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Data updated: Mar 10, 2026

RISPERDAL CONSTA

RISPERIDONE
Neurology Approved 2003-10-29
3
Indications
--
Phase 3 Trials
22
Years on Market

Details

Status
Prescription
First Approved
2003-10-29
Routes
INTRAMUSCULAR
Dosage Forms
POWDER

Companies

Active Ingredient: RISPERIDONE

RISPERDAL CONSTA Approval History

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What RISPERDAL CONSTA Treats

2 indications

RISPERDAL CONSTA is approved for 2 conditions since its original approval in 2003. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Schizophrenia
  • Bipolar Disorder
Source: FDA Label

RISPERDAL CONSTA Boxed Warning

INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. RISPERDAL CONSTA is not approved for the treatment of patients with dementia-related psychosis. [see Warnings and Precautions (5.1) ] WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS See full prescribing information for complete boxed warning. Elderly patients with dementia-rela...

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Trial Timeline

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

RISPERDAL CONSTA FDA Label Details

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Indications & Usage

FDA Label (PDF)

RISPERDAL CONSTA is an atypical antipsychotic indicated: for the treatment of schizophrenia. as monotherapy or as adjunctive therapy to lithium or valproate for the maintenance treatment of Bipolar I Disorder. 1.1 Schizophrenia RISPERDAL CONSTA (risperidone) is indicated for the treatment of schizophrenia [see Clinical Studies ]. 1.2 Bipolar Disorder RISPERDAL CONSTA is indicated as monotherapy or as adjunctive therapy to lithium or valproate for the maintenance treatment of Bipolar I Disorder [see Clinical Studies ] .

โš ๏ธ BOXED WARNING

WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. RISPERDAL CONSTA is not approved for the treatment of patients with dementia-related psychosis. [see W...

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.