TheraRadar

Pharma Intelligence, Simplified

Data updated: Mar 10, 2026

ZYCLARA

IMIQUIMOD Interferon Inducers
Dermatology Approved 2010-03-25
3
Indications
--
Phase 3 Trials
15
Years on Market

Details

Status
Prescription
First Approved
2010-03-25
Routes
TOPICAL
Dosage Forms
CREAM

Companies

Active Ingredient: IMIQUIMOD

ZYCLARA Approval History

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What ZYCLARA Treats

3 indications

ZYCLARA is approved for 3 conditions since its original approval in 2010. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Actinic Keratosis
  • Genital Warts
  • Perianal Warts
Source: FDA Label
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Active Pipeline

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Ongoing clinical trials by development phase

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Key Completed Trials

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Completed studies with published results, ranked by significance

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

ZYCLARA FDA Label Details

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Indications & Usage

FDA Label (PDF)

• ZYCLARA 2.5% and 3.75% is indicated for the topical treatment of clinically typical, visible, or palpable actinic keratoses (AK) of the face or balding scalp in immunocompetent adults. • ZYCLARA, 3.75% is indicated for the topical treatment of external genital and perianal warts (EGW) in immunocompetent patients 12 years of age or older. 1.1 Actinic Keratosis ZYCLARA, 2.5% and 3.75% are indicated for the topical treatment of clinically typical, visible or palpable actinic keratoses (AK) of the face or balding scalp in immunocompetent adults. 1.2 External Genital Warts ZYCLARA, 3.75% is indic...

ZYCLARA Patents & Exclusivity

Latest Patent: Apr 2030

Patents (30 active)

US11202752 Expires Apr 30, 2030
US11850245 Expires Apr 30, 2030
US10918635 Expires Apr 30, 2030
US8236816 Expires Dec 11, 2029
US8222270 Expires Dec 11, 2029
US8299109 Expires Dec 11, 2029
US11318130 Expires Dec 11, 2029
US10238644 Expires Dec 11, 2029
US10238645 Expires Aug 18, 2029
US8598196 Expires Aug 18, 2029
+ 20 more patents
Source: FDA Orange Book

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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.