TheraRadar

Pharma Intelligence, Simplified

Patent Cliff Analysis with Medicare Spending: 2026-2030

95 drugs losing exclusivity ($41.6B in Medicare Part D spending)

Medicare Part D as a Proxy for Revenue Impact

This analysis uses Medicare Part D spending as an approximate way to visualize patent cliff impact. It's not total drug revenue, but serves as a useful proxy for understanding the magnitude of losses:

  • Why it works as a proxy: Medicare Part D (~30% of US drug spending) shows the same decline patterns as total revenue after generic entry. When Lyrica lost exclusivity, Part D spending dropped 97% — and total revenue followed the same trajectory.
  • Public and verifiable: CMS publishes exact dollar amounts per drug annually. Company 10-K/10-Q filings also report revenue by drug — we could extend this analysis with that data.
  • Conservative estimate: For drugs with elderly patient populations (cardiovascular, diabetes, oncology), Medicare is often the largest single payer — so Part D may actually represent 40-50% of US sales.

For precise total revenue: Company SEC 10-K filings report product-level sales. This dashboard is an academic exercise using publicly available data to illustrate patent cliff dynamics.

Data through 2024 — Pre-cliff baseline for most drugs

CMS Medicare Part D data is available through 2024. For drugs with patents expiring in 2026+, the charts show pre-cliff spending — the actual decline will appear in future data releases after generic entry.

Drugs already showing decline (e.g., Spiriva Handihaler down 62%) have either: (1) generics entered via settlement, or (2) patients switching to newer formulations.

Understanding Drug Protection: Patents vs Exclusivity

Drugs are protected by two separate legal mechanisms. A generic can only launch when BOTH allow it.

Patents (USPTO)

  • What: Intellectual property right from Patent Office
  • Duration: 20 years from filing date
  • Granted by: USPTO (not FDA)
  • Can be challenged: Yes - Paragraph IV litigation
Types for drugs:
  • Compound/substance - the molecule itself
    Example: Humira's adalimumab molecule patent expired 2023, enabling biosimilars
  • Formulation - how it's made/delivered
    Example: Lantus pen device patents extended protection beyond insulin patent
  • Method of use - specific indications
    Example: Ozempic has compound patent expiring 2026, but another compound patent (with PTE) extends to 2031, plus use patents to 2038

Exclusivity (FDA)

  • What: Marketing protection as regulatory incentive
  • Duration: Varies by type (see below)
  • Granted by: FDA (not Patent Office)
  • Cannot be challenged: Automatic, runs its course
Code Type Duration Example
NCE New Chemical Entity 5 years Ozempic (2022-2027)
NEW New Indication 3 years Keytruda new cancer types
ODE Orphan Drug 7 years Revlimid for myeloma
PED Pediatric +6 months Added to existing patents
How this dashboard works: We use the LATEST of (patent expiry OR exclusivity expiry) as the effective protection end date. Generic/biosimilar entry is blocked until this date passes. Exclusivity shows "N/A" for older drugs where it has already expired.

Historical Evidence: What Actually Happens

Unlike analyst forecasts, this data shows actual Medicare Part D spending before and after patent expiry.

Note: Medicare Part D spending is not total drug revenue. It represents only one payer segment (~30% of US drug market). Total revenue includes commercial insurance, Medicare Part B, Medicaid, cash pay, and international sales. The same analysis can be performed with total revenue data from company SEC filings.

How we calculated these numbers (click to expand)
Data source: CMS Medicare Part D Spending by Drug (2019-2024)
Calculation: Decline % = (Peak Spending - Latest Spending) / Peak Spending × 100
Example - Lyrica (patent expired Dec 2018):
  • Peak: $2.03B (2019)
  • Latest: $0.06B (2024)
  • Decline: ($2.03B - $0.06B) / $2.03B = 97%
Key patterns observed:
  • Small molecules: 85-97% decline within 2-5 years
  • Complex generics: 60-70% decline (harder to copy)
  • Biologics: 2-40% decline in first years (biosimilar pathway slower)
How predictions are made: We apply historical patterns by drug type. Small molecule expiring in 2027? Expect 80-90% decline by 2029. Biologic? Expect 30-50% over 3-4 years.
Lyrica
Pregabalin
-97%
Expiry: 2018
Peak: $2.0B (2019)
Now: $62M (2024)
2.0B
19
147M
20
91M
21
79M
22
72M
23
62M
24
Small molecule, rapid generic entry
Latuda
Lurasidone HCl
-97%
Expiry: 2023
Peak: $1.4B (2022)
Now: $40M (2024)
1.2B
19
1.3B
20
1.4B
21
1.4B
22
455M
23
40M
24
Antipsychotic
Zytiga
Abiraterone Acetate
-97%
Expiry: 2022
Peak: $760M (2019)
Now: $22M (2024)
760M
19
347M
20
128M
21
54M
22
33M
23
22M
24
Prostate cancer
Tecfidera
Dimethyl Fumarate
-86%
Expiry: 2020
Peak: $1.1B (2019)
Now: $163M (2024)
1.1B
19
1.1B
20
569M
21
343M
22
235M
23
163M
24
MS drug, multiple generics
Copaxone
Glatiramer Acetate
-69%
Expiry: 2018
Peak: $837M (2019)
Now: $257M (2024)
837M
19
714M
20
556M
21
457M
22
369M
23
257M
24
MS drug
Revlimid
Lenalidomide
-30%
Expiry: 2022
Peak: $5.9B (2022)
Now: $4.2B (2024)
4.7B
19
5.4B
20
5.9B
21
5.9B
22
3.9B
23
4.2B
24
Oncology, settlement

2026 Patent Cliff 16 drugs | $4.6B Part D spending

#1 SPIRIVA (TIOTROPIUM BROMIDE) Generic exists Declining
Boehringer Ingelheim Respiratory
Patent Expiry
Jul 2026
Peak: $924M (2023)
Current: $877M (2024)
Decline: -5%
Medicare Part D Spending by Year
$671M
2019
$805M
2020
$857M
2021
$892M
2022
$924M
2023
$877M
2024
Peak
Latest
#2 PROMACTA KIT (ELTROMBOPAG OLAMINE) Generic exists
Novartis Immunology
Patent Expiry
Jan 2026
Peak: $672M (2024)
Current: $672M (2024)
Medicare Part D Spending by Year
$304M
2019
$342M
2020
$389M
2021
$455M
2022
$558M
2023
$672M
2024
Peak
Latest
#3 SPRYCEL (DASATINIB) Generic exists
Bristol-Myers Squibb Oncology
Patent Expiry
Sep 2026
Peak: $518M (2024)
Current: $518M (2024)
Medicare Part D Spending by Year
$379M
2019
$419M
2020
$450M
2021
$500M
2022
$510M
2023
$518M
2024
Peak
Latest
#4 PROTONIX (PANTOPRAZOLE SODIUM) Generic exists
WYETH PHARMS Gastroenterology
Patent Expiry
Dec 2026
Peak: $384M (2023)
Current: $384M (2023)
Medicare Part D Spending by Year
$251M
2019
$316M
2020
$375M
2021
$364M
2022
$384M
2023
Peak
Latest
#5 GATTEX KIT (TEDUGLUTIDE) Generic exists
TAKEDA PHARMS USA Gastroenterology
Patent Expiry
May 2026
Peak: $358M (2024)
Current: $358M (2024)
Medicare Part D Spending by Year
$277M
2019
$297M
2020
$294M
2021
$297M
2022
$330M
2023
$358M
2024
Peak
Latest
#6 VYNDAQEL (TAFAMIDIS MEGLUMINE)
FOLDRX PHARMS
Patent Expiry
Dec 2026
Peak: $304M (2024)
Current: $304M (2024)
Medicare Part D Spending by Year
$130M
2019
$200M
2020
$127M
2021
$109M
2022
$118M
2023
$304M
2024
Peak
Latest
#7 ZETIA (EZETIMIBE) Generic exists Declining
ORGANON Cardiovascular
Patent Expiry
Apr 2026
Peak: $332M (2022)
Current: $209M (2024)
Decline: -37%
Medicare Part D Spending by Year
$258M
2019
$281M
2020
$286M
2021
$332M
2022
$290M
2023
$209M
2024
Peak
Latest
#8 DUEXIS (FAMOTIDINE)
HORIZON
Patent Expiry
Jul 2026
Peak: $203M (2023)
Current: $203M (2023)
Medicare Part D Spending by Year
$75M
2019
$143M
2020
$201M
2021
$181M
2022
$203M
2023
Peak
Latest
#9 FLOVENT HFA (FLUTICASONE PROPIONATE) Generic exists
GLAXO GRP LTD Respiratory
Patent Expiry
Aug 2026
Peak: $206M (2020)
Current: $202M (2023)
Decline: -2%
Medicare Part D Spending by Year
$181M
2019
$206M
2020
$197M
2021
$202M
2022
$202M
2023
Peak
Latest
#10 ARNUITY ELLIPTA (FLUTICASONE FUROATE)
GSK Respiratory
Patent Expiry
Feb 2026
Peak: $200M (2024)
Current: $200M (2024)
Medicare Part D Spending by Year
$66M
2019
$81M
2020
$85M
2021
$89M
2022
$98M
2023
$200M
2024
Peak
Latest
#11 NUEDEXTA (DEXTROMETHORPHAN HYDROBROMIDE)
AVANIR PHARMS Rare Disease
Patent Expiry
Aug 2026
Peak: $235M (2019)
Current: $173M (2024)
Decline: -26%
Medicare Part D Spending by Year
$235M
2019
$213M
2020
$188M
2021
$183M
2022
$181M
2023
$173M
2024
Peak
Latest
#12 VIMPAT (LACOSAMIDE) Generic exists
UCB INC Neurology
Patent Expiry
Apr 2026
Peak: $161M (2023)
Current: $161M (2023)
Medicare Part D Spending by Year
$128M
2022
$161M
2023
Peak
Latest
#13 LEXAPRO (ESCITALOPRAM OXALATE) Generic exists Declining
AbbVie
Patent Expiry
May 2026
Peak: $172M (2023)
Current: $141M (2024)
Decline: -18%
Medicare Part D Spending by Year
$138M
2019
$137M
2020
$151M
2021
$165M
2022
$172M
2023
$141M
2024
Peak
Latest
#14 JUVISYNC (SIMVASTATIN) Generic exists Declining
MERCK SHARP DOHME
Patent Expiry
Oct 2026
Peak: $207M (2019)
Current: $126M (2024)
Decline: -39%
Medicare Part D Spending by Year
$207M
2019
$186M
2020
$164M
2021
$154M
2022
$173M
2023
$126M
2024
Peak
Latest
#15 ANDROGEL (TESTOSTERONE) Generic exists Declining
BESINS HLTHCARE Oncology
Patent Expiry
Oct 2026
Peak: $138M (2020)
Current: $93M (2024)
Decline: -33%
Medicare Part D Spending by Year
$118M
2019
$138M
2020
$125M
2021
$117M
2022
$117M
2023
$93M
2024
Peak
Latest
#16 SENSIPAR (CINACALCET HYDROCHLORIDE) Declining
Amgen
Patent Expiry
Sep 2026
Peak: $150M (2019)
Current: $1M (2024)
Decline: -99%
Medicare Part D Spending by Year
$150M
2019
$24M
2020
$7M
2021
$4M
2022
$3M
2023
$1M
2024
Peak
Latest

2027 Patent Cliff 14 drugs | $7.7B Part D spending

#1 JANUVIA (SITAGLIPTIN PHOSPHATE) Declining
MERCK SHARP DOHME Metabolic
Patent Expiry
May 2027
Peak: $4.1B (2022)
Current: $3.8B (2024)
Decline: -7%
Medicare Part D Spending by Year
$3.5B
2019
$3.9B
2020
$4.1B
2021
$4.1B
2022
$4.1B
2023
$3.8B
2024
Peak
Latest
#2 LUMIGAN (BIMATOPROST) Generic exists Declining
AbbVie
Patent Expiry
Jun 2027
Peak: $701M (2022)
Current: $647M (2024)
Decline: -8%
Medicare Part D Spending by Year
$594M
2019
$634M
2020
$669M
2021
$701M
2022
$697M
2023
$647M
2024
Peak
Latest
#3 ABILIFY (ARIPIPRAZOLE) Generic exists
OTSUKA
Patent Expiry
Mar 2027
Peak: $644M (2024)
Current: $644M (2024)
Medicare Part D Spending by Year
$422M
2019
$460M
2020
$499M
2021
$564M
2022
$637M
2023
$644M
2024
Peak
Latest
#4 DYLOJECT (DICLOFENAC SODIUM) Generic exists
JAVELIN PHARMS INC
Patent Expiry
Mar 2027
Peak: $396M (2023)
Current: $396M (2023)
Medicare Part D Spending by Year
$252M
2019
$275M
2020
$250M
2021
$304M
2022
$396M
2023
Peak
Latest
#5 PROTONIX IV (PANTOPRAZOLE SODIUM) Generic exists
WYETH PHARMS Gastroenterology
Patent Expiry
Aug 2027
Peak: $384M (2023)
Current: $384M (2023)
Medicare Part D Spending by Year
$251M
2019
$316M
2020
$375M
2021
$364M
2022
$384M
2023
Peak
Latest
#6 INCRUSE ELLIPTA (UMECLIDINIUM BROMIDE) Declining
GLAXO GRP ENGLAND Respiratory
Patent Expiry
Dec 2027
Peak: $605M (2020)
Current: $376M (2024)
Decline: -38%
Medicare Part D Spending by Year
$551M
2019
$605M
2020
$556M
2021
$499M
2022
$456M
2023
$376M
2024
Peak
Latest
#7 JANUMET XR (METFORMIN HYDROCHLORIDE) Declining
MSD SUB MERCK Metabolic
Patent Expiry
May 2027
Peak: $397M (2022)
Current: $358M (2024)
Decline: -10%
Medicare Part D Spending by Year
$323M
2019
$367M
2020
$389M
2021
$397M
2022
$392M
2023
$358M
2024
Peak
Latest
#8 ROWASA (MESALAMINE) Generic exists
MYLAN SPECIALITY LP Immunology
Patent Expiry
Jul 2027
Peak: $284M (2021)
Current: $272M (2023)
Decline: -4%
Medicare Part D Spending by Year
$244M
2019
$272M
2020
$284M
2021
$271M
2022
$272M
2023
Peak
Latest
#9 SFROWASA (MESALAMINE) Generic exists
MYLAN SPECIALITY LP Immunology
Patent Expiry
Jul 2027
Peak: $284M (2021)
Current: $272M (2023)
Decline: -4%
Medicare Part D Spending by Year
$244M
2019
$272M
2020
$284M
2021
$271M
2022
$272M
2023
Peak
Latest
#10 LYRICA CR (PREGABALIN) Generic exists Declining
UPJOHN Neurology
Patent Expiry
May 2027
Peak: $357M (2020)
Current: $199M (2024)
Decline: -44%
Medicare Part D Spending by Year
$185M
2019
$357M
2020
$308M
2021
$276M
2022
$288M
2023
$199M
2024
Peak
Latest
#11 ELEPSIA XR (LEVETIRACETAM) Generic exists
TRIPOINT
Patent Expiry
Oct 2027
Peak: $174M (2022)
Current: $171M (2023)
Decline: -2%
Medicare Part D Spending by Year
$136M
2019
$148M
2020
$173M
2021
$174M
2022
$171M
2023
Peak
Latest
#12 AXIRON (TESTOSTERONE) Generic exists Declining
Eli Lilly
Patent Expiry
Sep 2027
Peak: $138M (2020)
Current: $93M (2024)
Decline: -33%
Medicare Part D Spending by Year
$118M
2019
$138M
2020
$125M
2021
$117M
2022
$117M
2023
$93M
2024
Peak
Latest
#13 AMITIZA (LUBIPROSTONE) Generic exists Declining
SUCAMPO PHARMA LLC Oncology
Patent Expiry
Oct 2027
Peak: $115M (2022)
Current: $56M (2024)
Decline: -51%
Medicare Part D Spending by Year
$79M
2021
$115M
2022
$94M
2023
$56M
2024
Peak
Latest
#14 AZILECT (RASAGILINE MESYLATE) Generic exists Declining
TEVA Neurology
Patent Expiry
Aug 2027
Peak: $105M (2019)
Current: $28M (2024)
Decline: -73%
Medicare Part D Spending by Year
$105M
2019
$93M
2020
$66M
2021
$57M
2022
$44M
2023
$28M
2024
Peak
Latest

2028 Patent Cliff 21 drugs | $8.4B Part D spending

#1 REVLIMID (LENALIDOMIDE) Generic exists
Bristol-Myers Squibb Oncology
Patent Expiry
Mar 2028
Peak: $5.9B (2022)
Current: $4.2B (2024)
Decline: -30%
Medicare Part D Spending by Year
$4.7B
2019
$5.4B
2020
$5.9B
2021
$5.9B
2022
$3.9B
2023
$4.2B
2024
Peak
Latest
#2 PROMACTA (ELTROMBOPAG OLAMINE)
Novartis
Patent Expiry
Jan 2028
Peak: $672M (2024)
Current: $672M (2024)
Medicare Part D Spending by Year
$304M
2019
$342M
2020
$389M
2021
$455M
2022
$558M
2023
$672M
2024
Peak
Latest
#3 XELJANZ (TOFACITINIB CITRATE) Generic exists
PF PRISM CV Immunology
Patent Expiry
Aug 2028
Peak: $626M (2021)
Current: $590M (2024)
Decline: -6%
Medicare Part D Spending by Year
$474M
2019
$575M
2020
$626M
2021
$591M
2022
$586M
2023
$590M
2024
Peak
Latest
#4 STIOLTO RESPIMAT (OLODATEROL HYDROCHLORIDE)
Boehringer Ingelheim Respiratory
Patent Expiry
Sep 2028
Peak: $449M (2024)
Current: $449M (2024)
Medicare Part D Spending by Year
$221M
2019
$265M
2020
$346M
2021
$387M
2022
$432M
2023
$449M
2024
Peak
Latest
#5 BYDUREON (EXENATIDE SYNTHETIC)
ASTRAZENECA AB
Patent Expiry
Sep 2028
Peak: $284M (2023)
Current: $284M (2023)
Medicare Part D Spending by Year
$284M
2023
Peak
Latest
#6 RYTARY (CARBIDOPA) Generic exists
IMPAX Neurology
Patent Expiry
Dec 2028
Peak: $272M (2024)
Current: $272M (2024)
Medicare Part D Spending by Year
$134M
2019
$165M
2020
$192M
2021
$228M
2022
$267M
2023
$272M
2024
Peak
Latest
#7 CANASA (MESALAMINE) Generic exists
AbbVie
Patent Expiry
Jun 2028
Peak: $284M (2021)
Current: $272M (2023)
Decline: -4%
Medicare Part D Spending by Year
$244M
2019
$272M
2020
$284M
2021
$271M
2022
$272M
2023
Peak
Latest
#8 FLONASE SENSIMIST ALLERGY RELIEF (FLUTICASONE FUROATE) Generic exists
HALEON US HOLDINGS
Patent Expiry
Oct 2028
Peak: $200M (2024)
Current: $200M (2024)
Medicare Part D Spending by Year
$66M
2019
$81M
2020
$85M
2021
$89M
2022
$98M
2023
$200M
2024
Peak
Latest
#9 KEPPRA XR (LEVETIRACETAM) Generic exists
UCB INC Neurology
Patent Expiry
Sep 2028
Peak: $174M (2022)
Current: $171M (2023)
Decline: -2%
Medicare Part D Spending by Year
$136M
2019
$148M
2020
$173M
2021
$174M
2022
$171M
2023
Peak
Latest
#10 BONDLIDO (LIDOCAINE) Generic exists Declining
MEDRX USA Dermatology
Patent Expiry
Sep 2028
Peak: $179M (2023)
Current: $160M (2024)
Decline: -11%
Medicare Part D Spending by Year
$133M
2019
$139M
2020
$150M
2021
$167M
2022
$179M
2023
$160M
2024
Peak
Latest
#11 DOPTELET (AVATROMBOPAG MALEATE)
AKARX INC Immunology
Patent Expiry
Jul 2028
Peak: $160M (2024)
Current: $160M (2024)
Medicare Part D Spending by Year
$8M
2019
$19M
2020
$35M
2021
$61M
2022
$96M
2023
$160M
2024
Peak
Latest
#12 DOPTELET SPRINKLE (AVATROMBOPAG MALEATE) Generic exists
AKARX INC Immunology
Patent Expiry
Jul 2028
Peak: $160M (2024)
Current: $160M (2024)
Medicare Part D Spending by Year
$8M
2019
$19M
2020
$35M
2021
$61M
2022
$96M
2023
$160M
2024
Peak
Latest
#13 FLO-PRED (PREDNISOLONE ACETATE) Generic exists Declining
SUN PHARMA CANADA
Patent Expiry
Oct 2028
Peak: $164M (2023)
Current: $155M (2024)
Decline: -5%
Medicare Part D Spending by Year
$139M
2019
$126M
2020
$158M
2021
$164M
2022
$164M
2023
$155M
2024
Peak
Latest
#14 AFINITOR (EVEROLIMUS) Generic exists Declining
Novartis Oncology
Patent Expiry
Jun 2028
Peak: $241M (2023)
Current: $143M (2024)
Decline: -40%
Medicare Part D Spending by Year
$548,085.01
2019
$118M
2020
$162M
2021
$225M
2022
$241M
2023
$143M
2024
Peak
Latest
#15 OLUX E (CLOBETASOL PROPIONATE) Generic exists Declining
PHARMOBEDIENT
Patent Expiry
Nov 2028
Peak: $152M (2023)
Current: $127M (2024)
Decline: -17%
Medicare Part D Spending by Year
$144M
2019
$115M
2020
$118M
2021
$134M
2022
$152M
2023
$127M
2024
Peak
Latest
#16 ERIVEDGE (VISMODEGIB)
Roche Oncology
Patent Expiry
Dec 2028
Peak: $140M (2021)
Current: $117M (2024)
Decline: -17%
Medicare Part D Spending by Year
$123M
2019
$138M
2020
$140M
2021
$125M
2022
$103M
2023
$117M
2024
Peak
Latest
#17 PROGRAF (TACROLIMUS) Generic exists
ASTELLAS Immunology
Patent Expiry
Jul 2028
Peak: $107M (2022)
Current: $103M (2023)
Decline: -4%
Medicare Part D Spending by Year
$75M
2019
$105M
2020
$102M
2021
$107M
2022
$103M
2023
Peak
Latest
#18 ENVARSUS XR (TACROLIMUS) Generic exists
VELOXIS PHARMS INC Immunology
Patent Expiry
Aug 2028
Peak: $107M (2022)
Current: $103M (2023)
Decline: -4%
Medicare Part D Spending by Year
$75M
2019
$105M
2020
$102M
2021
$107M
2022
$103M
2023
Peak
Latest
#19 MORPHABOND ER (MORPHINE SULFATE) Generic exists Declining
OHEMO LIFE
Patent Expiry
Aug 2028
Peak: $103M (2019)
Current: $58M (2024)
Decline: -44%
Medicare Part D Spending by Year
$103M
2019
$91M
2020
$91M
2021
$83M
2022
$66M
2023
$58M
2024
Peak
Latest
#20 ONGLYZA (SAXAGLIPTIN HYDROCHLORIDE) Declining
ASTRAZENECA AB
Patent Expiry
Nov 2028
Peak: $195M (2019)
Current: $3M (2024)
Decline: -98%
Medicare Part D Spending by Year
$195M
2019
$137M
2020
$120M
2021
$91M
2022
$58M
2023
$3M
2024
Peak
Latest
#21 BYDUREON PEN (EXENATIDE SYNTHETIC) Declining
ASTRAZENECA AB
Patent Expiry
Sep 2028
Peak: $274M (2019)
Current: $60,841.05 (2023)
Decline: -100%
Medicare Part D Spending by Year
$274M
2019
$242M
2020
$61M
2021
$606,900.63
2022
$60,841.05
2023
Peak
Latest

2029 Patent Cliff 22 drugs | $12.6B Part D spending

#1 OFEV (NINTEDANIB ESYLATE)
Boehringer Ingelheim Respiratory
Patent Expiry
Dec 2029
Peak: $2.1B (2024)
Current: $2.1B (2024)
Medicare Part D Spending by Year
$790M
2019
$1.2B
2020
$1.5B
2021
$1.8B
2022
$1.8B
2023
$2.1B
2024
Peak
Latest
#2 JAKAFI (RUXOLITINIB PHOSPHATE) Generic exists
INCYTE CORP Respiratory
Patent Expiry
Mar 2029
Peak: $2.1B (2024)
Current: $2.1B (2024)
Medicare Part D Spending by Year
$1.1B
2019
$1.3B
2020
$1.5B
2021
$1.8B
2022
$1.9B
2023
$2.1B
2024
Peak
Latest
#3 VERKAZIA (CYCLOSPORINE) Generic exists Declining
HARROW EYE Immunology
Patent Expiry
Jun 2029
Peak: $1.6B (2022)
Current: $1.3B (2024)
Decline: -22%
Medicare Part D Spending by Year
$1.4B
2019
$1.5B
2020
$1.6B
2021
$1.6B
2022
$1.5B
2023
$1.3B
2024
Peak
Latest
#4 OPSUMIT (MACITENTAN)
ACTELION Cardiovascular
Patent Expiry
Oct 2029
Peak: $1.2B (2024)
Current: $1.2B (2024)
Medicare Part D Spending by Year
$542M
2019
$769M
2020
$863M
2021
$817M
2022
$1.0B
2023
$1.2B
2024
Peak
Latest
#5 XIFAXAN (RIFAXIMIN)
SALIX PHARMS Infectious Disease
Patent Expiry
Oct 2029
Peak: $1.2B (2024)
Current: $1.2B (2024)
Medicare Part D Spending by Year
$762M
2019
$845M
2020
$890M
2021
$970M
2022
$1.1B
2023
$1.2B
2024
Peak
Latest
#6 VRAYLAR (CARIPRAZINE HYDROCHLORIDE)
AbbVie Neurology
Patent Expiry
Sep 2029
Peak: $1.1B (2024)
Current: $1.1B (2024)
Medicare Part D Spending by Year
$305M
2019
$487M
2020
$583M
2021
$709M
2022
$936M
2023
$1.1B
2024
Peak
Latest
#7 REMODULIN (TREPROSTINIL) Generic exists
UNITED THERAP
Patent Expiry
Mar 2029
Peak: $729M (2024)
Current: $729M (2024)
Medicare Part D Spending by Year
$78M
2022
$437M
2023
$729M
2024
Peak
Latest
#8 JANUMET (METFORMIN HYDROCHLORIDE) Declining
MSD SUB MERCK Metabolic
Patent Expiry
Jan 2029
Peak: $816M (2022)
Current: $709M (2024)
Decline: -13%
Medicare Part D Spending by Year
$743M
2019
$792M
2020
$815M
2021
$816M
2022
$799M
2023
$709M
2024
Peak
Latest
#9 PRESTALIA (AMLODIPINE BESYLATE) Generic exists Declining
ADHERA
Patent Expiry
Oct 2029
Peak: $407M (2023)
Current: $316M (2024)
Decline: -22%
Medicare Part D Spending by Year
$308M
2019
$307M
2020
$310M
2021
$343M
2022
$407M
2023
$316M
2024
Peak
Latest
#10 NINLARO (IXAZOMIB CITRATE) Declining
TAKEDA PHARMS USA Oncology
Patent Expiry
Nov 2029
Peak: $379M (2020)
Current: $273M (2024)
Decline: -28%
Medicare Part D Spending by Year
$315M
2019
$379M
2020
$366M
2021
$341M
2022
$312M
2023
$273M
2024
Peak
Latest
#11 INVOKANA (CANAGLIFLOZIN) Declining
JANSSEN PHARMS Cardiovascular
Patent Expiry
Aug 2029
Peak: $571M (2020)
Current: $272M (2024)
Decline: -52%
Medicare Part D Spending by Year
$486M
2019
$571M
2020
$456M
2021
$427M
2022
$357M
2023
$272M
2024
Peak
Latest
#12 INVOKAMET XR (CANAGLIFLOZIN) Generic exists Declining
JANSSEN PHARMS Cardiovascular
Patent Expiry
Aug 2029
Peak: $571M (2020)
Current: $272M (2024)
Decline: -52%
Medicare Part D Spending by Year
$486M
2019
$571M
2020
$456M
2021
$427M
2022
$357M
2023
$272M
2024
Peak
Latest
#13 DEXILANT SOLUTAB (DEXLANSOPRAZOLE) Generic exists Declining
TAKEDA PHARMS USA
Patent Expiry
Mar 2029
Peak: $315M (2023)
Current: $221M (2024)
Decline: -30%
Medicare Part D Spending by Year
$168M
2022
$315M
2023
$221M
2024
Peak
Latest
#14 XELPROS (LATANOPROST) Generic exists Declining
SUN PHARM
Patent Expiry
Sep 2029
Peak: $218M (2022)
Current: $130M (2024)
Decline: -40%
Medicare Part D Spending by Year
$175M
2019
$196M
2020
$217M
2021
$218M
2022
$216M
2023
$130M
2024
Peak
Latest
#15 VYZULTA (LATANOPROSTENE BUNOD)
BAUSCH AND LOMB Cardiovascular
Patent Expiry
Feb 2029
Peak: $128M (2024)
Current: $128M (2024)
Medicare Part D Spending by Year
$24M
2019
$38M
2020
$58M
2021
$87M
2022
$117M
2023
$128M
2024
Peak
Latest
#16 RUKOBIA (FOSTEMSAVIR TROMETHAMINE)
VIIV HLTHCARE Infectious Disease
Patent Expiry
Jul 2029
Peak: $115M (2024)
Current: $115M (2024)
Medicare Part D Spending by Year
$7M
2020
$39M
2021
$64M
2022
$91M
2023
$115M
2024
Peak
Latest
#17 NAMZARIC (DONEPEZIL HYDROCHLORIDE) Declining
AbbVie Neurology
Patent Expiry
Dec 2029
Peak: $241M (2019)
Current: $90M (2024)
Decline: -63%
Medicare Part D Spending by Year
$241M
2019
$205M
2020
$168M
2021
$134M
2022
$108M
2023
$90M
2024
Peak
Latest
#18 COLCRYS (COLCHICINE) Generic exists Declining
AR HOLDING CO INC
Patent Expiry
Feb 2029
Peak: $145M (2019)
Current: $76M (2024)
Decline: -48%
Medicare Part D Spending by Year
$145M
2019
$133M
2020
$135M
2021
$117M
2022
$99M
2023
$76M
2024
Peak
Latest
#19 IZBA (TRAVOPROST) Generic exists Declining
Novartis
Patent Expiry
Oct 2029
Peak: $154M (2020)
Current: $75M (2024)
Decline: -51%
Medicare Part D Spending by Year
$864,119.2
2019
$154M
2020
$144M
2021
$129M
2022
$114M
2023
$75M
2024
Peak
Latest
#20 TRAVATAN Z (TRAVOPROST) Generic exists Declining
Novartis Cardiovascular
Patent Expiry
Oct 2029
Peak: $154M (2020)
Current: $75M (2024)
Decline: -51%
Medicare Part D Spending by Year
$864,119.2
2019
$154M
2020
$144M
2021
$129M
2022
$114M
2023
$75M
2024
Peak
Latest
#21 LAMICTAL XR (LAMOTRIGINE) Generic exists Declining
GLAXOSMITHKLINE LLC Neurology
Patent Expiry
Jan 2029
Peak: $112M (2023)
Current: $60M (2024)
Decline: -46%
Medicare Part D Spending by Year
$102M
2019
$103M
2020
$104M
2021
$109M
2022
$112M
2023
$60M
2024
Peak
Latest
#22 EMBEDA (MORPHINE SULFATE) Generic exists Declining
ALPHARMA PHARMS
Patent Expiry
Nov 2029
Peak: $103M (2019)
Current: $58M (2024)
Decline: -44%
Medicare Part D Spending by Year
$103M
2019
$91M
2020
$91M
2021
$83M
2022
$66M
2023
$58M
2024
Peak
Latest

2030 Patent Cliff 22 drugs | $8.4B Part D spending

#1 MYRBETRIQ (MIRABEGRON) Generic exists Declining
APGDI
Patent Expiry
Mar 2030
Peak: $2.5B (2023)
Current: $2.3B (2024)
Decline: -8%
Medicare Part D Spending by Year
$1.4B
2019
$1.7B
2020
$2.0B
2021
$2.3B
2022
$2.5B
2023
$2.3B
2024
Peak
Latest
#2 ANORO ELLIPTA (UMECLIDINIUM BROMIDE) Generic exists Declining
GSK Respiratory
Patent Expiry
Nov 2030
Peak: $1.0B (2020)
Current: $819M (2024)
Decline: -18%
Medicare Part D Spending by Year
$826M
2019
$1.0B
2020
$912M
2021
$867M
2022
$873M
2023
$819M
2024
Peak
Latest
#3 TIVICAY PD (DOLUTEGRAVIR SODIUM) Generic exists
VIIV HLTHCARE Infectious Disease
Patent Expiry
Jun 2030
Peak: $657M (2023)
Current: $629M (2024)
Decline: -4%
Medicare Part D Spending by Year
$644M
2019
$656M
2020
$649M
2021
$650M
2022
$657M
2023
$629M
2024
Peak
Latest
#4 TIVICAY (DOLUTEGRAVIR SODIUM)
VIIV HLTHCARE
Patent Expiry
Jun 2030
Peak: $657M (2023)
Current: $629M (2024)
Decline: -4%
Medicare Part D Spending by Year
$644M
2019
$656M
2020
$649M
2021
$650M
2022
$657M
2023
$629M
2024
Peak
Latest
#5 TRIUMEQ (ABACAVIR SULFATE) Generic exists Declining
VIIV HLTHCARE Infectious Disease
Patent Expiry
Jun 2030
Peak: $746M (2019)
Current: $566M (2024)
Decline: -24%
Medicare Part D Spending by Year
$746M
2019
$739M
2020
$698M
2021
$670M
2022
$632M
2023
$566M
2024
Peak
Latest
#6 AIRSUPRA (ALBUTEROL SULFATE) Generic exists Declining
AstraZeneca Respiratory
Patent Expiry
May 2030
Peak: $710M (2022)
Current: $553M (2024)
Decline: -22%
Medicare Part D Spending by Year
$177M
2019
$474M
2020
$635M
2021
$710M
2022
$584M
2023
$553M
2024
Peak
Latest
#7 PENNSAID (DICLOFENAC SODIUM) Generic exists
NUVO PHARMS INC
Patent Expiry
Aug 2030
Peak: $396M (2023)
Current: $396M (2023)
Medicare Part D Spending by Year
$252M
2019
$275M
2020
$250M
2021
$304M
2022
$396M
2023
Peak
Latest
#8 OXYCONTIN (OXYCODONE HYDROCHLORIDE) Declining
PURDUE PHARMA LP
Patent Expiry
Mar 2030
Peak: $623M (2019)
Current: $338M (2024)
Decline: -46%
Medicare Part D Spending by Year
$623M
2019
$559M
2020
$453M
2021
$416M
2022
$391M
2023
$338M
2024
Peak
Latest
#9 INVOKAMET (CANAGLIFLOZIN) Generic exists Declining
JANSSEN PHARMS Cardiovascular
Patent Expiry
Jul 2030
Peak: $571M (2020)
Current: $272M (2024)
Decline: -52%
Medicare Part D Spending by Year
$486M
2019
$571M
2020
$456M
2021
$427M
2022
$357M
2023
$272M
2024
Peak
Latest
#10 APRISO (MESALAMINE) Generic exists
SALIX Immunology
Patent Expiry
Apr 2030
Peak: $284M (2021)
Current: $272M (2023)
Decline: -4%
Medicare Part D Spending by Year
$244M
2019
$272M
2020
$284M
2021
$271M
2022
$272M
2023
Peak
Latest
#11 MINIVELLE (ESTRADIOL) Generic exists
NOVEN
Patent Expiry
Jul 2030
Peak: $239M (2023)
Current: $239M (2023)
Medicare Part D Spending by Year
$176M
2019
$183M
2020
$218M
2021
$220M
2022
$239M
2023
Peak
Latest
#12 BRIVIACT (BRIVARACETAM)
UCB INC Neurology
Patent Expiry
Apr 2030
Peak: $220M (2024)
Current: $220M (2024)
Medicare Part D Spending by Year
$220M
2024
Peak
Latest
#13 RENVELA (SEVELAMER CARBONATE) Generic exists Declining
Sanofi
Patent Expiry
Dec 2030
Peak: $320M (2019)
Current: $142M (2024)
Decline: -56%
Medicare Part D Spending by Year
$320M
2019
$218M
2020
$217M
2021
$229M
2022
$189M
2023
$142M
2024
Peak
Latest
#14 AURYXIA (FERRIC CITRATE) Declining
KERYX BIOPHARMS Hematology
Patent Expiry
Jul 2030
Peak: $199M (2021)
Current: $132M (2024)
Decline: -34%
Medicare Part D Spending by Year
$145M
2019
$196M
2020
$199M
2021
$195M
2022
$183M
2023
$132M
2024
Peak
Latest
#15 FLOLIPID (SIMVASTATIN) Generic exists Declining
SALERNO PHARMS Cardiovascular
Patent Expiry
Feb 2030
Peak: $207M (2019)
Current: $126M (2024)
Decline: -39%
Medicare Part D Spending by Year
$207M
2019
$186M
2020
$164M
2021
$154M
2022
$173M
2023
$126M
2024
Peak
Latest
#16 CUBICIN (DAPTOMYCIN) Generic exists Declining
CUBIST PHARMS LLC
Patent Expiry
Nov 2030
Peak: $167M (2020)
Current: $121M (2024)
Decline: -28%
Medicare Part D Spending by Year
$152M
2019
$167M
2020
$148M
2021
$137M
2022
$133M
2023
$121M
2024
Peak
Latest
#17 CUBICIN RF (DAPTOMYCIN) Generic exists Declining
CUBIST PHARMS LLC
Patent Expiry
Nov 2030
Peak: $167M (2020)
Current: $121M (2024)
Decline: -28%
Medicare Part D Spending by Year
$152M
2019
$167M
2020
$148M
2021
$137M
2022
$133M
2023
$121M
2024
Peak
Latest
#18 VONJO (PACRITINIB CITRATE)
SOBI Respiratory
Patent Expiry
Mar 2030
Peak: $111M (2024)
Current: $111M (2024)
Medicare Part D Spending by Year
$38M
2022
$93M
2023
$111M
2024
Peak
Latest
#19 SAMSCA (TOLVAPTAN) Generic exists
OTSUKA Cardiovascular
Patent Expiry
Apr 2030
Peak: $103M (2024)
Current: $103M (2024)
Medicare Part D Spending by Year
$25M
2019
$37M
2020
$46M
2021
$61M
2022
$76M
2023
$103M
2024
Peak
Latest
#20 JYNARQUE (TOLVAPTAN) Generic exists
OTSUKA
Patent Expiry
Apr 2030
Peak: $103M (2024)
Current: $103M (2024)
Medicare Part D Spending by Year
$25M
2019
$37M
2020
$46M
2021
$61M
2022
$76M
2023
$103M
2024
Peak
Latest
#21 SUBSYS (FENTANYL) Generic exists Declining
BTCP PHARMA
Patent Expiry
Apr 2030
Peak: $155M (2019)
Current: $92M (2024)
Decline: -40%
Medicare Part D Spending by Year
$155M
2019
$129M
2020
$120M
2021
$111M
2022
$98M
2023
$92M
2024
Peak
Latest
#22 SUBOXONE (BUPRENORPHINE HYDROCHLORIDE) Declining
INDIVIOR
Patent Expiry
Mar 2030
Peak: $188M (2019)
Current: $71M (2024)
Decline: -63%
Medicare Part D Spending by Year
$188M
2019
$140M
2020
$120M
2021
$105M
2022
$95M
2023
$71M
2024
Peak
Latest

Important: Patent Litigation Settlements

The dates shown are from the FDA Orange Book and reflect official patent/exclusivity expiration dates. However, many blockbuster drugs have litigation settlement agreements that allow generic entry before patent expiry.

Known examples:
  • Januvia - Orange Book shows May 2027, but Merck settled with 25+ companies for May 2026 generic entry [source]
  • Revlimid - Orange Book shows Mar 2028, but BMS settled for Jan 2026 unlimited generic entry [source]

Settlement terms are often confidential and not available in structured databases. For investment decisions, verify actual generic launch dates with SEC filings ( 8-K filings ) and news sources.

Methodology & Limitations

Data Sources

  • Patent/Exclusivity: FDA Orange Book (drug-patents.json)
  • Spending: CMS Medicare Part D (2023) (Part D only, not total revenue)

How Expiry Dates Are Calculated

Uses LATEST of (patent expiry, exclusivity expiry) as effective protection end date. This is when generic/biosimilar competition can legally begin.

Important Limitations

  • Medicare Part D spending is NOT total drug revenue - it represents ~30% of US drug market. Total revenue includes commercial insurance, Medicare Part B, Medicaid, cash pay, and international sales.
  • Drugs may have multiple patents - we use the LATEST expiry date
  • Method-of-use patents may be designed around by generics with carved-out labels
  • Patent litigation and settlements can delay or accelerate generic entry
  • Biologics follow biosimilar pathway (typically slower erosion than small molecules)
  • Does not account for 180-day exclusivity for first generic filer

Our Approach: Unlike analyst forecasts that rely on proprietary models, our predictions are grounded in actual historical Medicare spending data. We show you what really happened to drugs that lost exclusivity, then apply those patterns to predict future outcomes. This is public data you can verify.