HEMICLOR

DistributionApproximately 75 percent of the drug is bound to plasma proteins, 58 percent of the drug being bound to albumin. This is caused by an increased affinity of the drug to erythrocyte carbonic anhydrase. Data are not available regarding concentration of the drug in body fluids, degree of uptake by a particular organ or in the fetus, or passage across the blood-brain barrier.

EliminationThe mean plasma half-life of chlorthalidone is about 40 to 60 hours.

MetabolismData are not availabl...

The efficacy of a once daily dose of chlorthalidone 12.5 mg for the treatment of hypertension in adults is derived from a published randomized, double-blind, multinational, study (Sica et al, 2012) Sica D, Bakris GL, White WB, et al. J.Clin. Hypertens. 2012;14(5):284-292 along with other supportive studies from the published literature.

The following adverse reactions are described in more detail elsewhere in the label; Acute Kidney Injury [see Warnings and Precautions (5.1) ] Electrolyte Abnormalities [see Warnings and Precautions (5.2) ] Metabolic Disturbances [see Warnings and Precautions (5.3) ] The following adverse reactions have been observed with chlorthalidone, but there is not enough systematic collection of data to support an estimate of their frequency. Gastrointestinal System Reactions: anorexia, gastric irritation...

Chlorthalidone is contraindicated in patients with anuria, or hypersensitivity to chlorthalidone or other sulfonamide-derived drugs. Anuria ( 4 ). Hypersensitivity to chlorthalidone or other sulfonamide-derived drugs ( 4 ).

Acute Kidney Injury: Patients with pre-existing kidney disease may be at higher risk. ( 5.1 ). Electrolyte Abnormalities: Monitor serum electrolytes periodically ( 5.2 ). Metabolic Disturbances ( 5.3 ). Systemic Lupus Erythematosus ( 5.4 ). 5.1 Acute Kidney Injury Monitor kidney function periodically. Diuretics can cause hypovolemia which may precipitate acute kidney injury. Patients with chronic kidney disease, heart failure, or volume depletion may be at particular risk of developing acute ren...

7 DRUG INTERACTIONS Effect of chlorthalidone on other drugs Insulin requirements in diabetic patients may be increased, decreased or unchanged. Higher dosage of oral hypoglycemic agents may be required. Chlorthalidone may increase the responsiveness to tubocurarine. Chlorthalidone may decrease arterial responsiveness to norepinephrine. This diminution is not sufficient to preclude effectiveness of...