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Data updated: Mar 10, 2026

PENICILLIN G PROCAINE

PENICILLIN G PROCAINE
Immunology Approved 1948-04-26
2
Indications
--
Phase 3 Trials
77
Years on Market

Details

Status
Prescription
First Approved
1948-04-26
Routes
INJECTION
Dosage Forms
INJECTABLE

PENICILLIN G PROCAINE Approval History

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What PENICILLIN G PROCAINE Treats

6 indications

PENICILLIN G PROCAINE is approved for 6 conditions since its original approval in 1948. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Upper Respiratory Tract Infection
  • Scarlet Fever
  • Erysipelas
  • Skin and Soft Tissue Infection
  • Pneumonia
  • Otitis Media
Source: FDA Label

PENICILLIN G PROCAINE Boxed Warning

NOT FOR INTRAVENOUS USE. DO NOT INJECT INTRAVENOUSLY OR ADMIX WITH OTHER INTRAVENOUS SOLUTIONS. THERE HAVE BEEN REPORTS OF INADVERTENT INTRAVENOUS ADMINISTRATION OF PENICILLIN G BENZATHINE WHICH HAS BEEN ASSOCIATED WITH CARDIORESPIRATORY ARREST AND DEATH. Prior to administration of this drug, carefully read the WARNINGS , ADVERSE REACTIONS , and DOSAGE AND ADMINISTRATION sections of the labeling....

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Key Completed Trials

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

PENICILLIN G PROCAINE FDA Label Details

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Indications & Usage

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bicillin C-R and other antibacterial drugs, Bicillin C-R should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. This drug is indicated in the treatment of moderately severe infections due to ...

โš ๏ธ BOXED WARNING

WARNING: NOT FOR INTRAVENOUS USE. DO NOT INJECT INTRAVENOUSLY OR ADMIX WITH OTHER INTRAVENOUS SOLUTIONS. THERE HAVE BEEN REPORTS OF INADVERTENT INTRAVENOUS ADMINISTRATION OF PENICILLIN G BENZATHINE WHICH HAS BEEN ASSOCIATED WITH CARDIORESPIRATORY ARREST AND DEATH. Prior to administration of this dru...

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.