Sugar Control in People Living With Type 1 Diabetes

Novo Nordisk A/S

NCT05065372 RECRUITING

MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes

Kalie Tommerdahl

NCT04061746 RECRUITING

Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells

Medical University of South Carolina

NCT06408311 RECRUITING

Safety of ENC-201-CED ENCRT

Encellin

NCT06324604 RECRUITING

Safety, Pharmacokinetics, and Pharmacodynamics of MTX-101 in Healthy Adults and Patients

Mozart Therapeutics Australia Pty Ltd

NCT05610865 RECRUITING

Efficacy of Adipose Tissue Derived Stem Cells for the Treatment of Diabetic Foot Ulcers

University of the Punjab

NCT06708780 RECRUITING

Immunotherapy with Autologous Tregs in T1DM

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

NCT05689424 NOT YET RECRUITING

Suppression of Endogenous Glucose Production by Injectable HDV-Insulin Lispro: A Dose Response Study in Human Subjects With Type 1 Diabetes

University of California, San Diego

NCT03624062 COMPLETED

MER3101: MAS-1 Adjuvanted Antigen-specific Immunotherapeutic for Prevention and Treatment of Type 1 Diabetes

University of Colorado, Denver

NCT06588504 COMPLETED

Research Study in Japan to Compare Dasiglucagon With Glucagon in Treating Very Low Levels of Blood Sugar in Asian Adults With Type 1 Diabetes and Testing of Dasiglucagon for the Same Condition in Japanese Adolescents

Novo Nordisk A/S

NCT04698018 COMPLETED

A Research Study to Look at How Faster Aspart Works in Chinese People With Type 1 Diabetes or Type 2 Diabetes

Novo Nordisk A/S

NCT06057454 COMPLETED

R-5280 in Newly Diagnosed Patients With Type 1 Diabetes

Rise Therapeutics LLC

NCT03903016 COMPLETED

A Bioequivalence Study Comparing Two Different Strengths Formulations of Insulin Lispro in Patients With Type 1 Diabetes

Sanofi

NCT06809621 COMPLETED

A Study to Test How Insulin NNC0471-0119 H Works in the Body in Participants With Type 1 Diabetes When Given by an Insulin Pump

Novo Nordisk A/S

NCT05308836 COMPLETED

Evaluate Safety of Adipose Derived Mesenchymal Stem Cell Transplantation for Type 1 Diabetes Treatment

Vinmec Research Institute of Stem Cell and Gene Technology

NCT03840343 TERMINATED

Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease

Mayo Clinic

NCT04869761 COMPLETED

Stem Cell Therapy for Chronic Kidney Disease

LaTonya J. Hickson

NCT06272695 COMPLETED

Glucagon Rescue of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes Treated With Volagidemab

REMD Biotherapeutics, Inc.

NCT03073577 COMPLETED

Islet Transplantation Using PKX-001

University of Alberta

NCT05073302 COMPLETED

Device-Less Technique in Islet Transplantation

University of Alberta

NCT03723772 COMPLETED

A Research Study of How Different Doses of a New Medicine NNC0148-0287 C (Insulin 287) Work on the Blood Sugar in People With Type 1 Diabetes When it is Taken Once a Week

Novo Nordisk A/S

NCT03298542 COMPLETED

A Study to Evaluate SIMPONI (Golimumab) Therapy in Children, Adolescents and Young Adults With Pre-Symptomatic Type 1 Diabetes

Janssen Research & Development, LLC

NCT03444064 COMPLETED

PolyTreg Immunotherapy in Islet Transplantation

University of Alberta

NCT05794581 COMPLETED

A Study to Assess the Effects of CT-868 Treatment on Glucose Homeostasis in Participants with Type 1 Diabetes

Carmot Therapeutics, Inc.

NCT04234867 TERMINATED

Study to Explore the Effect of Dapagliflozin and Stress in Adolescent and Adult Subjects With Type 1 Diabetes (T1D)

Kinderkrankenhaus auf der Bult

NCT04114357 COMPLETED

Effect of Prebiotics on the Gut Microbiome Profile and Beta Cell Function

Indiana University

NCT04416737 COMPLETED

Evaluating the Benefits of Physiologic Insulin Delivery

Stanford University

NCT05262387 COMPLETED

A Study of LY900014 (Lyumjev) Versus Insulin Lispro (Humalog) in Participants With Type 1 Diabetes

Eli Lilly and Company

NCT04992312 COMPLETED

A Study of Nasal Glucagon (LY900018) in Pediatric Participants With Type 1 Diabetes

Eli Lilly and Company

NCT05428943 COMPLETED

OPT101 in Type 1 Diabetes Patients

Op-T LLC

NCT05887999 COMPLETED

A Study of LY3532226 in Participants With Type 1 Diabetes Mellitus

Eli Lilly and Company

NCT05262595 COMPLETED

A Study to Look at How Insulin NNC0471-0119 Works in the Body in People With Type 1 Diabetes When Injected by Insulin Pump

Novo Nordisk A/S

NCT05067270 COMPLETED

A Study of Infusion Site Pain After Infusion of Excipients in Participants With Type 1 Diabetes Mellitus

Eli Lilly and Company

NCT05373199 COMPLETED

A Trial Comparing the Pharmacodynamics and Pharmacokinetics of BC Combo THDB0207 and Lantus® and Humalog® in Subjects With Type 1 Diabetes

Adocia

NCT05007977 TERMINATED

Effect of ZT-01 on Glucagon During Hypoglycemia in Type 1 Diabetes Mellitus

Zucara Therapeutics Inc.

NCT04569994 COMPLETED

A Study to Look at the Safety of NNC0363-0845 in Healthy People and People With Type 1 Diabetes

Novo Nordisk A/S

NCT05210530 COMPLETED

An Open-Label, FIH Study Evaluating the Safety and Tolerability of VCTX210A Combination Product in Subjects With T1D

CRISPR Therapeutics AG

NCT05272059 WITHDRAWN

Multiple Ascending Dose Study of MHS552 in Adults With Type 1 Diabetes Mellitus

Novartis Pharmaceuticals

NCT02837094 COMPLETED

Enhanced Epidermal Antigen Specific Immunotherapy Trial -1

Cardiff University

NCT04655690 COMPLETED

A Study to Look at How Safe Insulin NNC0471-0119 is and How it Works in People With Type 1 Diabetes Mellitus

Novo Nordisk A/S

NCT05134987 COMPLETED

A Multiple Dose Study Investigating Pharmacokinetics and Pharmacodynamics of Subcutaneous NNC0363-0845 in Participants With Type 1 Diabetes Pharmacokinetics and Pharmacodynamics: How Insulin NNC0363-0845 is Transported Throughout the Body and How It Works

Novo Nordisk A/S

NCT04450563 COMPLETED

Low Dose Empagliflozin in Adults With Type 1 Diabetes on Closed Loop Insulin System

McGill University

NCT05248841 COMPLETED

A Study to Demonstrate Pharmacokinetic and Pharmacodynamic Biosimilarity Between HEC-Glargine and US-Lantus® in Healthy Male Volunteers

Lannett Company, Inc.

NCT05184868 COMPLETED

AT247, NovoLog® and Fiasp® Administered Via Continuous Subcutaneous Infusion in Glucose Clamp Study

Arecor Limited

NCT04201496 COMPLETED

SGLT2 Inhibitor Adjunctive Therapy to Closed Loop Control in Type 1 Diabetes Mellitus

Ananda Basu, MD

NCT04844164 COMPLETED

Vitamin D Metabolism in Patients With Endocrine Disorders

Endocrinology Research Centre, Moscow

NCT04141423 TERMINATED

Evaluation of Pharmacokinetics , Safety, Tolerability and Pharmacodynamics of Biocon Insulin Tregopil

Biocon Limited

NCT04190693 COMPLETED

IMCY-T1D-002: Long-term Follow-up Study of T1D Patients Previously Treated With IMCY-0098 or Placebo

Imcyse SA

NCT03436498 COMPLETED

Safety Assessment of SAR341402 and NovoLog® Used in Continuous Subcutaneous Insulin Infusion for Type 1 Diabetes Mellitus Patients

Sanofi

NCT03916601 COMPLETED

Comparison of Exposure and Activity of SAR341402 Mix 70/30 to NovoLog Mix 70/30, NovoMix 30 and SAR341402 Rapid-acting Solution in Patients With Type 1 Diabetes Mellitus

Sanofi

NCT03310944 COMPLETED

Comparison of Sotagliflozin Prototype Tablets With Reference Tablet in Healthy Subjects

Sanofi

NCT02772679 COMPLETED

T1DM Immunotherapy Using Polyclonal Tregs + IL-2

Jeffrey Bluestone

NCT02384889 COMPLETED

DFMO in Children With Type 1 Diabetes

Indiana University

NCT04276207 COMPLETED

A Study of LY900014 Versus Insulin Lispro (Humalog) on High Blood Sugar in Participants With Type 1 Diabetes Who Use Insulin Pumps

Eli Lilly and Company

NCT04660305 COMPLETED

AT278 and NovoRapid® in Glucose Clamp Study

Arecor Limited

NCT04026750 TERMINATED

Insulin Tolerance Test Study in Patients With Type 1 Diabetes

High Point Clinical Trials Center

NCT03766854 COMPLETED

A Research Study of How Different Amounts of a New Medicine NNC0148-0287 C (Insulin 287) Works on the Blood Sugar of People Who Are Japanese With Type 1 Diabetes When Given Once a Week

Novo Nordisk A/S

NCT03965013 COMPLETED

A Study to Look at How Safe NNC0268-0965 is in Healthy People and People With Type 1 Diabetes

Novo Nordisk A/S

NCT04501107 COMPLETED

A Trial to Compare BioChaperone Insulin Lispro Formulations With US Approved Humalog® and With EU Approved Humalog® in Patients With Type 1 Diabetes Mellitus

Adocia

NCT04161976 COMPLETED

A Study of LY900027 Given by Insulin Pump to Participants With Type 1 Diabetes Mellitus

Eli Lilly and Company

NCT03465878 COMPLETED

A Study of LY900014 in Participants With Type 1 Diabetes Mellitus

Eli Lilly and Company

NCT02703324 COMPLETED

A Study of LY900014 Formulation in Participants With Type 1 Diabetes Mellitus Using Insulin Pumps

Eli Lilly and Company

NCT02703350 COMPLETED

A Study of LY900014 in Participants With Type 1 Diabetes on Insulin Injection Therapy

Eli Lilly and Company

NCT03341299 COMPLETED

A Comparative Study of LY900014 With Insulin Lispro (Humalog) in Participants With Type 1 Diabetes Mellitus

Eli Lilly and Company

NCT03407118 COMPLETED

A Study of LY900014 in Japanese Participants With Type 1 Diabetes Mellitus

Eli Lilly and Company

NCT03056456 COMPLETED

A Study of LY900014 Administered in Participants With Type 1 Diabetes Using an Insulin Pump

Eli Lilly and Company

NCT03166124 COMPLETED

A Study of LY900014 in Elderly and Younger Adult Participants With Type 1 Diabetes Mellitus

Eli Lilly and Company

NCT03449433 COMPLETED

A Meal Test Study of LY900014 in Participants With Type 1 Diabetes Mellitus

Eli Lilly and Company

NCT02352974 COMPLETED

GAD-Alum (Diamyd) Administered Into Lymph Nodes in Combination With Vitamin D in Type 1 Diabetes (DIAGNODE-1)

Johnny Ludvigsson

NCT03723759 COMPLETED

A Research Study Looking at How Faster Aspart Injected in Double Concentration Works in the Body of People With Type 1 Diabetes Mellitus

Novo Nordisk A/S

NCT04237129 COMPLETED

PK/PD Study of Gan & Lee Insulin Aspart Injection vs. US & EU NovoLog®/NovoRapid® in Healthy Males

Gan and Lee Pharmaceuticals, USA

NCT04236895 COMPLETED

PK/PD Biosimilarity Study of Gan & Lee Insulin Glargine Injection vs.US & EU Lantus® in Type 1 Diabetes Mellitus Patients

Gan and Lee Pharmaceuticals, USA

NCT03170544 COMPLETED

Single Ascending Dose Study of MK-1092 in Healthy Participants and in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-1092-001)

Merck Sharp & Dohme LLC

NCT02806973 COMPLETED

A Study of Single or Repeated Doses of Glucagon in Participants With Diabetes

Eli Lilly and Company

NCT03959514 COMPLETED

AT247, NovoRapid® and Fiasp® in Glucose Clamp Study

Arecor Limited

NCT03339453 COMPLETED

A Study of Nasal Glucagon in Participants With Type 1 Diabetes Mellitus

Eli Lilly and Company

NCT03272269 COMPLETED

Study of IMCY-0098 in Patients With Recent Onset Type 1 Diabetes

Imcyse SA

NCT02620332 COMPLETED

Multiple Islet Peptide Administration in Type 1 Diabetes (MultiPepT1De)

King's College London

NCT02971202 COMPLETED

Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2)

Vanderbilt University

NCT03407599 COMPLETED

A Trial Comparing the Pharmacokinetic Properties of Fast-acting Insulin Aspart Between Children, Adolescents and Adults With Type 1 Diabetes

Novo Nordisk A/S

NCT02536859 COMPLETED

Comparing Pharmacodynamic and Pharmacokinetic Properties of Insulin Degludec and Insulin Glargine 300 U/mL at Steady-state Conditions in Subjects With Type 1 Diabetes Mellitus

Novo Nordisk A/S

NCT03916640 COMPLETED

A Trial to Assess a Co-formulation of an Insulin Analog and Pramlintide in Subjects With Type 1 Diabetes Mellitus

Adocia

NCT03228004 COMPLETED

Type 1 Diabetes Data Acquisition and Transfer Adherence Study

University of Florida

NCT03095651 COMPLETED

Multiple Ascending Dose Study of MK-5160 in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-5160-002)

Merck Sharp & Dohme LLC

NCT03215498 COMPLETED

A Research Study of How Faster-acting Insulin Aspart Moves Into, Through, and Out of the Body and How it Works in the Body When Given Through an Insulin Pump to People With Type 1 Diabetes

Novo Nordisk A/S

NCT03512236 COMPLETED

A Trial to Investigate Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BioChaperone® Pramlintide Insulin in Patients With Type 1 Diabetes Mellitus

Adocia

NCT02582840 COMPLETED

The PK and PD of Dapagliflozin Therapy in Combination With Insulin in Japanese Subjects With T1DM

AstraZeneca

NCT02568280 COMPLETED

Investigating the Postprandial Glucose Metabolism After Treatment With Faster-acting Insulin Aspart in Subjects With Type 1 Diabetes

Novo Nordisk A/S

NCT02500979 COMPLETED

Effect of a Fixed Pramlintide: Insulin Dose Ratio on Postprandial Glucose in Type 1 Diabetes Mellitus

AstraZeneca

NCT03162926 COMPLETED

A Safety and Tolerability Study of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus

ViaCyte

NCT03444467 COMPLETED

First Research Study to Compare a Possible New Medicine NNC9204-1513 to the Medicine Glucagon, in Healthy People.

Novo Nordisk A/S

NCT02687256 COMPLETED

Evaluation of Extended Infusion Set Wear Using Medtronic Extended Wear Sof-set Infusion Set

Stanford University

NCT02938572 COMPLETED

A Randomised Proof-of-Principle Trial Investigating Pharmacodynamics, Pharmacokinetics, and Safety of NNC0143-0406 in Subjects With Type 1 Diabetes Mellitus

Novo Nordisk A/S

NCT02627287 COMPLETED

A Comparative Trial Focusing on Injections With the Medical Device DV3316 Pen-injector Versus FlexPen®

Novo Nordisk A/S

NCT03176524 COMPLETED

A Trial to Investigate the Safety and the Pharmacokinetic, Pharmacodynamic Characteristics of Two BioChaperone® Glucagon Formulations Compared to Marketed GlucaGen® in Subjects With T1DM

Adocia

NCT02612844 COMPLETED

A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneous NNC0143-0406 A 0.6 mmol/L in Subjects With Type 1 Diabetes

Novo Nordisk A/S

NCT02623478 WITHDRAWN

A Study of a Novel Insulin Lispro Formulation in Participants With Type 1 Diabetes Mellitus Using Insulin Pumps

Eli Lilly and Company

NCT02623452 WITHDRAWN

A Study of a New Type of Insulin in Participants With Type 1 Diabetes on Insulin Injection Therapy

Eli Lilly and Company

NCT02470637 COMPLETED

Single Dose Clamp Study to Evaluate Concentration-time Profile and Metabolic Activity of 3 Dose Levels of Afrezza and 3 Dose Levels of Insulin Lispro in Patients With Type 1 Diabetes Mellitus

Mannkind Corporation

NCT02485327 COMPLETED

PK and PD Within-Subject Variability of a Single Dose of Afrezza Inhaled Technosphere Insulin in Patients With Diabetes Mellitus Type 1 (T1DM)

Mannkind Corporation

NCT02715193 COMPLETED

Single-dose Study to Evaluate Safety, Tolerability, and Pharmacodynamics of REMD-477 in Subjects With Type 1 Diabetes Mellitus

REMD Biotherapeutics, Inc.

NCT02506647 COMPLETED

PK/PD Study of Gan & Lee's Insulin Glargine Injection in Comparison to Lantus in Type 1 Diabetes

Gan and Lee Pharmaceuticals, USA

NCT02849288 COMPLETED

Bigfoot Biomedical Clinical Research Center (CRC) Trial

Bigfoot Biomedical Inc.

NCT02562313 COMPLETED

A Trial Investigating the Continuous Subcutaneous Insulin Infusion of a Liquid Formulation of BioChaperone Insulin Lispro in Comparison to Humalog®

Adocia

NCT02635243 WITHDRAWN

A Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Single Dose of SAR438544 in Comparison to Glucagon in Type 1 Diabetes Mellitus Patients Under Induced Hypoglycemia

Sanofi

NCT02877771 COMPLETED

Tandem Predictive Low Glucose Suspend Inpatient Feasibility Study

Tandem Diabetes Care, Inc.

NCT02625636 COMPLETED

A Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Doses of SAR438544 in Comparison to Placebo and Glucagon in Healthy Subjects and Type 1 Diabetes Mellitus Patients

Sanofi

NCT02603510 COMPLETED

Assessment of the Safety of SAR342434 and Humalog® When Administered as Continuous Subcutaneous Insulin Infusion

Sanofi

NCT02579148 WITHDRAWN

Collagen Scaffolds Loaded With HUCMSCs for the Improvement of Erectile Function in Men With Diabetes

Leilei Zhu

NCT02528396 COMPLETED

To Investigate the Efficacy and Safety of Individualized Doses of BioChaperone Insulin Lispro in Comparison to Humalog® U-100 in Patients With Type 1 Diabetes Mellitus

Adocia

NCT02514954 COMPLETED

Postprandial Blood Glucose Control With BioChaperone® Combo and Insulin Lispro (Humalog®) Mix 25 in People With Type 1 Diabetes Mellitus

Adocia

NCT07427251 NOT YET RECRUITING

The Postprandial Hypo-Avoid Study

Steno Diabetes Center Copenhagen

NCT07159282 RECRUITING

A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers

Applied Biologics, LLC

NCT05757713 ACTIVE NOT RECRUITING

Teplizumab in Pediatric Stage 2 Type 1 Diabetes

Sanofi

NCT03570632 ACTIVE NOT RECRUITING

Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus

Maisa N. Feghali, MD

NCT05641753 RECRUITING

Cholesterol Lowering and Residual Risk in Diabetes, Type 1

NYU Langone Health

NCT07293715 NOT YET RECRUITING

Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D)

Ohio State University

NCT06452654 RECRUITING

Anti-viral Action Against Type 1 Diabetes Autoimmunity

Technical University of Munich

NCT06922656 NOT YET RECRUITING

Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration?

Dasman Diabetes Institute

NCT07086443 RECRUITING

Randomized Evaluation of Nonhealing Diabetic Foot Ulcers With Exclusive Wound Therapy

Sequence LifeScience, Inc.

NCT03878459 RECRUITING

Dapagliflozin Plus Pioglitazone in T1DM

The University of Texas Health Science Center at San Antonio

NCT05454891 RECRUITING

Extended Bolus for Meals in a Closed-loop System

University of California, San Francisco

NCT05585983 RECRUITING

INfluenza VaccInation To Mitigate typE 1 Diabetes

Aarhus University Hospital

NCT06600776 NOT YET RECRUITING

Mealtime or Post-meal Dosing of URLi in Medtronic 780G Hybrid Closed Loop System

Tel-Aviv Sourasky Medical Center

NCT06021145 RECRUITING

Effectiveness of Empagliflozin Added to Automated Insulin Delivery (AID) Systems in Adults With Type 1 Diabetes With Sub-optimal Glycemic Outcomes

McGill University Health Centre/Research Institute of the McGill University Health Centre

NCT06532682 ACTIVE NOT RECRUITING

Efficacy of Dapagliflozin in Early Diabetic Nephropathy in Type 1 Diabetes

The First Affiliated Hospital with Nanjing Medical University

NCT06326489 RECRUITING

Evaluating the Efficacy and Quality of Life Impact of Transitioning to Advanced Hybrid Closed-Loop Insulin Pump Therapy in Romanian Children With Type 1 Diabetes Mellitus

ELIAS Emergency University Hospital

NCT04698330 NOT YET RECRUITING

Effects Of Berberine Plus Inulin On Diabetes Care in Patients With LADA

Second Xiangya Hospital of Central South University

NCT03463564 RECRUITING

Insulin Pump vs Multiple Daily Injections of Insulin and Glyco-metabolic Control in Type 1 Diabetic Patients

University of Campania Luigi Vanvitelli

NCT04124302 COMPLETED

The Impact of Two Different Insulin Dose Calculation on Postprandial Glycemia After Mixed Meal.

Medical University of Warsaw

NCT06845891 COMPLETED

Clinical Study: Analysis of Glycemic Control and Satisfaction With a Connected Smart Cap in Patients With Type 1 Diabetes Mellitus

Fernando Sebastián Valles

NCT03608163 TERMINATED

Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF)

Albert Einstein College of Medicine

NCT05614089 COMPLETED

Human Versus Analogue Insulin for Youth With Type 1 Diabetes in Low-Resource Settings

Jing Luo

NCT06717191 COMPLETED

Impact of Introducing Basaglar Insulin to the Treatment Regimen of Youth With Diabetes in Pakistan

Life for a Child Program, Diabetes Australia

NCT05243628 COMPLETED

Afrezza With Basal Combination (ABC): Afrezza® Combined With AID Pump or Insulin Degludec in Adults With Type 1 Diabetes

Mannkind Corporation

NCT05541484 COMPLETED

Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency

Washington University School of Medicine

NCT04016662 COMPLETED

Automated Insulin Delivery in Elderly With Type 1 Diabetes (AIDE T1D)

Jaeb Center for Health Research

NCT05768191 COMPLETED

Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin

Université NAZI BONI

NCT02914886 COMPLETED

Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS)

Kinderkrankenhaus auf der Bult

NCT06624943 COMPLETED

Introducing Biosimilar Insulin Glargine to the Treatment Regimen of Children and Youth with Type 1 Diabetes in Mali

Life for a Child Program, Diabetes Australia

NCT05904743 COMPLETED

INHALE-3: Afrezza® Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 Diabetes

Mannkind Corporation

NCT04599075 COMPLETED

Intravenous Insulin vs Subcutaneous Insulin Infusion in Intrapartum Management of Type 1 Diabetes Mellitus

Gianna Wilkie

NCT04623086 COMPLETED

Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dose

University of Washington

NCT04019821 COMPLETED

Super-Bolus: Effects on Postprandial Glycemia After High Glycemic Index Meal

Medical University of Warsaw

NCT04481243 COMPLETED

A Study to Evaluate Pneumococcal Polysaccharide Vaccine Effectiveness in Children With Type 1 Diabetes

Mayo Clinic

NCT04849845 COMPLETED

Afrezza® Dosing Optimization Study

Mannkind Corporation

NCT03659799 COMPLETED

Comparison of FiAsp and Aspart During Postprandial Exercise in Adults With Type 1 Diabetes

Institut de Recherches Cliniques de Montreal

NCT05857085 COMPLETED

Novel Therapeutics and Endothelial Dysfunction in T1DM Patients

General and Teaching Hospital Celje

NCT05709938 COMPLETED

Comparison of Insulin Glargine and Regular Insulin Versus NPH and Regular Insulin in the Treatment of T1DM

King Edward Medical University

NCT04075513 COMPLETED

Comparison of Glucose Values and Variability Between TOUJEO and TRESIBA During Continuous Glucose Monitoring in Type 1 Diabetes Patients

Sanofi

NCT03668808 COMPLETED

Comparison of Insulin Degludec With Insulin Glargine U100 for Adults With Type 1 Diabetes Crossing Multiple Time Zones.

Sansum Diabetes Research Institute

NCT04567225 TERMINATED

Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management

The Cleveland Clinic

NCT04949867 COMPLETED

Dual-Hormone Closed-Loop Glucose Control in Adolescents With Type 1 Diabetes

Steno Diabetes Center Copenhagen

NCT04053712 COMPLETED

Dual-hormone Closed-loop Glucose Control in Type 1 Diabetes

Steno Diabetes Center Copenhagen

NCT03556631 COMPLETED

Effect of Live Combined Bifidobacterium and Lactobacillus on Glycemic Control and Other Outcomes in Type 1 Diabetes

Shenzhen People's Hospital

NCT03107208 COMPLETED

Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes

University of Colorado, Denver

NCT03312478 COMPLETED

Association of Type 1 Diabetes Mellitus in Offsprings With Positive Parental History of Diabetes

Sanofi

NCT03260868 TERMINATED

Evaluation of Virtual Versus Traditional Study Conducted in a Group Pilot Study in Adult Patients With Type 1 Diabetes Mellitus (eStudy)

Sanofi

NCT02688933 COMPLETED

A Study Comparing the Efficacy and Safety of the Morning Injection of Toujeo Versus Lantus in Patients With Type 1 Diabetes Mellitus

Sanofi

NCT04783376 COMPLETED

Effect of Splitting Mealtime Insulin Doses After Mixed Meals High in Fat and Protein

Sohag University

NCT03143816 COMPLETED

Study Comparing Prandial Insulin Aspart vs. Technosphere Insulin in Patients With Type 1 Diabetes on Multiple Daily Injections: Investigator-Initiated A Real-life Pilot Study-STAT Study

University of Colorado, Denver

NCT02502071 COMPLETED

Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes

University of Colorado, Denver

NCT03328845 COMPLETED

Impact on the Oxidative Stress of the Different Analogues of Insulin in People With Type 1 Diabetes. (Ineox Study)

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud

NCT04157738 COMPLETED

A Study of Rapid-Acting Mealtime Insulin in Children and Adolescents With Newly Diagnosed Type 1 Diabetes Mellitus

Emory University

NCT03987191 COMPLETED

Insulin Pump to Multiple Daily Injection Transition Clinical Trial

University of Colorado, Denver

NCT03554486 COMPLETED

Evaluation of Fiasp® (Fast Acting Insulin Aspart) in 670G Hybrid Closed-Loop Therapy

Stanford University

NCT02407899 COMPLETED

Protective Effects of Saxagliptin (And Vitamin D3) on β Cell Function in Adult-onset Latent Autoimmune Diabetes

Second Xiangya Hospital of Central South University

NCT04030091 COMPLETED

Pulsatile Insulin Infusion Therapy in Patients With Type 1 and Type 2 Diabetes Mellitus

Sciema UG

NCT04193566 COMPLETED

Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes

Steno Diabetes Center Copenhagen

NCT02680054 TERMINATED

Additional Insulin for Fat and Protein in Children With Diabetes Study

Oxford University Hospitals NHS Trust

NCT02192450 COMPLETED

Insulin Degludec and Symptomatic Nocturnal Hypoglycaemia

Nordsjaellands Hospital

NCT02765347 COMPLETED

The Effects of Metformin on Glycemic Control and Insulin Sensitivity in Adolescents With T1DM

Third Affiliated Hospital, Sun Yat-Sen University

NCT02516150 COMPLETED

Effect of Ethanol Intoxication on the Anti-Hypoglycemic Action of Glucagon

Massachusetts General Hospital

NCT02881060 COMPLETED

The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes

Hvidovre University Hospital

NCT02578498 COMPLETED

Glucagon Efficiency After High and Low Carbohydrate Diet

Hvidovre University Hospital

Data: ClinicalTrials.gov