Drug Targets
Biological targets being pursued by FDA-approved drugs
943
Unique Targets
59
Major Targets (10+ drugs)
2465
Company-Target Pairs
1198
Indications Covered
Most Targeted (10+ approved drugs)
DNA
36 drugs Oncology
EPIC PHARMA LLC, Fresenius Kabi, Hikma +26 more
COX-2
32 drugs Pain, CNS
Teva, NOVITIUM PHARMA, Lupin +24 more
Glucocorticoid receptor
30 drugs Respiratory, Immunology
Teva, ETON, PARATEK PHARMS +18 more
COX-1
28 drugs Pain, CNS
NOVITIUM PHARMA, Lupin, AFT PHARMS US +20 more
AT1 receptor
26 drugs Cardiovascular
Lupin, COSETTE, ALEMBIC +14 more
Estrogen Receptor
26 drugs Oncology
Bayer, JIANGSU HANSOH PHARM, MAYNE PHARMA +19 more
Beta-2 adrenergic receptor
25 drugs Cardiovascular, Respiratory
IPCA LABS LTD, RISING, Teva +14 more
Mu-opioid receptor
24 drugs Pain
Fresenius Kabi, BDSI, ALKEM LABS LTD +14 more
HER2
22 drugs Oncology
Viatris, CELLTRION INC, DAIICHI SANKYO +13 more
ACE
20 drugs Cardiovascular
SENORES PHARMS, JUBILANT CADISTA, Aurobindo Pharma +9 more
D2 receptor
20 drugs CNS
Teva, UNICHEM, AbbVie +13 more
Insulin receptor
20 drugs Metabolic
Eli Lilly, Novo Nordisk, SANOFI-AVENTIS U.S. LLC +4 more
TNF-alpha
19 drugs Immunology
IMMUNEX, Johnson & Johnson, CELLTRION INC +12 more
Factor Xa
19 drugs Cardiovascular
Pfizer, ALEMBIC, Bristol-Myers Squibb +7 more
beta-adrenergic receptor
18 drugs Cardiovascular, Ophthalmology
GLENMARK PHARMS LTD, ADAMIS PHARMS CORP, Fresenius Kabi +12 more
HMG-CoA reductase
17 drugs Cardiovascular, Metabolic
SENORES PHARMS, LANNETT CO INC, Viatris +14 more
GABA A receptor
17 drugs CNS, Pain
NEURELIS INC, BRECKENRIDGE, AMNEAL +12 more
EGFR
17 drugs Oncology
Cipla, Takeda, MSN +11 more
RANKL
17 drugs Oncology
Novartis, BIOCON BIOLOGICS INC, SAMSUNG BIOEPIS CO LTD +6 more
Beta-1 adrenergic receptor
16 drugs Cardiovascular, Ophthalmology
IPCA LABS LTD, RISING, AMNEAL +9 more
alpha-adrenergic receptor
16 drugs ADAMIS PHARMS CORP, Fresenius Kabi, PH HEALTH +10 more
DPP-4
16 drugs Metabolic
Takeda, Boehringer Ingelheim, Dr. Reddy's +3 more
H+/K+ ATPase
15 drugs Dr. Reddy's, CHARTWELL RX, ZYDUS PHARMS +9 more
FKBP-12
15 drugs Oncology, Immunology
ACCORD HLTHCARE, ASTELLAS, AADI SUB +8 more
CD20
15 drugs Oncology, CNS
Novartis, CELLTRION INC, Roche +5 more
SGLT2
15 drugs Metabolic, Cardiovascular
Boehringer Ingelheim, AstraZeneca, Merck +3 more
Sodium channels
14 drugs CNS
Viatris, ACCORD HLTHCARE, Hikma +8 more
Antithrombin III
14 drugs Cardiovascular
Pfizer, Fresenius Kabi, Dr. Reddy's +3 more
KIT
14 drugs Oncology
Viatris, DECIPHERA PHARMS, EISAI INC +10 more
RET
14 drugs Oncology
Viatris, EISAI INC, EXELIXIS +10 more
Tubulin
13 drugs Oncology
EISAI INC, ASTELLAS, Roche +9 more
JAK2
13 drugs Immunology
PF PRISM CV, AbbVie, INCYTE CORP +8 more
Thyroid hormone receptor
13 drugs Oncology
PIRAMAL CRITICAL, AbbVie, Viatris +7 more
Calcium channel
13 drugs Cardiovascular
AZURITY, BIONPHARMA, STRIDES PHARMA INTL +7 more
Norepinephrine transporter
12 drugs CNS, Cardiovascular
GLENMARK PHARMS LTD, AbbVie, AXSOME +8 more
Factor IIa
12 drugs Cardiovascular
Pfizer, Fresenius Kabi, Baxter +1 more
JAK1
12 drugs Immunology
PF PRISM CV, AbbVie, INCYTE CORP +6 more
GnRH receptor
12 drugs Oncology
INVAGEN PHARMS, TOLMAR, AZURITY +5 more
D2
12 drugs CNS
VANDA PHARMS INC, Johnson & Johnson, STERISCIENCE +6 more
alpha-2 adrenergic receptor
11 drugs CNS, Ophthalmology
Novartis, GALDERMA LABS LP, Merck +6 more
5-HT2A receptor
11 drugs CNS
Teva, UNICHEM, AbbVie +6 more
VEGF-A
11 drugs Metabolic, Oncology
Roche, Novartis, Regeneron +4 more
GLP-1R
11 drugs Metabolic
Eli Lilly, ORBICULAR, Novo Nordisk +2 more
PDE5
11 drugs Cardiovascular
Aurobindo Pharma, ZYDUS PHARMS, Viatris +7 more
ROS1
11 drugs Oncology
Roche, Takeda, Novartis +8 more
Glucocorticoid Receptor
11 drugs Rare Disease, Respiratory
UPSHER SMITH LABS, GSK, PADAGIS ISRAEL +7 more
IL-23
11 drugs Immunology
SUN PHARMA GLOBAL, ALVOTECH USA INC, Johnson & Johnson +7 more
PD-1
11 drugs Oncology
BEIGENE, Bristol-Myers Squibb, GSK +5 more
Hyaluronan
11 drugs CNS, Oncology
Roche, Bristol-Myers Squibb, ARGENX BV +2 more
CD3
11 drugs Metabolic, Oncology
PROVENTION BIO INC, Roche, GENMAB US, INC. +5 more
Carbonic anhydrase
10 drugs CNS, Metabolic
ACCORD HLTHCARE, AZURITY, Johnson & Johnson +6 more
opioid receptor
10 drugs DIFGEN PHARMS, Fresenius Kabi, RISING
RNA
10 drugs Oncology
EPIC PHARMA LLC, Fresenius Kabi, PENN LIFE +6 more
Calcineurin
10 drugs Immunology, Ophthalmology
ACCORD HLTHCARE, ASTELLAS, Sun Pharma +6 more
VEGFR-1
10 drugs Oncology
Viatris, NOVUGEN, EXELIXIS +7 more
VEGFR-2
10 drugs Oncology
Viatris, NOVUGEN, EXELIXIS +7 more
VEGFR-3
10 drugs Oncology
Viatris, NOVUGEN, EXELIXIS +7 more
Phospholipase A2
10 drugs Pain, Immunology
Cipla, GALDERMA LABS, ALIMERA SCIENCES INC +5 more
FLT3
10 drugs Oncology
NATCO PHARMA, SOBI, BLUEPRINT MEDICINES +6 more
Other Notable Targets (3-9 drugs)
H1 receptor 9
Muscarinic receptor 9
Respiratory
SERT 9
CNS
Cyclooxygenase 9
Immunology
5-HT1B 9
CNS
5-HT1D 9
CNS
mTOR 9
Oncology
CSF receptor 9
GH receptor 9
MET 9
Oncology
beta 2-adrenergic receptor 8
Respiratory
Dihydrofolate reductase 8
Oncology
Sodium Channels 8
5-HT1A receptor 8
CNS
CYP3A 8
Infectious Disease
P2Y12 8
Cardiovascular
Kappa-opioid receptor 8
Pain
TRKB 8
Oncology
VEGFR2 8
Oncology
Muscarinic acetylcholine receptor 8
CNS
Calcium channels 7
Cardiovascular
cholinergic receptor 7
CNS
Ribonucleotide reductase 7
Oncology
Mu opioid receptor 7
Pain
Topoisomerase II 7
Oncology
NET 7
CNS
BRAF 7
Oncology
FLT-3 7
Oncology
NK1R 7
Androgen Receptor 7
Oncology
ALK 7
Oncology
Opioid receptor 7
CNS
IL-12 7
Immunology
FGFR1 7
Oncology
C5 7
Dopamine transporter 7
CNS
Potassium channels 6
CNS
GABA-A receptor 6
CNS
Somatostatin receptor 6
Beta-adrenoreceptor 6
Cardiovascular
SV2A 6
CNS
Cholinesterase 6
CNS
IL-6R 6
Immunology
MAO-B 6
CNS
TYK2 6
Immunology
Topoisomerase I 6
Oncology
MEK1 6
Oncology
M3 6
Respiratory
VMAT2 6
CNS
Thrombin 6
Cardiovascular
PDE4 6
Respiratory
RARα 6
Immunology
RARβ 6
Immunology
Voltage-gated sodium channels 6
TRKA 6
Oncology
TRKC 6
Oncology
5-HT3 receptor 6
CNS
FGFR2 6
Oncology
VEGFR1 6
Oncology
VEGFR3 6
Oncology
+ 177 more targets