HYDROCHLOROTHIAZIDE
Details
- Status
- Prescription
- First Approved
- 1973-01-12
- Routes
- ORAL
- Dosage Forms
- CAPSULE, TABLET, SOLUTION
Companies
HYDROCHLOROTHIAZIDE Approval History
What HYDROCHLOROTHIAZIDE Treats
8 indicationsHYDROCHLOROTHIAZIDE is approved for 8 conditions since its original approval in 1973. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Edema
- Congestive Heart Failure
- Hepatic Cirrhosis
- Renal Dysfunction
- Nephrotic Syndrome
- Acute Glomerulonephritis
- Chronic Renal Failure
- Hypertension
HYDROCHLOROTHIAZIDE Target & Pathway
ProTarget
An enzyme that converts angiotensin I to angiotensin II, a potent vasoconstrictor. ACE inhibitors lower blood pressure and protect the heart and kidneys. They are foundational treatments for hypertension and heart failure.
HYDROCHLOROTHIAZIDE Competitors
Pro10 other drugs also target ANGIOTENSIN-CONVERTING. Compare mechanisms, indications, and trial activity.
Competitors share the same molecular target (ANGIOTENSIN-CONVERTING). Earlier expiry dates signal biosimilar/generic opportunities.
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Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
HYDROCHLOROTHIAZIDE FDA Label Details
ProIndications & Usage
FDA Label (PDF)Hydrochlorothiazide tablets are indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Hydrochlorothiazide has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. Hydrochlorothiazide tablets are indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. Use in Pregnancy Routine us...
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.