MEMANTINE HYDROCHLORIDE AND DONEPEZIL HYDROCHLORIDE

Memantine and donepezil hydrochlorides extended-release capsules Memantine and donepezil hydrochlorides extended-release capsules was bioequivalent to co-administration of individual memantine hydrochloride extended-release and donepezil hydrochloride. Exposure (AUC and C max ) of memantine and donepezil following memantine and donepezil hydrochlorides extended-release capsules administration in the fed or fasted state was similar. Further, exposure of memantine and donepezil following memantine...

The effectiveness of memantine and donepezil hydrochlorides extended-release capsules as a treatment for patients with moderate to severe Alzheimer's disease was established by demonstrating the bioequivalence of memantine and donepezil hydrochlorides extended-release capsules with co-administered memantine hydrochloride extended-release and donepezil hydrochloride [see Clinical Pharmacology ( 12.3 )] . Memantine Hydrochloride The effectiveness of memantine hydrochloride extended-release as a treatment for patients with moderate to severe Alzheimer's disease when coadministered with acetylchol...

The following serious adverse reactions are discussed below and elsewhere in the labeling. Cardiovascular Conditions [see Warnings and Precautions ( 5.2 )] Peptic Ulcer Disease and Gastrointestinal Bleeding [see Warnings and Precautions ( 5.3 )] Nausea and Vomiting [see Warnings and Precautions ( 5.4 )] Genitourinary Conditions [see Warnings and Precautions ( 5.5 )] Seizures [see Warnings and Precautions ( 5.6 )] Pulmonary Conditions [see Warnings and Precautions ( 5.7 )] The most common adverse...

Memantine and donepezil hydrochlorides extended-release capsules is contraindicated in patients with known hypersensitivity to memantine hydrochloride, donepezil hydrochloride, piperidine derivatives, or to any excipients used in the formulation. Memantine and donepezil hydrochlorides extended-release capsules is contraindicated in patients with known hypersensitivity to memantine hydrochloride, d...

Memantine and donepezil hydrochlorides extended-release capsules is likely to exaggerate succinylcholine-type muscle relaxation during anesthesia. ( 5.1 ) Memantine and donepezil hydrochlorides extended-release capsules may have vagotonic effects on the sinoatrial and atrioventricular nodes manifesting as bradycardia or heart block. ( 5.2 ) Monitor patients for symptoms of active or occult gastrointestinal bleeding, especially those at increased risk for developing ulcers. ( 5.3 ) Memantine and ...

7 DRUG INTERACTIONS Combined use with NMDA antagonists: use with caution. ( 7.2 ) Memantine and donepezil hydrochlorides extended-release capsules may interfere with anticholinergic medications. ( 7.4 ) Concomitant administration of succinylcholine, similar neuromuscular blocking agents, or cholinergic agonists may lead to synergistic effect. ( 7.5 ) 7.1 Use of Memantine with Drugs That Make the U...