TheraRadar

Pharma Intelligence, Simplified

Data updated: Mar 10, 2026

CRINONE

PROGESTERONE
Approved 1997-05-13
2
Indications
--
Phase 3 Trials
1
Priority Reviews
28
Years on Market

Details

Status
Prescription
First Approved
1997-05-13
Routes
VAGINAL
Dosage Forms
GEL

Companies

Active Ingredient: PROGESTERONE

CRINONE Approval History

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What CRINONE Treats

3 indications

CRINONE is approved for 3 conditions since its original approval in 1997. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Infertility
  • Progesterone Deficiency
  • Secondary Amenorrhea
Source: FDA Label
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Active Pipeline

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Ongoing clinical trials by development phase

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

CRINONE FDA Label Details

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Indications & Usage

FDA Label (PDF)

Assisted Reproductive Technology Crinone 8% is indicated for progesterone supplementation or replacement as part of an Assisted Reproductive Technology ("ART") treatment for infertile women with progesterone deficiency. Secondary Amenorrhea Crinone 4% is indicated for the treatment of secondary amenorrhea. Crinone 8% is indicated for use in women who have failed to respond to treatment with Crinone 4%.

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.