Competitive Density

Active trials by therapeutic area and indication

Density Legend (based on active Phase 3 trials & sponsor count)

Hot (crowded)

Warm (competitive)

Cool (moderate)

Cold (sparse)

Oncology

21938 active trials

Solid Tumor (Advanced)

Ph3: 328 • Ph2: 1738 • 15 sponsors

Breast Cancer

Ph3: 293 • Ph2: 850 • 15 sponsors

NSCLC

Ph3: 267 • Ph2: 869 • 15 sponsors

Colorectal Cancer

Ph3: 174 • Ph2: 709 • 15 sponsors

Non-Hodgkin Lymphoma

Ph3: 163 • Ph2: 930 • 15 sponsors

Prostate Cancer

Ph3: 153 • Ph2: 534 • 15 sponsors

ALL

Ph3: 150 • Ph2: 613 • 15 sponsors

Multiple Myeloma

Ph3: 103 • Ph2: 388 • 15 sponsors

Hepatocellular Carcinoma

Ph3: 91 • Ph2: 369 • 15 sponsors

Bladder Cancer

Ph3: 85 • Ph2: 268 • 15 sponsors

Gastric Cancer

Ph3: 80 • Ph2: 315 • 15 sponsors

Esophageal Cancer

Ph3: 79 • Ph2: 292 • 15 sponsors

Ovarian Cancer

Ph3: 74 • Ph2: 287 • 15 sponsors

Lung Cancer (General)

Ph3: 73 • Ph2: 333 • 15 sponsors

AML

Ph3: 71 • Ph2: 351 • 15 sponsors

Pancreatic Cancer

Ph3: 69 • Ph2: 410 • 15 sponsors

Melanoma

Ph3: 59 • Ph2: 303 • 15 sponsors

Hematologic Malignancies

Ph3: 55 • Ph2: 309 • 15 sponsors

SCLC

Ph3: 52 • Ph2: 192 • 15 sponsors

Head and Neck Cancer

Ph3: 50 • Ph2: 335 • 15 sponsors

Neuroendocrine Tumors

Ph3: 45 • Ph2: 116 • 15 sponsors

Cervical Cancer

Ph3: 44 • Ph2: 177 • 15 sponsors

Sarcoma

Ph3: 40 • Ph2: 324 • 15 sponsors

Brain Tumor

Ph3: 38 • Ph2: 169 • 15 sponsors

Triple Negative Breast Cancer

Ph3: 38 • Ph2: 199 • 15 sponsors

CLL

Ph3: 35 • Ph2: 134 • 15 sponsors

Renal Cell Carcinoma

Ph3: 33 • Ph2: 169 • 15 sponsors

Squamous Cell Carcinoma

Ph3: 33 • Ph2: 224 • 15 sponsors

MDS

Ph3: 32 • Ph2: 220 • 15 sponsors

Endometrial Cancer

Ph3: 32 • Ph2: 137 • 15 sponsors

Glioblastoma

Ph3: 28 • Ph2: 198 • 15 sponsors

Cholangiocarcinoma

Ph3: 28 • Ph2: 192 • 15 sponsors

HER2+ Breast Cancer

Ph3: 24 • Ph2: 64 • 15 sponsors

Hodgkin Lymphoma

Ph3: 18 • Ph2: 158 • 15 sponsors

Thyroid Cancer

Ph3: 18 • Ph2: 58 • 15 sponsors

Myelofibrosis

Ph3: 16 • Ph2: 66 • 15 sponsors

HER2- Breast Cancer

Ph3: 14 • Ph2: 74 • 15 sponsors

CML

Ph3: 9 • Ph2: 75 • 15 sponsors

Merkel Cell Carcinoma

Ph3: 4 • Ph2: 36 • 15 sponsors

Mesothelioma

Ph3: 3 • Ph2: 52 • 15 sponsors

Immunology

8806 active trials

Rheumatoid Arthritis

Ph3: 871 • Ph2: 1988 • 15 sponsors

Ankylosing Spondylitis

Ph3: 801 • Ph2: 1797 • 15 sponsors

Ulcerative Colitis

Ph3: 109 • Ph2: 253 • 15 sponsors

Lupus

Ph3: 73 • Ph2: 174 • 15 sponsors

Psoriasis

Ph3: 56 • Ph2: 32 • 15 sponsors

Atopic Dermatitis

Ph3: 52 • Ph2: 68 • 15 sponsors

Crohn's Disease

Ph3: 43 • Ph2: 52 • 15 sponsors

Psoriatic Arthritis

Ph3: 23 • Ph2: 12 • 15 sponsors

IBD

Ph3: 8 • Ph2: 26 • 11 sponsors

Cardiovascular

3257 active trials

Myocardial Infarction

Ph3: 383 • Ph2: 745 • 15 sponsors

Stroke

Ph3: 145 • Ph2: 138 • 15 sponsors

Atrial Fibrillation

Ph3: 98 • Ph2: 185 • 15 sponsors

Hypertension

Ph3: 91 • Ph2: 103 • 15 sponsors

Heart Failure

Ph3: 63 • Ph2: 104 • 15 sponsors

Coronary Artery Disease

Ph3: 40 • Ph2: 44 • 15 sponsors

Thrombosis

Ph3: 28 • Ph2: 8 • 6 sponsors

Arrhythmia

Ph3: 10 • Ph2: 11 • 4 sponsors

Hypertrophic Cardiomyopathy

Ph3: 8 • Ph2: 9 • 8 sponsors

CNS

2328 active trials

Alzheimer's Disease

Ph3: 85 • Ph2: 199 • 15 sponsors

Major Depression

Ph3: 72 • Ph2: 174 • 15 sponsors

Multiple Sclerosis

Ph3: 71 • Ph2: 138 • 15 sponsors

Migraine

Ph3: 41 • Ph2: 18 • 13 sponsors

Epilepsy

Ph3: 34 • Ph2: 36 • 15 sponsors

Schizophrenia

Ph3: 33 • Ph2: 37 • 15 sponsors

Neuropathy

Ph3: 32 • Ph2: 53 • 15 sponsors

Opioid Use Disorder

Ph3: 29 • Ph2: 57 • 11 sponsors

ALS

Ph3: 28 • Ph2: 68 • 15 sponsors

Parkinson's Disease

Ph3: 24 • Ph2: 100 • 15 sponsors

Anxiety

Ph3: 23 • Ph2: 47 • 15 sponsors

Autism Spectrum Disorder

Ph3: 16 • Ph2: 58 • 12 sponsors

Alcohol Use Disorder

Ph3: 16 • Ph2: 81 • 10 sponsors

Bipolar Disorder

Ph3: 16 • Ph2: 14 • 8 sponsors

PTSD

Ph3: 11 • Ph2: 44 • 5 sponsors

ADHD

Ph3: 11 • Ph2: 12 • 5 sponsors

Huntington's Disease

Ph3: 4 • Ph2: 14 • 8 sponsors

OCD

Ph3: 2 • Ph2: 15 • 1 sponsors

Metabolic

1398 active trials

Obesity

Ph3: 132 • Ph2: 182 • 15 sponsors

Type 2 Diabetes

Ph3: 80 • Ph2: 76 • 15 sponsors

Diabetes (General)

Ph3: 50 • Ph2: 81 • 15 sponsors

Dyslipidemia

Ph3: 30 • Ph2: 26 • 15 sponsors

Diabetic Complications

Ph3: 28 • Ph2: 52 • 15 sponsors

Type 1 Diabetes

Ph3: 26 • Ph2: 70 • 15 sponsors

NASH/NAFLD

Ph3: 21 • Ph2: 59 • 15 sponsors

Infectious Disease

1251 active trials

HIV

Ph3: 72 • Ph2: 123 • 15 sponsors

COVID-19

Ph3: 59 • Ph2: 102 • 15 sponsors

Tuberculosis

Ph3: 41 • Ph2: 43 • 12 sponsors

Influenza

Ph3: 35 • Ph2: 46 • 15 sponsors

Sepsis

Ph3: 30 • Ph2: 44 • 9 sponsors

Hepatitis B

Ph3: 16 • Ph2: 54 • 15 sponsors

RSV

Ph3: 16 • Ph2: 20 • 15 sponsors

Malaria

Ph3: 14 • Ph2: 22 • 8 sponsors

Fungal Infections

Ph3: 13 • Ph2: 14 • 10 sponsors

H. pylori

Ph3: 11 • Ph2: 9 • 2 sponsors

C. difficile

Ph3: 5 • Ph2: 10 • 4 sponsors

Bacterial Infections

Ph3: 4 • Ph2: 8 • 11 sponsors

Hepatitis C

Ph3: 2 • Ph2: 5 • 1 sponsors

Urology

930 active trials

Erectile Dysfunction

Ph3: 203 • Ph2: 382 • 15 sponsors

Benign Prostatic Hyperplasia

Ph3: 9 • Ph2: 7 • 7 sponsors

Overactive Bladder

Ph3: 9 • Ph2: 16 • 6 sponsors

Pain

685 active trials

Acute Pain

Ph3: 100 • Ph2: 130 • 15 sponsors

Postoperative Pain

Ph3: 28 • Ph2: 32 • 11 sponsors

Chronic Pain

Ph3: 16 • Ph2: 31 • 4 sponsors

Neuropathic Pain

Ph3: 14 • Ph2: 33 • 15 sponsors

Respiratory

608 active trials

Asthma

Ph3: 52 • Ph2: 73 • 15 sponsors

Pneumonia

Ph3: 41 • Ph2: 57 • 15 sponsors

COPD

Ph3: 37 • Ph2: 57 • 15 sponsors

Idiopathic Pulmonary Fibrosis

Ph3: 16 • Ph2: 38 • 15 sponsors

Cystic Fibrosis

Ph3: 13 • Ph2: 26 • 15 sponsors

Allergic Rhinitis

Ph3: 13 • Ph2: 16 • 15 sponsors

Rare Disease

542 active trials

Spinal Muscular Atrophy

Ph3: 37 • Ph2: 89 • 15 sponsors

Immune Thrombocytopenia

Ph3: 36 • Ph2: 84 • 15 sponsors

Hemophilia

Ph3: 33 • Ph2: 19 • 15 sponsors

Sickle Cell Disease

Ph3: 22 • Ph2: 62 • 15 sponsors

Duchenne Muscular Dystrophy

Ph3: 9 • Ph2: 32 • 15 sponsors

Fabry Disease

Ph3: 9 • Ph2: 7 • 10 sponsors

CDKL5 Deficiency Disorder

Ph3: 2 • Ph2: 0 • 2 sponsors

Gaucher Disease

Ph3: 1 • Ph2: 6 • 4 sponsors

Mastocytosis

Ph3: 1 • Ph2: 5 • 4 sponsors

Musculoskeletal

424 active trials

Osteoarthritis

Ph3: 82 • Ph2: 122 • 15 sponsors

Osteoporosis

Ph3: 12 • Ph2: 14 • 9 sponsors

Gout

Ph3: 11 • Ph2: 15 • 15 sponsors

Muscle Spasm

Ph3: 5 • Ph2: 5 • 5 sponsors

Renal

302 active trials

Chronic Kidney Disease

Ph3: 59 • Ph2: 78 • 15 sponsors

Acute Kidney Injury

Ph3: 25 • Ph2: 54 • 15 sponsors

Ophthalmology

252 active trials

Age-Related Macular Degeneration

Ph3: 35 • Ph2: 64 • 15 sponsors

Glaucoma

Ph3: 18 • Ph2: 19 • 15 sponsors

Dry Eye

Ph3: 10 • Ph2: 18 • 15 sponsors

Gastrointestinal

250 active trials

Peptic Ulcer

Ph3: 24 • Ph2: 51 • 15 sponsors

Nausea/Vomiting

Ph3: 14 • Ph2: 13 • 4 sponsors

Constipation

Ph3: 11 • Ph2: 20 • 3 sponsors

Diarrhea

Ph3: 7 • Ph2: 11 • 7 sponsors

GERD

Ph3: 6 • Ph2: 4 • 7 sponsors

Women's Health

187 active trials

Infertility

Ph3: 24 • Ph2: 21 • 10 sponsors

Menopause

Ph3: 13 • Ph2: 17 • 8 sponsors

Endometriosis

Ph3: 12 • Ph2: 8 • 9 sponsors

PCOS

Ph3: 10 • Ph2: 10 • 2 sponsors

Contraception

Ph3: 3 • Ph2: 6 • 3 sponsors

Dermatology

157 active trials

Alopecia

Ph3: 25 • Ph2: 35 • 15 sponsors

Acne

Ph3: 14 • Ph2: 16 • 11 sponsors

Vitiligo

Ph3: 11 • Ph2: 19 • 15 sponsors

Skin Infections

Ph3: 1 • Ph2: 0 • 0 sponsors

Rosacea

Ph3: 0 • Ph2: 3 • 1 sponsors

Hepatology

112 active trials

Cirrhosis

Ph3: 24 • Ph2: 33 • 13 sponsors

Liver Failure

Ph3: 5 • Ph2: 16 • 8 sponsors

Sleep

77 active trials

Insomnia

Ph3: 15 • Ph2: 26 • 14 sponsors

Narcolepsy

Ph3: 4 • Ph2: 6 • 5 sponsors

Endocrine

37 active trials

Growth Hormone Deficiency

Ph3: 4 • Ph2: 8 • 2 sponsors

Hypothyroidism

Ph3: 4 • Ph2: 3 • 1 sponsors

Acromegaly

Ph3: 3 • Ph2: 2 • 4 sponsors

Hyperthyroidism

Ph3: 1 • Ph2: 2 • 3 sponsors

Adrenal Insufficiency

Ph3: 0 • Ph2: 0 • 0 sponsors

Hot = Crowded space, many late-stage competitors

Cold = Less competition, potential opportunity or difficult indication